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The map label for this gene is ndhS [H]

Identifier: 170756562

GI number: 170756562

Start: 330188

End: 330661

Strand: Direct

Name: ndhS [H]

Synonym: CLD_0498

Alternate gene names: 170756562

Gene position: 330188-330661 (Clockwise)

Preceding gene: 170756032

Following gene: 170756237

Centisome position: 8.34

GC content: 35.44

Gene sequence:

>474_bases
ATGATATCATATATTGAAGAGACAAAGATAGAACTAGACATAAATGGCGAAAAGAGAAGCGTGATTGTAAGACCGGCAGA
TACACTTCTTAGAGTACTTAGAGAAAAATTGGGATTAACCGGAGGAAAGCCTGGTTGTGAAAATGGAGATTGCGGTGCTT
GTACTGTACTTTTAGATGGAATACCAATTAAATCATGTATTATATTGGCGGTTGAGGCCGTTGGACATAAATTAATCACC
ATTGAGGGGTTAAAAGAAGAACCAATTCAAAAAGCCTTTGTTGAAAAAATGGGCTTTCAATGTGGGTATTGTACCCCTGG
TTTCATAATGAATTGCTATGGACTCATAAAAGACAGCCCTTATGCAGATGATGAAACTATTGAAAAATGGCTACAGTCTA
ATATTTGTAGATGTACCGGATATGAAGAAATCAGAGATGCTGTAAAATCAGTATTATTCTCAAACAAAAAATAA

Upstream 100 bases:

>100_bases
CTCCTATATTTGGCAATATCCAAGGCTCTTCTGAATATAAAAGGTTTGTATTAAGAAATTTACTTGAGTATACTTTGGAA
ACACTGGATGGTGAGGGAAG

Downstream 100 bases:

>100_bases
GGGAGATACCTTTATGATGAGTTTGATTATTTAGAGATGCGATTTAACTTGCTATATTAAGTGGTTTTGAGTCTGTAAAG
GAATGTTTCCCCGCGGATGA

Product: xanthine dehydrogenase family protein, iron-sulfur-binding subunit

Products: NA

Alternate protein names: NDH; Nicotinic acid hydroxylase small FeS subunit; NAH [H]

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MISYIEETKIELDINGEKRSVIVRPADTLLRVLREKLGLTGGKPGCENGDCGACTVLLDGIPIKSCIILAVEAVGHKLIT
IEGLKEEPIQKAFVEKMGFQCGYCTPGFIMNCYGLIKDSPYADDETIEKWLQSNICRCTGYEEIRDAVKSVLFSNKK

Sequences:

>Translated_157_residues
MISYIEETKIELDINGEKRSVIVRPADTLLRVLREKLGLTGGKPGCENGDCGACTVLLDGIPIKSCIILAVEAVGHKLIT
IEGLKEEPIQKAFVEKMGFQCGYCTPGFIMNCYGLIKDSPYADDETIEKWLQSNICRCTGYEEIRDAVKSVLFSNKK
>Mature_157_residues
MISYIEETKIELDINGEKRSVIVRPADTLLRVLREKLGLTGGKPGCENGDCGACTVLLDGIPIKSCIILAVEAVGHKLIT
IEGLKEEPIQKAFVEKMGFQCGYCTPGFIMNCYGLIKDSPYADDETIEKWLQSNICRCTGYEEIRDAVKSVLFSNKK

Specific function: Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=160, Percent_Identity=36.25, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI71773480, Length=155, Percent_Identity=38.0645161290323, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1786480, Length=159, Percent_Identity=37.7358490566038, Blast_Score=107, Evalue=3e-25,
Organism=Escherichia coli, GI1789232, Length=154, Percent_Identity=39.6103896103896, Blast_Score=101, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17540638, Length=164, Percent_Identity=36.5853658536585, Blast_Score=106, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17539860, Length=158, Percent_Identity=37.3417721518987, Blast_Score=103, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI32566215, Length=158, Percent_Identity=36.0759493670886, Blast_Score=99, Evalue=7e-22,
Organism=Drosophila melanogaster, GI17737937, Length=153, Percent_Identity=35.2941176470588, Blast_Score=96, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24647193, Length=158, Percent_Identity=39.2405063291139, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24647197, Length=160, Percent_Identity=36.875, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24647195, Length=160, Percent_Identity=36.875, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24647199, Length=153, Percent_Identity=39.2156862745098, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24647201, Length=152, Percent_Identity=39.4736842105263, Blast_Score=90, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.17.1.5 [H]

Molecular weight: Translated: 17366; Mature: 17366

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
5.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
7.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISYIEETKIELDINGEKRSVIVRPADTLLRVLREKLGLTGGKPGCENGDCGACTVLLDG
CCCCCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECC
IPIKSCIILAVEAVGHKLITIEGLKEEPIQKAFVEKMGFQCGYCTPGFIMNCYGLIKDSP
CCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
YADDETIEKWLQSNICRCTGYEEIRDAVKSVLFSNKK
CCCHHHHHHHHHCCCEECCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MISYIEETKIELDINGEKRSVIVRPADTLLRVLREKLGLTGGKPGCENGDCGACTVLLDG
CCCCCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECC
IPIKSCIILAVEAVGHKLITIEGLKEEPIQKAFVEKMGFQCGYCTPGFIMNCYGLIKDSP
CCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
YADDETIEKWLQSNICRCTGYEEIRDAVKSVLFSNKK
CCCHHHHHHHHHCCCEECCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA