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The map label for this gene is prs

Identifier: 170762174

GI number: 170762174

Start: 236217

End: 237209

Strand: Direct

Name: prs

Synonym: UPA3_0199

Alternate gene names: 170762174

Gene position: 236217-237209 (Clockwise)

Preceding gene: 170761884

Following gene: 170762056

Centisome position: 31.43

GC content: 31.12

Gene sequence:

>993_bases
ATGTCAAAAAATGATGATATATTATTATTTAGTCTTTCAAATTCACATCAATTAGCTAATAAAATTGCTAATTTACTAAA
AATTGAATTATCACCAATTAGAATTGATAAGTTTGCAGATGGTGAATTAATTGTTGCACCTCAAGTTCCAGTGCGTGGAC
GTCGAGTTATTATTATTCAATCAACATCTAAACCTGTTAACGATAGTTTAATGGAATTATTAATCGCTATTGACTCAATT
AAACGAGCTAGTGCCAAAGCAATTAGTGTTGTAATTCCTTATTATGGATATGCACGTCAAGACCGTAAAGCTAAACCACG
TGAACCAATTACAGCACGTTTAGTTGCAAAAATGATTGAGAGTGCGGGCGCAACTAGTGTATTAACTTGAGATATTCATT
CTTTACAAACACAAGGTTTTTTTGATATTCCGTTTGATTCATTAGAGGCTGTATGAGTTTTAATGAAACATTATTTTAGT
GCTTATAAAGATTCATCAAATATAACTATTGTTTCACCAGATTATGGTGGTGTCAAACGTGCTCGTGAAATTTCAATAGC
TACAGGTGCAACATTAGCAATTGTTGATAAACGAAGATCTGGCAAAAATCAGGTGGAAATTAATAATGTATTAGGTGATG
TTAAAGATCGTGATTGTGTAATTGTTGATGATATGATTGATACTGGTGGCACAATTTTAGGTGCTGCTAAAATTGTGCGT
GAAAAAGGCGCTAAATCAATAACAATTATTGCTACACATGGTTTGTTTAATAATAATGCACGACAACATTTTCAACAAGC
AATTAAAGATCGAATTATTAATAAAATTTGTATAGCTGATACAATTGAAAATGAACCTTTTGATGGTCTTGAAATTGTAA
GTATCGCTCCAGCAATTGCCAAATGTATTGAAATTTATTCAGAGGGTACAGGTTCGATGTCGTTTGTACATGATGAAAAT
TCAAAAGTTTTATTTGCTAAAAAAATATATTAA

Upstream 100 bases:

>100_bases
TTTAATTCACAAGGAATTGTCGAACTTAATGATGAATATCAGGTTGGTCAATTGTTTACAAAAGTTTATAGTAATTTATA
ATTTAAAGTAGGTAAAATTA

Downstream 100 bases:

>100_bases
ATAAAAATGAATAAACCAATTATCAAAGAAGTTATTATTGTAGAAGGTAAAACAGATGCACAAAAAATTGATCAATTAGT
AAATGCACAAATTATTACTA

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MSKNDDILLFSLSNSHQLANKIANLLKIELSPIRIDKFADGELIVAPQVPVRGRRVIIIQSTSKPVNDSLMELLIAIDSI
KRASAKAISVVIPYYGYARQDRKAKPREPITARLVAKMIESAGATSVLTWDIHSLQTQGFFDIPFDSLEAVWVLMKHYFS
AYKDSSNITIVSPDYGGVKRAREISIATGATLAIVDKRRSGKNQVEINNVLGDVKDRDCVIVDDMIDTGGTILGAAKIVR
EKGAKSITIIATHGLFNNNARQHFQQAIKDRIINKICIADTIENEPFDGLEIVSIAPAIAKCIEIYSEGTGSMSFVHDEN
SKVLFAKKIY

Sequences:

>Translated_330_residues
MSKNDDILLFSLSNSHQLANKIANLLKIELSPIRIDKFADGELIVAPQVPVRGRRVIIIQSTSKPVNDSLMELLIAIDSI
KRASAKAISVVIPYYGYARQDRKAKPREPITARLVAKMIESAGATSVLT*DIHSLQTQGFFDIPFDSLEAV*VLMKHYFS
AYKDSSNITIVSPDYGGVKRAREISIATGATLAIVDKRRSGKNQVEINNVLGDVKDRDCVIVDDMIDTGGTILGAAKIVR
EKGAKSITIIATHGLFNNNARQHFQQAIKDRIINKICIADTIENEPFDGLEIVSIAPAIAKCIEIYSEGTGSMSFVHDEN
SKVLFAKKIY
>Mature_329_residues
SKNDDILLFSLSNSHQLANKIANLLKIELSPIRIDKFADGELIVAPQVPVRGRRVIIIQSTSKPVNDSLMELLIAIDSIK
RASAKAISVVIPYYGYARQDRKAKPREPITARLVAKMIESAGATSVLT*DIHSLQTQGFFDIPFDSLEAV*VLMKHYFSA
YKDSSNITIVSPDYGGVKRAREISIATGATLAIVDKRRSGKNQVEINNVLGDVKDRDCVIVDDMIDTGGTILGAAKIVRE
KGAKSITIIATHGLFNNNARQHFQQAIKDRIINKICIADTIENEPFDGLEIVSIAPAIAKCIEIYSEGTGSMSFVHDENS
KVLFAKKIY

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=280, Percent_Identity=41.7857142857143, Blast_Score=197, Evalue=9e-51,
Organism=Homo sapiens, GI4506129, Length=283, Percent_Identity=41.3427561837456, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI28557709, Length=268, Percent_Identity=41.7910447761194, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI84875539, Length=286, Percent_Identity=40.9090909090909, Blast_Score=187, Evalue=8e-48,
Organism=Homo sapiens, GI4506133, Length=313, Percent_Identity=33.8658146964856, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI194018537, Length=306, Percent_Identity=30.3921568627451, Blast_Score=108, Evalue=8e-24,
Organism=Escherichia coli, GI1787458, Length=317, Percent_Identity=41.3249211356467, Blast_Score=230, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI25149168, Length=255, Percent_Identity=40.7843137254902, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17554702, Length=255, Percent_Identity=40.7843137254902, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17554704, Length=252, Percent_Identity=40.8730158730159, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI71989924, Length=255, Percent_Identity=40.7843137254902, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17570245, Length=275, Percent_Identity=31.6363636363636, Blast_Score=122, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6319403, Length=308, Percent_Identity=38.3116883116883, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6320946, Length=320, Percent_Identity=37.1875, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6321776, Length=301, Percent_Identity=37.5415282392027, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6322667, Length=192, Percent_Identity=37.5, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324511, Length=108, Percent_Identity=38.8888888888889, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355239, Length=333, Percent_Identity=39.039039039039, Blast_Score=191, Evalue=6e-49,
Organism=Drosophila melanogaster, GI45551540, Length=356, Percent_Identity=36.5168539325843, Blast_Score=178, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24651458, Length=345, Percent_Identity=27.536231884058, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24651456, Length=345, Percent_Identity=27.536231884058, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI281362873, Length=354, Percent_Identity=27.683615819209, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24651454, Length=354, Percent_Identity=27.683615819209, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24651462, Length=346, Percent_Identity=28.0346820809249, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24651464, Length=346, Percent_Identity=28.0346820809249, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI45552010, Length=346, Percent_Identity=28.0346820809249, Blast_Score=118, Evalue=5e-27,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 35963; Mature: 35832

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKNDDILLFSLSNSHQLANKIANLLKIELSPIRIDKFADGELIVAPQVPVRGRRVIIIQ
CCCCCCEEEEEECCCHHHHHHHHHHHEEECCEEEEEEECCCCEEEECCCCCCCCEEEEEE
STSKPVNDSLMELLIAIDSIKRASAKAISVVIPYYGYARQDRKAKPREPITARLVAKMIE
CCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHH
SAGATSVLTDIHSLQTQGFFDIPFDSLEAVVLMKHYFSAYKDSSNITIVSPDYGGVKRAR
HCCCHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHH
EISIATGATLAIVDKRRSGKNQVEINNVLGDVKDRDCVIVDDMIDTGGTILGAAKIVREK
EEEEECCCEEEEEECCCCCCCEEEEHHHHCCCCCCCEEEEECHHCCCCHHHHHHHHHHHC
GAKSITIIATHGLFNNNARQHFQQAIKDRIINKICIADTIENEPFDGLEIVSIAPAIAKC
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHH
IEIYSEGTGSMSFVHDENSKVLFAKKIY
HHHHHCCCCCEEEEECCCCEEEEEEECC
>Mature Secondary Structure 
SKNDDILLFSLSNSHQLANKIANLLKIELSPIRIDKFADGELIVAPQVPVRGRRVIIIQ
CCCCCEEEEEECCCHHHHHHHHHHHEEECCEEEEEEECCCCEEEECCCCCCCCEEEEEE
STSKPVNDSLMELLIAIDSIKRASAKAISVVIPYYGYARQDRKAKPREPITARLVAKMIE
CCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHH
SAGATSVLTDIHSLQTQGFFDIPFDSLEAVVLMKHYFSAYKDSSNITIVSPDYGGVKRAR
HCCCHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHH
EISIATGATLAIVDKRRSGKNQVEINNVLGDVKDRDCVIVDDMIDTGGTILGAAKIVREK
EEEEECCCEEEEEECCCCCCCEEEEHHHHCCCCCCCEEEEECHHCCCCHHHHHHHHHHHC
GAKSITIIATHGLFNNNARQHFQQAIKDRIINKICIADTIENEPFDGLEIVSIAPAIAKC
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHH
IEIYSEGTGSMSFVHDENSKVLFAKKIY
HHHHHCCCCCEEEEECCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11048724 [H]