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The map label for this gene is maeB [H]

Identifier: 182680830

GI number: 182680830

Start: 346452

End: 348746

Strand: Direct

Name: maeB [H]

Synonym: XfasM23_0265

Alternate gene names: 182680830

Gene position: 346452-348746 (Clockwise)

Preceding gene: 182680829

Following gene: 182680832

Centisome position: 13.66

GC content: 54.2

Gene sequence:

>2295_bases
ATGTCAAACGATACATTTAAACAGGCGGCGATTGATTATCACCGCACGCAGCCAGCCGGTAAGATCAAGGTGGTCGCAAC
CAAGCCAATGCTGACGCAGCGTGATTTGTCGTTGGCGTATTCCCCAGGTGTGGCGTTTGCTTGCCAAGCGATTGTCGAAA
ATCCTCAGCAGGCAAGTGAGCTCACGGCGCGCGGTAACTTGGTTGCGGTGATTTCCAACGGCACTGCGGTGTTGGGTTTG
GGGAACATTGGTCCACTGGCGGGTAAGCCGGTGATGGAAGGCAAGGGCGTGCTGTTTCAGAAGTTCGCTGGCATTGATGT
GTTTGATATCGAGATTGACGAGTCTGACCCGGATAAGTTGGTAGACATTATTGCCAGTCTGGAGCCGACTTTCGGTGGTG
TGAACTTAGAGGACATCAAAGCCCCGGAATGTTTCATCGTCGAGCGTAAGTTGCGTGAGCGGATGAGTATTCCGGTCTTT
CACGATGATCAGCACGGTACTGCGATCATTGTCGGTGCGGCTGTGCTTAACGCGATGGTCATCACTGGAAAGAAGATCGG
AGAGGTGAAGTTGGCAACCACCGGCATGGGAGCGGCGGGTGTCTCCTGCGTCAATATGCTGGTTTCGCTGGGGTTGAACC
CGGATAACATTCTGGCTTATGACCGGGAGGGGGTGATCCATACTGGCCGTACCGATTTGGATCCGGAGAAGCAGCGTTAT
GCACGGGATACGGATAAGCGCACTTTGGCGGAGATTGTGGAGGGTGCGGATATTTTTCTTGGGCTTTCTGCTGCTGGCAT
CTTGACGCCAGAGATGGTGGCGACGATGGCGCCTGACCCAGTGATCTTTGCCTTGGCCAATCCCATTCCGGAGATCATGC
CTGAGGTGGTATGTGCGGTGCGTACGGATGCCATTATTGGAACTGGGCGTTCGGATTATCCAAATCAAATCAACAATGTT
TTGTGTTTTCCCTACTTGTTCCGTGGTGCGTTGGATGTGGGTGCGACCACGATCAATGAGGAGATGAAGATTGCTTGCGT
TAAGGCGATTGCTGCGTTAGCACGGTGTGAGGCTTCCGATCTGGGCGCTGCTTACGGTGGTGAGACGCCAAGTTTTGGCC
GGGAGTATTTGATTCCGCGTCCGCTTGACCCACGTTTATTAGTGGAACTGTCTTCGGCGGTGGCGCAGGCGGCGATGGAT
TCTGGGGTGGCGACTCGCCCGATTACGGATATGAGCGCCTACCATGACAAGTTGAGCCAATTTGTTTACCGCACCAGCTT
GATGATGAAGCCGGTTTACGATCGTGCGCGTGCTGATAAGCAGCGGGTGGTGTATGCCGAGGGTGAGGAAGAGGTGATTC
TGCGTGCGGTGCAGAATGTGATTGACGAAGGGTTGGCGTTCCCGATTCTGATTGGTCGTCCGGATGTGATCGAAAGCAGG
ATTCAGCGCATGGGGCTGCGCATGAAGGTTGGTGTCGATTTCGAGGTGACCAATATCCACGATGATCCTCGCTTCAACGA
TTATTGGCAGTACTACCATGGGGTGACGGAGCGTCGTGGGGTGACGGTCAGTGCGGCGAAGGAGTTAATGCGTTCGCGTC
CTACTCTGATTGCCTCGGTGATGGTTGCACGTGGTGAGGCCGATGCGTTGTTGACTGGAGCCGTCGGTCGTTTCCATAAG
AGGCTCGGTTATGCGCGCAGTGTGATCCCTCTGGAACCTCGGGTGAGTTCAACGGCGGCGATGACAGGCGTGATTAACCA
ACATGGTGCGTTTTTCTTTGTGGATACCCATGTGCAGGAAGATCCGAGCGCCGAGCAGATTACCGAGGCCACGTTGCAGG
CGTGTTACCGCTTGAGGTTGTTTGGCATTGAGCCGAGTGTGGCGTTACTGTCGCACAGTAATTTTGGTAGTCACGATTCG
CGTGATGCATTGAAGATGCGCCAGGTGCGTGAGCTGCTGCTCAAGCGTAGCCCCAGGTTGAATATTGATGGGGAGATGCA
GGCGGATACAGCGTGGGATGAGGTGCTGCGCGAGCGCATTATGCCCAATACAACGTTGAAAGGTCGGGCTAATCTGTTTG
TGTTTCCAAATTTGGAGGCGGCCAATATTGCTTACAACTTGGTGCGTGTGTTTACCGATGGTGTGGCGATTGGCCCGATT
TTGATGGGTATTTCCAAGGCAGTGCATATTTTGACGAGTAGCACCACGTCACGGCGGGTGATGAATATGACGGCAATCGC
TGCGGTGGATGCGCAGATTCGCAAGCAGTTTGAAGGCGGGAAGCGCGGGGGATAA

Upstream 100 bases:

>100_bases
GCCGTATTTAGCATCGGCTGTCACTGTTGCGTGACAGGTCTCGTCATTGGTATGTAGTTAGAGTGGGCTCTTCCTACGCC
TATTTAGGTATTCAAGCGCG

Downstream 100 bases:

>100_bases
ATGAAACGACGCCGGGTGTGATGCAGCGTGCTGAGGCATTGATGTTTTTTTGAGTGTATTTGAGGAACGTTTTTGTTCCT
CCACTCAGCAGCGTTTGTTT

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 764; Mature: 763

Protein sequence:

>764_residues
MSNDTFKQAAIDYHRTQPAGKIKVVATKPMLTQRDLSLAYSPGVAFACQAIVENPQQASELTARGNLVAVISNGTAVLGL
GNIGPLAGKPVMEGKGVLFQKFAGIDVFDIEIDESDPDKLVDIIASLEPTFGGVNLEDIKAPECFIVERKLRERMSIPVF
HDDQHGTAIIVGAAVLNAMVITGKKIGEVKLATTGMGAAGVSCVNMLVSLGLNPDNILAYDREGVIHTGRTDLDPEKQRY
ARDTDKRTLAEIVEGADIFLGLSAAGILTPEMVATMAPDPVIFALANPIPEIMPEVVCAVRTDAIIGTGRSDYPNQINNV
LCFPYLFRGALDVGATTINEEMKIACVKAIAALARCEASDLGAAYGGETPSFGREYLIPRPLDPRLLVELSSAVAQAAMD
SGVATRPITDMSAYHDKLSQFVYRTSLMMKPVYDRARADKQRVVYAEGEEEVILRAVQNVIDEGLAFPILIGRPDVIESR
IQRMGLRMKVGVDFEVTNIHDDPRFNDYWQYYHGVTERRGVTVSAAKELMRSRPTLIASVMVARGEADALLTGAVGRFHK
RLGYARSVIPLEPRVSSTAAMTGVINQHGAFFFVDTHVQEDPSAEQITEATLQACYRLRLFGIEPSVALLSHSNFGSHDS
RDALKMRQVRELLLKRSPRLNIDGEMQADTAWDEVLRERIMPNTTLKGRANLFVFPNLEAANIAYNLVRVFTDGVAIGPI
LMGISKAVHILTSSTTSRRVMNMTAIAAVDAQIRKQFEGGKRGG

Sequences:

>Translated_764_residues
MSNDTFKQAAIDYHRTQPAGKIKVVATKPMLTQRDLSLAYSPGVAFACQAIVENPQQASELTARGNLVAVISNGTAVLGL
GNIGPLAGKPVMEGKGVLFQKFAGIDVFDIEIDESDPDKLVDIIASLEPTFGGVNLEDIKAPECFIVERKLRERMSIPVF
HDDQHGTAIIVGAAVLNAMVITGKKIGEVKLATTGMGAAGVSCVNMLVSLGLNPDNILAYDREGVIHTGRTDLDPEKQRY
ARDTDKRTLAEIVEGADIFLGLSAAGILTPEMVATMAPDPVIFALANPIPEIMPEVVCAVRTDAIIGTGRSDYPNQINNV
LCFPYLFRGALDVGATTINEEMKIACVKAIAALARCEASDLGAAYGGETPSFGREYLIPRPLDPRLLVELSSAVAQAAMD
SGVATRPITDMSAYHDKLSQFVYRTSLMMKPVYDRARADKQRVVYAEGEEEVILRAVQNVIDEGLAFPILIGRPDVIESR
IQRMGLRMKVGVDFEVTNIHDDPRFNDYWQYYHGVTERRGVTVSAAKELMRSRPTLIASVMVARGEADALLTGAVGRFHK
RLGYARSVIPLEPRVSSTAAMTGVINQHGAFFFVDTHVQEDPSAEQITEATLQACYRLRLFGIEPSVALLSHSNFGSHDS
RDALKMRQVRELLLKRSPRLNIDGEMQADTAWDEVLRERIMPNTTLKGRANLFVFPNLEAANIAYNLVRVFTDGVAIGPI
LMGISKAVHILTSSTTSRRVMNMTAIAAVDAQIRKQFEGGKRGG
>Mature_763_residues
SNDTFKQAAIDYHRTQPAGKIKVVATKPMLTQRDLSLAYSPGVAFACQAIVENPQQASELTARGNLVAVISNGTAVLGLG
NIGPLAGKPVMEGKGVLFQKFAGIDVFDIEIDESDPDKLVDIIASLEPTFGGVNLEDIKAPECFIVERKLRERMSIPVFH
DDQHGTAIIVGAAVLNAMVITGKKIGEVKLATTGMGAAGVSCVNMLVSLGLNPDNILAYDREGVIHTGRTDLDPEKQRYA
RDTDKRTLAEIVEGADIFLGLSAAGILTPEMVATMAPDPVIFALANPIPEIMPEVVCAVRTDAIIGTGRSDYPNQINNVL
CFPYLFRGALDVGATTINEEMKIACVKAIAALARCEASDLGAAYGGETPSFGREYLIPRPLDPRLLVELSSAVAQAAMDS
GVATRPITDMSAYHDKLSQFVYRTSLMMKPVYDRARADKQRVVYAEGEEEVILRAVQNVIDEGLAFPILIGRPDVIESRI
QRMGLRMKVGVDFEVTNIHDDPRFNDYWQYYHGVTERRGVTVSAAKELMRSRPTLIASVMVARGEADALLTGAVGRFHKR
LGYARSVIPLEPRVSSTAAMTGVINQHGAFFFVDTHVQEDPSAEQITEATLQACYRLRLFGIEPSVALLSHSNFGSHDSR
DALKMRQVRELLLKRSPRLNIDGEMQADTAWDEVLRERIMPNTTLKGRANLFVFPNLEAANIAYNLVRVFTDGVAIGPIL
MGISKAVHILTSSTTSRRVMNMTAIAAVDAQIRKQFEGGKRGG

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI62420882, Length=397, Percent_Identity=24.9370277078086, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI62420880, Length=397, Percent_Identity=24.9370277078086, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI239049447, Length=397, Percent_Identity=24.9370277078086, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI4505143, Length=395, Percent_Identity=24.0506329113924, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1788806, Length=756, Percent_Identity=57.2751322751323, Blast_Score=885, Evalue=0.0,
Organism=Escherichia coli, GI1788800, Length=315, Percent_Identity=27.9365079365079, Blast_Score=132, Evalue=7e-32,
Organism=Escherichia coli, GI1788635, Length=346, Percent_Identity=26.878612716763, Blast_Score=129, Evalue=9e-31,
Organism=Escherichia coli, GI87081919, Length=237, Percent_Identity=25.7383966244726, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17537199, Length=397, Percent_Identity=26.9521410579345, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322823, Length=245, Percent_Identity=28.9795918367347, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21356279, Length=506, Percent_Identity=26.4822134387352, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI281362674, Length=490, Percent_Identity=27.1428571428571, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI281362672, Length=490, Percent_Identity=27.1428571428571, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI78707242, Length=410, Percent_Identity=25.1219512195122, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI78707238, Length=410, Percent_Identity=25.1219512195122, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI78707240, Length=410, Percent_Identity=25.1219512195122, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 83156; Mature: 83025

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNDTFKQAAIDYHRTQPAGKIKVVATKPMLTQRDLSLAYSPGVAFACQAIVENPQQASE
CCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCEEECCCHHHHHHHHHCCHHHHHH
LTARGNLVAVISNGTAVLGLGNIGPLAGKPVMEGKGVLFQKFAGIDVFDIEIDESDPDKL
HHHCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHCCCEEEEEEECCCCHHHH
VDIIASLEPTFGGVNLEDIKAPECFIVERKLRERMSIPVFHDDQHGTAIIVGAAVLNAMV
HHHHHHCCCCCCCCCHHHCCCCCCEEHHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHHH
ITGKKIGEVKLATTGMGAAGVSCVNMLVSLGLNPDNILAYDREGVIHTGRTDLDPEKQRY
CCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCCCHHHHHH
ARDTDKRTLAEIVEGADIFLGLSAAGILTPEMVATMAPDPVIFALANPIPEIMPEVVCAV
HCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHCCCCCEEEEECCCHHHHHHHHHHHH
RTDAIIGTGRSDYPNQINNVLCFPYLFRGALDVGATTINEEMKIACVKAIAALARCEASD
HCCEEEECCCCCCCHHHHCEEEHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHCCHHH
LGAAYGGETPSFGREYLIPRPLDPRLLVELSSAVAQAAMDSGVATRPITDMSAYHDKLSQ
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
FVYRTSLMMKPVYDRARADKQRVVYAEGEEEVILRAVQNVIDEGLAFPILIGRPDVIESR
HHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHH
IQRMGLRMKVGVDFEVTNIHDDPRFNDYWQYYHGVTERRGVTVSAAKELMRSRPTLIASV
HHHCCCEEEECCEEEEECCCCCCCCCHHHHHHCCHHHHCCEEHHHHHHHHHCCCHHHHHH
MVARGEADALLTGAVGRFHKRLGYARSVIPLEPRVSSTAAMTGVINQHGAFFFVDTHVQE
HHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCC
DPSAEQITEATLQACYRLRLFGIEPSVALLSHSNFGSHDSRDALKMRQVRELLLKRSPRL
CCCHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCC
NIDGEMQADTAWDEVLRERIMPNTTLKGRANLFVFPNLEAANIAYNLVRVFTDGVAIGPI
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCHHHHH
LMGISKAVHILTSSTTSRRVMNMTAIAAVDAQIRKQFEGGKRGG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SNDTFKQAAIDYHRTQPAGKIKVVATKPMLTQRDLSLAYSPGVAFACQAIVENPQQASE
CCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCEEECCCHHHHHHHHHCCHHHHHH
LTARGNLVAVISNGTAVLGLGNIGPLAGKPVMEGKGVLFQKFAGIDVFDIEIDESDPDKL
HHHCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHCCCEEEEEEECCCCHHHH
VDIIASLEPTFGGVNLEDIKAPECFIVERKLRERMSIPVFHDDQHGTAIIVGAAVLNAMV
HHHHHHCCCCCCCCCHHHCCCCCCEEHHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHHH
ITGKKIGEVKLATTGMGAAGVSCVNMLVSLGLNPDNILAYDREGVIHTGRTDLDPEKQRY
CCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCCCHHHHHH
ARDTDKRTLAEIVEGADIFLGLSAAGILTPEMVATMAPDPVIFALANPIPEIMPEVVCAV
HCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHCCCCCEEEEECCCHHHHHHHHHHHH
RTDAIIGTGRSDYPNQINNVLCFPYLFRGALDVGATTINEEMKIACVKAIAALARCEASD
HCCEEEECCCCCCCHHHHCEEEHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHCCHHH
LGAAYGGETPSFGREYLIPRPLDPRLLVELSSAVAQAAMDSGVATRPITDMSAYHDKLSQ
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
FVYRTSLMMKPVYDRARADKQRVVYAEGEEEVILRAVQNVIDEGLAFPILIGRPDVIESR
HHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHH
IQRMGLRMKVGVDFEVTNIHDDPRFNDYWQYYHGVTERRGVTVSAAKELMRSRPTLIASV
HHHCCCEEEECCEEEEECCCCCCCCCHHHHHHCCHHHHCCEEHHHHHHHHHCCCHHHHHH
MVARGEADALLTGAVGRFHKRLGYARSVIPLEPRVSSTAAMTGVINQHGAFFFVDTHVQE
HHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCC
DPSAEQITEATLQACYRLRLFGIEPSVALLSHSNFGSHDSRDALKMRQVRELLLKRSPRL
CCCHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCC
NIDGEMQADTAWDEVLRERIMPNTTLKGRANLFVFPNLEAANIAYNLVRVFTDGVAIGPI
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCHHHHH
LMGISKAVHILTSSTTSRRVMNMTAIAAVDAQIRKQFEGGKRGG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]