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The map label for this gene is pth

Identifier: 169824177

GI number: 169824177

Start: 539173

End: 539742

Strand: Direct

Name: pth

Synonym: FMG_0480

Alternate gene names: 169824177

Gene position: 539173-539742 (Clockwise)

Preceding gene: 169824176

Following gene: 169824178

Centisome position: 29.99

GC content: 31.23

Gene sequence:

>570_bases
ATGTATTTAATCGCAGGACTGGGTAATCCAGGAAGTAAATACGAATACACTAGACACAATGCCGGATTTATGGTTATAGA
TGATTTGGCAAAAAAATTGAATATTAAGGTGAACAAATTAAAGTTCAAATCTTTGATTGGAGAGGGATTCATTGGAGACG
AAAAGGTGATTTTGATGAAACCATCAACTTACATGAATGATTCAGGGAAAGCTATTTTAGATTGTTTTAATTATTATAAT
TTATCAGCAGAAAATCTTATTGTCATTTGTGATGACATTGATATTCCTTTCGGAACTATTAGGATAAAAAAGAAGGGCTC
CGCTGGAACTCACAATGGTTTAAAATCAATAATTTATCTTATTGAATCTCAAGATTTTGCAAGAATAAAAGTTTCTGTTG
GTCAAAATGACAAATATGATTTGAAAGATTTTGTGTTGTCACAATTTAGCAAGAAGGAATTCGAAGTTTTGGAAAAAGAA
ATTGACATGTCAAGTGATGCTGCTATCAAAATAGTAGAAGAAAATGTCGATTATGCTATGAATAACTTCAACGGGAAAAG
CGTGATATGA

Upstream 100 bases:

>100_bases
TGAAGATGTTGAAGAAGGTGCACTTTCAATTGGAAGAAGTCGCCAAGAAAATAAAAAAGATTGGGTTTATAAGAAAAAAA
GATAGAAATGGAATGATTAT

Downstream 100 bases:

>100_bases
ATTTTTTAACGAAAATTTATGAAGATAACACAGAATTTCAAGGTTATTTGGATTCTTTGTCAGCCAATAACTCGTCGATT
TACATTCACGGTGTTATTAA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MYLIAGLGNPGSKYEYTRHNAGFMVIDDLAKKLNIKVNKLKFKSLIGEGFIGDEKVILMKPSTYMNDSGKAILDCFNYYN
LSAENLIVICDDIDIPFGTIRIKKKGSAGTHNGLKSIIYLIESQDFARIKVSVGQNDKYDLKDFVLSQFSKKEFEVLEKE
IDMSSDAAIKIVEENVDYAMNNFNGKSVI

Sequences:

>Translated_189_residues
MYLIAGLGNPGSKYEYTRHNAGFMVIDDLAKKLNIKVNKLKFKSLIGEGFIGDEKVILMKPSTYMNDSGKAILDCFNYYN
LSAENLIVICDDIDIPFGTIRIKKKGSAGTHNGLKSIIYLIESQDFARIKVSVGQNDKYDLKDFVLSQFSKKEFEVLEKE
IDMSSDAAIKIVEENVDYAMNNFNGKSVI
>Mature_189_residues
MYLIAGLGNPGSKYEYTRHNAGFMVIDDLAKKLNIKVNKLKFKSLIGEGFIGDEKVILMKPSTYMNDSGKAILDCFNYYN
LSAENLIVICDDIDIPFGTIRIKKKGSAGTHNGLKSIIYLIESQDFARIKVSVGQNDKYDLKDFVLSQFSKKEFEVLEKE
IDMSSDAAIKIVEENVDYAMNNFNGKSVI

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=178, Percent_Identity=29.2134831460674, Blast_Score=105, Evalue=2e-23,
Organism=Escherichia coli, GI1787455, Length=186, Percent_Identity=32.7956989247312, Blast_Score=92, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_FINM2 (B0S0D9)

Other databases:

- EMBL:   AP008971
- RefSeq:   YP_001691788.1
- ProteinModelPortal:   B0S0D9
- SMR:   B0S0D9
- GeneID:   6019936
- GenomeReviews:   AP008971_GR
- KEGG:   fma:FMG_0480
- HOGENOM:   HBG610927
- OMA:   NESGRQV
- BioCyc:   FMAG334413:FMG_0480-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21232; Mature: 21232

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLIAGLGNPGSKYEYTRHNAGFMVIDDLAKKLNIKVNKLKFKSLIGEGFIGDEKVILMK
CEEEEECCCCCCCCEEEECCCCEEEHHHHHHHHCCEEEEEEHHHHHCCCCCCCCEEEEEC
PSTYMNDSGKAILDCFNYYNLSAENLIVICDDIDIPFGTIRIKKKGSAGTHNGLKSIIYL
CCCCCCCCCCEEEEHHHHCCCCCCCEEEEECCCCCCEEEEEEEECCCCCCHHHHHHHEEE
IESQDFARIKVSVGQNDKYDLKDFVLSQFSKKEFEVLEKEIDMSSDAAIKIVEENVDYAM
ECCCCEEEEEEEECCCCCCCHHHHHHHHHCHHHHHHHHHHCCCCCCCEEEEEECCCCCHH
NNFNGKSVI
CCCCCCCCC
>Mature Secondary Structure
MYLIAGLGNPGSKYEYTRHNAGFMVIDDLAKKLNIKVNKLKFKSLIGEGFIGDEKVILMK
CEEEEECCCCCCCCEEEECCCCEEEHHHHHHHHCCEEEEEEHHHHHCCCCCCCCEEEEEC
PSTYMNDSGKAILDCFNYYNLSAENLIVICDDIDIPFGTIRIKKKGSAGTHNGLKSIIYL
CCCCCCCCCCEEEEHHHHCCCCCCCEEEEECCCCCCEEEEEEEECCCCCCHHHHHHHEEE
IESQDFARIKVSVGQNDKYDLKDFVLSQFSKKEFEVLEKEIDMSSDAAIKIVEENVDYAM
ECCCCEEEEEEEECCCCCCCHHHHHHHHHCHHHHHHHHHHCCCCCCCEEEEEECCCCCHH
NNFNGKSVI
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA