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The map label for this gene is glmU [H]

Identifier: 169824176

GI number: 169824176

Start: 537793

End: 539157

Strand: Direct

Name: glmU [H]

Synonym: FMG_0479

Alternate gene names: 169824176

Gene position: 537793-539157 (Clockwise)

Preceding gene: 169824173

Following gene: 169824177

Centisome position: 29.92

GC content: 32.89

Gene sequence:

>1365_bases
ATGAAGAAAGCTATTATACTTTCTGCCGGAGAAGGCACTAGAATGAAATCTCACAACTCAAAAGTTTTGCATAAACTTTT
GAACAAGCCTATGATTGATTATGTCATGGATGCTTGTGATTTTGTGGATCAAAAGATAGTTGTCGGCGGAAATAATTACG
ATATTTTAAGAGAAAACTTAGATGAAAGTATTCATCTAGTAAAACAAAATATAGGAGAAAATTATCCATATGGAACGGGA
TATGCCGTTAAATTGTGTTTGGATGAAATAAATGACGACGATAAAGTTATTATTTTAACAGGAGATACTCCACTAATAAA
GCAAGAGACGTTGAAGAAGTTTTTTGATTATCATGAACAACAAAATTCTGTTGCAACAGTTCTTACAAGTGAAATCGACG
ATCCATTTGGATATGGAAGAATTGTAAAAGACGAAAATGGCAATTTGCTTAAAATCGTTGAGCAAAAAGATTGCAATGAT
CAACAACTTTTAATAAAAGAATTCAACAGTGGAATGATGATAGTAAATGGCGATGTGTTGAAGATGTCAATCGAAAAAAT
CGACACAAATAATTCAAAAGGTGAAATGTATTTGACTGATATTTTCGAAATCATTAGAAAAGATGGCAAAATCATCAAAA
CTTTCAAACATTCTGATGTAAACGAAACTTACGGCATCAATACAAAAGCTCAATTGTATTTTTGCGAAGAAATTTTAAAA
CAAAGAGTTAATGAAAAGTTCATGGAAGATGGTGTTGTTATTTCTAATTCAGATTCTGTAATCATTGAACCGTCTGTAAA
AATCGGAAGGGACACTGTGATTATTGGACCTTCAAGAATTTACGGAAGTACTGAAATAGGCTCTGATTGTTTGATTAAGG
GAGATTGTGAAATCGTGGATTCCAAAATCGATGACAATGTGGTTATTAAATCATCATACATTGAAAATTCTGTTGTAGGA
AAGAACACAGACATCGGACCTTTCGCTCATTTGAGACCAAACAGCGTTTTAAAAGAAAATGTTCATATTGGAAACTTTGT
TGAAATCAAAAACTCAACTGTTGGAAACAAAACAAAGGCAGGTCATTTGGCTTATGTTGGAGACAGCGATTTGAAGGAAA
ATATCAACATCGGTTGCGGAGTGATTTTTGTGAATTACGACGGCAAAAACAAACACAGATCTGTTGTTGAAGACAATGTG
TTTGTAGGTTCAAATTCAAATGTGATTGCTCCTGTAACTTTGAAAAAAGACAGCTTCATTGCTTGTGGAACTACAATTAC
TGAAGATGTTGAAGAAGGTGCACTTTCAATTGGAAGAAGTCGCCAAGAAAATAAAAAAGATTGGGTTTATAAGAAAAAAA
GATAG

Upstream 100 bases:

>100_bases
TAGAAAAAAGTTGACATCTTTGACTTATTTTAGCATTATATGCTTTTAAATTTCCTATTTTATAGTATAATGGTAATGAC
AATTTTTTAGGAGATGAATA

Downstream 100 bases:

>100_bases
AAATGGAATGATTATATGTATTTAATCGCAGGACTGGGTAATCCAGGAAGTAAATACGAATACACTAGACACAATGCCGG
ATTTATGGTTATAGATGATT

Product: UDP-N-acetylglucosamine pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MKKAIILSAGEGTRMKSHNSKVLHKLLNKPMIDYVMDACDFVDQKIVVGGNNYDILRENLDESIHLVKQNIGENYPYGTG
YAVKLCLDEINDDDKVIILTGDTPLIKQETLKKFFDYHEQQNSVATVLTSEIDDPFGYGRIVKDENGNLLKIVEQKDCND
QQLLIKEFNSGMMIVNGDVLKMSIEKIDTNNSKGEMYLTDIFEIIRKDGKIIKTFKHSDVNETYGINTKAQLYFCEEILK
QRVNEKFMEDGVVISNSDSVIIEPSVKIGRDTVIIGPSRIYGSTEIGSDCLIKGDCEIVDSKIDDNVVIKSSYIENSVVG
KNTDIGPFAHLRPNSVLKENVHIGNFVEIKNSTVGNKTKAGHLAYVGDSDLKENINIGCGVIFVNYDGKNKHRSVVEDNV
FVGSNSNVIAPVTLKKDSFIACGTTITEDVEEGALSIGRSRQENKKDWVYKKKR

Sequences:

>Translated_454_residues
MKKAIILSAGEGTRMKSHNSKVLHKLLNKPMIDYVMDACDFVDQKIVVGGNNYDILRENLDESIHLVKQNIGENYPYGTG
YAVKLCLDEINDDDKVIILTGDTPLIKQETLKKFFDYHEQQNSVATVLTSEIDDPFGYGRIVKDENGNLLKIVEQKDCND
QQLLIKEFNSGMMIVNGDVLKMSIEKIDTNNSKGEMYLTDIFEIIRKDGKIIKTFKHSDVNETYGINTKAQLYFCEEILK
QRVNEKFMEDGVVISNSDSVIIEPSVKIGRDTVIIGPSRIYGSTEIGSDCLIKGDCEIVDSKIDDNVVIKSSYIENSVVG
KNTDIGPFAHLRPNSVLKENVHIGNFVEIKNSTVGNKTKAGHLAYVGDSDLKENINIGCGVIFVNYDGKNKHRSVVEDNV
FVGSNSNVIAPVTLKKDSFIACGTTITEDVEEGALSIGRSRQENKKDWVYKKKR
>Mature_454_residues
MKKAIILSAGEGTRMKSHNSKVLHKLLNKPMIDYVMDACDFVDQKIVVGGNNYDILRENLDESIHLVKQNIGENYPYGTG
YAVKLCLDEINDDDKVIILTGDTPLIKQETLKKFFDYHEQQNSVATVLTSEIDDPFGYGRIVKDENGNLLKIVEQKDCND
QQLLIKEFNSGMMIVNGDVLKMSIEKIDTNNSKGEMYLTDIFEIIRKDGKIIKTFKHSDVNETYGINTKAQLYFCEEILK
QRVNEKFMEDGVVISNSDSVIIEPSVKIGRDTVIIGPSRIYGSTEIGSDCLIKGDCEIVDSKIDDNVVIKSSYIENSVVG
KNTDIGPFAHLRPNSVLKENVHIGNFVEIKNSTVGNKTKAGHLAYVGDSDLKENINIGCGVIFVNYDGKNKHRSVVEDNV
FVGSNSNVIAPVTLKKDSFIACGTTITEDVEEGALSIGRSRQENKKDWVYKKKR

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=369, Percent_Identity=22.4932249322493, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI11761619, Length=346, Percent_Identity=22.8323699421965, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1790168, Length=448, Percent_Identity=38.6160714285714, Blast_Score=308, Evalue=4e-85,
Organism=Saccharomyces cerevisiae, GI6320148, Length=357, Percent_Identity=25.7703081232493, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 50740; Mature: 50740

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKAIILSAGEGTRMKSHNSKVLHKLLNKPMIDYVMDACDFVDQKIVVGGNNYDILRENL
CCCEEEEECCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHH
DESIHLVKQNIGENYPYGTGYAVKLCLDEINDDDKVIILTGDTPLIKQETLKKFFDYHEQ
HHHHHHHHHHCCCCCCCCCCCEEEEEEHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHH
QNSVATVLTSEIDDPFGYGRIVKDENGNLLKIVEQKDCNDQQLLIKEFNSGMMIVNGDVL
CCCEEEEHHHHCCCCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHCCCCEEEEECCEE
KMSIEKIDTNNSKGEMYLTDIFEIIRKDGKIIKTFKHSDVNETYGINTKAQLYFCEEILK
EEEEEEECCCCCCCCEEHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEHHHHHHHHH
QRVNEKFMEDGVVISNSDSVIIEPSVKIGRDTVIIGPSRIYGSTEIGSDCLIKGDCEIVD
HHHHHHHHHCCEEEECCCCEEECCCCCCCCEEEEECCHHCCCCCCCCCCCEEECCCEEEC
SKIDDNVVIKSSYIENSVVGKNTDIGPFAHLRPNSVLKENVHIGNFVEIKNSTVGNKTKA
CCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEEEECCCCCCCCCCC
GHLAYVGDSDLKENINIGCGVIFVNYDGKNKHRSVVEDNVFVGSNSNVIAPVTLKKDSFI
CEEEEECCCCCCCCCCCEEEEEEEEECCCCCCCHHHCCCEEECCCCCEEEEEEECCCCEE
ACGTTITEDVEEGALSIGRSRQENKKDWVYKKKR
EECCHHHHHHHHHHHHHCCCCCCCCCCCCEECCC
>Mature Secondary Structure
MKKAIILSAGEGTRMKSHNSKVLHKLLNKPMIDYVMDACDFVDQKIVVGGNNYDILRENL
CCCEEEEECCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHH
DESIHLVKQNIGENYPYGTGYAVKLCLDEINDDDKVIILTGDTPLIKQETLKKFFDYHEQ
HHHHHHHHHHCCCCCCCCCCCEEEEEEHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHH
QNSVATVLTSEIDDPFGYGRIVKDENGNLLKIVEQKDCNDQQLLIKEFNSGMMIVNGDVL
CCCEEEEHHHHCCCCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHCCCCEEEEECCEE
KMSIEKIDTNNSKGEMYLTDIFEIIRKDGKIIKTFKHSDVNETYGINTKAQLYFCEEILK
EEEEEEECCCCCCCCEEHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEHHHHHHHHH
QRVNEKFMEDGVVISNSDSVIIEPSVKIGRDTVIIGPSRIYGSTEIGSDCLIKGDCEIVD
HHHHHHHHHCCEEEECCCCEEECCCCCCCCEEEEECCHHCCCCCCCCCCCEEECCCEEEC
SKIDDNVVIKSSYIENSVVGKNTDIGPFAHLRPNSVLKENVHIGNFVEIKNSTVGNKTKA
CCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEEEECCCCCCCCCCC
GHLAYVGDSDLKENINIGCGVIFVNYDGKNKHRSVVEDNVFVGSNSNVIAPVTLKKDSFI
CEEEEECCCCCCCCCCCEEEEEEEEECCCCCCCHHHCCCEEECCCCCEEEEEEECCCCEE
ACGTTITEDVEEGALSIGRSRQENKKDWVYKKKR
EECCHHHHHHHHHHHHHCCCCCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA