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The map label for this gene is lepB [H]

Identifier: 182681905

GI number: 182681905

Start: 1521246

End: 1522040

Strand: Direct

Name: lepB [H]

Synonym: XfasM23_1373

Alternate gene names: 182681905

Gene position: 1521246-1522040 (Clockwise)

Preceding gene: 182681904

Following gene: 182681906

Centisome position: 59.99

GC content: 49.69

Gene sequence:

>795_bases
ATGAAATGGTTTGAAATCATCTTAGTAGTACTGACTCTAGGAACAGGCATCATCTCATTGCTGGACAAGCTATTTCTGGC
TAAACGCAGGGCCGCACGCGCCGGCTTGCTTGACACCGAACCGCCGATCATTGACTACTGCCGTTCATTTTTTCCAGTAC
TAGCAGCCGTGCTCATCCTGCGCAGCTTCATCGCAGAGCCTTACAAAATTCCCTCAAGCTCAATGATGCCGAACTTGCTG
ATCGGCGACTTCATTTTGGTCAATAAATTTGCCTATGGCCTGCGCTTGCCAATCACCAACACCAAAATCATTCCAATCAG
CAAACCGAACCGTGGCGACGTGGCCGTATTCAAACCACCACATAAACCTGACGAGAATTGGATCAAACGCGTCATTGGTC
TACCAGGAGATCGCATCGGGTTCCATGGCGACACCCTGTACATCAACGGCGAACCCGTTAAATACATATTAAAAGGCCAA
TACACCGGCAAAAATGCTGGCGTACCGGATCCGACCCTACTCGTCGAAGAGCTACCAAACCATCCACACACCATCCTGGA
ATCAATCGGTCGTGGCCGTGAAGAAGGAGAAGGCGAGTGGGTCGTTCCTCCGGGCCAGTACTTTGTGATGGGTGACAATC
GTGACAACAGCGAGGACAGCAGATTTTGGATAAAAACACATTTTCTTCCAGAACAGAACCTGCGCGGCAAAGCCTTCCTG
ATTTGGCTCAACTGCGAAAATTGGCTCTGCAAGGGAAGCTTTGATCCATCAAGAATCGGAACCGTCATTCGTTGA

Upstream 100 bases:

>100_bases
ACTGGTTCAAGGAACCAAGCAGTAATGACATGACTACTCCACGTCGCTTCTGCCCACTTACTTGCACCATTCCCTATTCC
CATCGTACTAAGGAATGCGA

Downstream 100 bases:

>100_bases
ATGAAAGATTGGTTATTACCAAGGAAAATCTAGTGAAACGCACGCAATATGGAATCACACTGAGATCCACCTTAATTTTT
ACGATCATCATATTTTTTAC

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MKWFEIILVVLTLGTGIISLLDKLFLAKRRAARAGLLDTEPPIIDYCRSFFPVLAAVLILRSFIAEPYKIPSSSMMPNLL
IGDFILVNKFAYGLRLPITNTKIIPISKPNRGDVAVFKPPHKPDENWIKRVIGLPGDRIGFHGDTLYINGEPVKYILKGQ
YTGKNAGVPDPTLLVEELPNHPHTILESIGRGREEGEGEWVVPPGQYFVMGDNRDNSEDSRFWIKTHFLPEQNLRGKAFL
IWLNCENWLCKGSFDPSRIGTVIR

Sequences:

>Translated_264_residues
MKWFEIILVVLTLGTGIISLLDKLFLAKRRAARAGLLDTEPPIIDYCRSFFPVLAAVLILRSFIAEPYKIPSSSMMPNLL
IGDFILVNKFAYGLRLPITNTKIIPISKPNRGDVAVFKPPHKPDENWIKRVIGLPGDRIGFHGDTLYINGEPVKYILKGQ
YTGKNAGVPDPTLLVEELPNHPHTILESIGRGREEGEGEWVVPPGQYFVMGDNRDNSEDSRFWIKTHFLPEQNLRGKAFL
IWLNCENWLCKGSFDPSRIGTVIR
>Mature_264_residues
MKWFEIILVVLTLGTGIISLLDKLFLAKRRAARAGLLDTEPPIIDYCRSFFPVLAAVLILRSFIAEPYKIPSSSMMPNLL
IGDFILVNKFAYGLRLPITNTKIIPISKPNRGDVAVFKPPHKPDENWIKRVIGLPGDRIGFHGDTLYINGEPVKYILKGQ
YTGKNAGVPDPTLLVEELPNHPHTILESIGRGREEGEGEWVVPPGQYFVMGDNRDNSEDSRFWIKTHFLPEQNLRGKAFL
IWLNCENWLCKGSFDPSRIGTVIR

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=307, Percent_Identity=38.1107491856677, Blast_Score=177, Evalue=8e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 29807; Mature: 29807

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKWFEIILVVLTLGTGIISLLDKLFLAKRRAARAGLLDTEPPIIDYCRSFFPVLAAVLIL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
RSFIAEPYKIPSSSMMPNLLIGDFILVNKFAYGLRLPITNTKIIPISKPNRGDVAVFKPP
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCEEECCCCCCEEEECCCCCCCCEEEECCC
HKPDENWIKRVIGLPGDRIGFHGDTLYINGEPVKYILKGQYTGKNAGVPDPTLLVEELPN
CCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCHHHHHHHCCC
HPHTILESIGRGREEGEGEWVVPPGQYFVMGDNRDNSEDSRFWIKTHFLPEQNLRGKAFL
CHHHHHHHHCCCCCCCCCCEEECCCCEEEEECCCCCCCCCEEEEEEECCCCCCCCCCEEE
IWLNCENWLCKGSFDPSRIGTVIR
EEEECCCEEEECCCCHHHHHHCCC
>Mature Secondary Structure
MKWFEIILVVLTLGTGIISLLDKLFLAKRRAARAGLLDTEPPIIDYCRSFFPVLAAVLIL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
RSFIAEPYKIPSSSMMPNLLIGDFILVNKFAYGLRLPITNTKIIPISKPNRGDVAVFKPP
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCEEECCCCCCEEEECCCCCCCCEEEECCC
HKPDENWIKRVIGLPGDRIGFHGDTLYINGEPVKYILKGQYTGKNAGVPDPTLLVEELPN
CCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCHHHHHHHCCC
HPHTILESIGRGREEGEGEWVVPPGQYFVMGDNRDNSEDSRFWIKTHFLPEQNLRGKAFL
CHHHHHHHHCCCCCCCCCCEEECCCCEEEEECCCCCCCCCEEEEEEECCCCCCCCCCEEE
IWLNCENWLCKGSFDPSRIGTVIR
EEEECCCEEEECCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]