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The map label for this gene is guaB [H]

Identifier: 169824006

GI number: 169824006

Start: 357021

End: 358472

Strand: Direct

Name: guaB [H]

Synonym: FMG_0309

Alternate gene names: 169824006

Gene position: 357021-358472 (Clockwise)

Preceding gene: 169824005

Following gene: 169824007

Centisome position: 19.86

GC content: 36.16

Gene sequence:

>1452_bases
ATGCAATTTATCGGCGAAGGATTAACATTTGATGACGTACTTCTAGTACCAGGTCCATCAGAAGTTTTACCTAACGAAAC
TATCTTGAAAACAAGATTAACAAAAAAAATTGAATTGAACATTCCTATGATGTCAGCAGGAATGGACACTGTAACTGAGT
CAAAAATGGCTATCGCAATGGCGAGACAAGGCGGGATCGGAATTATTCACAAGAACATGACTATTGAAGAACAAGCAAGA
GAAGTAGATAGAGTTAAACGTTCAGAAAATGGAATAATTACTGATCCTTTTTACTTATCTGCAGATGACAAAATCGTTGA
TGCATTAAAATTGATGAGTCACTACAGAATTAGCGGTGTACCTATAGTTAAAGAAGATATGACTTTGGTCGGAATCTTAA
CTAACAGAGACGTTAGATTCGTAAAAGATGAACAACTTCCAATCGGAGATGTTATGACTAAGGATAATTTAATAACAGGT
CACGAAAACATATCAATGGATGAAGCCTTGGAAAAAATGATGAACGCCAAGATTGAAAAACTTCCAATTGTAGATGAAAA
CTTCAAATTAAAAGGACTTATCACTACAAAAGATGTTGAAAAGTCAATACAATATCCAAATTCAGCAAGAGATTCACAAG
GAAGATTATTAGTTGGTGCAGCAGTAGGTATCACAACTGATATGATTGAAAGATGCCAAGCTTTAGTGGATGCAAAAGTT
GACGTCGTAACAATCGATACTGCTCATGGTCATTCAAGAGGAGTTTTGAATGCTGTAACTAAATTAAAGAAAGCTTTCCC
AGATCTTCAAATTATCGCAGGTAATGTTGCAACAGCAGATGCTACAAGAGATTTAATAAAAGCAGGTGCAGATTGCGTTA
AAGTCGGTATTGGACCTGGATCTATTTGTACAACAAGAGTTGTAACAGGTATCGGTGTTCCTCAAATGACAGCTATAATT
GAATGTGCAAAAGAAGCTGACAAATACGATATTCCAATCATTGCCGATGGTGGTATTAAATATTCTGGAGATATTACAAA
AGCATTAGCAGCTGGTGCATCTGTTATCATGGCAGGTAGCTTGTTTGCTGGTACTGAAGAAAGCCCTGGAGAATTAGTTG
TATTAGAAGGTAGACAATACAAAGAATACAGAGGAATGGGTTCACTTGGTGCTATGAGAGCAGGAAGTGGCGACAGATAT
TTCCAAAACAACACTAAGAAATACGTTCCAGAAGGAGTAGAAGGTAGAGTTGCTTACAAAGGATCTGTAGCAGAAGTTGT
GTACCAATTAGTTGGTGGACTTCGTTCAGGTATGGGTTATGTAGGAAGCAAAGACTTAATTGAATTAAAAGAAAAATCAA
AATTCGTGAAGATTTCTCCAGCATCACTTGTAGAAAATCATCCACATGATATTACTATTACTAGAGAATCTCCAAACTAT
ACAAAAAAATAG

Upstream 100 bases:

>100_bases
GGGATAAATTTGCTTGACTTGTTATCGTTTGTATGGTAAATTTATTCCTAACATTAAAAATTTTTAACAAAGTTTTTATT
TATTTTATGAGGAGGGTATT

Downstream 100 bases:

>100_bases
GAGCAAAAAATGGATATTAGATTAATAATGGGAAGCAGCTCAGATATTGAAGTTGCAAAAAAAGTTACTAAAATGTTGAA
AAAATTTGGCCTTTCTTATG

Product: inositol-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MQFIGEGLTFDDVLLVPGPSEVLPNETILKTRLTKKIELNIPMMSAGMDTVTESKMAIAMARQGGIGIIHKNMTIEEQAR
EVDRVKRSENGIITDPFYLSADDKIVDALKLMSHYRISGVPIVKEDMTLVGILTNRDVRFVKDEQLPIGDVMTKDNLITG
HENISMDEALEKMMNAKIEKLPIVDENFKLKGLITTKDVEKSIQYPNSARDSQGRLLVGAAVGITTDMIERCQALVDAKV
DVVTIDTAHGHSRGVLNAVTKLKKAFPDLQIIAGNVATADATRDLIKAGADCVKVGIGPGSICTTRVVTGIGVPQMTAII
ECAKEADKYDIPIIADGGIKYSGDITKALAAGASVIMAGSLFAGTEESPGELVVLEGRQYKEYRGMGSLGAMRAGSGDRY
FQNNTKKYVPEGVEGRVAYKGSVAEVVYQLVGGLRSGMGYVGSKDLIELKEKSKFVKISPASLVENHPHDITITRESPNY
TKK

Sequences:

>Translated_483_residues
MQFIGEGLTFDDVLLVPGPSEVLPNETILKTRLTKKIELNIPMMSAGMDTVTESKMAIAMARQGGIGIIHKNMTIEEQAR
EVDRVKRSENGIITDPFYLSADDKIVDALKLMSHYRISGVPIVKEDMTLVGILTNRDVRFVKDEQLPIGDVMTKDNLITG
HENISMDEALEKMMNAKIEKLPIVDENFKLKGLITTKDVEKSIQYPNSARDSQGRLLVGAAVGITTDMIERCQALVDAKV
DVVTIDTAHGHSRGVLNAVTKLKKAFPDLQIIAGNVATADATRDLIKAGADCVKVGIGPGSICTTRVVTGIGVPQMTAII
ECAKEADKYDIPIIADGGIKYSGDITKALAAGASVIMAGSLFAGTEESPGELVVLEGRQYKEYRGMGSLGAMRAGSGDRY
FQNNTKKYVPEGVEGRVAYKGSVAEVVYQLVGGLRSGMGYVGSKDLIELKEKSKFVKISPASLVENHPHDITITRESPNY
TKK
>Mature_483_residues
MQFIGEGLTFDDVLLVPGPSEVLPNETILKTRLTKKIELNIPMMSAGMDTVTESKMAIAMARQGGIGIIHKNMTIEEQAR
EVDRVKRSENGIITDPFYLSADDKIVDALKLMSHYRISGVPIVKEDMTLVGILTNRDVRFVKDEQLPIGDVMTKDNLITG
HENISMDEALEKMMNAKIEKLPIVDENFKLKGLITTKDVEKSIQYPNSARDSQGRLLVGAAVGITTDMIERCQALVDAKV
DVVTIDTAHGHSRGVLNAVTKLKKAFPDLQIIAGNVATADATRDLIKAGADCVKVGIGPGSICTTRVVTGIGVPQMTAII
ECAKEADKYDIPIIADGGIKYSGDITKALAAGASVIMAGSLFAGTEESPGELVVLEGRQYKEYRGMGSLGAMRAGSGDRY
FQNNTKKYVPEGVEGRVAYKGSVAEVVYQLVGGLRSGMGYVGSKDLIELKEKSKFVKISPASLVENHPHDITITRESPNY
TKK

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=480, Percent_Identity=41.25, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI217035146, Length=479, Percent_Identity=41.3361169102296, Blast_Score=341, Evalue=1e-93,
Organism=Homo sapiens, GI34328930, Length=479, Percent_Identity=41.3361169102296, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI34328928, Length=479, Percent_Identity=41.3361169102296, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI156616279, Length=479, Percent_Identity=41.3361169102296, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI217035152, Length=473, Percent_Identity=41.2262156448203, Blast_Score=331, Evalue=7e-91,
Organism=Homo sapiens, GI217035148, Length=479, Percent_Identity=40.7098121085595, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI217035150, Length=479, Percent_Identity=38.2045929018789, Blast_Score=300, Evalue=2e-81,
Organism=Homo sapiens, GI50541956, Length=244, Percent_Identity=38.1147540983607, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI50541954, Length=244, Percent_Identity=38.1147540983607, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI50541952, Length=244, Percent_Identity=38.1147540983607, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI50541948, Length=244, Percent_Identity=38.1147540983607, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI156104880, Length=245, Percent_Identity=37.9591836734694, Blast_Score=170, Evalue=3e-42,
Organism=Escherichia coli, GI1788855, Length=483, Percent_Identity=55.2795031055901, Blast_Score=488, Evalue=1e-139,
Organism=Escherichia coli, GI1786293, Length=254, Percent_Identity=37.4015748031496, Blast_Score=167, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71994385, Length=496, Percent_Identity=36.6935483870968, Blast_Score=287, Evalue=9e-78,
Organism=Caenorhabditis elegans, GI71994389, Length=420, Percent_Identity=39.0476190476191, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17560440, Length=222, Percent_Identity=37.8378378378378, Blast_Score=168, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6323464, Length=480, Percent_Identity=41.6666666666667, Blast_Score=342, Evalue=6e-95,
Organism=Saccharomyces cerevisiae, GI6322012, Length=480, Percent_Identity=39.7916666666667, Blast_Score=338, Evalue=1e-93,
Organism=Saccharomyces cerevisiae, GI6323585, Length=455, Percent_Identity=41.5384615384615, Blast_Score=337, Evalue=3e-93,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=41.1242603550296, Blast_Score=256, Evalue=5e-69,
Organism=Saccharomyces cerevisiae, GI6319353, Length=113, Percent_Identity=42.4778761061947, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24641071, Length=482, Percent_Identity=38.5892116182573, Blast_Score=324, Evalue=9e-89,
Organism=Drosophila melanogaster, GI24641073, Length=482, Percent_Identity=38.5892116182573, Blast_Score=324, Evalue=9e-89,
Organism=Drosophila melanogaster, GI28571163, Length=439, Percent_Identity=38.496583143508, Blast_Score=290, Evalue=1e-78,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52248; Mature: 52248

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFIGEGLTFDDVLLVPGPSEVLPNETILKTRLTKKIELNIPMMSAGMDTVTESKMAIAM
CCCCCCCCCCCCEEECCCCHHHCCCCHHHHHHCCEEEEECCCEECCCCCHHHHHHHEEEE
ARQGGIGIIHKNMTIEEQAREVDRVKRSENGIITDPFYLSADDKIVDALKLMSHYRISGV
ECCCCEEEEECCCCHHHHHHHHHHHHHCCCCEECCCEEECCCHHHHHHHHHHHHCCCCCC
PIVKEDMTLVGILTNRDVRFVKDEQLPIGDVMTKDNLITGHENISMDEALEKMMNAKIEK
CEEECCCEEEEEEECCCEEEEECCCCCCCCEECCCCEEECCCCCCHHHHHHHHHHCHHHH
LPIVDENFKLKGLITTKDVEKSIQYPNSARDSQGRLLVGAAVGITTDMIERCQALVDAKV
CCCCCCCEEEEEEEEHHHHHHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCE
DVVTIDTAHGHSRGVLNAVTKLKKAFPDLQIIAGNVATADATRDLIKAGADCVKVGIGPG
EEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCEEEECCCCC
SICTTRVVTGIGVPQMTAIIECAKEADKYDIPIIADGGIKYSGDITKALAAGASVIMAGS
CHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEECCCEEECCCHHHHHHCCCCEEEECC
LFAGTEESPGELVVLEGRQYKEYRGMGSLGAMRAGSGDRYFQNNTKKYVPEGVEGRVAYK
EECCCCCCCCCEEEECCCCCHHHCCCCCCCCCCCCCCCCHHHCCCHHCCCCCCCCEEEEC
GSVAEVVYQLVGGLRSGMGYVGSKDLIELKEKSKFVKISPASLVENHPHDITITRESPNY
CCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEECCHHHHCCCCCEEEEEECCCCC
TKK
CCC
>Mature Secondary Structure
MQFIGEGLTFDDVLLVPGPSEVLPNETILKTRLTKKIELNIPMMSAGMDTVTESKMAIAM
CCCCCCCCCCCCEEECCCCHHHCCCCHHHHHHCCEEEEECCCEECCCCCHHHHHHHEEEE
ARQGGIGIIHKNMTIEEQAREVDRVKRSENGIITDPFYLSADDKIVDALKLMSHYRISGV
ECCCCEEEEECCCCHHHHHHHHHHHHHCCCCEECCCEEECCCHHHHHHHHHHHHCCCCCC
PIVKEDMTLVGILTNRDVRFVKDEQLPIGDVMTKDNLITGHENISMDEALEKMMNAKIEK
CEEECCCEEEEEEECCCEEEEECCCCCCCCEECCCCEEECCCCCCHHHHHHHHHHCHHHH
LPIVDENFKLKGLITTKDVEKSIQYPNSARDSQGRLLVGAAVGITTDMIERCQALVDAKV
CCCCCCCEEEEEEEEHHHHHHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCE
DVVTIDTAHGHSRGVLNAVTKLKKAFPDLQIIAGNVATADATRDLIKAGADCVKVGIGPG
EEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCEEEECCCCC
SICTTRVVTGIGVPQMTAIIECAKEADKYDIPIIADGGIKYSGDITKALAAGASVIMAGS
CHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEECCCEEECCCHHHHHHCCCCEEEECC
LFAGTEESPGELVVLEGRQYKEYRGMGSLGAMRAGSGDRYFQNNTKKYVPEGVEGRVAYK
EECCCCCCCCCEEEECCCCCHHHCCCCCCCCCCCCCCCCHHHCCCHHCCCCCCCCEEEEC
GSVAEVVYQLVGGLRSGMGYVGSKDLIELKEKSKFVKISPASLVENHPHDITITRESPNY
CCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEECCHHHHCCCCCEEEEEECCCCC
TKK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]