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The map label for this gene is purM

Identifier: 169824008

GI number: 169824008

Start: 358955

End: 359980

Strand: Direct

Name: purM

Synonym: FMG_0311

Alternate gene names: 169824008

Gene position: 358955-359980 (Clockwise)

Preceding gene: 169824007

Following gene: 169824009

Centisome position: 19.97

GC content: 35.28

Gene sequence:

>1026_bases
ATGGGATTAACTTACAAAGATTCTGGTGTAGATAAAGAAAAAGGCTACGAAGAAGTTCAAATTATAAAAGAAATCGTAAA
GAAAACTCATGGCAAAGAAGTTCTAACAGGAATTGGTGGATTTGCTGGTCTATTTAAACCAGAACTTACCGATATGAAAG
AGCCTGTATTGGTTAGTGGAACTGATGGCGTTGGAACAAAAATCAAACTAGCAATGGAACTAGATAAACACGATACAGTT
GGTATTGATTTGGTTGCAATGTGTGTTAATGATGTTTTGTGCCAAGGAGCAAAGCCATTGTTTTTCTTAGATTACATTGC
GACTGGAAGCTTGAAACCAGCAAAAATGGCGGATTTGGTTCGTGGTGTAGCAGAAGGTTGTAGCCAATCTGAATGTGCAT
TAATCGGCGGAGAAACTGCTGAAATGCCAGGATTGTACAAGGAAAATGATTATGATTTGGCGGGATTTGCAGTTGGTATT
GTAGATCGCGATAAAATAATCGATGGAAGTGGAATTAAAGAAGGAGACGTTGCAATATCACTATCTTCAAGTGGAGTTCA
CAGCAATGGATTTTCACTTGTAAGAGCGGCATTGGATATGGCAAATGTAAAATTATCCGACAAATTCGAAGATACTACAG
TTGGAGAAAGACTTTTGGTTCCTACGAGAATTTACGAAAAAGAAATCTCAGCATTATTAAAAGAAGTTGAAATCAAAGGG
ATTGCTCACATCACTGGTGGTGGATTATACGAAAACGTACCAAGAATGTTACCTGAAAATATCGGAATAGAATTTGATAT
TAAAGAATCAGAAATTGATTCTGTGTTCAAAGCTATTCAAAAATGGGGAAATGTAGAAACAAAAGAAATGTTCTCTACTT
TCAACATGGGAATAGGCATGGTAGTTGTAGTTGATGCAAAAGATGTGGATAAATCTCTTGAAATATTACAAAAAATAGAT
CCAAAAGCAAAACAATGTGGAGTTTGCAAAAAAACAGAAACTTCTGTAAAGATTAATTTAAAATAA

Upstream 100 bases:

>100_bases
TTGCTCTATCTGACGAAAAATTAGCTCAAAAATTAAAAGATTACAAAGAAGAAATGAAACAAGCCGTAATTGATTCTGAC
AAGGAGTTAGAAGAAATATA

Downstream 100 bases:

>100_bases
TTTAGTGAGGATTTTATGAAAAAAAAGTATTTTTCGTTTGTAGATGAAGGATTAATCAAGATGACTTACACAGAAAGATT
GAAGTCATATTTAGATGGTA

Product: phosphoribosylformylglycinamidine cyclo-ligase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MGLTYKDSGVDKEKGYEEVQIIKEIVKKTHGKEVLTGIGGFAGLFKPELTDMKEPVLVSGTDGVGTKIKLAMELDKHDTV
GIDLVAMCVNDVLCQGAKPLFFLDYIATGSLKPAKMADLVRGVAEGCSQSECALIGGETAEMPGLYKENDYDLAGFAVGI
VDRDKIIDGSGIKEGDVAISLSSSGVHSNGFSLVRAALDMANVKLSDKFEDTTVGERLLVPTRIYEKEISALLKEVEIKG
IAHITGGGLYENVPRMLPENIGIEFDIKESEIDSVFKAIQKWGNVETKEMFSTFNMGIGMVVVVDAKDVDKSLEILQKID
PKAKQCGVCKKTETSVKINLK

Sequences:

>Translated_341_residues
MGLTYKDSGVDKEKGYEEVQIIKEIVKKTHGKEVLTGIGGFAGLFKPELTDMKEPVLVSGTDGVGTKIKLAMELDKHDTV
GIDLVAMCVNDVLCQGAKPLFFLDYIATGSLKPAKMADLVRGVAEGCSQSECALIGGETAEMPGLYKENDYDLAGFAVGI
VDRDKIIDGSGIKEGDVAISLSSSGVHSNGFSLVRAALDMANVKLSDKFEDTTVGERLLVPTRIYEKEISALLKEVEIKG
IAHITGGGLYENVPRMLPENIGIEFDIKESEIDSVFKAIQKWGNVETKEMFSTFNMGIGMVVVVDAKDVDKSLEILQKID
PKAKQCGVCKKTETSVKINLK
>Mature_340_residues
GLTYKDSGVDKEKGYEEVQIIKEIVKKTHGKEVLTGIGGFAGLFKPELTDMKEPVLVSGTDGVGTKIKLAMELDKHDTVG
IDLVAMCVNDVLCQGAKPLFFLDYIATGSLKPAKMADLVRGVAEGCSQSECALIGGETAEMPGLYKENDYDLAGFAVGIV
DRDKIIDGSGIKEGDVAISLSSSGVHSNGFSLVRAALDMANVKLSDKFEDTTVGERLLVPTRIYEKEISALLKEVEIKGI
AHITGGGLYENVPRMLPENIGIEFDIKESEIDSVFKAIQKWGNVETKEMFSTFNMGIGMVVVVDAKDVDKSLEILQKIDP
KAKQCGVCKKTETSVKINLK

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=345, Percent_Identity=46.3768115942029, Blast_Score=305, Evalue=6e-83,
Organism=Homo sapiens, GI209869995, Length=345, Percent_Identity=46.3768115942029, Blast_Score=305, Evalue=6e-83,
Organism=Homo sapiens, GI209869993, Length=345, Percent_Identity=46.3768115942029, Blast_Score=305, Evalue=6e-83,
Organism=Escherichia coli, GI1788845, Length=338, Percent_Identity=49.7041420118343, Blast_Score=339, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI17567511, Length=325, Percent_Identity=42.1538461538462, Blast_Score=230, Evalue=7e-61,
Organism=Saccharomyces cerevisiae, GI6321203, Length=316, Percent_Identity=46.8354430379747, Blast_Score=275, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24582400, Length=294, Percent_Identity=44.8979591836735, Blast_Score=237, Evalue=9e-63,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_FINM2 (B0S0R2)

Other databases:

- EMBL:   AP008971
- RefSeq:   YP_001691619.1
- ProteinModelPortal:   B0S0R2
- SMR:   B0S0R2
- GeneID:   6019065
- GenomeReviews:   AP008971_GR
- KEGG:   fma:FMG_0311
- HOGENOM:   HBG531222
- OMA:   HYDLAGF
- ProtClustDB:   CLSK2541947
- BioCyc:   FMAG334413:FMG_0311-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 36848; Mature: 36717

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLTYKDSGVDKEKGYEEVQIIKEIVKKTHGKEVLTGIGGFAGLFKPELTDMKEPVLVSG
CCCCCCCCCCCHHCCHHHHHHHHHHHHHCCCHHHHHHCCHHHHHCCCCHHCCCCCEEEEC
TDGVGTKIKLAMELDKHDTVGIDLVAMCVNDVLCQGAKPLFFLDYIATGSLKPAKMADLV
CCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCHHHHHHHH
RGVAEGCSQSECALIGGETAEMPGLYKENDYDLAGFAVGIVDRDKIIDGSGIKEGDVAIS
HHHHHCCCCCCEEEECCCHHHCCCCCCCCCCCEEEEEEEEECCCCEECCCCCCCCCEEEE
LSSSGVHSNGFSLVRAALDMANVKLSDKFEDTTVGERLLVPTRIYEKEISALLKEVEIKG
EECCCCCCCCHHHHHHHHHHHCCEECCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCC
IAHITGGGLYENVPRMLPENIGIEFDIKESEIDSVFKAIQKWGNVETKEMFSTFNMGIGM
EEEECCCCHHHHHHHHCHHHCCEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCE
VVVVDAKDVDKSLEILQKIDPKAKQCGVCKKTETSVKINLK
EEEEECCCHHHHHHHHHHCCCCHHHCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
GLTYKDSGVDKEKGYEEVQIIKEIVKKTHGKEVLTGIGGFAGLFKPELTDMKEPVLVSG
CCCCCCCCCCHHCCHHHHHHHHHHHHHCCCHHHHHHCCHHHHHCCCCHHCCCCCEEEEC
TDGVGTKIKLAMELDKHDTVGIDLVAMCVNDVLCQGAKPLFFLDYIATGSLKPAKMADLV
CCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCHHHHHHHH
RGVAEGCSQSECALIGGETAEMPGLYKENDYDLAGFAVGIVDRDKIIDGSGIKEGDVAIS
HHHHHCCCCCCEEEECCCHHHCCCCCCCCCCCEEEEEEEEECCCCEECCCCCCCCCEEEE
LSSSGVHSNGFSLVRAALDMANVKLSDKFEDTTVGERLLVPTRIYEKEISALLKEVEIKG
EECCCCCCCCHHHHHHHHHHHCCEECCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCC
IAHITGGGLYENVPRMLPENIGIEFDIKESEIDSVFKAIQKWGNVETKEMFSTFNMGIGM
EEEECCCCHHHHHHHHCHHHCCEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCE
VVVVDAKDVDKSLEILQKIDPKAKQCGVCKKTETSVKINLK
EEEEECCCHHHHHHHHHHCCCCHHHCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA