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The map label for this gene is purM [H]

Identifier: 170746925

GI number: 170746925

Start: 524541

End: 525620

Strand: Reverse

Name: purM [H]

Synonym: Mrad2831_0491

Alternate gene names: 170746925

Gene position: 525620-524541 (Counterclockwise)

Preceding gene: 170746931

Following gene: 170746924

Centisome position: 8.65

GC content: 73.24

Gene sequence:

>1080_bases
ATGACGGCCAAGGACGGCAACGAGCCGAAGACGGGGCTGACCTACGCGGCGGCGGGCGTCGATATCGATGCCGGCAACGC
CATGGTCGAGACGATCAAGCCGCTGGTGCGGTCGACCCGGCGGCCGGGTGCCGACGCCGAGATCGGCGGTTTCGGCGGCC
TGTTCGACCTGAAGGCCGCGGGCTTCCGCGACCCGATCCTGGTCGCGGCCAACGACGGCGTCGGCACCAAGGTCAAGATC
GCCATCGAGACCGGCCGGCACGACACGATCGGCATCGACCTCGTGGCCATGTGCGTGAACGACATCATCGTCCAGGGCGC
CGAACCGCTGTTCTTCCTCGACTACTACGCCACCGGCAAGCTGGTGCCGGGCGTCGGCGCCGACATCGTGCGCGGCATCG
CCGAGGGCTGCCGGCAGGCCGGCTGCGCGCTGATCGGCGGCGAGACCGCCGAGATGCCGGGCCTCTACGACGGGTCCGAC
TACGATCTCGCGGGCTTCTCGGTCGGCGCCGCCGAGCGCGGCGCGCTGCTGCCGCGGCCCGGCATCCGGCCCGGCGACGT
CGTGCTCGGCCTGCCCTCCTCGGGCGTCCATTCCAACGGCTTCTCGCTGGTGCGCCGGATCGTCGCGAAGACCGGCCTCG
GCTGGGACGCGCCGGCGCCGTTCGCCCCGGGCCGGAGTCTCGGCGACGAGCTGCTGGAGCCGACCCGGATCTACGTGAAG
CCGCTCCTCGCGGCTCTGGGGGCCACCGACGGGATCCGGGCGCTCGCCCACATCACGGGCGGCGGCTTCCCCGACAATCT
CCCGCGGGTCCTGCCGGACGATGTCGGCATCGCCGTCGACCTCGACGCCGTGACTCCGCCGCCGGTCTTCGGCTGGCTCG
CCCGCGAGGGCGGCGTCGCCGAGGCCGAGATGCTGCGCACCTTCAACTGCGGGATCGGCATGGTGGTGATCGCCGCCGCT
GACGCGGTCGACGACGTCGACGAGGCGTTGACCCGGGCCGGCGAGACCCCGGTCCGCCTCGGGCGGATCACGGCGCGCGG
GCCCGAGCCGGTCACCTTCGCCGGCCGCCTCGCCCTCTGA

Upstream 100 bases:

>100_bases
TGGGTATGCGAGGCGCGCCGATCAAGGCGCCGCCGGCCGACTCGCGCGCCGCGCGCGAAGTCGCTAGAGCGGGGCCTGGA
TAGAACGAGGTGGCGCGGGC

Downstream 100 bases:

>100_bases
TGGCGGCCGCCCGCAAGACCCGCGTCGCCGTCCTGATCTCGGGGCGCGGTTCGAACATGGTCGCGCTGCTCGAGGCCGCG
AAGGATCCCGCCTTCCCGGC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MTAKDGNEPKTGLTYAAAGVDIDAGNAMVETIKPLVRSTRRPGADAEIGGFGGLFDLKAAGFRDPILVAANDGVGTKVKI
AIETGRHDTIGIDLVAMCVNDIIVQGAEPLFFLDYYATGKLVPGVGADIVRGIAEGCRQAGCALIGGETAEMPGLYDGSD
YDLAGFSVGAAERGALLPRPGIRPGDVVLGLPSSGVHSNGFSLVRRIVAKTGLGWDAPAPFAPGRSLGDELLEPTRIYVK
PLLAALGATDGIRALAHITGGGFPDNLPRVLPDDVGIAVDLDAVTPPPVFGWLAREGGVAEAEMLRTFNCGIGMVVIAAA
DAVDDVDEALTRAGETPVRLGRITARGPEPVTFAGRLAL

Sequences:

>Translated_359_residues
MTAKDGNEPKTGLTYAAAGVDIDAGNAMVETIKPLVRSTRRPGADAEIGGFGGLFDLKAAGFRDPILVAANDGVGTKVKI
AIETGRHDTIGIDLVAMCVNDIIVQGAEPLFFLDYYATGKLVPGVGADIVRGIAEGCRQAGCALIGGETAEMPGLYDGSD
YDLAGFSVGAAERGALLPRPGIRPGDVVLGLPSSGVHSNGFSLVRRIVAKTGLGWDAPAPFAPGRSLGDELLEPTRIYVK
PLLAALGATDGIRALAHITGGGFPDNLPRVLPDDVGIAVDLDAVTPPPVFGWLAREGGVAEAEMLRTFNCGIGMVVIAAA
DAVDDVDEALTRAGETPVRLGRITARGPEPVTFAGRLAL
>Mature_358_residues
TAKDGNEPKTGLTYAAAGVDIDAGNAMVETIKPLVRSTRRPGADAEIGGFGGLFDLKAAGFRDPILVAANDGVGTKVKIA
IETGRHDTIGIDLVAMCVNDIIVQGAEPLFFLDYYATGKLVPGVGADIVRGIAEGCRQAGCALIGGETAEMPGLYDGSDY
DLAGFSVGAAERGALLPRPGIRPGDVVLGLPSSGVHSNGFSLVRRIVAKTGLGWDAPAPFAPGRSLGDELLEPTRIYVKP
LLAALGATDGIRALAHITGGGFPDNLPRVLPDDVGIAVDLDAVTPPPVFGWLAREGGVAEAEMLRTFNCGIGMVVIAAAD
AVDDVDEALTRAGETPVRLGRITARGPEPVTFAGRLAL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=342, Percent_Identity=53.5087719298246, Blast_Score=364, Evalue=1e-101,
Organism=Homo sapiens, GI209869995, Length=342, Percent_Identity=53.5087719298246, Blast_Score=364, Evalue=1e-101,
Organism=Homo sapiens, GI209869993, Length=342, Percent_Identity=53.5087719298246, Blast_Score=364, Evalue=1e-101,
Organism=Escherichia coli, GI1788845, Length=340, Percent_Identity=52.3529411764706, Blast_Score=348, Evalue=2e-97,
Organism=Caenorhabditis elegans, GI17567511, Length=351, Percent_Identity=44.7293447293447, Blast_Score=293, Evalue=9e-80,
Organism=Saccharomyces cerevisiae, GI6321203, Length=347, Percent_Identity=54.178674351585, Blast_Score=367, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24582400, Length=287, Percent_Identity=49.1289198606272, Blast_Score=278, Evalue=4e-75,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36901; Mature: 36769

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAKDGNEPKTGLTYAAAGVDIDAGNAMVETIKPLVRSTRRPGADAEIGGFGGLFDLKAA
CCCCCCCCCCCCEEEEECCCEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCC
GFRDPILVAANDGVGTKVKIAIETGRHDTIGIDLVAMCVNDIIVQGAEPLFFLDYYATGK
CCCCCEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCC
LVPGVGADIVRGIAEGCRQAGCALIGGETAEMPGLYDGSDYDLAGFSVGAAERGALLPRP
CCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCC
GIRPGDVVLGLPSSGVHSNGFSLVRRIVAKTGLGWDAPAPFAPGRSLGDELLEPTRIYVK
CCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCHHHHHH
PLLAALGATDGIRALAHITGGGFPDNLPRVLPDDVGIAVDLDAVTPPPVFGWLAREGGVA
HHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHCCCCCH
EAEMLRTFNCGIGMVVIAAADAVDDVDEALTRAGETPVRLGRITARGPEPVTFAGRLAL
HHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEECCEECC
>Mature Secondary Structure 
TAKDGNEPKTGLTYAAAGVDIDAGNAMVETIKPLVRSTRRPGADAEIGGFGGLFDLKAA
CCCCCCCCCCCEEEEECCCEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCC
GFRDPILVAANDGVGTKVKIAIETGRHDTIGIDLVAMCVNDIIVQGAEPLFFLDYYATGK
CCCCCEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCC
LVPGVGADIVRGIAEGCRQAGCALIGGETAEMPGLYDGSDYDLAGFSVGAAERGALLPRP
CCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCC
GIRPGDVVLGLPSSGVHSNGFSLVRRIVAKTGLGWDAPAPFAPGRSLGDELLEPTRIYVK
CCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCHHHHHH
PLLAALGATDGIRALAHITGGGFPDNLPRVLPDDVGIAVDLDAVTPPPVFGWLAREGGVA
HHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHCCCCCH
EAEMLRTFNCGIGMVVIAAADAVDDVDEALTRAGETPVRLGRITARGPEPVTFAGRLAL
HHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEECCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA