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The map label for this gene is purE [H]

Identifier: 169824007

GI number: 169824007

Start: 358482

End: 358955

Strand: Direct

Name: purE [H]

Synonym: FMG_0310

Alternate gene names: 169824007

Gene position: 358482-358955 (Clockwise)

Preceding gene: 169824006

Following gene: 169824008

Centisome position: 19.94

GC content: 35.44

Gene sequence:

>474_bases
ATGGATATTAGATTAATAATGGGAAGCAGCTCAGATATTGAAGTTGCAAAAAAAGTTACTAAAATGTTGAAAAAATTTGG
CCTTTCTTATGAAGTATCAGTAATTTCAGCACACAGAGCATTGGATGTTTTAAAAGAAACTGTTGAAAAAGACGACTGTA
AAGTTTACATCACAATCGCTGGAAAAGCAGCACATTTGGGTGGAGTAACAGCTGGAATTACAACAAAACCAGTTATAGGA
ATTCCTGTAAAAGGATCTGCACTTGCTGGAATGGACGCATTATATTCAATCGTTCAAATGCCAAAAGGAGTTCCAGTTGC
AACTGTTGCAATCGACGGTGGAGAAAACGCAGCTATCCTAGCAGCTCAAATGATTGCTCTATCTGACGAAAAATTAGCTC
AAAAATTAAAAGATTACAAAGAAGAAATGAAACAAGCCGTAATTGATTCTGACAAGGAGTTAGAAGAAATATAA

Upstream 100 bases:

>100_bases
ATTCGTGAAGATTTCTCCAGCATCACTTGTAGAAAATCATCCACATGATATTACTATTACTAGAGAATCTCCAAACTATA
CAAAAAAATAGGAGCAAAAA

Downstream 100 bases:

>100_bases
TGGGATTAACTTACAAAGATTCTGGTGTAGATAAAGAAAAAGGCTACGAAGAAGTTCAAATTATAAAAGAAATCGTAAAG
AAAACTCATGGCAAAGAAGT

Product: phosphoribosylaminoimidazole carboxylase

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MDIRLIMGSSSDIEVAKKVTKMLKKFGLSYEVSVISAHRALDVLKETVEKDDCKVYITIAGKAAHLGGVTAGITTKPVIG
IPVKGSALAGMDALYSIVQMPKGVPVATVAIDGGENAAILAAQMIALSDEKLAQKLKDYKEEMKQAVIDSDKELEEI

Sequences:

>Translated_157_residues
MDIRLIMGSSSDIEVAKKVTKMLKKFGLSYEVSVISAHRALDVLKETVEKDDCKVYITIAGKAAHLGGVTAGITTKPVIG
IPVKGSALAGMDALYSIVQMPKGVPVATVAIDGGENAAILAAQMIALSDEKLAQKLKDYKEEMKQAVIDSDKELEEI
>Mature_157_residues
MDIRLIMGSSSDIEVAKKVTKMLKKFGLSYEVSVISAHRALDVLKETVEKDDCKVYITIAGKAAHLGGVTAGITTKPVIG
IPVKGSALAGMDALYSIVQMPKGVPVATVAIDGGENAAILAAQMIALSDEKLAQKLKDYKEEMKQAVIDSDKELEEI

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=137, Percent_Identity=32.8467153284672, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI5453539, Length=137, Percent_Identity=32.8467153284672, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI119220559, Length=137, Percent_Identity=32.8467153284672, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1786734, Length=153, Percent_Identity=40.5228758169935, Blast_Score=98, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6324702, Length=156, Percent_Identity=42.9487179487179, Blast_Score=127, Evalue=6e-31,
Organism=Drosophila melanogaster, GI18860083, Length=137, Percent_Identity=31.3868613138686, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16704; Mature: 16704

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRLIMGSSSDIEVAKKVTKMLKKFGLSYEVSVISAHRALDVLKETVEKDDCKVYITIA
CCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEC
GKAAHLGGVTAGITTKPVIGIPVKGSALAGMDALYSIVQMPKGVPVATVAIDGGENAAIL
CCCHHCCCEECCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHH
AAQMIALSDEKLAQKLKDYKEEMKQAVIDSDKELEEI
HHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCC
>Mature Secondary Structure
MDIRLIMGSSSDIEVAKKVTKMLKKFGLSYEVSVISAHRALDVLKETVEKDDCKVYITIA
CCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEC
GKAAHLGGVTAGITTKPVIGIPVKGSALAGMDALYSIVQMPKGVPVATVAIDGGENAAIL
CCCHHCCCEECCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHH
AAQMIALSDEKLAQKLKDYKEEMKQAVIDSDKELEEI
HHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]