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The map label for this gene is clpA [H]

Identifier: 167623652

GI number: 167623652

Start: 2064478

End: 2066736

Strand: Direct

Name: clpA [H]

Synonym: Shal_1721

Alternate gene names: 167623652

Gene position: 2064478-2066736 (Clockwise)

Preceding gene: 167623651

Following gene: 167623656

Centisome position: 39.5

GC content: 45.64

Gene sequence:

>2259_bases
ATGCTAAATAAAGATCTTGAAGTCACCTTAAACCTGGCTTTTCAACAAGCCAGAGATGCACGTCATGAGTACATGACGGT
AGAGCATCTATTGTTGGCGTTAATCGATAATCCTGCCGCACAAGAGGCGCTAGTTGCTTGCGGAGCAAATTTAGAAAAAC
TCAGGGATGAAGTCTCTAGCTTCATTCAACAAACCACTCCGATTATTTCCGACCCTGAAGACGAAAAAGAAACTCAGCCA
ACGCTTGGTTTTCAACGTGTGTTACAAAGAGCGGTATTTCATGTGCAGTCTTCAGGGCGCAATGAGGTCAATGGTGCCAA
TGTCTTGGTTGCCATTTTTAGTGAGCAAGAGTCTCAAGCTGTTTACCTGCTGCGTACAGGCGATGTGACTCGTTTAGATG
TCGTTAATTATATTTCTCATGGCTTTTCTAAAAACGATATCGATACTGACTCTGAGCCCAATAGAGCCGAAGAGCAGTCT
GAGGCAGAGGAAGAGCGCAGTATCTTGTCGCAGTTTACCGCTAACCTTAATGAGTTAGCCAAGAGCGGCAGTATCGACCC
ACTTATCGGTCGTACAGAAGAGATCGAGCGTTCAATTCAAATTCTTTGTCGTCGCCGTAAGAATAACCCTTTGCTTGTCG
GTGAAGCGGGTGTGGGTAAAACGGCAATAGCCGAAGGGCTAGCTTATCGCATCGTCAAGGAAGAAGTGCCTGAAGTGATG
AGTCAGGCAACAGTGTACTCACTCGACTTAGGTGCACTGCTTGCTGGTACCAAGTACCGCGGTGACTTTGAGAAGCGCTT
TAAAGGCTTACTTAAAGAATTAGCGAATGACGAGCATGCGATTTTATTTATCGATGAGATCCACACTATTATCGGTGCCG
GTTCAGCCTCTGGCGGCGTCATGGATGCCTCTAACTTACTTAAACCGTTATTATCGGGTGGTAAGCTGCGTTGCATGGGC
TCGACGACGTTCCAAGAATACCAAAGTATTTTTGAAAAAGACCGTGCCTTAGCGCGTCGATTCCAAAAGGTGGATATCAA
CGAGCCTTCAGTTGCAGAAACCACCAAAATTTTACAAGGTCTTAAGTCAAAGTATGAAGAGCACCATAATGTGCGTTATA
CCTTGGCTGCACTGAGTGTTGCAGCAAGACTGTCTGACAAGCACATCAATGATAGACATCTACCCGATAAAGCCATTGAC
GTGATTGATGAAGCGGGTGCGCGTATGGCGATGCAGCCAGCGAGCAAACGTAAAAAGACCATTGGCCAATCAGAGATCGA
AGCCATTATTGCTAAAATGGCACGTATTCCAGAGAAGTCTGTATCGAGCTCTGACAAGGATATGCTGAAAAACCTTGAGC
GTAACCTTAAGATGGTGGTGTTTGGTCAAGACCTTGCCATTGAGGGGCTTAGCGCTGCAATTCGCTTGTCTCGAAGTGGA
CTCGGTGGTGAAAACAAACCTGTAGGTAGTTTCTTGTTTGCAGGTCCTACGGGTGTCGGTAAGACTGAGGTTACCAGCCA
GTTAGCTAAGTGCTTAAGCCTTAATCTGGTTCGTTTTGATATGTCTGAATACATGGAAAGTCATACGGTGTCGCGCCTAA
TTGGTGCGCCTCCAGGCTATGTTGGTTATGACCAAGGTGGATTACTTACTGATGCGGTAATTAAGAATCCACACTGTGTG
GTGCTGCTTGATGAGATCGAGAAAGCTCACCCAGATGTTTATAACTTACTGTTGCAGGTAATGGATCACGGTACCTTAAC
CGACAATAATGGCCGTAAGGCTGACTTTAGACACGTGACCTTAGTCATGACCACGAACGCTGGTGTACAAGAGACCATTC
GTAAATCGATTGGTTTTAAGCAGCAAGATCATACTCAGGATGCACTATCGGAAATCAATAAGGTGTTCTCACCTGAGTTC
CGTAACCGTTTAGATTCGATTATCTGGTTTAATCACTTAGATATGACGGTTATCGCCAAAGTAGTTGATAAGTTCTTAGT
TGAACTGCAAGCGCAGCTTGATGATAAGTCAGTGACACTGGAAGTGAGTGATGAGGCTCGAACATTGCTTGCCGAGAAAG
GTTATGACAAGTCCATGGGCGCACGTCCTATGGCCAGAGTCGTGACTGAACTGATTAAGCGACCATTAGCCGATGAGATC
CTATTTGGTGAGCTTGAGAAGGGCGGTATTGCTCGTGTTGATACTAAGGGGGATGAGATCGTTATCACGACTGAATCGTT
AGAGAAAGTAACGCATTAG

Upstream 100 bases:

>100_bases
CAAGTAAATCAATTTGCAAGACAAAACCAACATCCGTTACTGTGTTCATTAGAGGAAGCCTAATTGGGTTCACTCTGTTG
TTAATTTTTAGGGGGTGCTT

Downstream 100 bases:

>100_bases
CTTGATCGTGAGGGCCAATAAGCGGCATTAGCTTGTTGTTTATTGGCTCAGCTTAGGCTCCAAAGTGAGTTAACAGTAAA
TTTCAGACAACAAAAAGCCG

Product: ATP-dependent Clp protease, ATP-binding subunit clpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 752; Mature: 752

Protein sequence:

>752_residues
MLNKDLEVTLNLAFQQARDARHEYMTVEHLLLALIDNPAAQEALVACGANLEKLRDEVSSFIQQTTPIISDPEDEKETQP
TLGFQRVLQRAVFHVQSSGRNEVNGANVLVAIFSEQESQAVYLLRTGDVTRLDVVNYISHGFSKNDIDTDSEPNRAEEQS
EAEEERSILSQFTANLNELAKSGSIDPLIGRTEEIERSIQILCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVKEEVPEVM
SQATVYSLDLGALLAGTKYRGDFEKRFKGLLKELANDEHAILFIDEIHTIIGAGSASGGVMDASNLLKPLLSGGKLRCMG
STTFQEYQSIFEKDRALARRFQKVDINEPSVAETTKILQGLKSKYEEHHNVRYTLAALSVAARLSDKHINDRHLPDKAID
VIDEAGARMAMQPASKRKKTIGQSEIEAIIAKMARIPEKSVSSSDKDMLKNLERNLKMVVFGQDLAIEGLSAAIRLSRSG
LGGENKPVGSFLFAGPTGVGKTEVTSQLAKCLSLNLVRFDMSEYMESHTVSRLIGAPPGYVGYDQGGLLTDAVIKNPHCV
VLLDEIEKAHPDVYNLLLQVMDHGTLTDNNGRKADFRHVTLVMTTNAGVQETIRKSIGFKQQDHTQDALSEINKVFSPEF
RNRLDSIIWFNHLDMTVIAKVVDKFLVELQAQLDDKSVTLEVSDEARTLLAEKGYDKSMGARPMARVVTELIKRPLADEI
LFGELEKGGIARVDTKGDEIVITTESLEKVTH

Sequences:

>Translated_752_residues
MLNKDLEVTLNLAFQQARDARHEYMTVEHLLLALIDNPAAQEALVACGANLEKLRDEVSSFIQQTTPIISDPEDEKETQP
TLGFQRVLQRAVFHVQSSGRNEVNGANVLVAIFSEQESQAVYLLRTGDVTRLDVVNYISHGFSKNDIDTDSEPNRAEEQS
EAEEERSILSQFTANLNELAKSGSIDPLIGRTEEIERSIQILCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVKEEVPEVM
SQATVYSLDLGALLAGTKYRGDFEKRFKGLLKELANDEHAILFIDEIHTIIGAGSASGGVMDASNLLKPLLSGGKLRCMG
STTFQEYQSIFEKDRALARRFQKVDINEPSVAETTKILQGLKSKYEEHHNVRYTLAALSVAARLSDKHINDRHLPDKAID
VIDEAGARMAMQPASKRKKTIGQSEIEAIIAKMARIPEKSVSSSDKDMLKNLERNLKMVVFGQDLAIEGLSAAIRLSRSG
LGGENKPVGSFLFAGPTGVGKTEVTSQLAKCLSLNLVRFDMSEYMESHTVSRLIGAPPGYVGYDQGGLLTDAVIKNPHCV
VLLDEIEKAHPDVYNLLLQVMDHGTLTDNNGRKADFRHVTLVMTTNAGVQETIRKSIGFKQQDHTQDALSEINKVFSPEF
RNRLDSIIWFNHLDMTVIAKVVDKFLVELQAQLDDKSVTLEVSDEARTLLAEKGYDKSMGARPMARVVTELIKRPLADEI
LFGELEKGGIARVDTKGDEIVITTESLEKVTH
>Mature_752_residues
MLNKDLEVTLNLAFQQARDARHEYMTVEHLLLALIDNPAAQEALVACGANLEKLRDEVSSFIQQTTPIISDPEDEKETQP
TLGFQRVLQRAVFHVQSSGRNEVNGANVLVAIFSEQESQAVYLLRTGDVTRLDVVNYISHGFSKNDIDTDSEPNRAEEQS
EAEEERSILSQFTANLNELAKSGSIDPLIGRTEEIERSIQILCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVKEEVPEVM
SQATVYSLDLGALLAGTKYRGDFEKRFKGLLKELANDEHAILFIDEIHTIIGAGSASGGVMDASNLLKPLLSGGKLRCMG
STTFQEYQSIFEKDRALARRFQKVDINEPSVAETTKILQGLKSKYEEHHNVRYTLAALSVAARLSDKHINDRHLPDKAID
VIDEAGARMAMQPASKRKKTIGQSEIEAIIAKMARIPEKSVSSSDKDMLKNLERNLKMVVFGQDLAIEGLSAAIRLSRSG
LGGENKPVGSFLFAGPTGVGKTEVTSQLAKCLSLNLVRFDMSEYMESHTVSRLIGAPPGYVGYDQGGLLTDAVIKNPHCV
VLLDEIEKAHPDVYNLLLQVMDHGTLTDNNGRKADFRHVTLVMTTNAGVQETIRKSIGFKQQDHTQDALSEINKVFSPEF
RNRLDSIIWFNHLDMTVIAKVVDKFLVELQAQLDDKSVTLEVSDEARTLLAEKGYDKSMGARPMARVVTELIKRPLADEI
LFGELEKGGIARVDTKGDEIVITTESLEKVTH

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=298, Percent_Identity=32.8859060402685, Blast_Score=151, Evalue=2e-36,
Organism=Escherichia coli, GI1787109, Length=755, Percent_Identity=69.0066225165563, Blast_Score=1083, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=414, Percent_Identity=43.4782608695652, Blast_Score=299, Evalue=4e-82,
Organism=Saccharomyces cerevisiae, GI6320464, Length=330, Percent_Identity=43.9393939393939, Blast_Score=277, Evalue=4e-75,
Organism=Saccharomyces cerevisiae, GI6323002, Length=434, Percent_Identity=38.0184331797235, Blast_Score=259, Evalue=1e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 83149; Mature: 83149

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNKDLEVTLNLAFQQARDARHEYMTVEHLLLALIDNPAAQEALVACGANLEKLRDEVSS
CCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHH
FIQQTTPIISDPEDEKETQPTLGFQRVLQRAVFHVQSSGRNEVNGANVLVAIFSEQESQA
HHHHCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCE
VYLLRTGDVTRLDVVNYISHGFSKNDIDTDSEPNRAEEQSEAEEERSILSQFTANLNELA
EEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KSGSIDPLIGRTEEIERSIQILCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVKEEVPEVM
HCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
SQATVYSLDLGALLAGTKYRGDFEKRFKGLLKELANDEHAILFIDEIHTIIGAGSASGGV
HHHHHHEECHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCCCC
MDASNLLKPLLSGGKLRCMGSTTFQEYQSIFEKDRALARRFQKVDINEPSVAETTKILQG
CCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LKSKYEEHHNVRYTLAALSVAARLSDKHINDRHLPDKAIDVIDEAGARMAMQPASKRKKT
HHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHCCCHHHHHHH
IGQSEIEAIIAKMARIPEKSVSSSDKDMLKNLERNLKMVVFGQDLAIEGLSAAIRLSRSG
CCHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCC
LGGENKPVGSFLFAGPTGVGKTEVTSQLAKCLSLNLVRFDMSEYMESHTVSRLIGAPPGY
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VGYDQGGLLTDAVIKNPHCVVLLDEIEKAHPDVYNLLLQVMDHGTLTDNNGRKADFRHVT
CCCCCCCCCHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCEECCCCCCCCCEEEE
LVMTTNAGVQETIRKSIGFKQQDHTQDALSEINKVFSPEFRNRLDSIIWFNHLDMTVIAK
EEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHH
VVDKFLVELQAQLDDKSVTLEVSDEARTLLAEKGYDKSMGARPMARVVTELIKRPLADEI
HHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHH
LFGELEKGGIARVDTKGDEIVITTESLEKVTH
HHHCCCCCCEEEEECCCCEEEEEHHHHHHHCC
>Mature Secondary Structure
MLNKDLEVTLNLAFQQARDARHEYMTVEHLLLALIDNPAAQEALVACGANLEKLRDEVSS
CCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHH
FIQQTTPIISDPEDEKETQPTLGFQRVLQRAVFHVQSSGRNEVNGANVLVAIFSEQESQA
HHHHCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCE
VYLLRTGDVTRLDVVNYISHGFSKNDIDTDSEPNRAEEQSEAEEERSILSQFTANLNELA
EEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KSGSIDPLIGRTEEIERSIQILCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVKEEVPEVM
HCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
SQATVYSLDLGALLAGTKYRGDFEKRFKGLLKELANDEHAILFIDEIHTIIGAGSASGGV
HHHHHHEECHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCCCC
MDASNLLKPLLSGGKLRCMGSTTFQEYQSIFEKDRALARRFQKVDINEPSVAETTKILQG
CCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LKSKYEEHHNVRYTLAALSVAARLSDKHINDRHLPDKAIDVIDEAGARMAMQPASKRKKT
HHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHCCCHHHHHHH
IGQSEIEAIIAKMARIPEKSVSSSDKDMLKNLERNLKMVVFGQDLAIEGLSAAIRLSRSG
CCHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCC
LGGENKPVGSFLFAGPTGVGKTEVTSQLAKCLSLNLVRFDMSEYMESHTVSRLIGAPPGY
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VGYDQGGLLTDAVIKNPHCVVLLDEIEKAHPDVYNLLLQVMDHGTLTDNNGRKADFRHVT
CCCCCCCCCHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCEECCCCCCCCCEEEE
LVMTTNAGVQETIRKSIGFKQQDHTQDALSEINKVFSPEFRNRLDSIIWFNHLDMTVIAK
EEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHH
VVDKFLVELQAQLDDKSVTLEVSDEARTLLAEKGYDKSMGARPMARVVTELIKRPLADEI
HHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHH
LFGELEKGGIARVDTKGDEIVITTESLEKVTH
HHHCCCCCCEEEEECCCCEEEEEHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]