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The map label for this gene is csd [H]

Identifier: 169824169

GI number: 169824169

Start: 530355

End: 531605

Strand: Direct

Name: csd [H]

Synonym: FMG_0472

Alternate gene names: 169824169

Gene position: 530355-531605 (Clockwise)

Preceding gene: 169824168

Following gene: 169824170

Centisome position: 29.5

GC content: 33.97

Gene sequence:

>1251_bases
ATGTTAGATAAAAAGCAAGTAGAAGATATAAGAAAGGACTTTTTGTATTTGAGTAAAGAATACAAAAATCCGATAGTTTA
TTTGGACAATGCAGCTACCAGCCAAAAACCGATACAAGTTATAGACAGCGTAAGTGAATTTTACAAATATGAAAACGCAA
ATCCTCACAGAGGAGCACACACATTAAGCGTTTTATCGACAGATGTTTACGAATCTGGAAGAGAAAAAGTCGCGAAATTC
ATCAACGCAACAGATTCTTCAGAAATAGTATTCACAAGAAATACTACTGAATCTTTAAATTTACTAGCTTATTCGTATGG
ATATGAAAATTTAAAAGAAGATGATGAAATTGTCATATCAATAATGGAGCATCACAGTAATTTAGTAACTTGGCAAGAAG
TTTGCAAGAAAACAGGCGCCAAACTAAAATATTTGTATGTAGACAAGGGAAATATGCAATTAGATTTTGAAGAATTCAAG
AAAACAATCACGAAAAAAACGAAAATTTTCTCGATAACACAAGCATCAAACGTAGTGGGAACTATGCCCGATGTTGAAAA
AATGATAAAATACGTTAAATCAGTAAACAAGGATTGCATATGCATCGTGGATAGTGCACAATATATTCCACACAACAAAG
TTGACGTACAAAAATTGGGATGTGATTTCCTAGTATTTTCAGGTCACAAAATGCTAAGCATAATGGGAGTCGGAATACTT
TATGGAAAGAAAGAATTGTTGAACAACCTAAAACCATTCTTGTACGGTGGAGACATGATTGAATATGTATTTGAAGACAA
ATCATCGTACTTGGATGCGCCTGGAAGATTTGAGGCCGGAACACAAGATGTAGGAGCAGTAAAATCACTAATCACAGCGA
TTGATTACATCGAAAAAATAGGAATCGAAAACATTAGAGATTATGAAAAAGCATTGATGGATTATGCTTATGACAAAATC
AAACAAAAATCAGATATTATCGATGTATACACAACAAGTGATACTCACAGATCTCCAGTTTTAGATTTTAACTTTAAAGA
AGCTCATCCACATGATGTTGCAAGTATTATGGACAGTTACGGAATTGCAATCAGAAGTGGCCACCATTGTGCACAACCGC
TTCACAGATATTTGAAGACGAATTTCTCATGCAGAGCAAGCTTTGCATTCTATAATACATTTGAAGAAGTTGACTTTTTC
ATTGAACATCTTGAAGACGTAAGGAGATTGATGAGAATTGGAACTAGGTAG

Upstream 100 bases:

>100_bases
GAATCCAAATTCAGCGAATCTCTAAGTAGATTAGATGACAAAAATTTGGAAGAAAAACTACTTTCATTCATCAGAGAAAA
AATGTCAAAGAGGGAATTGG

Downstream 100 bases:

>100_bases
TTTATATACAGAATTAATATTGGAAAAAAGCAGGGATAAATCAAACAGACGTGAATTGGAACATCCAACTCATTGTGAGT
TGGGACACAATCCTAGCTGT

Product: selenocysteine lyase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MLDKKQVEDIRKDFLYLSKEYKNPIVYLDNAATSQKPIQVIDSVSEFYKYENANPHRGAHTLSVLSTDVYESGREKVAKF
INATDSSEIVFTRNTTESLNLLAYSYGYENLKEDDEIVISIMEHHSNLVTWQEVCKKTGAKLKYLYVDKGNMQLDFEEFK
KTITKKTKIFSITQASNVVGTMPDVEKMIKYVKSVNKDCICIVDSAQYIPHNKVDVQKLGCDFLVFSGHKMLSIMGVGIL
YGKKELLNNLKPFLYGGDMIEYVFEDKSSYLDAPGRFEAGTQDVGAVKSLITAIDYIEKIGIENIRDYEKALMDYAYDKI
KQKSDIIDVYTTSDTHRSPVLDFNFKEAHPHDVASIMDSYGIAIRSGHHCAQPLHRYLKTNFSCRASFAFYNTFEEVDFF
IEHLEDVRRLMRIGTR

Sequences:

>Translated_416_residues
MLDKKQVEDIRKDFLYLSKEYKNPIVYLDNAATSQKPIQVIDSVSEFYKYENANPHRGAHTLSVLSTDVYESGREKVAKF
INATDSSEIVFTRNTTESLNLLAYSYGYENLKEDDEIVISIMEHHSNLVTWQEVCKKTGAKLKYLYVDKGNMQLDFEEFK
KTITKKTKIFSITQASNVVGTMPDVEKMIKYVKSVNKDCICIVDSAQYIPHNKVDVQKLGCDFLVFSGHKMLSIMGVGIL
YGKKELLNNLKPFLYGGDMIEYVFEDKSSYLDAPGRFEAGTQDVGAVKSLITAIDYIEKIGIENIRDYEKALMDYAYDKI
KQKSDIIDVYTTSDTHRSPVLDFNFKEAHPHDVASIMDSYGIAIRSGHHCAQPLHRYLKTNFSCRASFAFYNTFEEVDFF
IEHLEDVRRLMRIGTR
>Mature_416_residues
MLDKKQVEDIRKDFLYLSKEYKNPIVYLDNAATSQKPIQVIDSVSEFYKYENANPHRGAHTLSVLSTDVYESGREKVAKF
INATDSSEIVFTRNTTESLNLLAYSYGYENLKEDDEIVISIMEHHSNLVTWQEVCKKTGAKLKYLYVDKGNMQLDFEEFK
KTITKKTKIFSITQASNVVGTMPDVEKMIKYVKSVNKDCICIVDSAQYIPHNKVDVQKLGCDFLVFSGHKMLSIMGVGIL
YGKKELLNNLKPFLYGGDMIEYVFEDKSSYLDAPGRFEAGTQDVGAVKSLITAIDYIEKIGIENIRDYEKALMDYAYDKI
KQKSDIIDVYTTSDTHRSPVLDFNFKEAHPHDVASIMDSYGIAIRSGHHCAQPLHRYLKTNFSCRASFAFYNTFEEVDFF
IEHLEDVRRLMRIGTR

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=407, Percent_Identity=22.8501228501229, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI156713448, Length=429, Percent_Identity=23.0769230769231, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1787970, Length=408, Percent_Identity=42.8921568627451, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI1789175, Length=386, Percent_Identity=37.3056994818653, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI48994898, Length=394, Percent_Identity=25.1269035532995, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI193211090, Length=342, Percent_Identity=26.9005847953216, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI25143064, Length=232, Percent_Identity=28.0172413793103, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319831, Length=401, Percent_Identity=25.9351620947631, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI20129463, Length=406, Percent_Identity=25.1231527093596, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 47749; Mature: 47749

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKKQVEDIRKDFLYLSKEYKNPIVYLDNAATSQKPIQVIDSVSEFYKYENANPHRGAH
CCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCH
TLSVLSTDVYESGREKVAKFINATDSSEIVFTRNTTESLNLLAYSYGYENLKEDDEIVIS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHEEEECCCCCCCCCHHHHHH
IMEHHSNLVTWQEVCKKTGAKLKYLYVDKGNMQLDFEEFKKTITKKTKIFSITQASNVVG
HHHHCCCCHHHHHHHHHCCCEEEEEEEECCCCEECHHHHHHHHHHHHHEEEEEECCCCCC
TMPDVEKMIKYVKSVNKDCICIVDSAQYIPHNKVDVQKLGCDFLVFSGHKMLSIMGVGIL
CCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHCCCCEEEECCCHHHHHHHHHHH
YGKKELLNNLKPFLYGGDMIEYVFEDKSSYLDAPGRFEAGTQDVGAVKSLITAIDYIEKI
HCHHHHHHCCCCCEECCHHHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
GIENIRDYEKALMDYAYDKIKQKSDIIDVYTTSDTHRSPVLDFNFKEAHPHDVASIMDSY
CCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEECCCCCCCCHHHHHHHHHC
GIAIRSGHHCAQPLHRYLKTNFSCRASFAFYNTFEEVDFFIEHLEDVRRLMRIGTR
CCEEECCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLDKKQVEDIRKDFLYLSKEYKNPIVYLDNAATSQKPIQVIDSVSEFYKYENANPHRGAH
CCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCH
TLSVLSTDVYESGREKVAKFINATDSSEIVFTRNTTESLNLLAYSYGYENLKEDDEIVIS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHEEEECCCCCCCCCHHHHHH
IMEHHSNLVTWQEVCKKTGAKLKYLYVDKGNMQLDFEEFKKTITKKTKIFSITQASNVVG
HHHHCCCCHHHHHHHHHCCCEEEEEEEECCCCEECHHHHHHHHHHHHHEEEEEECCCCCC
TMPDVEKMIKYVKSVNKDCICIVDSAQYIPHNKVDVQKLGCDFLVFSGHKMLSIMGVGIL
CCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHCCCCEEEECCCHHHHHHHHHHH
YGKKELLNNLKPFLYGGDMIEYVFEDKSSYLDAPGRFEAGTQDVGAVKSLITAIDYIEKI
HCHHHHHHCCCCCEECCHHHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
GIENIRDYEKALMDYAYDKIKQKSDIIDVYTTSDTHRSPVLDFNFKEAHPHDVASIMDSY
CCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEECCCCCCCCHHHHHHHHHC
GIAIRSGHHCAQPLHRYLKTNFSCRASFAFYNTFEEVDFFIEHLEDVRRLMRIGTR
CCEEECCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]