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The map label for this gene is gltP [H]

Identifier: 182681458

GI number: 182681458

Start: 1079624

End: 1080922

Strand: Direct

Name: gltP [H]

Synonym: XfasM23_0909

Alternate gene names: 182681458

Gene position: 1079624-1080922 (Clockwise)

Preceding gene: 182681457

Following gene: 182681459

Centisome position: 42.58

GC content: 51.73

Gene sequence:

>1299_bases
ATGACTTCATCTGCTGCTGCTTCTCATTCCGGCCTGCCAATGCACTGGAAGATGAGCATAGGTTTTCTTGGCGGTTTGCT
AATCGGCTTGGCTGCGCACTATTGGGTTGGTGCTGATGTCGTTTGGGTGCAACATGCCACCCATTATCTCACCACACCGT
TTTCCAAGTTATTCCTCAATCTGATCTTCATGCTGATTGTGCCCTTGATGTTCTCGGCACTCGTGGTCGGCGTGGCCGAA
ATGGGGGACATCAGCGCACTCGGTCGCATCGGTTGGCGTACCCTGGGTTATACCGTTGTGCTCTCATCCGTGGCTGTGTT
AATCGGATTGGTGCTTGTCAACGTACTCAAACCAGGTGTGGGTGTCGATCCGCAGTTGGCGCAGCAGCTGCTTAGTGAAA
ATGCGGAGCGTAGCCGCCAGATCGTCGATTCCACAGATACCCAAATCCACGGCATGGATATGCTGTTATCAATCGTACCG
AGCAACGTAGTCGCAGCGGCTTCCAGCAACGATGCCATTTTATCGCTGATGTTCTTCACGATCATGTTTGGCATTGGTAT
GGTTCTGGTGCCGCAGGAGAAGGTAGAGACACTGAAGCGTGCTATTGAGGGTGTATTTGAAGTTTCGATGGTCTTGATTG
GACTGGTGATCCGTCTTGCACCCTATGCAGTAGCCTGCTTTATGTTCAACTTGACGTCGTTATTCGGCCTAGAGTTGTTG
ATACGGTTGGCGGCTTATGTCGGTGTTGTGGTCCTGGGGTTGTCGCTGCATATGTTTGTTACCTATGGTTTAGCAGTATG
GTGGGCGGGGCGTTCACCGCTGCGTTTTTTCCGCGAAACTCAAGAAGCAACCTTGATGGCGTTCTCTACAGCCTCTAGCA
ATGCCACTTTGCCAACCGCGCTGCGTGTTGCTGACGATATGAAGCTACCGAAAAAAATTTCGCGTTTCGTACTGACCATT
GGTGCAACTGCTAATCAAAATGGCACGGCATTGTTTGAAGGTTTGACCGTCATTTTCCTGGCGCAATTTTTTGGTGTGGA
CCTCAGTTTTAGTCAGCAAGCGATGGTCATGGCAGTATGCATCCTGGGTGGCATCGGCACCGCTGGTGTACCGTCCGGCT
CGCTTCCAGTGGTGGCACTCATCTGTGCCATGGTCGGGGTTGATCCTGTCGGTATTGGGCTGATTTTGGGGGTGAACCAC
TTCCTGGACATGTGCCGCACTGCATTAAATGTGACTGGCGATCTAGCATTGACTACATTGGTGTGCAGAGGCGAGCCTCA
GGCAGAAGGAAGTGCTTAG

Upstream 100 bases:

>100_bases
TCCTGCCTTTGTTGTATCAGTGTGAGTGTGATTGCGTGTGTGGTTTAGCGATAATGTTTGCTACTCTTCGCTTCCATCTT
TGCCTGAGAGGCTAGAATTG

Downstream 100 bases:

>100_bases
TGGCTTATGGAATCAGTGGGCCTTGATCTGAGATCGTGTCACTGTGGGACAATAGTGGGGCATCGTATGACTTTCACGAT
GCCCCTTTCTCTACCGTCGA

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MTSSAAASHSGLPMHWKMSIGFLGGLLIGLAAHYWVGADVVWVQHATHYLTTPFSKLFLNLIFMLIVPLMFSALVVGVAE
MGDISALGRIGWRTLGYTVVLSSVAVLIGLVLVNVLKPGVGVDPQLAQQLLSENAERSRQIVDSTDTQIHGMDMLLSIVP
SNVVAAASSNDAILSLMFFTIMFGIGMVLVPQEKVETLKRAIEGVFEVSMVLIGLVIRLAPYAVACFMFNLTSLFGLELL
IRLAAYVGVVVLGLSLHMFVTYGLAVWWAGRSPLRFFRETQEATLMAFSTASSNATLPTALRVADDMKLPKKISRFVLTI
GATANQNGTALFEGLTVIFLAQFFGVDLSFSQQAMVMAVCILGGIGTAGVPSGSLPVVALICAMVGVDPVGIGLILGVNH
FLDMCRTALNVTGDLALTTLVCRGEPQAEGSA

Sequences:

>Translated_432_residues
MTSSAAASHSGLPMHWKMSIGFLGGLLIGLAAHYWVGADVVWVQHATHYLTTPFSKLFLNLIFMLIVPLMFSALVVGVAE
MGDISALGRIGWRTLGYTVVLSSVAVLIGLVLVNVLKPGVGVDPQLAQQLLSENAERSRQIVDSTDTQIHGMDMLLSIVP
SNVVAAASSNDAILSLMFFTIMFGIGMVLVPQEKVETLKRAIEGVFEVSMVLIGLVIRLAPYAVACFMFNLTSLFGLELL
IRLAAYVGVVVLGLSLHMFVTYGLAVWWAGRSPLRFFRETQEATLMAFSTASSNATLPTALRVADDMKLPKKISRFVLTI
GATANQNGTALFEGLTVIFLAQFFGVDLSFSQQAMVMAVCILGGIGTAGVPSGSLPVVALICAMVGVDPVGIGLILGVNH
FLDMCRTALNVTGDLALTTLVCRGEPQAEGSA
>Mature_431_residues
TSSAAASHSGLPMHWKMSIGFLGGLLIGLAAHYWVGADVVWVQHATHYLTTPFSKLFLNLIFMLIVPLMFSALVVGVAEM
GDISALGRIGWRTLGYTVVLSSVAVLIGLVLVNVLKPGVGVDPQLAQQLLSENAERSRQIVDSTDTQIHGMDMLLSIVPS
NVVAAASSNDAILSLMFFTIMFGIGMVLVPQEKVETLKRAIEGVFEVSMVLIGLVIRLAPYAVACFMFNLTSLFGLELLI
RLAAYVGVVVLGLSLHMFVTYGLAVWWAGRSPLRFFRETQEATLMAFSTASSNATLPTALRVADDMKLPKKISRFVLTIG
ATANQNGTALFEGLTVIFLAQFFGVDLSFSQQAMVMAVCILGGIGTAGVPSGSLPVVALICAMVGVDPVGIGLILGVNHF
LDMCRTALNVTGDLALTTLVCRGEPQAEGSA

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI4827012, Length=437, Percent_Identity=27.4599542334096, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI40254478, Length=419, Percent_Identity=26.9689737470167, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI66773030, Length=387, Percent_Identity=26.6149870801034, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI21314632, Length=405, Percent_Identity=27.4074074074074, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI5032093, Length=381, Percent_Identity=30.1837270341207, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI169790839, Length=432, Percent_Identity=27.0833333333333, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI223468564, Length=248, Percent_Identity=33.0645161290323, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI223468566, Length=248, Percent_Identity=33.0645161290323, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI194239697, Length=189, Percent_Identity=34.9206349206349, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI301601644, Length=146, Percent_Identity=34.9315068493151, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI262359914, Length=370, Percent_Identity=25.9459459459459, Blast_Score=86, Evalue=9e-17,
Organism=Escherichia coli, GI1790514, Length=415, Percent_Identity=31.3253012048193, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1789947, Length=375, Percent_Identity=28, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1788024, Length=414, Percent_Identity=26.0869565217391, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1789473, Length=266, Percent_Identity=28.1954887218045, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71996953, Length=439, Percent_Identity=28.4738041002278, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI71983106, Length=411, Percent_Identity=29.1970802919708, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI71983099, Length=411, Percent_Identity=29.1970802919708, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17537407, Length=391, Percent_Identity=28.1329923273657, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI193206505, Length=403, Percent_Identity=29.7766749379653, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17541374, Length=403, Percent_Identity=28.0397022332506, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI193206654, Length=405, Percent_Identity=25.9259259259259, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24583025, Length=428, Percent_Identity=28.7383177570093, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI17137668, Length=428, Percent_Identity=28.7383177570093, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI24583023, Length=428, Percent_Identity=28.7383177570093, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI281360481, Length=415, Percent_Identity=25.0602409638554, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281360483, Length=415, Percent_Identity=25.0602409638554, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17137666, Length=415, Percent_Identity=25.0602409638554, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45927; Mature: 45796

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSAAASHSGLPMHWKMSIGFLGGLLIGLAAHYWVGADVVWVQHATHYLTTPFSKLFLN
CCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHH
LIFMLIVPLMFSALVVGVAEMGDISALGRIGWRTLGYTVVLSSVAVLIGLVLVNVLKPGV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GVDPQLAQQLLSENAERSRQIVDSTDTQIHGMDMLLSIVPSNVVAAASSNDAILSLMFFT
CCCHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHCCHHEEECCCCHHHHHHHHHH
IMFGIGMVLVPQEKVETLKRAIEGVFEVSMVLIGLVIRLAPYAVACFMFNLTSLFGLELL
HHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRLAAYVGVVVLGLSLHMFVTYGLAVWWAGRSPLRFFRETQEATLMAFSTASSNATLPTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEEECCCCCCCHHH
LRVADDMKLPKKISRFVLTIGATANQNGTALFEGLTVIFLAQFFGVDLSFSQQAMVMAVC
HHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ILGGIGTAGVPSGSLPVVALICAMVGVDPVGIGLILGVNHFLDMCRTALNVTGDLALTTL
HHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
VCRGEPQAEGSA
EECCCCCCCCCC
>Mature Secondary Structure 
TSSAAASHSGLPMHWKMSIGFLGGLLIGLAAHYWVGADVVWVQHATHYLTTPFSKLFLN
CCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHH
LIFMLIVPLMFSALVVGVAEMGDISALGRIGWRTLGYTVVLSSVAVLIGLVLVNVLKPGV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GVDPQLAQQLLSENAERSRQIVDSTDTQIHGMDMLLSIVPSNVVAAASSNDAILSLMFFT
CCCHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHCCHHEEECCCCHHHHHHHHHH
IMFGIGMVLVPQEKVETLKRAIEGVFEVSMVLIGLVIRLAPYAVACFMFNLTSLFGLELL
HHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRLAAYVGVVVLGLSLHMFVTYGLAVWWAGRSPLRFFRETQEATLMAFSTASSNATLPTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEEECCCCCCCHHH
LRVADDMKLPKKISRFVLTIGATANQNGTALFEGLTVIFLAQFFGVDLSFSQQAMVMAVC
HHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ILGGIGTAGVPSGSLPVVALICAMVGVDPVGIGLILGVNHFLDMCRTALNVTGDLALTTL
HHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
VCRGEPQAEGSA
EECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]