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The map label for this gene is ilvY [H]

Identifier: 170026262

GI number: 170026262

Start: 4470957

End: 4471838

Strand: Direct

Name: ilvY [H]

Synonym: YPK_4052

Alternate gene names: 170026262

Gene position: 4470957-4471838 (Clockwise)

Preceding gene: 170026256

Following gene: 170026264

Centisome position: 95.34

GC content: 52.72

Gene sequence:

>882_bases
ATGGATTTACGTGACCTGAAAGTATTTCTGCATCTGGCTGAAAGCCGCCATTTTGGGCGCTCGGCCAAAGCTATGCACGT
CAGTCCCTCTACGCTTTCCCGCCAGATCCAGCGGCTGGAAGAGACTATCGGCCAGCCCCTGTTTTTACGCGATAACCGCA
CAGTGCAATTAACCGATGCGGGTAACCAATTAAAGGCGTTTGCCCAACAAACCCTCTTACAATATCAACAGTTGCTCCAT
GCATTGGGCCAGCACGGTCCTTCCCTAAGCGGTGAATTGCGCTTATTTTGCTCCGTTACCGCCGCTTACAGCCACTTGCC
GCCAATTTTGGACCGCTTTCGCGCACGCCATCCGTTGGTTGAAATTAAACTCACCACGGGTGATGCCGCCGATGCAGTCA
ATAAAGTGCAATCCAATGAGGCTGATTTGGGGATCGCCGGCCGCCCTGAAGTGCTCCCCACCAGCGTGGCCTTTACCCAG
ATTGGTGAAATCCCATTAGTATTGATTGCCCCTGCACTGCCGTGTGCGGTGCGTTCGCAAGTGGCGGTTGAAAAACCGGA
TTGGGCGATGATCCCGTTTATCTTGCCGGAACACGGGCCGTCACGAAAACGTATCGATTTATGGTTCCGTCGCCAGCGTA
TAACTAACCCATTGATTTATGCCACGGTGTCCGGCCATGAAGCGATTGTTTCCATGGTGGCATTGGGTTGCGGTGTCGCC
CTGATCCCGTCGGTAGTGGTGGATAACAGCCCGGAGCCAGTCCGTAACCGTATTTCTCTGCTAGATGATGTCTCGTTAGT
CGAGCCATTTGAGTTGGGGGTTTGTGTACCGAAAAAACGGCTCCAAGAGCCGTTGATTGATGCATTTTGGGGATTGTTAT
AA

Upstream 100 bases:

>100_bases
GCGGAAATTGATATATTAACAATGTGATATTGCAGTTTCTGCAATACACCCGATTTCTTATGCAATACACTACATCATCT
CAACCAAGAGGCTGTCTGTG

Downstream 100 bases:

>100_bases
TCCTTGGTGTCTCAATAGCATAAATATCAGTGACACCATTGATAATAATATTGATTAAGCGGCAATAACACGGCCTATTG
AATAACAGCTAATCATTGCA

Product: DNA-binding transcriptional regulator IlvY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MDLRDLKVFLHLAESRHFGRSAKAMHVSPSTLSRQIQRLEETIGQPLFLRDNRTVQLTDAGNQLKAFAQQTLLQYQQLLH
ALGQHGPSLSGELRLFCSVTAAYSHLPPILDRFRARHPLVEIKLTTGDAADAVNKVQSNEADLGIAGRPEVLPTSVAFTQ
IGEIPLVLIAPALPCAVRSQVAVEKPDWAMIPFILPEHGPSRKRIDLWFRRQRITNPLIYATVSGHEAIVSMVALGCGVA
LIPSVVVDNSPEPVRNRISLLDDVSLVEPFELGVCVPKKRLQEPLIDAFWGLL

Sequences:

>Translated_293_residues
MDLRDLKVFLHLAESRHFGRSAKAMHVSPSTLSRQIQRLEETIGQPLFLRDNRTVQLTDAGNQLKAFAQQTLLQYQQLLH
ALGQHGPSLSGELRLFCSVTAAYSHLPPILDRFRARHPLVEIKLTTGDAADAVNKVQSNEADLGIAGRPEVLPTSVAFTQ
IGEIPLVLIAPALPCAVRSQVAVEKPDWAMIPFILPEHGPSRKRIDLWFRRQRITNPLIYATVSGHEAIVSMVALGCGVA
LIPSVVVDNSPEPVRNRISLLDDVSLVEPFELGVCVPKKRLQEPLIDAFWGLL
>Mature_293_residues
MDLRDLKVFLHLAESRHFGRSAKAMHVSPSTLSRQIQRLEETIGQPLFLRDNRTVQLTDAGNQLKAFAQQTLLQYQQLLH
ALGQHGPSLSGELRLFCSVTAAYSHLPPILDRFRARHPLVEIKLTTGDAADAVNKVQSNEADLGIAGRPEVLPTSVAFTQ
IGEIPLVLIAPALPCAVRSQVAVEKPDWAMIPFILPEHGPSRKRIDLWFRRQRITNPLIYATVSGHEAIVSMVALGCGVA
LIPSVVVDNSPEPVRNRISLLDDVSLVEPFELGVCVPKKRLQEPLIDAFWGLL

Specific function: This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790208, Length=293, Percent_Identity=73.7201365187713, Blast_Score=437, Evalue=1e-124,
Organism=Escherichia coli, GI157672245, Length=244, Percent_Identity=28.2786885245902, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1788887, Length=247, Percent_Identity=28.7449392712551, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI2367136, Length=276, Percent_Identity=26.8115942028986, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1787879, Length=248, Percent_Identity=29.8387096774194, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790399, Length=264, Percent_Identity=29.1666666666667, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI145693105, Length=167, Percent_Identity=29.3413173652695, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787530, Length=271, Percent_Identity=24.3542435424354, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788297, Length=245, Percent_Identity=27.7551020408163, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787806, Length=258, Percent_Identity=24.4186046511628, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788748, Length=254, Percent_Identity=27.5590551181102, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787601, Length=145, Percent_Identity=24.8275862068966, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1790262, Length=253, Percent_Identity=26.0869565217391, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1788296, Length=246, Percent_Identity=27.2357723577236, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789440, Length=148, Percent_Identity=28.3783783783784, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789204, Length=298, Percent_Identity=23.8255033557047, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI145693193, Length=123, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1787589, Length=252, Percent_Identity=26.1904761904762, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1788481, Length=249, Percent_Identity=23.6947791164659, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32381; Mature: 32381

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRDLKVFLHLAESRHFGRSAKAMHVSPSTLSRQIQRLEETIGQPLFLRDNRTVQLTDA
CCHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHCCCEEEECCCEEEEECC
GNQLKAFAQQTLLQYQQLLHALGQHGPSLSGELRLFCSVTAAYSHLPPILDRFRARHPLV
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHCCHHHHHHHHCCCCEE
EIKLTTGDAADAVNKVQSNEADLGIAGRPEVLPTSVAFTQIGEIPLVLIAPALPCAVRSQ
EEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCHHHHCC
VAVEKPDWAMIPFILPEHGPSRKRIDLWFRRQRITNPLIYATVSGHEAIVSMVALGCGVA
CEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCHH
LIPSVVVDNSPEPVRNRISLLDDVSLVEPFELGVCVPKKRLQEPLIDAFWGLL
HHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDLRDLKVFLHLAESRHFGRSAKAMHVSPSTLSRQIQRLEETIGQPLFLRDNRTVQLTDA
CCHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHCCCEEEECCCEEEEECC
GNQLKAFAQQTLLQYQQLLHALGQHGPSLSGELRLFCSVTAAYSHLPPILDRFRARHPLV
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHCCHHHHHHHHCCCCEE
EIKLTTGDAADAVNKVQSNEADLGIAGRPEVLPTSVAFTQIGEIPLVLIAPALPCAVRSQ
EEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCHHHHCC
VAVEKPDWAMIPFILPEHGPSRKRIDLWFRRQRITNPLIYATVSGHEAIVSMVALGCGVA
CEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCHH
LIPSVVVDNSPEPVRNRISLLDDVSLVEPFELGVCVPKKRLQEPLIDAFWGLL
HHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3003115; 1379743; 9278503; 3550695 [H]