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The map label for this gene is ada [H]

Identifier: 169629419

GI number: 169629419

Start: 2385436

End: 2386917

Strand: Reverse

Name: ada [H]

Synonym: MAB_2333c

Alternate gene names: 169629419

Gene position: 2386917-2385436 (Counterclockwise)

Preceding gene: 169629433

Following gene: 169629418

Centisome position: 47.11

GC content: 65.11

Gene sequence:

>1482_bases
ATGGAGCTTGACGCGGAGGCCTGCTACCGGGCCGTTCAATCCCGCGACACACGATTCGACGGGCAGTTCTTCACCGCCGT
ACACACCACCGGAATCTACTGTCGGCCATCCTGTCCCGCCATCACGCCGAAACGACAGAACGTTTCCTTCCACCCCACCG
CCGCCTCGGCGCAGGCGGCGGGATACCGGGCCTGCCGGCGCTGCCTTCCCGACGCAGCACCGGGATCGCCATTGTGGAAT
ATCAAGTCCGATTTGGCCGTCCGCGCGATGCGACTTATCGGGGACGGCCTGGTCGAGCGCGACGGTGTAGACGGGCTGTC
CCGGGCACTCGGATACTCGAGTCGCCAGCTGAACAGGGTCCTGCTGGCCGAGCTCGGGGCGAGCCCACTGGCACTTGCCC
GCGCCAATCGGGCCACCACGGCGCGTGTGCTGATTCAGCGCACTGATCTGCCGATGTCCGATATCGCCTTTGCCGCAGGA
TTTTCCAGCATTCGCCAATTCAACGACACGATTGCCGCAGTCTTCGCGACCACACCCTCCAAGCTACGGACCGAGCTCCC
CCGCAAGGAATGTCCCGCGCCGGAACCCATTCCCGGCGCCGTCAGCCTCAAACTTCCTCTACGGCAGCCACACAACATCG
CATGGTCAACGTGGCTGTTGGAGCATCATTGCGCGCGAGGCGTAGAGGATTTTTCCGACGGCCGGTATACGCGGGCGTTG
CGGATGCCGCATGGGCCGGTGATCGCGACGTTGACGGTCAGCGCCGACCAGGTGCGGGCCGACTTGCAGCTCACGGACAT
GCGCGACTTGGCCCCCGCGGTGGCACGCCTGCGCCACCTGCTGGATCTGGACGCCGACCCGTCGGCTGTCGACGAAGCCC
TACTGTCACACCGCGTCCTTGCCCCGCTGGTGACCGAGGCCCCGGGGATCAGGGTTCCAGGGACCGTCGACGGTGCAGAG
CTATTGTTGCGCACCATGATCGGCCAGCAGATCTCCGTGGCGGCGGCCAATACGGCGACGGCGTCCCTGGTGGCGGCCCT
TGGCGAGGAAGTTACCGACGCCACGGGACGAGTGACCCATCTTTTTCCGACCGCCGAAACCGTTGCTGCCGCAGCCCAGG
AGGTCATGGCCGGGCCAGCGGCACGGATCGCAGCGATCGCCGGGGCCGCCGACAGGCTCGCAACAGGAAAATTGGAGTTG
CATCATGGCATGACTGGCACCGATCTACGTCGGCAGTTGTTGGATATCAAGGGGATTGGCCCATGGACCGCAGACTACGT
GGTCATGCGCCAACTGGCCGACCCCGACGTGCTGCTGGAACACGATCTTGTGCTGCGGCGCGGCGCCACCGCCGCAGGTG
TCGACATGGCAACCGCCCGTGCTAGTTCGCCATGGCGCTCTTATGTCTCCATGCACCTGTGGCGCAAGGGAATCGCCGCG
CTACCGCGGCAACTCACTCGCAAACCGAAGGGAAAATCGTGA

Upstream 100 bases:

>100_bases
CTGGTCGGCCCGGTATGCCTAAATACCCGCGGAGGGCCGGCCAGACGATAATGTCCGATTTCCGCTAGCGCCGACCCCAG
CGGCCGGGCATGCTCAAGTC

Downstream 100 bases:

>100_bases
CCGATCATGCGACTCTCACCACCCCGGTGGGCCCATTTACCGCCATCGTGGATGATACGGGCGCCGTCTTGGCCTCGGGG
TGGACCGACTCACCTGAACT

Product: putative 3-methyladenine DNA glycosylase AlkA

Products: NA

Alternate protein names: Regulatory protein of adaptative response; Methylated-DNA--protein-cysteine methyltransferase; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MELDAEACYRAVQSRDTRFDGQFFTAVHTTGIYCRPSCPAITPKRQNVSFHPTAASAQAAGYRACRRCLPDAAPGSPLWN
IKSDLAVRAMRLIGDGLVERDGVDGLSRALGYSSRQLNRVLLAELGASPLALARANRATTARVLIQRTDLPMSDIAFAAG
FSSIRQFNDTIAAVFATTPSKLRTELPRKECPAPEPIPGAVSLKLPLRQPHNIAWSTWLLEHHCARGVEDFSDGRYTRAL
RMPHGPVIATLTVSADQVRADLQLTDMRDLAPAVARLRHLLDLDADPSAVDEALLSHRVLAPLVTEAPGIRVPGTVDGAE
LLLRTMIGQQISVAAANTATASLVAALGEEVTDATGRVTHLFPTAETVAAAAQEVMAGPAARIAAIAGAADRLATGKLEL
HHGMTGTDLRRQLLDIKGIGPWTADYVVMRQLADPDVLLEHDLVLRRGATAAGVDMATARASSPWRSYVSMHLWRKGIAA
LPRQLTRKPKGKS

Sequences:

>Translated_493_residues
MELDAEACYRAVQSRDTRFDGQFFTAVHTTGIYCRPSCPAITPKRQNVSFHPTAASAQAAGYRACRRCLPDAAPGSPLWN
IKSDLAVRAMRLIGDGLVERDGVDGLSRALGYSSRQLNRVLLAELGASPLALARANRATTARVLIQRTDLPMSDIAFAAG
FSSIRQFNDTIAAVFATTPSKLRTELPRKECPAPEPIPGAVSLKLPLRQPHNIAWSTWLLEHHCARGVEDFSDGRYTRAL
RMPHGPVIATLTVSADQVRADLQLTDMRDLAPAVARLRHLLDLDADPSAVDEALLSHRVLAPLVTEAPGIRVPGTVDGAE
LLLRTMIGQQISVAAANTATASLVAALGEEVTDATGRVTHLFPTAETVAAAAQEVMAGPAARIAAIAGAADRLATGKLEL
HHGMTGTDLRRQLLDIKGIGPWTADYVVMRQLADPDVLLEHDLVLRRGATAAGVDMATARASSPWRSYVSMHLWRKGIAA
LPRQLTRKPKGKS
>Mature_493_residues
MELDAEACYRAVQSRDTRFDGQFFTAVHTTGIYCRPSCPAITPKRQNVSFHPTAASAQAAGYRACRRCLPDAAPGSPLWN
IKSDLAVRAMRLIGDGLVERDGVDGLSRALGYSSRQLNRVLLAELGASPLALARANRATTARVLIQRTDLPMSDIAFAAG
FSSIRQFNDTIAAVFATTPSKLRTELPRKECPAPEPIPGAVSLKLPLRQPHNIAWSTWLLEHHCARGVEDFSDGRYTRAL
RMPHGPVIATLTVSADQVRADLQLTDMRDLAPAVARLRHLLDLDADPSAVDEALLSHRVLAPLVTEAPGIRVPGTVDGAE
LLLRTMIGQQISVAAANTATASLVAALGEEVTDATGRVTHLFPTAETVAAAAQEVMAGPAARIAAIAGAADRLATGKLEL
HHGMTGTDLRRQLLDIKGIGPWTADYVVMRQLADPDVLLEHDLVLRRGATAAGVDMATARASSPWRSYVSMHLWRKGIAA
LPRQLTRKPKGKS

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus [H]

COG id: COG2169

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788383, Length=280, Percent_Identity=29.6428571428571, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788542, Length=170, Percent_Identity=34.1176470588235, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR010316
- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR023170
- InterPro:   IPR012294 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF06029 AlkA_N; PF00730 HhH-GPD [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 52962; Mature: 52962

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELDAEACYRAVQSRDTRFDGQFFTAVHTTGIYCRPSCPAITPKRQNVSFHPTAASAQAA
CCCCHHHHHHHHHHCCCCCCCEEEEEEECCCEEECCCCCCCCCCCCCCEECCCCCCHHHH
GYRACRRCLPDAAPGSPLWNIKSDLAVRAMRLIGDGLVERDGVDGLSRALGYSSRQLNRV
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHCCCCCHHHHHHHCCCHHHHHHH
LLAELGASPLALARANRATTARVLIQRTDLPMSDIAFAAGFSSIRQFNDTIAAVFATTPS
HHHHCCCCCHHHHHCCCHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
KLRTELPRKECPAPEPIPGAVSLKLPLRQPHNIAWSTWLLEHHCARGVEDFSDGRYTRAL
HHHHHCCHHHCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHCCCCEEEEE
RMPHGPVIATLTVSADQVRADLQLTDMRDLAPAVARLRHLLDLDADPSAVDEALLSHRVL
ECCCCCEEEEEEECHHHHHHCCEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
APLVTEAPGIRVPGTVDGAELLLRTMIGQQISVAAANTATASLVAALGEEVTDATGRVTH
HHHHHCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCCEEE
LFPTAETVAAAAQEVMAGPAARIAAIAGAADRLATGKLELHHGMTGTDLRRQLLDIKGIG
ECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCCC
PWTADYVVMRQLADPDVLLEHDLVLRRGATAAGVDMATARASSPWRSYVSMHLWRKGIAA
CCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHH
LPRQLTRKPKGKS
HHHHHHCCCCCCC
>Mature Secondary Structure
MELDAEACYRAVQSRDTRFDGQFFTAVHTTGIYCRPSCPAITPKRQNVSFHPTAASAQAA
CCCCHHHHHHHHHHCCCCCCCEEEEEEECCCEEECCCCCCCCCCCCCCEECCCCCCHHHH
GYRACRRCLPDAAPGSPLWNIKSDLAVRAMRLIGDGLVERDGVDGLSRALGYSSRQLNRV
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHCCCCCHHHHHHHCCCHHHHHHH
LLAELGASPLALARANRATTARVLIQRTDLPMSDIAFAAGFSSIRQFNDTIAAVFATTPS
HHHHCCCCCHHHHHCCCHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
KLRTELPRKECPAPEPIPGAVSLKLPLRQPHNIAWSTWLLEHHCARGVEDFSDGRYTRAL
HHHHHCCHHHCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHCCCCEEEEE
RMPHGPVIATLTVSADQVRADLQLTDMRDLAPAVARLRHLLDLDADPSAVDEALLSHRVL
ECCCCCEEEEEEECHHHHHHCCEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
APLVTEAPGIRVPGTVDGAELLLRTMIGQQISVAAANTATASLVAALGEEVTDATGRVTH
HHHHHCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCCEEE
LFPTAETVAAAAQEVMAGPAARIAAIAGAADRLATGKLELHHGMTGTDLRRQLLDIKGIG
ECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCCC
PWTADYVVMRQLADPDVLLEHDLVLRRGATAAGVDMATARASSPWRSYVSMHLWRKGIAA
CCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHH
LPRQLTRKPKGKS
HHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]