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The map label for this gene is msrA

Identifier: 182681457

GI number: 182681457

Start: 1078378

End: 1079028

Strand: Direct

Name: msrA

Synonym: XfasM23_0908

Alternate gene names: 182681457

Gene position: 1078378-1079028 (Clockwise)

Preceding gene: 182681456

Following gene: 182681458

Centisome position: 42.53

GC content: 49.62

Gene sequence:

>651_bases
ATGGTAATGACAATCGAAGCCCTCAAGCATCTAGGGCGCGTTGATGAATCTCGGGTAGGACGTACTGAACCATTGCCATT
GGATAATCGCCATTACGTCAATGGCCATCCACTATGCGATTCCTTCCCGGGTTTGGCGCTGATCCAATTTGGATTAGGTT
GTTTTTGGGGTGCAGAACGTCTGTTTTGGCAATTGCCTGGAGTATTCAGTACAGCAGCAGGTTATGCTGGCGGCGGGGTG
CCATATCCGACTTATCGTGAAGTCTGTTCTGGGGAGACGGGGCATGCAGAGGTTGTCTTGGTAGTGTATGACCACACTGT
TATTTCATTTGAGCAGTTGTTGCAGACATTTTGGGAATCCCATGATCCCACACAAGGGATGCGCCAGGGCAATGATATCG
GTACCCAGTACCGTTCTGTGATCCATTGCACTACATCTGAGCAATATGCTGCAGCATCAGCCAGCCGAGAGGTTTACCAG
CAACAACTAAATACTGCTGGTTACACTGCAATTACGACAGAGATACTCCATCCGGCACCACCTTTCTACTATGCTGAGAA
TGAGCACCAACAATATCTTGCAAAACATCCCAACGGCTATTGCGGACTGGGAGGGACTGGAGTGACCTGCGCGATTCGCT
TGCAGGTTTGA

Upstream 100 bases:

>100_bases
TCGGTATCTGTGCCGTGTTTCCGTTTCGCGTTGTAACAGGGTTTGCAAGCCTGTCTGCACATTGCTGCACAGCATGAACA
TATTCGATCGAGGTTACATC

Downstream 100 bases:

>100_bases
GTGGCGATATAGAGAGTTCCATATCCACAGGCTCAGGTACATGCGGCCAGCCAGTCCTTGAATTGCAATGGTGGAGTGAA
AAGAGCCAGCCATCGCATAC

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MVMTIEALKHLGRVDESRVGRTEPLPLDNRHYVNGHPLCDSFPGLALIQFGLGCFWGAERLFWQLPGVFSTAAGYAGGGV
PYPTYREVCSGETGHAEVVLVVYDHTVISFEQLLQTFWESHDPTQGMRQGNDIGTQYRSVIHCTTSEQYAAASASREVYQ
QQLNTAGYTAITTEILHPAPPFYYAENEHQQYLAKHPNGYCGLGGTGVTCAIRLQV

Sequences:

>Translated_216_residues
MVMTIEALKHLGRVDESRVGRTEPLPLDNRHYVNGHPLCDSFPGLALIQFGLGCFWGAERLFWQLPGVFSTAAGYAGGGV
PYPTYREVCSGETGHAEVVLVVYDHTVISFEQLLQTFWESHDPTQGMRQGNDIGTQYRSVIHCTTSEQYAAASASREVYQ
QQLNTAGYTAITTEILHPAPPFYYAENEHQQYLAKHPNGYCGLGGTGVTCAIRLQV
>Mature_216_residues
MVMTIEALKHLGRVDESRVGRTEPLPLDNRHYVNGHPLCDSFPGLALIQFGLGCFWGAERLFWQLPGVFSTAAGYAGGGV
PYPTYREVCSGETGHAEVVLVVYDHTVISFEQLLQTFWESHDPTQGMRQGNDIGTQYRSVIHCTTSEQYAAASASREVYQ
QQLNTAGYTAITTEILHPAPPFYYAENEHQQYLAKHPNGYCGLGGTGVTCAIRLQV

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=202, Percent_Identity=56.9306930693069, Blast_Score=234, Evalue=5e-62,
Organism=Homo sapiens, GI208609995, Length=187, Percent_Identity=58.8235294117647, Blast_Score=225, Evalue=2e-59,
Organism=Homo sapiens, GI208609993, Length=200, Percent_Identity=43.5, Blast_Score=155, Evalue=3e-38,
Organism=Escherichia coli, GI1790665, Length=196, Percent_Identity=59.1836734693878, Blast_Score=230, Evalue=6e-62,
Organism=Caenorhabditis elegans, GI17533973, Length=143, Percent_Identity=34.2657342657343, Blast_Score=81, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6320881, Length=163, Percent_Identity=33.7423312883436, Blast_Score=92, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24664627, Length=160, Percent_Identity=40.625, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24664631, Length=160, Percent_Identity=39.375, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45553131, Length=141, Percent_Identity=41.8439716312057, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_XYLF2 (B2I4P8)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001829617.1
- ProteinModelPortal:   B2I4P8
- SMR:   B2I4P8
- GeneID:   6203315
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_0908
- HOGENOM:   HBG748152
- OMA:   TRHITTE
- ProtClustDB:   PRK00058
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 23858; Mature: 23858

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: ACT_SITE 54-54

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMTIEALKHLGRVDESRVGRTEPLPLDNRHYVNGHPLCDSFPGLALIQFGLGCFWGAER
CEEEHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LFWQLPGVFSTAAGYAGGGVPYPTYREVCSGETGHAEVVLVVYDHTVISFEQLLQTFWES
HHHHCCCHHHHHCCCCCCCCCCCHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHHC
HDPTQGMRQGNDIGTQYRSVIHCTTSEQYAAASASREVYQQQLNTAGYTAITTEILHPAP
CCCHHHHHCCCHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCC
PFYYAENEHQQYLAKHPNGYCGLGGTGVTCAIRLQV
CCEECCCHHHHHHHHCCCCCCCCCCCCEEEEEEEEC
>Mature Secondary Structure
MVMTIEALKHLGRVDESRVGRTEPLPLDNRHYVNGHPLCDSFPGLALIQFGLGCFWGAER
CEEEHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LFWQLPGVFSTAAGYAGGGVPYPTYREVCSGETGHAEVVLVVYDHTVISFEQLLQTFWES
HHHHCCCHHHHHCCCCCCCCCCCHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHHC
HDPTQGMRQGNDIGTQYRSVIHCTTSEQYAAASASREVYQQQLNTAGYTAITTEILHPAP
CCCHHHHHCCCHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCC
PFYYAENEHQQYLAKHPNGYCGLGGTGVTCAIRLQV
CCEECCCHHHHHHHHCCCCCCCCCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA