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The map label for this gene is gyrA

Identifier: 170761893

GI number: 170761893

Start: 99097

End: 101619

Strand: Direct

Name: gyrA

Synonym: UPA3_0081

Alternate gene names: 170761893

Gene position: 99097-101619 (Clockwise)

Preceding gene: 170762124

Following gene: 170761979

Centisome position: 13.18

GC content: 29.73

Gene sequence:

>2523_bases
ATGGCATTAAAAAAACCAAAAAAAAGTCGTTTAACCACCGAAGAAATTAAGCAACAATTAGAAGGTTCAACGATTAAAGA
ACAATCAATTACAAAAGAAGTCGAAACATCATTTTTAGATTATTCAATGTCTGTAATCGTTGCACGTGCTTTGCCTGATG
TGCGTGATGGATTTAAGCCCGTGCATCGCCGAGCTTTATTTGCTGCTTTCGAAAACGGAATGACACATGATAAGCCTTAT
AAAAAATCTGCACGTTGAGTTGGGGATGTAATTGGAAAATATCATCCACATGGAGATCAAGCTGTTTATCAAACTATTGT
AAGAATGGCACAAGACTTTTCAATGCGTTATTTATTAGTTGATGGTCATGGTAATTTTGGTTCGATTGATGGTGATAGTG
CAGCTGCGATGCGTTATACAGAAGCACGATTATCAAAAATCTCTTATGAATTATTAAAATACATTGATAAAGAAACAGTA
GATTTTGTACCTAATTATGATGCATCAGAACAAGAACCAAGTGTTTTACCATCAGGTTTTCCAAATTTATTAACAAATGG
AACTACAGGAATAGCTGTTGGGATGGCAACAAATATTCCACCACATAATTTAACTGAAGTTTGTCAAGCAATAAAAGCTT
ATGCTAAAAACCATAATGTTACTATTTCTGAAATTATGGAATATCTAAAAGGTCCTGATTTTCCAACAGGCGCTGAAATT
TATGGTGATAGCGGTATTATTAAATATTTTAATACAGGTCGTGGTTCAGTAACAATTCGTTCAAAATATGAAATTGAAGA
TATTGGGCAAGGACGTGTAGCAATTGTTGTGACAGAAATTCCTTATATGGTTAATAAAGCTAATTTAATTGAAAAAATTG
TTGAATTAGTAACAAACAAACAAATCGAAGGAATTTCTGATTTACGTGACGAGTCAAGTCGTGATGGAATTCGAATTGTT
ATTGAAGTTAAACGTGATGTTATACCTGAAGTTTTATTAAACAAATTATTTAAAACAACACCTTTACAAACAAATTTTAG
TGTTAATAATTTAGCTTTAGTTAATGGTGTACCAATGGTATTAAACATTAAGGAAATGATTAAATACTATTTTGAACACC
AAATTGAGATTTTAGTAAGAAGAACAAATTTTGATTTAAAAAAAGCAAAAGAACGAATTCATATTGTTGAAGGTTTAGTA
ATTGCTGTTAATAATATCGATGAAGTAATTAAAATTATTAAAGCCTCAGGTGATGATGATATTGCTTCAAAATCACTAAT
TCAACGTTTCGATTTAACAGAATTGCAAACGAAAGCAATTTTAGAAATGCGTTTACGCGCTTTAACAGGACTAAATATTG
ATAAATTAAAAAAAGAATATGAAGATTTAATATTAGTTATTAAAGATTTAGAAGATGTTTTAAACAACTACAATCGTCAA
GTTAATATTATTTGTGAAAATTTAGATTATTTAATTGAAAAATTTGGTGATGAGCGTCGTACAGAAATTATGTATGGAGT
TAGTTCGCATATTGATGATGAAGATTTAATACCAGTCGAAGATATTGTTGTAACAATGTCAAAACGTGGTTATTTTAAAC
GTTTGCCAATTGATACATATAAAAATCAACGACGTGGTGGTGTAGGTGTACAAGGATTAAAAACGTATGAGGATGATGAT
GTTGAAAAAATCTTAGTTGCTAATACCCATACAGATTTATTATTCTTTTCTGATTTAGGTCGTGTTTATCGATTACGAGG
ACATGAAGTACCATTGGGATCACGACAATCAAAAGGAATTCCAGCAATTAATTTTTTACCAATTGAAAAAAGTGAAAGCA
TTTTAACTATTTTACCAATAGATAATTATGATCAAGGTTCATTATTCTTTACAACAAGTAAAGGAATTATAAAACGAGCT
AATCTAAGTGATTTCGAGTCAATTCGTGCTAATGGTAAAATTGCTATTACTTTAAAAGATGGTGATAAATTATTTTCAGT
AATGCAAACACTAGGTAATGATGAAGTATTTATCGGCGCATCAAATGGTAATGTAATTCGTTTCAATGAAAATGATGCAC
GTGAAATGGGAAGAATTGCGACAGGTGTTAAAGGAATTAATTTAGAAAATGATGAATATGTTGTAGGAACAGGGTTATCT
AGTCATGGAGAATATGTTTTAGCTGTTGGTTCTAAAGGATTAGGTAAATTAACTGACATCAATGATTATCGTTTAACTAA
GCGTGGAGCAAAAGGTGTTAATACACTAAAAGTAAATGATAAAACAGGTAACTTAGTAAGTATTAAAGTTGTTAATCGTG
AAGAAGAAGCTTTAATTATTACAACTAGTGGAAAAGTTATTCGTTTATCGATTAAAGACATTAGTGTAATTGGAAGAAAT
ACATCAGGAGTTAAATTAATTTCATTAGAAAATAAAGAAGAAGTAAAATCAATTGCTATCTTTAAAAAAGAAGAAATTAA
TGATGAACAATTATTACAAGAAAATGATTACAATCTAAAATAA

Upstream 100 bases:

>100_bases
ATTAATGGGTGATGATGTAGCTCCAAGAAAAGAATTTATTGAAAAAAATGCAAAATATGTAAAAAATATTGATGCTTAAA
ATTGAGGTATATAAAATATT

Downstream 100 bases:

>100_bases
ATGACAATAAAAACTACTTTAAAAAATAAAGTTATACTTTACTTTTTCTAAAAGTGGTTTTTATTATCTAAACTAATAAT
TATTCAATTTGAAAGGATTT

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 840; Mature: 839

Protein sequence:

>840_residues
MALKKPKKSRLTTEEIKQQLEGSTIKEQSITKEVETSFLDYSMSVIVARALPDVRDGFKPVHRRALFAAFENGMTHDKPY
KKSARWVGDVIGKYHPHGDQAVYQTIVRMAQDFSMRYLLVDGHGNFGSIDGDSAAAMRYTEARLSKISYELLKYIDKETV
DFVPNYDASEQEPSVLPSGFPNLLTNGTTGIAVGMATNIPPHNLTEVCQAIKAYAKNHNVTISEIMEYLKGPDFPTGAEI
YGDSGIIKYFNTGRGSVTIRSKYEIEDIGQGRVAIVVTEIPYMVNKANLIEKIVELVTNKQIEGISDLRDESSRDGIRIV
IEVKRDVIPEVLLNKLFKTTPLQTNFSVNNLALVNGVPMVLNIKEMIKYYFEHQIEILVRRTNFDLKKAKERIHIVEGLV
IAVNNIDEVIKIIKASGDDDIASKSLIQRFDLTELQTKAILEMRLRALTGLNIDKLKKEYEDLILVIKDLEDVLNNYNRQ
VNIICENLDYLIEKFGDERRTEIMYGVSSHIDDEDLIPVEDIVVTMSKRGYFKRLPIDTYKNQRRGGVGVQGLKTYEDDD
VEKILVANTHTDLLFFSDLGRVYRLRGHEVPLGSRQSKGIPAINFLPIEKSESILTILPIDNYDQGSLFFTTSKGIIKRA
NLSDFESIRANGKIAITLKDGDKLFSVMQTLGNDEVFIGASNGNVIRFNENDAREMGRIATGVKGINLENDEYVVGTGLS
SHGEYVLAVGSKGLGKLTDINDYRLTKRGAKGVNTLKVNDKTGNLVSIKVVNREEEALIITTSGKVIRLSIKDISVIGRN
TSGVKLISLENKEEVKSIAIFKKEEINDEQLLQENDYNLK

Sequences:

>Translated_840_residues
MALKKPKKSRLTTEEIKQQLEGSTIKEQSITKEVETSFLDYSMSVIVARALPDVRDGFKPVHRRALFAAFENGMTHDKPY
KKSAR*VGDVIGKYHPHGDQAVYQTIVRMAQDFSMRYLLVDGHGNFGSIDGDSAAAMRYTEARLSKISYELLKYIDKETV
DFVPNYDASEQEPSVLPSGFPNLLTNGTTGIAVGMATNIPPHNLTEVCQAIKAYAKNHNVTISEIMEYLKGPDFPTGAEI
YGDSGIIKYFNTGRGSVTIRSKYEIEDIGQGRVAIVVTEIPYMVNKANLIEKIVELVTNKQIEGISDLRDESSRDGIRIV
IEVKRDVIPEVLLNKLFKTTPLQTNFSVNNLALVNGVPMVLNIKEMIKYYFEHQIEILVRRTNFDLKKAKERIHIVEGLV
IAVNNIDEVIKIIKASGDDDIASKSLIQRFDLTELQTKAILEMRLRALTGLNIDKLKKEYEDLILVIKDLEDVLNNYNRQ
VNIICENLDYLIEKFGDERRTEIMYGVSSHIDDEDLIPVEDIVVTMSKRGYFKRLPIDTYKNQRRGGVGVQGLKTYEDDD
VEKILVANTHTDLLFFSDLGRVYRLRGHEVPLGSRQSKGIPAINFLPIEKSESILTILPIDNYDQGSLFFTTSKGIIKRA
NLSDFESIRANGKIAITLKDGDKLFSVMQTLGNDEVFIGASNGNVIRFNENDAREMGRIATGVKGINLENDEYVVGTGLS
SHGEYVLAVGSKGLGKLTDINDYRLTKRGAKGVNTLKVNDKTGNLVSIKVVNREEEALIITTSGKVIRLSIKDISVIGRN
TSGVKLISLENKEEVKSIAIFKKEEINDEQLLQENDYNLK
>Mature_839_residues
ALKKPKKSRLTTEEIKQQLEGSTIKEQSITKEVETSFLDYSMSVIVARALPDVRDGFKPVHRRALFAAFENGMTHDKPYK
KSAR*VGDVIGKYHPHGDQAVYQTIVRMAQDFSMRYLLVDGHGNFGSIDGDSAAAMRYTEARLSKISYELLKYIDKETVD
FVPNYDASEQEPSVLPSGFPNLLTNGTTGIAVGMATNIPPHNLTEVCQAIKAYAKNHNVTISEIMEYLKGPDFPTGAEIY
GDSGIIKYFNTGRGSVTIRSKYEIEDIGQGRVAIVVTEIPYMVNKANLIEKIVELVTNKQIEGISDLRDESSRDGIRIVI
EVKRDVIPEVLLNKLFKTTPLQTNFSVNNLALVNGVPMVLNIKEMIKYYFEHQIEILVRRTNFDLKKAKERIHIVEGLVI
AVNNIDEVIKIIKASGDDDIASKSLIQRFDLTELQTKAILEMRLRALTGLNIDKLKKEYEDLILVIKDLEDVLNNYNRQV
NIICENLDYLIEKFGDERRTEIMYGVSSHIDDEDLIPVEDIVVTMSKRGYFKRLPIDTYKNQRRGGVGVQGLKTYEDDDV
EKILVANTHTDLLFFSDLGRVYRLRGHEVPLGSRQSKGIPAINFLPIEKSESILTILPIDNYDQGSLFFTTSKGIIKRAN
LSDFESIRANGKIAITLKDGDKLFSVMQTLGNDEVFIGASNGNVIRFNENDAREMGRIATGVKGINLENDEYVVGTGLSS
HGEYVLAVGSKGLGKLTDINDYRLTKRGAKGVNTLKVNDKTGNLVSIKVVNREEEALIITTSGKVIRLSIKDISVIGRNT
SGVKLISLENKEEVKSIAIFKKEEINDEQLLQENDYNLK

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=349, Percent_Identity=25.7879656160458, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI19913406, Length=334, Percent_Identity=26.0479041916168, Blast_Score=80, Evalue=1e-14,
Organism=Escherichia coli, GI1788562, Length=823, Percent_Identity=47.7521263669502, Blast_Score=749, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=690, Percent_Identity=35.3623188405797, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17535065, Length=171, Percent_Identity=34.5029239766082, Blast_Score=84, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI212645657, Length=227, Percent_Identity=30.3964757709251, Blast_Score=80, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI115534553, Length=165, Percent_Identity=32.1212121212121, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI212645845, Length=211, Percent_Identity=30.3317535545024, Blast_Score=71, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=217, Percent_Identity=29.9539170506912, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI17136538, Length=355, Percent_Identity=26.1971830985915, Blast_Score=81, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 94049; Mature: 93918

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALKKPKKSRLTTEEIKQQLEGSTIKEQSITKEVETSFLDYSMSVIVARALPDVRDGFKP
CCCCCCCHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VHRRALFAAFENGMTHDKPYKKSARVGDVIGKYHPHGDQAVYQTIVRMAQDFSMRYLLVD
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEE
GHGNFGSIDGDSAAAMRYTEARLSKISYELLKYIDKETVDFVPNYDASEQEPSVLPSGFP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCCCCCC
NLLTNGTTGIAVGMATNIPPHNLTEVCQAIKAYAKNHNVTISEIMEYLKGPDFPTGAEIY
HHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCCCCCEEE
GDSGIIKYFNTGRGSVTIRSKYEIEDIGQGRVAIVVTEIPYMVNKANLIEKIVELVTNKQ
CCCCEEEEEECCCCEEEEEEECCHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCC
IEGISDLRDESSRDGIRIVIEVKRDVIPEVLLNKLFKTTPLQTNFSVNNLALVNGVPMVL
CCCHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCEE
NIKEMIKYYFEHQIEILVRRTNFDLKKAKERIHIVEGLVIAVNNIDEVIKIIKASGDDDI
EHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHHHHEEEEEECCHHHHHHHHHCCCCCHH
ASKSLIQRFDLTELQTKAILEMRLRALTGLNIDKLKKEYEDLILVIKDLEDVLNNYNRQV
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
NIICENLDYLIEKFGDERRTEIMYGVSSHIDDEDLIPVEDIVVTMSKRGYFKRLPIDTYK
EEEEHHHHHHHHHHCCCHHHHEEECHHHCCCCCCCCCHHHHHEEECCCCCEEECCCHHHC
NQRRGGVGVQGLKTYEDDDVEKILVANTHTDLLFFSDLGRVYRLRGHEVPLGSRQSKGIP
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEHHHHHHHEEECCCCCCCCCCCCCCCC
AINFLPIEKSESILTILPIDNYDQGSLFFTTSKGIIKRANLSDFESIRANGKIAITLKDG
EEEEEECCCCCCEEEEEECCCCCCCCEEEEECCCEEEECCCCHHHHHCCCCEEEEEECCC
DKLFSVMQTLGNDEVFIGASNGNVIRFNENDAREMGRIATGVKGINLENDEYVVGTGLSS
HHHHHHHHHHCCCCEEEECCCCCEEEECCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCC
HGEYVLAVGSKGLGKLTDINDYRLTKRGAKGVNTLKVNDKTGNLVSIKVVNREEEALIIT
CCCEEEEECCCCCCCCCCCCCCEEHHCCCCCCEEEEEECCCCCEEEEEEECCCCCEEEEE
TSGKVIRLSIKDISVIGRNTSGVKLISLENKEEVKSIAIFKKEEINDEQLLQENDYNLK
ECCCEEEEEEEEEEEEECCCCCEEEEEECCHHHHHHHHEEHHHCCCHHHHHHCCCCCCC
>Mature Secondary Structure 
ALKKPKKSRLTTEEIKQQLEGSTIKEQSITKEVETSFLDYSMSVIVARALPDVRDGFKP
CCCCCCHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VHRRALFAAFENGMTHDKPYKKSARVGDVIGKYHPHGDQAVYQTIVRMAQDFSMRYLLVD
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEE
GHGNFGSIDGDSAAAMRYTEARLSKISYELLKYIDKETVDFVPNYDASEQEPSVLPSGFP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCCCCCC
NLLTNGTTGIAVGMATNIPPHNLTEVCQAIKAYAKNHNVTISEIMEYLKGPDFPTGAEIY
HHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCCCCCEEE
GDSGIIKYFNTGRGSVTIRSKYEIEDIGQGRVAIVVTEIPYMVNKANLIEKIVELVTNKQ
CCCCEEEEEECCCCEEEEEEECCHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCC
IEGISDLRDESSRDGIRIVIEVKRDVIPEVLLNKLFKTTPLQTNFSVNNLALVNGVPMVL
CCCHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCEE
NIKEMIKYYFEHQIEILVRRTNFDLKKAKERIHIVEGLVIAVNNIDEVIKIIKASGDDDI
EHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHHHHEEEEEECCHHHHHHHHHCCCCCHH
ASKSLIQRFDLTELQTKAILEMRLRALTGLNIDKLKKEYEDLILVIKDLEDVLNNYNRQV
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
NIICENLDYLIEKFGDERRTEIMYGVSSHIDDEDLIPVEDIVVTMSKRGYFKRLPIDTYK
EEEEHHHHHHHHHHCCCHHHHEEECHHHCCCCCCCCCHHHHHEEECCCCCEEECCCHHHC
NQRRGGVGVQGLKTYEDDDVEKILVANTHTDLLFFSDLGRVYRLRGHEVPLGSRQSKGIP
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEHHHHHHHEEECCCCCCCCCCCCCCCC
AINFLPIEKSESILTILPIDNYDQGSLFFTTSKGIIKRANLSDFESIRANGKIAITLKDG
EEEEEECCCCCCEEEEEECCCCCCCCEEEEECCCEEEECCCCHHHHHCCCCEEEEEECCC
DKLFSVMQTLGNDEVFIGASNGNVIRFNENDAREMGRIATGVKGINLENDEYVVGTGLSS
HHHHHHHHHHCCCCEEEECCCCCEEEECCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCC
HGEYVLAVGSKGLGKLTDINDYRLTKRGAKGVNTLKVNDKTGNLVSIKVVNREEEALIIT
CCCEEEEECCCCCCCCCCCCCCEEHHCCCCCCEEEEEECCCCCEEEEEEECCCCCEEEEE
TSGKVIRLSIKDISVIGRNTSGVKLISLENKEEVKSIAIFKKEEINDEQLLQENDYNLK
ECCCEEEEEEEEEEEEECCCCCEEEEEECCHHHHHHHHEEHHHCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11048724 [H]