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The map label for this gene is hemA [H]

Identifier: 170024411

GI number: 170024411

Start: 2418834

End: 2420150

Strand: Reverse

Name: hemA [H]

Synonym: YPK_2180

Alternate gene names: 170024411

Gene position: 2420150-2418834 (Counterclockwise)

Preceding gene: 170024416

Following gene: 170024410

Centisome position: 51.61

GC content: 50.11

Gene sequence:

>1317_bases
ATGCGCTTCAGACGAGAATCCATACTAACACCAGTATTACTCGAAGCCGTTCCCATGACTCTGCTTGCATTAGGCATTAA
TCACAAAACCGCACCTGTATCGTTACGTGAACGAGTGACGTTTTCACCGGAATCGATGGATCAGGCGCTGAATAGCTTGC
TCCAACAGCCGTTGGTACAGGGCGGTGTCGTGTTGTCCACGTGCAACCGGACTGAACTGTATCTCAGTGTGGAACAGCAA
GAAAACCTACACGAACAATTAACCGCCTGGCTGTGTAACTATCATAAACTCAGCCCGGATGACGTGAGACAAAGCCTGTA
CTGGCATCATGGTAATGACGCTGTCCGCCATTTGATGCGGGTCGCCAGTGGTTTGGATTCCCAAGTTTTGGGTGAACCAC
AAATATTAGGCCAGGTGAAAAAAGCGTTTGCTGAATCTCAGCGCGGGCAATCTCTGTCGAGTGAACTGGAACGGTTATTC
CAGAAATCTTTTTCTGTCGCCAAACGTGTACGCACAGAAACTGAAATTGGTGCCAGTGCGGTTTCGGTCGCTTTTGCTGC
CTGTTCTCTGGCTCGGCAAATTTTCGAATCATTATCAGAACTGCATTTATTATTGGTCGGGGCCGGTGAGACGATTGAAT
TGGTGGCGCGCCACCTGCGTGAACATCAGGTCAAACATATGATTATTGCCAACCGCACCCGTGAACGTGCGCAATCTCTG
GCAAGCGAGGTCGGTGCCGAAGTGATAACGTTGCCAGAAATTGATGCTCGTCTGGCGGATGCTGATATTATTATCAGTTC
TACCGCCAGCCCGTTACCTATTATTGGTAAGGGAATGGTCGAGCGGGCATTGAAAACCCGTCGTAATCAGCCAATGTTAT
TTATTGATATTGCCGTACCCCGTGATATCGAACCGGAGGTCGGTAAGTTGTCGAACGCCTATTTATACAGTGTTGATGAT
TTGCAGGCGATCATTCAGCACAACATGGCTCAGCGGCAGGCTGCGGCTGTTCAGGCTGAATCGATAGTACAACAGGAAAG
CATGAACTTTATGACCTGGCTGCGGGCTCAGGGAGCGGTAGAAACGATCCGTGACTATCGCTCTCAAGCTGAGCAGGTCC
GCAGTGAAATGACCGCTAAAGCCTTGGTAGCCATTGAGCAGGGCGCTAACGTGGAACAGGTCATTAATGAGTTGGCCTAT
AAGCTGACCAACCGCCTTATTCATGCGCCTACCAAATCCCTCCAGCAAGCCGCCAGCGATGGCGATATGGAGCGGTTGCA
ATTATTACGCGACAGCCTTGGGCTGGATCAGCATTAG

Upstream 100 bases:

>100_bases
GTTCTATATTGAACAGCAGATAATCAATTATTGTGCATAATTTGGGATAATACTCAGGATGATGCCGTGCGACTTTTATT
GATCTCACGCATCAAGTAGA

Downstream 100 bases:

>100_bases
TTTCCTCTAATTAATAGGGTTTAAAACCACGGATGAAGTCTTCTATTGTTGCCAAACTGGAAGCGTTACAAGAGCGCCAT
GAAGAAGTTCTGGCATATCT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MRFRRESILTPVLLEAVPMTLLALGINHKTAPVSLRERVTFSPESMDQALNSLLQQPLVQGGVVLSTCNRTELYLSVEQQ
ENLHEQLTAWLCNYHKLSPDDVRQSLYWHHGNDAVRHLMRVASGLDSQVLGEPQILGQVKKAFAESQRGQSLSSELERLF
QKSFSVAKRVRTETEIGASAVSVAFAACSLARQIFESLSELHLLLVGAGETIELVARHLREHQVKHMIIANRTRERAQSL
ASEVGAEVITLPEIDARLADADIIISSTASPLPIIGKGMVERALKTRRNQPMLFIDIAVPRDIEPEVGKLSNAYLYSVDD
LQAIIQHNMAQRQAAAVQAESIVQQESMNFMTWLRAQGAVETIRDYRSQAEQVRSEMTAKALVAIEQGANVEQVINELAY
KLTNRLIHAPTKSLQQAASDGDMERLQLLRDSLGLDQH

Sequences:

>Translated_438_residues
MRFRRESILTPVLLEAVPMTLLALGINHKTAPVSLRERVTFSPESMDQALNSLLQQPLVQGGVVLSTCNRTELYLSVEQQ
ENLHEQLTAWLCNYHKLSPDDVRQSLYWHHGNDAVRHLMRVASGLDSQVLGEPQILGQVKKAFAESQRGQSLSSELERLF
QKSFSVAKRVRTETEIGASAVSVAFAACSLARQIFESLSELHLLLVGAGETIELVARHLREHQVKHMIIANRTRERAQSL
ASEVGAEVITLPEIDARLADADIIISSTASPLPIIGKGMVERALKTRRNQPMLFIDIAVPRDIEPEVGKLSNAYLYSVDD
LQAIIQHNMAQRQAAAVQAESIVQQESMNFMTWLRAQGAVETIRDYRSQAEQVRSEMTAKALVAIEQGANVEQVINELAY
KLTNRLIHAPTKSLQQAASDGDMERLQLLRDSLGLDQH
>Mature_438_residues
MRFRRESILTPVLLEAVPMTLLALGINHKTAPVSLRERVTFSPESMDQALNSLLQQPLVQGGVVLSTCNRTELYLSVEQQ
ENLHEQLTAWLCNYHKLSPDDVRQSLYWHHGNDAVRHLMRVASGLDSQVLGEPQILGQVKKAFAESQRGQSLSSELERLF
QKSFSVAKRVRTETEIGASAVSVAFAACSLARQIFESLSELHLLLVGAGETIELVARHLREHQVKHMIIANRTRERAQSL
ASEVGAEVITLPEIDARLADADIIISSTASPLPIIGKGMVERALKTRRNQPMLFIDIAVPRDIEPEVGKLSNAYLYSVDD
LQAIIQHNMAQRQAAAVQAESIVQQESMNFMTWLRAQGAVETIRDYRSQAEQVRSEMTAKALVAIEQGANVEQVINELAY
KLTNRLIHAPTKSLQQAASDGDMERLQLLRDSLGLDQH

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=418, Percent_Identity=79.4258373205742, Blast_Score=671, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR003462
- InterPro:   IPR018214
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 48785; Mature: 48785

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00747 GLUTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFRRESILTPVLLEAVPMTLLALGINHKTAPVSLRERVTFSPESMDQALNSLLQQPLVQ
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHH
GGVVLSTCNRTELYLSVEQQENLHEQLTAWLCNYHKLSPDDVRQSLYWHHGNDAVRHLMR
CCEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHH
VASGLDSQVLGEPQILGQVKKAFAESQRGQSLSSELERLFQKSFSVAKRVRTETEIGASA
HHCCCCHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSVAFAACSLARQIFESLSELHLLLVGAGETIELVARHLREHQVKHMIIANRTRERAQSL
HHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASEVGAEVITLPEIDARLADADIIISSTASPLPIIGKGMVERALKTRRNQPMLFIDIAVP
HHHHCCCEEECCCHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECC
RDIEPEVGKLSNAYLYSVDDLQAIIQHNMAQRQAAAVQAESIVQQESMNFMTWLRAQGAV
CCCCCCHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ETIRDYRSQAEQVRSEMTAKALVAIEQGANVEQVINELAYKLTNRLIHAPTKSLQQAASD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCC
GDMERLQLLRDSLGLDQH
CCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRFRRESILTPVLLEAVPMTLLALGINHKTAPVSLRERVTFSPESMDQALNSLLQQPLVQ
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHH
GGVVLSTCNRTELYLSVEQQENLHEQLTAWLCNYHKLSPDDVRQSLYWHHGNDAVRHLMR
CCEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHH
VASGLDSQVLGEPQILGQVKKAFAESQRGQSLSSELERLFQKSFSVAKRVRTETEIGASA
HHCCCCHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSVAFAACSLARQIFESLSELHLLLVGAGETIELVARHLREHQVKHMIIANRTRERAQSL
HHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASEVGAEVITLPEIDARLADADIIISSTASPLPIIGKGMVERALKTRRNQPMLFIDIAVP
HHHHCCCEEECCCHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECC
RDIEPEVGKLSNAYLYSVDDLQAIIQHNMAQRQAAAVQAESIVQQESMNFMTWLRAQGAV
CCCCCCHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ETIRDYRSQAEQVRSEMTAKALVAIEQGANVEQVINELAYKLTNRLIHAPTKSLQQAASD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCC
GDMERLQLLRDSLGLDQH
CCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA