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The map label for this gene is hpt [H]

Identifier: 182681992

GI number: 182681992

Start: 1619144

End: 1619698

Strand: Reverse

Name: hpt [H]

Synonym: XfasM23_1467

Alternate gene names: 182681992

Gene position: 1619698-1619144 (Counterclockwise)

Preceding gene: 182681993

Following gene: 182681991

Centisome position: 63.88

GC content: 51.35

Gene sequence:

>555_bases
ATGTCTAACTTCACTATTTCTCAGATACTTGCTCGGGCTGATTTATTGGTAGACCGTCCCAGTATTGATGTGGCTATTGC
GCATATCGCCGATGACATCGCCAGGGACTATCAGGGGGATGTGCCGTTGTTTGTCACCATCATGCATGGTGGGTTGCCGT
TTGCGGGTCAATTAGCATTGGAGCTGGGCCAGCGTGGTCAGGACATAGAGTTGGATTCCTTACATGCGACGCGTTACCGT
GGTGAGCAGACTGGCGGTGCATTGGTGTGGAGGCATTATCCGGTCAGTGCCATGTCTGGTCGTCGTGTGATTCTGGTTGA
CGATATTCTCGACGAGGGTCATACCTTGTCTGAGATACGTCAGTGGTGCCTAAAGCGGGGGGCTACCGATGTGTCGCTAG
TGGTGCTGATGATTAAATGTCATGATCGTTGTATACCCAATATGAGGGCAGATTATTATGGCGTGGAGGTTCCGGATCGC
TATGTGTTTGGTTTTGGAATGGACATAGCGGGGCAGCTGCGCGGTATCCCGGCAATTTATGCGATGAGGCAATAG

Upstream 100 bases:

>100_bases
TGATCGGTCGCGGTGTGCTTGGTTGGGATGGGCTACTGGCCGATGTTCGTTATGGTTCCATTCAATCCCATTTATTTGAA
CGATTCGGAACATCCACTTG

Downstream 100 bases:

>100_bases
TATGCAAACGATTGCTCTGGCGGTGATTGGTGGTACTGGTGTTTATACGTTGTCTCAGTTCGACGATGTACAGGTGTATG
AGGTTGAGACGTTGTATGGC

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 184; Mature: 183

Protein sequence:

>184_residues
MSNFTISQILARADLLVDRPSIDVAIAHIADDIARDYQGDVPLFVTIMHGGLPFAGQLALELGQRGQDIELDSLHATRYR
GEQTGGALVWRHYPVSAMSGRRVILVDDILDEGHTLSEIRQWCLKRGATDVSLVVLMIKCHDRCIPNMRADYYGVEVPDR
YVFGFGMDIAGQLRGIPAIYAMRQ

Sequences:

>Translated_184_residues
MSNFTISQILARADLLVDRPSIDVAIAHIADDIARDYQGDVPLFVTIMHGGLPFAGQLALELGQRGQDIELDSLHATRYR
GEQTGGALVWRHYPVSAMSGRRVILVDDILDEGHTLSEIRQWCLKRGATDVSLVVLMIKCHDRCIPNMRADYYGVEVPDR
YVFGFGMDIAGQLRGIPAIYAMRQ
>Mature_183_residues
SNFTISQILARADLLVDRPSIDVAIAHIADDIARDYQGDVPLFVTIMHGGLPFAGQLALELGQRGQDIELDSLHATRYRG
EQTGGALVWRHYPVSAMSGRRVILVDDILDEGHTLSEIRQWCLKRGATDVSLVVLMIKCHDRCIPNMRADYYGVEVPDRY
VFGFGMDIAGQLRGIPAIYAMRQ

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20513; Mature: 20382

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNFTISQILARADLLVDRPSIDVAIAHIADDIARDYQGDVPLFVTIMHGGLPFAGQLAL
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHH
ELGQRGQDIELDSLHATRYRGEQTGGALVWRHYPVSAMSGRRVILVDDILDEGHTLSEIR
HHCCCCCCCCCCCCHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCHHHHH
QWCLKRGATDVSLVVLMIKCHDRCIPNMRADYYGVEVPDRYVFGFGMDIAGQLRGIPAIY
HHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCEEEEECCCHHHHHCCCCCEE
AMRQ
EECC
>Mature Secondary Structure 
SNFTISQILARADLLVDRPSIDVAIAHIADDIARDYQGDVPLFVTIMHGGLPFAGQLAL
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHH
ELGQRGQDIELDSLHATRYRGEQTGGALVWRHYPVSAMSGRRVILVDDILDEGHTLSEIR
HHCCCCCCCCCCCCHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCHHHHH
QWCLKRGATDVSLVVLMIKCHDRCIPNMRADYYGVEVPDRYVFGFGMDIAGQLRGIPAIY
HHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCEEEEECCCHHHHHCCCCCEE
AMRQ
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]