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The map label for this gene is cusR [H]

Identifier: 170746673

GI number: 170746673

Start: 237711

End: 238391

Strand: Reverse

Name: cusR [H]

Synonym: Mrad2831_0224

Alternate gene names: 170746673

Gene position: 238391-237711 (Counterclockwise)

Preceding gene: 170746674

Following gene: 170746672

Centisome position: 3.92

GC content: 64.46

Gene sequence:

>681_bases
ATGGCCAACGTATTGGTAGTCGAGGACGACCGGCGGGTCGCCGCCGAGATCGGGTCGGCCCTCGCGGAATACGGATTTCA
GGTAGACGAAGCGCCGAGCGGCAGCATCGGACTACGCAAGGCCCTCGACGGTAACTTTGACGTGATCGTGCTCGATCGGA
TGCTCCCGGAGATCGACGGCCTGTCGCTGCTCACCGAGCTGCGCGCCGCCAAAGTCTCGACGCCGGTCCTGATCCTCAGC
GCCCTTTCGGCCGTCAACGAGCGCGTCGACGGGCTGCGCGCCGGCGGCGACGACTACCTCGCCAAGCCGTTCGAGTTCAT
CGAGCTGACGGCGCGCGTCGACGCGCTCGCCCGGCGCAAGATGGCGGCCGAGGCGGTGAACGAGCTGGTAGTCGGCGATC
TCCGCCTGGACCTGATCGAGCGCGTCCTCTACTGCGCGGGGCGCGAGATCGAGCTCCTCCCCAAGGAGTTCGCGATCATC
GAATTTCTGATGCAGAACGCCGGCACGCTGGTCAGCCGGAAGATGATCTTCGAATCCGTCTGGGGCTACAGCTTCAACCA
CCAGTCCAGCGTCATCGACGTCCATATCGGCAAGATCCGTAAGAAGTTGGATCCCGACGGGCTGAACCCGCGGATCCACA
CGGTGCGCAACACCGGCTTCATTCTCCGTGCGCCTTCTTGA

Upstream 100 bases:

>100_bases
CCCATTTGACTCCGGGACCGAAGAGGATAATTGCACTCCTCCCTCCGAGCCGCAGGAGACTAGACAGGGCCGGCGAATAC
AAAATAAGAAGGAAAAACGA

Downstream 100 bases:

>100_bases
GATCCGGCGCACCAGCGGCTTCCGGGTCGCCTGCCTGTTCTTCGCGACCTTCGGGACCGCGTCGCTCGCGCTGTCGGGCT
TCCTGTACGTCGACACGCGC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MANVLVVEDDRRVAAEIGSALAEYGFQVDEAPSGSIGLRKALDGNFDVIVLDRMLPEIDGLSLLTELRAAKVSTPVLILS
ALSAVNERVDGLRAGGDDYLAKPFEFIELTARVDALARRKMAAEAVNELVVGDLRLDLIERVLYCAGREIELLPKEFAII
EFLMQNAGTLVSRKMIFESVWGYSFNHQSSVIDVHIGKIRKKLDPDGLNPRIHTVRNTGFILRAPS

Sequences:

>Translated_226_residues
MANVLVVEDDRRVAAEIGSALAEYGFQVDEAPSGSIGLRKALDGNFDVIVLDRMLPEIDGLSLLTELRAAKVSTPVLILS
ALSAVNERVDGLRAGGDDYLAKPFEFIELTARVDALARRKMAAEAVNELVVGDLRLDLIERVLYCAGREIELLPKEFAII
EFLMQNAGTLVSRKMIFESVWGYSFNHQSSVIDVHIGKIRKKLDPDGLNPRIHTVRNTGFILRAPS
>Mature_225_residues
ANVLVVEDDRRVAAEIGSALAEYGFQVDEAPSGSIGLRKALDGNFDVIVLDRMLPEIDGLSLLTELRAAKVSTPVLILSA
LSAVNERVDGLRAGGDDYLAKPFEFIELTARVDALARRKMAAEAVNELVVGDLRLDLIERVLYCAGREIELLPKEFAIIE
FLMQNAGTLVSRKMIFESVWGYSFNHQSSVIDVHIGKIRKKLDPDGLNPRIHTVRNTGFILRAPS

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=39.0134529147982, Blast_Score=171, Evalue=4e-44,
Organism=Escherichia coli, GI1789402, Length=219, Percent_Identity=41.0958904109589, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=36.2385321100917, Blast_Score=140, Evalue=5e-35,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=34.841628959276, Blast_Score=137, Evalue=5e-34,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=36.1607142857143, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=33.9366515837104, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=32.579185520362, Blast_Score=110, Evalue=5e-26,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=32.15859030837, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=33.6283185840708, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=30.3418803418803, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI2367329, Length=234, Percent_Identity=32.0512820512821, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=28.3842794759825, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788550, Length=122, Percent_Identity=35.2459016393443, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=27.3127753303965, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1787229, Length=214, Percent_Identity=28.5046728971963, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790437, Length=112, Percent_Identity=34.8214285714286, Blast_Score=72, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24888; Mature: 24757

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANVLVVEDDRRVAAEIGSALAEYGFQVDEAPSGSIGLRKALDGNFDVIVLDRMLPEIDG
CCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCEEEHHHHCCCCCH
LSLLTELRAAKVSTPVLILSALSAVNERVDGLRAGGDDYLAKPFEFIELTARVDALARRK
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHH
MAAEAVNELVVGDLRLDLIERVLYCAGREIELLPKEFAIIEFLMQNAGTLVSRKMIFESV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHCCCHHHHHHHHHHHH
WGYSFNHQSSVIDVHIGKIRKKLDPDGLNPRIHTVRNTGFILRAPS
HCCCCCCCCCEEEEEHHHHHHHCCCCCCCCCEEEEECCCEEEECCC
>Mature Secondary Structure 
ANVLVVEDDRRVAAEIGSALAEYGFQVDEAPSGSIGLRKALDGNFDVIVLDRMLPEIDG
CCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCEEEHHHHCCCCCH
LSLLTELRAAKVSTPVLILSALSAVNERVDGLRAGGDDYLAKPFEFIELTARVDALARRK
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHH
MAAEAVNELVVGDLRLDLIERVLYCAGREIELLPKEFAIIEFLMQNAGTLVSRKMIFESV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHCCCHHHHHHHHHHHH
WGYSFNHQSSVIDVHIGKIRKKLDPDGLNPRIHTVRNTGFILRAPS
HCCCCCCCCCEEEEEHHHHHHHCCCCCCCCCEEEEECCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]