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The map label for this gene is pcoA [H]

Identifier: 182680663

GI number: 182680663

Start: 127509

End: 129329

Strand: Direct

Name: pcoA [H]

Synonym: XfasM23_0092

Alternate gene names: 182680663

Gene position: 127509-129329 (Clockwise)

Preceding gene: 182680662

Following gene: 182680664

Centisome position: 5.03

GC content: 57.77

Gene sequence:

>1821_bases
ATGAACACTGTTACCTTCCCTTCCCAGGGAGGCATTGACCGGCGTCGCTTCCTAAAAGGCTTGGCGTTGGGAGGCGTCGT
CGCCGGTACCGGCTTATGGCGTCTTCCTGTCCATGCAGCCAACCCTGAGTTGCCGCCACTGCAGCGGCGTACCACTCCCC
TAGAGCTGCGTATCGGACAGTCCAGCGTTAATTTCACCGGACGTATGCGTCCAGCCATCACCGTTAATAACAGCTTGCCT
GGACCCGTATTGCGTTGGCGCCAAGGCGATACGGTCCAAATACATGTCACCAATACCTTGCCCGATGTGATGACCTCAAT
TCATTGGCACGGCATCGTTCTGCCCTCCAACATGGATGGCGTACCGGGCATGAGTTTCGACGGTATTGCACCAGGCGAAC
ACTATCTATACCGCTTTCAGTTACACCAGTCTGGGACCTACTGGTACCACAGCCACGCCATGTTTCAAGAACAGGCCGGC
CTGTATGGAGCGTTGATTATTGATCCACTGGAGCCGCCTCCCTACCGCGCCGACCGCGAGCACATCCTCCTATTCTCAGA
TTGGACCGACCTGGACCCTGCCGCACTGTTTCGCAGGCTCAAAAAAATGTCCTCTTACGACAACACCTACCAACGCACCG
TCCGCGATTTCTTCCATGACATACACCGTGATGGCCTGCGCACCACACTGGCCGATCGCCGCATGTGGGGCAGAATGCGG
ATGACCCCGACAGACCTGTCCGATGTCAATGCCCATACCTATACCTACCTGCTGAACGGCACCACGCCAGCCGGCCACTG
GACTGGATTGTTCCGCCCCGGAGAAAAAGTGCTATTACGGCTGATTAATGGTTCGGCGATGACCTATTTTGACGTCCGTA
TTCCAGGCCTGAAACTGACCGTTGTCGCCGTGGATGGCCAATACGTCCATCCGGTGACCGTGGATGAATTACGTATTGCC
CTCGCCGAAACCTATGATGTCCTGATCCAACCCCACGGCCAGGATGCCTTTGCAATCTTTGCCCAGGACATGGGCCGCAC
CGGCTACGCCTGCGGCACCCTCGCCGTGCGTCCCGGCTTACACGCCCCCCTGCCGGCATTGGACCCGCGTCCTCGCCTGA
CAATGCAGGACATGGGACACGGGATGACGCATGATCAGCATGGGAGTCGCGTCTCTGAAATGGCGGACATCCCAGGAATG
ACCCATCCTGGCAGACTGGGCGATCATGCCAGCCACGCCAACCAGCCTCCTGCGCAGCCCCCTCATGGTTTACATAGCCT
TCCGGCGGACAGAACAGCGCCGCAGCATCCTGCCAGCGAACAGAACAATCCCTTGGTGGACATGCATGTGGACGCACCAC
AGCCGCGTTTGAATGATCCCGGCATTGGCTTGCGTGACAATGGCCGCCACGTCTTGACGTACGCTGATCTGCATAGCCTG
TTCGATGATCCGGATGGACGTGAACCAGGGCGTGAGATCGAATTACATCTCACCGGCAATATGGAGAAATTCGCCTGGTC
GTTTGATGGCATCCCATTTGCCTCCGCGCAACCCTTACGACTCAACTACGGTGAACGTGTACGCATCGTCTTGGTCAATG
ACACCATGATGGCGCACCCCATTCACCTGCACGGCTTATGGAGTGACTTAGAGGATGCCAACGCCGCGTTTCAGGTCCGT
AAACACACCATCGATATGCCGCCGGGTACACGCCGCAGCTACCGTGTGCGTGCCGATGCACTGGGGCGCTGGGCCTACCA
CTGCCACATGCTGTACCACATGGAAAGCGGCATGATGCGTGAAGTACAGGTGCGCCCATGA

Upstream 100 bases:

>100_bases
AGTCCCTGAGGGATGTTTCCTGTCCCCCATAGCGCACCTCCTCCGTATTCCCCTTGCTTGCTATCGTTCCGTCGCCAAAG
CGCCGGACATGGGAGTCTCT

Downstream 100 bases:

>100_bases
ACACCCGTACCTGGTTCGTATTGTTCTGCGTCGCTCTGCCACTCGTACCGCTGCAAGCGCAGCCGCGCCCGCAGACCGAA
CAGACATCACCGGCGTTGAG

Product: CopA family copper resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 606; Mature: 606

Protein sequence:

>606_residues
MNTVTFPSQGGIDRRRFLKGLALGGVVAGTGLWRLPVHAANPELPPLQRRTTPLELRIGQSSVNFTGRMRPAITVNNSLP
GPVLRWRQGDTVQIHVTNTLPDVMTSIHWHGIVLPSNMDGVPGMSFDGIAPGEHYLYRFQLHQSGTYWYHSHAMFQEQAG
LYGALIIDPLEPPPYRADREHILLFSDWTDLDPAALFRRLKKMSSYDNTYQRTVRDFFHDIHRDGLRTTLADRRMWGRMR
MTPTDLSDVNAHTYTYLLNGTTPAGHWTGLFRPGEKVLLRLINGSAMTYFDVRIPGLKLTVVAVDGQYVHPVTVDELRIA
LAETYDVLIQPHGQDAFAIFAQDMGRTGYACGTLAVRPGLHAPLPALDPRPRLTMQDMGHGMTHDQHGSRVSEMADIPGM
THPGRLGDHASHANQPPAQPPHGLHSLPADRTAPQHPASEQNNPLVDMHVDAPQPRLNDPGIGLRDNGRHVLTYADLHSL
FDDPDGREPGREIELHLTGNMEKFAWSFDGIPFASAQPLRLNYGERVRIVLVNDTMMAHPIHLHGLWSDLEDANAAFQVR
KHTIDMPPGTRRSYRVRADALGRWAYHCHMLYHMESGMMREVQVRP

Sequences:

>Translated_606_residues
MNTVTFPSQGGIDRRRFLKGLALGGVVAGTGLWRLPVHAANPELPPLQRRTTPLELRIGQSSVNFTGRMRPAITVNNSLP
GPVLRWRQGDTVQIHVTNTLPDVMTSIHWHGIVLPSNMDGVPGMSFDGIAPGEHYLYRFQLHQSGTYWYHSHAMFQEQAG
LYGALIIDPLEPPPYRADREHILLFSDWTDLDPAALFRRLKKMSSYDNTYQRTVRDFFHDIHRDGLRTTLADRRMWGRMR
MTPTDLSDVNAHTYTYLLNGTTPAGHWTGLFRPGEKVLLRLINGSAMTYFDVRIPGLKLTVVAVDGQYVHPVTVDELRIA
LAETYDVLIQPHGQDAFAIFAQDMGRTGYACGTLAVRPGLHAPLPALDPRPRLTMQDMGHGMTHDQHGSRVSEMADIPGM
THPGRLGDHASHANQPPAQPPHGLHSLPADRTAPQHPASEQNNPLVDMHVDAPQPRLNDPGIGLRDNGRHVLTYADLHSL
FDDPDGREPGREIELHLTGNMEKFAWSFDGIPFASAQPLRLNYGERVRIVLVNDTMMAHPIHLHGLWSDLEDANAAFQVR
KHTIDMPPGTRRSYRVRADALGRWAYHCHMLYHMESGMMREVQVRP
>Mature_606_residues
MNTVTFPSQGGIDRRRFLKGLALGGVVAGTGLWRLPVHAANPELPPLQRRTTPLELRIGQSSVNFTGRMRPAITVNNSLP
GPVLRWRQGDTVQIHVTNTLPDVMTSIHWHGIVLPSNMDGVPGMSFDGIAPGEHYLYRFQLHQSGTYWYHSHAMFQEQAG
LYGALIIDPLEPPPYRADREHILLFSDWTDLDPAALFRRLKKMSSYDNTYQRTVRDFFHDIHRDGLRTTLADRRMWGRMR
MTPTDLSDVNAHTYTYLLNGTTPAGHWTGLFRPGEKVLLRLINGSAMTYFDVRIPGLKLTVVAVDGQYVHPVTVDELRIA
LAETYDVLIQPHGQDAFAIFAQDMGRTGYACGTLAVRPGLHAPLPALDPRPRLTMQDMGHGMTHDQHGSRVSEMADIPGM
THPGRLGDHASHANQPPAQPPHGLHSLPADRTAPQHPASEQNNPLVDMHVDAPQPRLNDPGIGLRDNGRHVLTYADLHSL
FDDPDGREPGREIELHLTGNMEKFAWSFDGIPFASAQPLRLNYGERVRIVLVNDTMMAHPIHLHGLWSDLEDANAAFQVR
KHTIDMPPGTRRSYRVRADALGRWAYHCHMLYHMESGMMREVQVRP

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=359, Percent_Identity=24.5125348189415, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323703, Length=267, Percent_Identity=30.3370786516854, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6320714, Length=303, Percent_Identity=25.7425742574257, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6321067, Length=267, Percent_Identity=28.0898876404494, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24650186, Length=616, Percent_Identity=22.2402597402597, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI281360167, Length=299, Percent_Identity=27.7591973244147, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24585842, Length=299, Percent_Identity=27.7591973244147, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221330000, Length=299, Percent_Identity=27.7591973244147, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221329998, Length=299, Percent_Identity=27.7591973244147, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI18859919, Length=571, Percent_Identity=23.292469352014, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28574104, Length=139, Percent_Identity=36.6906474820144, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 68070; Mature: 68070

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTVTFPSQGGIDRRRFLKGLALGGVVAGTGLWRLPVHAANPELPPLQRRTTPLELRIGQ
CCCCCCCCCCCCCHHHHHHHHHHCCEEECCCEEEEEEECCCCCCCCCCCCCCCEEEEECC
SSVNFTGRMRPAITVNNSLPGPVLRWRQGDTVQIHVTNTLPDVMTSIHWHGIVLPSNMDG
CCCCCCEECCCEEEECCCCCCCEEEECCCCEEEEEECCCCHHHHHHCCCCEEEECCCCCC
VPGMSFDGIAPGEHYLYRFQLHQSGTYWYHSHAMFQEQAGLYGALIIDPLEPPPYRADRE
CCCCCCCCCCCCCCEEEEEEEECCCCEEEECHHHHHHHCCCEEEEEEECCCCCCCCCCCC
HILLFSDWTDLDPAALFRRLKKMSSYDNTYQRTVRDFFHDIHRDGLRTTLADRRMWGRMR
EEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MTPTDLSDVNAHTYTYLLNGTTPAGHWTGLFRPGEKVLLRLINGSAMTYFDVRIPGLKLT
CCCCCCCCCCCEEEEEEEECCCCCCCCEECCCCHHHHHHHHHCCCEEEEEEEEECCEEEE
VVAVDGQYVHPVTVDELRIALAETYDVLIQPHGQDAFAIFAQDMGRTGYACGTLAVRPGL
EEEECCCEECCCCHHHHHHHHHHCEEEEEECCCCCEEEEEEHHCCCCCCEEEEEEECCCC
HAPLPALDPRPRLTMQDMGHGMTHDQHGSRVSEMADIPGMTHPGRLGDHASHANQPPAQP
CCCCCCCCCCCCEEHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
PHGLHSLPADRTAPQHPASEQNNPLVDMHVDAPQPRLNDPGIGLRDNGRHVLTYADLHSL
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEHHHHHH
FDDPDGREPGREIELHLTGNMEKFAWSFDGIPFASAQPLRLNYGERVRIVLVNDTMMAHP
HCCCCCCCCCCEEEEEEECCCHHEEEECCCCCCCCCCCEEECCCCEEEEEEEECCEEECC
IHLHGLWSDLEDANAAFQVRKHTIDMPPGTRRSYRVRADALGRWAYHCHMLYHMESGMMR
EEEEECCCCHHCCCCEEEEEEEEECCCCCCCCEEEEEHHHHHHHHHEEEEEEEECCCCEE
EVQVRP
EEEECC
>Mature Secondary Structure
MNTVTFPSQGGIDRRRFLKGLALGGVVAGTGLWRLPVHAANPELPPLQRRTTPLELRIGQ
CCCCCCCCCCCCCHHHHHHHHHHCCEEECCCEEEEEEECCCCCCCCCCCCCCCEEEEECC
SSVNFTGRMRPAITVNNSLPGPVLRWRQGDTVQIHVTNTLPDVMTSIHWHGIVLPSNMDG
CCCCCCEECCCEEEECCCCCCCEEEECCCCEEEEEECCCCHHHHHHCCCCEEEECCCCCC
VPGMSFDGIAPGEHYLYRFQLHQSGTYWYHSHAMFQEQAGLYGALIIDPLEPPPYRADRE
CCCCCCCCCCCCCCEEEEEEEECCCCEEEECHHHHHHHCCCEEEEEEECCCCCCCCCCCC
HILLFSDWTDLDPAALFRRLKKMSSYDNTYQRTVRDFFHDIHRDGLRTTLADRRMWGRMR
EEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MTPTDLSDVNAHTYTYLLNGTTPAGHWTGLFRPGEKVLLRLINGSAMTYFDVRIPGLKLT
CCCCCCCCCCCEEEEEEEECCCCCCCCEECCCCHHHHHHHHHCCCEEEEEEEEECCEEEE
VVAVDGQYVHPVTVDELRIALAETYDVLIQPHGQDAFAIFAQDMGRTGYACGTLAVRPGL
EEEECCCEECCCCHHHHHHHHHHCEEEEEECCCCCEEEEEEHHCCCCCCEEEEEEECCCC
HAPLPALDPRPRLTMQDMGHGMTHDQHGSRVSEMADIPGMTHPGRLGDHASHANQPPAQP
CCCCCCCCCCCCEEHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
PHGLHSLPADRTAPQHPASEQNNPLVDMHVDAPQPRLNDPGIGLRDNGRHVLTYADLHSL
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEHHHHHH
FDDPDGREPGREIELHLTGNMEKFAWSFDGIPFASAQPLRLNYGERVRIVLVNDTMMAHP
HCCCCCCCCCCEEEEEEECCCHHEEEECCCCCCCCCCCEEECCCCEEEEEEEECCEEECC
IHLHGLWSDLEDANAAFQVRKHTIDMPPGTRRSYRVRADALGRWAYHCHMLYHMESGMMR
EEEEECCCCHHCCCCEEEEEEEEECCCCCCCCEEEEEHHHHHHHHHEEEEEEEECCCCEE
EVQVRP
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]