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The map label for this gene is panC

Identifier: 170025688

GI number: 170025688

Start: 3815212

End: 3816066

Strand: Direct

Name: panC

Synonym: YPK_3473

Alternate gene names: 170025688

Gene position: 3815212-3816066 (Clockwise)

Preceding gene: 170025687

Following gene: 170025689

Centisome position: 81.36

GC content: 52.75

Gene sequence:

>855_bases
ATGCTGATTATTGAGACATTGCCATTGCTACGTCAACAGATCCGCCGTTGGCGTCAGGAAGGCAAACGAATTGCCTTAGT
ACCCACCATGGGTAACCTGCACGAAGGGCATATGACGCTGGTGGATGAAGCAAAAACCCGCGCTGACGTGGTCGTGGTGA
CTATTTTTGTTAATCCGCTGCAATTTGAACGGCCAGATGACTTAGCCCATTACCCGCGCACCTTACAGGAAGATTGCGAG
AAACTGACCCGCCACGGTGCAGATCTGGTGTTCGCACCGGCCGCAGCCGATATCTACCCTGCGGGGCTGGAAAAGCAAAC
GTATGTTGATGTTCCTGCCCTATCGACCATTTTAGAAGGGGCCAGCCGCCCTGGTCATTTCCGCGGTGTTTCAACCATCG
TCAGCAAGCTGTTTAATCTGATCCAGCCAGATGTCGCCTGTTTCGGCGAAAAAGATTACCAGCAGCTCGCCTTGATCCGC
AAAATGGTGGCGGATATGGGTTATGACATCAACATTGTTGGGGTACCAACGGTGCGCGCGAAAGATGGTTTGGCGCTGAG
TTCCCGTAACGGCTATCTGACGGAAGAAGAACGTCAGATTGCGCCACAGCTCAGTAAGATCATGTGGGCGCTGGCAGAGA
AAATGGCCTTAGGCGAACGGCAGATTGACGCACTGTTGGAAGACGCTGCAGCGCAACTACTCCGTGCAGGCTTTACACCC
GATGAATTGTTTATCCGCGATGCCGAGACCTTACAGCCACTGACTGTCGATAGCCAGCAAGCGGTGATTTTGATGGCCGC
CTGGTTGGGTAAAGCTCGTCTGATTGATAACCAACTGGTTGATTTACGCCACTGA

Upstream 100 bases:

>100_bases
TACATTCCAGTAACTGAGCCACTAATATTTCTTCTAAAATAGGGAGTTTTCAAAATAGGATCCTCCTAAAATAGATCGTT
CCTAAAACAGGAGAAAGGGA

Downstream 100 bases:

>100_bases
TATTTTACCGATCAGGCGGTTGCTCATTCCCCTCAAGCCGTGAGTTGGCCCAAAATCAACCAGGAACGCCAAGGCAAAAG
TCACTATCAACGGCATTCCC

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MLIIETLPLLRQQIRRWRQEGKRIALVPTMGNLHEGHMTLVDEAKTRADVVVVTIFVNPLQFERPDDLAHYPRTLQEDCE
KLTRHGADLVFAPAAADIYPAGLEKQTYVDVPALSTILEGASRPGHFRGVSTIVSKLFNLIQPDVACFGEKDYQQLALIR
KMVADMGYDINIVGVPTVRAKDGLALSSRNGYLTEEERQIAPQLSKIMWALAEKMALGERQIDALLEDAAAQLLRAGFTP
DELFIRDAETLQPLTVDSQQAVILMAAWLGKARLIDNQLVDLRH

Sequences:

>Translated_284_residues
MLIIETLPLLRQQIRRWRQEGKRIALVPTMGNLHEGHMTLVDEAKTRADVVVVTIFVNPLQFERPDDLAHYPRTLQEDCE
KLTRHGADLVFAPAAADIYPAGLEKQTYVDVPALSTILEGASRPGHFRGVSTIVSKLFNLIQPDVACFGEKDYQQLALIR
KMVADMGYDINIVGVPTVRAKDGLALSSRNGYLTEEERQIAPQLSKIMWALAEKMALGERQIDALLEDAAAQLLRAGFTP
DELFIRDAETLQPLTVDSQQAVILMAAWLGKARLIDNQLVDLRH
>Mature_284_residues
MLIIETLPLLRQQIRRWRQEGKRIALVPTMGNLHEGHMTLVDEAKTRADVVVVTIFVNPLQFERPDDLAHYPRTLQEDCE
KLTRHGADLVFAPAAADIYPAGLEKQTYVDVPALSTILEGASRPGHFRGVSTIVSKLFNLIQPDVACFGEKDYQQLALIR
KMVADMGYDINIVGVPTVRAKDGLALSSRNGYLTEEERQIAPQLSKIMWALAEKMALGERQIDALLEDAAAQLLRAGFTP
DELFIRDAETLQPLTVDSQQAVILMAAWLGKARLIDNQLVDLRH

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=282, Percent_Identity=71.9858156028369, Blast_Score=429, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6322046, Length=302, Percent_Identity=36.4238410596026, Blast_Score=171, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_YERP3 (A7FM23)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001402301.1
- ProteinModelPortal:   A7FM23
- SMR:   A7FM23
- STRING:   A7FM23
- GeneID:   5385613
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_3344
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- ProtClustDB:   PRK00380
- BioCyc:   YPSE349747:YPSIP31758_3344-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31730; Mature: 31730

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 155-155 BINDING 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIIETLPLLRQQIRRWRQEGKRIALVPTMGNLHEGHMTLVDEAKTRADVVVVTIFVNPL
CEEEHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHCCCCCEEEEEEEECCC
QFERPDDLAHYPRTLQEDCEKLTRHGADLVFAPAAADIYPAGLEKQTYVDVPALSTILEG
CCCCCCHHHHCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEECHHHHHHHHHC
ASRPGHFRGVSTIVSKLFNLIQPDVACFGEKDYQQLALIRKMVADMGYDINIVGVPTVRA
CCCCCCCHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCEEC
KDGLALSSRNGYLTEEERQIAPQLSKIMWALAEKMALGERQIDALLEDAAAQLLRAGFTP
CCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCC
DELFIRDAETLQPLTVDSQQAVILMAAWLGKARLIDNQLVDLRH
HHHEEECHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCC
>Mature Secondary Structure
MLIIETLPLLRQQIRRWRQEGKRIALVPTMGNLHEGHMTLVDEAKTRADVVVVTIFVNPL
CEEEHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHCCCCCEEEEEEEECCC
QFERPDDLAHYPRTLQEDCEKLTRHGADLVFAPAAADIYPAGLEKQTYVDVPALSTILEG
CCCCCCHHHHCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEECHHHHHHHHHC
ASRPGHFRGVSTIVSKLFNLIQPDVACFGEKDYQQLALIRKMVADMGYDINIVGVPTVRA
CCCCCCCHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCEEC
KDGLALSSRNGYLTEEERQIAPQLSKIMWALAEKMALGERQIDALLEDAAAQLLRAGFTP
CCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCC
DELFIRDAETLQPLTVDSQQAVILMAAWLGKARLIDNQLVDLRH
HHHEEECHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA