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The map label for this gene is acsA [H]

Identifier: 182681913

GI number: 182681913

Start: 1530122

End: 1532065

Strand: Direct

Name: acsA [H]

Synonym: XfasM23_1381

Alternate gene names: 182681913

Gene position: 1530122-1532065 (Clockwise)

Preceding gene: 182681909

Following gene: 182681914

Centisome position: 60.34

GC content: 55.3

Gene sequence:

>1944_bases
ATGTCTGACCTGTACACCATTGATCCGATGTTGGCCAAAGATGCGCACATAGACCGTGCGCACTACAAAACGCTTTACCA
CGAATCCATCGAACAACCAGAAGCATTCTGGAACAAAGTCTCACAGCGCCTGGAGTGGTTTAAAGCGCCGACCAAAATCA
AAAATGTCAGCTACCAACTGGAAGATGTTCACATCCGTTGGTTCGAAGACGGTGAACTCAATGCCAGCGTCAACTGCCTG
GACCGCCATCTCACCTTACGTGGCGACAAAACAGCACTCCTGTTTGAACCTGACGCCCCAGACGCCCCATCCTCACGCAT
CACCTACCGTGAACTATACGAGCGCGTCTGCCAACTCGGTAACGCACTGCGTCACCTCGGCATCGAAAAGGGCGACCGCG
TCACCATCTACTTACCAATGATTCCAGATGCAGTCGTCGCCATCCTCGCTTGCGCACGCATTGGAGCAATCCACTCCGTC
GTCTTCGGCGGTTTTGCAGCAAACTCCATTGCCGACCGAGTGAATGACTGCGGTAGCAAACTCATCATCACCGCAGATGA
AGGCCTGCGTGGTGGCAGAAAAATTCCATTGAAAGCCAATGTCGATGCCGCATTAAAAATCCACGGAACCCAGTCCGTCG
AAACCGTACTCGTCGTGCGTCACACCGGCAGTACGATCAACATGCATACCCCGCGCGACCGCTGGTTCCATGACCTCGTC
GACATCCAAGCAACCGAATGCGCCCCAGAACGCATGAACGCTGAAGACTCCCTTTTCATCCTCTATACCTCCGGCTCCAC
AGGCAAACCCAAAGGAGTCCTGCACACCACCGGCGGCTACCTGGTGTACACCAGCTACACTCATGAAACCGTGTTTGACC
TACGCGAAAACGACATCTACTGGTGCACTGCCGACATCGGCTGGATTACTGGTCACAGCTACATCGTTTACGGCCCCCTA
GCCAATGGCACCACCGTCTTGCTGTTTGAAGGCACCCCCCACTACCCAACCGTGTCGCGCTTCTGGGAAGTGATCGACAA
ACATCACGTCACCCTCTTCTACACCGCGCCGACCGCAATCCGTGCATTGATGCGCGAAGGCGACACTCCTGTAAAAAAAA
CCTCCCGCAAAAGCTTGCGGTTACTTGGCAGCGTTGGCGAACCCATCAACCCCGAAGCCTGGCACTGGTACTACACCATC
GTTGGCAACGGACGTTGTCCCATTGTCGACACCTGGTGGCAAACCGAGACAGGAGGAATCCTCATCACCCCACTGATCGG
TGCAACCGACCTTAAACCAGGCTCAGTCACCCTCCCCTTCTTCGGCATACGCCCCGCCCTAGTGGATACCAACGGACAAA
CACTGGATGGCCCCGCAGCAGGTAACCTAGTCCTGCTCGATTCCTGGCCGGGTCAAATGCGTACCCTCTACGGTGACCAC
CAACGTTTTATAGACACTTACTTTCGCACCTACCCCAATACTTACTTCACCGGCGACGGCTGCCGCCGCGATGCCGACGG
CTATTACTGGATCACTGGACGTGTTGATGACGTCATCAACATCTCCGGCCATCGCATCGGCACCGCCGAAATCGAAAGCA
CACTCGTCGCTCACCCCAAAGTGGCTGAAGCCGCGGTCGTCGGCTTCCCTCACCCGATCAAAGGCCAGGGCATCTACGCA
TACGTGACATTAATTACCGGCGAGACACCCAGCGAAGCACTGCACCAAGAACTGCTCACCTGGGTACGCAAAGAAATCGG
AGCAATCGCCATACCCGATCACGTGCAATGGGCATCCAACCTCCCCAAAACCCGCTCCGGAAAGATCATGCGCCGCATCC
TGCGCAAAATTGCAGAAAACGCACCAGACCAACTCGGTGACACCTCCACACTAGCTGATCCGTCTATCGTCGACTTATTG
CTCAACGAACGACTGAAACACTGA

Upstream 100 bases:

>100_bases
GTGTAACAGTGTGGAAACGATACGGCACACTGCACACCTGTAAGCCGGCACCAGAACGCCAGCCCATTCCCATCGCATTG
ACAACACAACTGAGAATCCC

Downstream 100 bases:

>100_bases
CACACAAGCCCCACCCGGGATGGGGTCATACACCATGTCCTCATCCCAGAATAAACCTCCCAACATCTCCCCTTACACCA
TCTCATTATCTTTGCATCCC

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 647; Mature: 646

Protein sequence:

>647_residues
MSDLYTIDPMLAKDAHIDRAHYKTLYHESIEQPEAFWNKVSQRLEWFKAPTKIKNVSYQLEDVHIRWFEDGELNASVNCL
DRHLTLRGDKTALLFEPDAPDAPSSRITYRELYERVCQLGNALRHLGIEKGDRVTIYLPMIPDAVVAILACARIGAIHSV
VFGGFAANSIADRVNDCGSKLIITADEGLRGGRKIPLKANVDAALKIHGTQSVETVLVVRHTGSTINMHTPRDRWFHDLV
DIQATECAPERMNAEDSLFILYTSGSTGKPKGVLHTTGGYLVYTSYTHETVFDLRENDIYWCTADIGWITGHSYIVYGPL
ANGTTVLLFEGTPHYPTVSRFWEVIDKHHVTLFYTAPTAIRALMREGDTPVKKTSRKSLRLLGSVGEPINPEAWHWYYTI
VGNGRCPIVDTWWQTETGGILITPLIGATDLKPGSVTLPFFGIRPALVDTNGQTLDGPAAGNLVLLDSWPGQMRTLYGDH
QRFIDTYFRTYPNTYFTGDGCRRDADGYYWITGRVDDVINISGHRIGTAEIESTLVAHPKVAEAAVVGFPHPIKGQGIYA
YVTLITGETPSEALHQELLTWVRKEIGAIAIPDHVQWASNLPKTRSGKIMRRILRKIAENAPDQLGDTSTLADPSIVDLL
LNERLKH

Sequences:

>Translated_647_residues
MSDLYTIDPMLAKDAHIDRAHYKTLYHESIEQPEAFWNKVSQRLEWFKAPTKIKNVSYQLEDVHIRWFEDGELNASVNCL
DRHLTLRGDKTALLFEPDAPDAPSSRITYRELYERVCQLGNALRHLGIEKGDRVTIYLPMIPDAVVAILACARIGAIHSV
VFGGFAANSIADRVNDCGSKLIITADEGLRGGRKIPLKANVDAALKIHGTQSVETVLVVRHTGSTINMHTPRDRWFHDLV
DIQATECAPERMNAEDSLFILYTSGSTGKPKGVLHTTGGYLVYTSYTHETVFDLRENDIYWCTADIGWITGHSYIVYGPL
ANGTTVLLFEGTPHYPTVSRFWEVIDKHHVTLFYTAPTAIRALMREGDTPVKKTSRKSLRLLGSVGEPINPEAWHWYYTI
VGNGRCPIVDTWWQTETGGILITPLIGATDLKPGSVTLPFFGIRPALVDTNGQTLDGPAAGNLVLLDSWPGQMRTLYGDH
QRFIDTYFRTYPNTYFTGDGCRRDADGYYWITGRVDDVINISGHRIGTAEIESTLVAHPKVAEAAVVGFPHPIKGQGIYA
YVTLITGETPSEALHQELLTWVRKEIGAIAIPDHVQWASNLPKTRSGKIMRRILRKIAENAPDQLGDTSTLADPSIVDLL
LNERLKH
>Mature_646_residues
SDLYTIDPMLAKDAHIDRAHYKTLYHESIEQPEAFWNKVSQRLEWFKAPTKIKNVSYQLEDVHIRWFEDGELNASVNCLD
RHLTLRGDKTALLFEPDAPDAPSSRITYRELYERVCQLGNALRHLGIEKGDRVTIYLPMIPDAVVAILACARIGAIHSVV
FGGFAANSIADRVNDCGSKLIITADEGLRGGRKIPLKANVDAALKIHGTQSVETVLVVRHTGSTINMHTPRDRWFHDLVD
IQATECAPERMNAEDSLFILYTSGSTGKPKGVLHTTGGYLVYTSYTHETVFDLRENDIYWCTADIGWITGHSYIVYGPLA
NGTTVLLFEGTPHYPTVSRFWEVIDKHHVTLFYTAPTAIRALMREGDTPVKKTSRKSLRLLGSVGEPINPEAWHWYYTIV
GNGRCPIVDTWWQTETGGILITPLIGATDLKPGSVTLPFFGIRPALVDTNGQTLDGPAAGNLVLLDSWPGQMRTLYGDHQ
RFIDTYFRTYPNTYFTGDGCRRDADGYYWITGRVDDVINISGHRIGTAEIESTLVAHPKVAEAAVVGFPHPIKGQGIYAY
VTLITGETPSEALHQELLTWVRKEIGAIAIPDHVQWASNLPKTRSGKIMRRILRKIAENAPDQLGDTSTLADPSIVDLLL
NERLKH

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=667, Percent_Identity=51.5742128935532, Blast_Score=679, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=680, Percent_Identity=50.5882352941176, Blast_Score=674, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=625, Percent_Identity=49.6, Blast_Score=623, Evalue=1e-178,
Organism=Homo sapiens, GI13375727, Length=630, Percent_Identity=36.8253968253968, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI31982927, Length=635, Percent_Identity=25.3543307086614, Blast_Score=196, Evalue=5e-50,
Organism=Homo sapiens, GI42544132, Length=520, Percent_Identity=30.1923076923077, Blast_Score=191, Evalue=3e-48,
Organism=Homo sapiens, GI38505220, Length=519, Percent_Identity=30.0578034682081, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI122937307, Length=517, Percent_Identity=27.852998065764, Blast_Score=176, Evalue=9e-44,
Organism=Homo sapiens, GI115511026, Length=524, Percent_Identity=28.0534351145038, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI58082049, Length=521, Percent_Identity=26.4875239923225, Blast_Score=153, Evalue=6e-37,
Organism=Homo sapiens, GI157311624, Length=524, Percent_Identity=26.9083969465649, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI157311622, Length=524, Percent_Identity=26.9083969465649, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI187761345, Length=572, Percent_Identity=26.2237762237762, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI187761343, Length=572, Percent_Identity=26.2237762237762, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI195947378, Length=424, Percent_Identity=25.7075471698113, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI42544134, Length=339, Percent_Identity=26.2536873156342, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI156151445, Length=564, Percent_Identity=23.0496453900709, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI1790505, Length=641, Percent_Identity=61.1544461778471, Blast_Score=827, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=632, Percent_Identity=36.8670886075949, Blast_Score=384, Evalue=1e-107,
Organism=Escherichia coli, GI221142682, Length=548, Percent_Identity=23.1751824817518, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1788107, Length=542, Percent_Identity=24.3542435424354, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI145693145, Length=528, Percent_Identity=23.6742424242424, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1786810, Length=522, Percent_Identity=22.6053639846743, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71983001, Length=651, Percent_Identity=49.3087557603687, Blast_Score=605, Evalue=1e-173,
Organism=Caenorhabditis elegans, GI71982997, Length=651, Percent_Identity=49.3087557603687, Blast_Score=604, Evalue=1e-173,
Organism=Caenorhabditis elegans, GI17569507, Length=594, Percent_Identity=22.0538720538721, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17558820, Length=547, Percent_Identity=24.6800731261426, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI32563687, Length=555, Percent_Identity=22.8828828828829, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17538037, Length=126, Percent_Identity=35.7142857142857, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17557194, Length=122, Percent_Identity=35.2459016393443, Blast_Score=72, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6323182, Length=641, Percent_Identity=48.5179407176287, Blast_Score=609, Evalue=1e-175,
Organism=Saccharomyces cerevisiae, GI6319264, Length=650, Percent_Identity=48.4615384615385, Blast_Score=582, Evalue=1e-167,
Organism=Saccharomyces cerevisiae, GI6319699, Length=527, Percent_Identity=22.7703984819734, Blast_Score=120, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24667955, Length=660, Percent_Identity=51.3636363636364, Blast_Score=679, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=562, Percent_Identity=55.6939501779359, Blast_Score=632, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=520, Percent_Identity=55.9615384615385, Blast_Score=589, Evalue=1e-168,
Organism=Drosophila melanogaster, GI21355225, Length=657, Percent_Identity=34.3987823439878, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI18859661, Length=505, Percent_Identity=23.3663366336634, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21355181, Length=554, Percent_Identity=22.5631768953069, Blast_Score=90, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24581924, Length=530, Percent_Identity=22.4528301886792, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24656500, Length=549, Percent_Identity=22.9508196721311, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24648260, Length=378, Percent_Identity=24.3386243386243, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24648257, Length=380, Percent_Identity=25.2631578947368, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21356947, Length=374, Percent_Identity=24.0641711229947, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 72223; Mature: 72092

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLYTIDPMLAKDAHIDRAHYKTLYHESIEQPEAFWNKVSQRLEWFKAPTKIKNVSYQL
CCCCEECCCHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHCCCEEEE
EDVHIRWFEDGELNASVNCLDRHLTLRGDKTALLFEPDAPDAPSSRITYRELYERVCQLG
EEEEEEEEECCCCCCEEEEEEEEEEEECCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHH
NALRHLGIEKGDRVTIYLPMIPDAVVAILACARIGAIHSVVFGGFAANSIADRVNDCGSK
HHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCE
LIITADEGLRGGRKIPLKANVDAALKIHGTQSVETVLVVRHTGSTINMHTPRDRWFHDLV
EEEEECCCCCCCEECCEEECCCEEEEEECCCCEEEEEEEEECCCEEEECCCHHHHHHHHH
DIQATECAPERMNAEDSLFILYTSGSTGKPKGVLHTTGGYLVYTSYTHETVFDLRENDIY
CCEECCCCHHHCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEEECCCCEEEEECCCCEE
WCTADIGWITGHSYIVYGPLANGTTVLLFEGTPHYPTVSRFWEVIDKHHVTLFYTAPTAI
EEEECCCEEECCCEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHCCCCEEEEEECHHHH
RALMREGDTPVKKTSRKSLRLLGSVGEPINPEAWHWYYTIVGNGRCPIVDTWWQTETGGI
HHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCEEECCCCCCCCCE
LITPLIGATDLKPGSVTLPFFGIRPALVDTNGQTLDGPAAGNLVLLDSWPGQMRTLYGDH
EEEECCCCCCCCCCEEEEEEECCCEEEECCCCCEECCCCCCCEEEEECCCCHHHHHHCHH
QRFIDTYFRTYPNTYFTGDGCRRDADGYYWITGRVDDVINISGHRIGTAEIESTLVAHPK
HHHHHHHHHHCCCCEECCCCCCCCCCCEEEEECCCCCEEECCCCEEEHHHHHHHHCCCCC
VAEAAVVGFPHPIKGQGIYAYVTLITGETPSEALHQELLTWVRKEIGAIAIPDHVQWASN
HHCEEEECCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHCCEEECCCCHHHHHC
LPKTRSGKIMRRILRKIAENAPDQLGDTSTLADPSIVDLLLNERLKH
CCCCCCCHHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDLYTIDPMLAKDAHIDRAHYKTLYHESIEQPEAFWNKVSQRLEWFKAPTKIKNVSYQL
CCCEECCCHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHCCCEEEE
EDVHIRWFEDGELNASVNCLDRHLTLRGDKTALLFEPDAPDAPSSRITYRELYERVCQLG
EEEEEEEEECCCCCCEEEEEEEEEEEECCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHH
NALRHLGIEKGDRVTIYLPMIPDAVVAILACARIGAIHSVVFGGFAANSIADRVNDCGSK
HHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCE
LIITADEGLRGGRKIPLKANVDAALKIHGTQSVETVLVVRHTGSTINMHTPRDRWFHDLV
EEEEECCCCCCCEECCEEECCCEEEEEECCCCEEEEEEEEECCCEEEECCCHHHHHHHHH
DIQATECAPERMNAEDSLFILYTSGSTGKPKGVLHTTGGYLVYTSYTHETVFDLRENDIY
CCEECCCCHHHCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEEECCCCEEEEECCCCEE
WCTADIGWITGHSYIVYGPLANGTTVLLFEGTPHYPTVSRFWEVIDKHHVTLFYTAPTAI
EEEECCCEEECCCEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHCCCCEEEEEECHHHH
RALMREGDTPVKKTSRKSLRLLGSVGEPINPEAWHWYYTIVGNGRCPIVDTWWQTETGGI
HHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCEEECCCCCCCCCE
LITPLIGATDLKPGSVTLPFFGIRPALVDTNGQTLDGPAAGNLVLLDSWPGQMRTLYGDH
EEEECCCCCCCCCCEEEEEEECCCEEEECCCCCEECCCCCCCEEEEECCCCHHHHHHCHH
QRFIDTYFRTYPNTYFTGDGCRRDADGYYWITGRVDDVINISGHRIGTAEIESTLVAHPK
HHHHHHHHHHCCCCEECCCCCCCCCCCEEEEECCCCCEEECCCCEEEHHHHHHHHCCCCC
VAEAAVVGFPHPIKGQGIYAYVTLITGETPSEALHQELLTWVRKEIGAIAIPDHVQWASN
HHCEEEECCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHCCEEECCCCHHHHHC
LPKTRSGKIMRRILRKIAENAPDQLGDTSTLADPSIVDLLLNERLKH
CCCCCCCHHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]