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The map label for this gene is envZ [H]

Identifier: 167622180

GI number: 167622180

Start: 286906

End: 288165

Strand: Reverse

Name: envZ [H]

Synonym: Shal_0239

Alternate gene names: 167622180

Gene position: 288165-286906 (Counterclockwise)

Preceding gene: 167622181

Following gene: 167622176

Centisome position: 5.51

GC content: 47.78

Gene sequence:

>1260_bases
ATGCTAATTGGCTGCCTGCTGCTAACAAACCAACTAGTGTCATACATCTCTGTTGCGGTTTACTTTATAAAACCCAGCTA
TCAGCAGATAAACCAATTGATAGCACGGCAAGTGAAGCTATTATTTGTTGGCGGCATCGATATTGGTCGTGAACACCTCA
CCATGGTCGATGCCCTCAACGCCAAAGTGCGTGATGACACCATGCAGTTTTATAACCTAAAACAAGCTCGCCAAGCCGGT
ATCGATCGTGCGACTTACTACAGTTTTTTATCTTCTCAAATGTCCGAATACCTAGGTGGCGAGGCTGAAGTGCGCATCGC
TCAGGGGGAAGAATTTGAGATCTGGATCCGCCCTCCTCAAGCGCCCTCAATCTGGATCAGAGTGCCATTAACCGGGCTCA
ATGAGAAAAACCTTTCACCGCTTACCCTATATTTAATGGTTATTGGCGCCCTAAGCGTGGCCGGAGGCTGGTGGTTTGCC
CGGCAACAGAATCGTCCGTTGAGGCGATTACAAAAAGCGGCGATTGCCGTATCACGAGGTGATTACCCTGACCCTTTACC
ATTGAGTGGCTCAACAGAGATTGTTGAGGTGACTAACACCTTCAATCAGATGTCTCATAGCATGAAGCAGCTGGAGCAAG
ATAGGGCGCTGCTGATGGCTGGCATATCTCATGACTTACGTACCCCGCTAACTCGCATTCGACTGGCCTCTGAAATGATG
GTCGAAGAAGATCAGTATCTGAAAGATGGCATAGTTAACGATATCGAAGATATGGATGCCATCATCAATCAGTTCATCTC
CTATATCCGCCAAGATCAGGAAGGCACTCGAGAGTTAGAGCAGATAAACGACTTAATTCAAGATGTGATTCAGGCCGAAT
CTAACCGTGAGGGCAGCATCGATTCAGAGTTAGTTGAGTGTCCACGCATTCCGATGCAAGGTATTGCCGTAAAACGTGTG
CTCAGCAATTTAGTCGAAAATGCCTACCGCTACGGTAACGGCTGGGTAAGAATTAACTCACAATTTAATGGTCAGTACGT
CGGCTTTAGTGTCGAAGATAACGGTCCTGGGATCGATGAAGAGCAGATCCCTAAACTCTTTCAACCTTTTACTCAAGGTG
ATACGGCCCGCGGCAGTGTTGGCTCAGGGCTTGGTCTGGCGATTATCAAACGTATTGTCGATAGGCATCAGGGCAAGGTG
ATCCTTACCAACCGCAGTGAAGGTGGATTGCATGCTCAGGTCTGGTTGCCGATTGAATAA

Upstream 100 bases:

>100_bases
AATAGCTAGGCGACGATAACTAAGTGATAATAACTAAGTGGCTATAAACAGACGATGGTGGCAACGCTTTTTGCCACGCA
GTTCCTTCAGCCAAACCGTA

Downstream 100 bases:

>100_bases
CCTCTAATTAACGGTTATTAATTGCGACACTATTACCCATAATAGTCAGAATTATCAACTTCTAATAATAGGGGCGACCT
CTGGCCTTTCATATTGACGA

Product: osmolarity sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MLIGCLLLTNQLVSYISVAVYFIKPSYQQINQLIARQVKLLFVGGIDIGREHLTMVDALNAKVRDDTMQFYNLKQARQAG
IDRATYYSFLSSQMSEYLGGEAEVRIAQGEEFEIWIRPPQAPSIWIRVPLTGLNEKNLSPLTLYLMVIGALSVAGGWWFA
RQQNRPLRRLQKAAIAVSRGDYPDPLPLSGSTEIVEVTNTFNQMSHSMKQLEQDRALLMAGISHDLRTPLTRIRLASEMM
VEEDQYLKDGIVNDIEDMDAIINQFISYIRQDQEGTRELEQINDLIQDVIQAESNREGSIDSELVECPRIPMQGIAVKRV
LSNLVENAYRYGNGWVRINSQFNGQYVGFSVEDNGPGIDEEQIPKLFQPFTQGDTARGSVGSGLGLAIIKRIVDRHQGKV
ILTNRSEGGLHAQVWLPIE

Sequences:

>Translated_419_residues
MLIGCLLLTNQLVSYISVAVYFIKPSYQQINQLIARQVKLLFVGGIDIGREHLTMVDALNAKVRDDTMQFYNLKQARQAG
IDRATYYSFLSSQMSEYLGGEAEVRIAQGEEFEIWIRPPQAPSIWIRVPLTGLNEKNLSPLTLYLMVIGALSVAGGWWFA
RQQNRPLRRLQKAAIAVSRGDYPDPLPLSGSTEIVEVTNTFNQMSHSMKQLEQDRALLMAGISHDLRTPLTRIRLASEMM
VEEDQYLKDGIVNDIEDMDAIINQFISYIRQDQEGTRELEQINDLIQDVIQAESNREGSIDSELVECPRIPMQGIAVKRV
LSNLVENAYRYGNGWVRINSQFNGQYVGFSVEDNGPGIDEEQIPKLFQPFTQGDTARGSVGSGLGLAIIKRIVDRHQGKV
ILTNRSEGGLHAQVWLPIE
>Mature_419_residues
MLIGCLLLTNQLVSYISVAVYFIKPSYQQINQLIARQVKLLFVGGIDIGREHLTMVDALNAKVRDDTMQFYNLKQARQAG
IDRATYYSFLSSQMSEYLGGEAEVRIAQGEEFEIWIRPPQAPSIWIRVPLTGLNEKNLSPLTLYLMVIGALSVAGGWWFA
RQQNRPLRRLQKAAIAVSRGDYPDPLPLSGSTEIVEVTNTFNQMSHSMKQLEQDRALLMAGISHDLRTPLTRIRLASEMM
VEEDQYLKDGIVNDIEDMDAIINQFISYIRQDQEGTRELEQINDLIQDVIQAESNREGSIDSELVECPRIPMQGIAVKRV
LSNLVENAYRYGNGWVRINSQFNGQYVGFSVEDNGPGIDEEQIPKLFQPFTQGDTARGSVGSGLGLAIIKRIVDRHQGKV
ILTNRSEGGLHAQVWLPIE

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=422, Percent_Identity=43.1279620853081, Blast_Score=347, Evalue=8e-97,
Organism=Escherichia coli, GI1790346, Length=274, Percent_Identity=28.4671532846715, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1788393, Length=289, Percent_Identity=26.643598615917, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1790551, Length=270, Percent_Identity=29.2592592592593, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787894, Length=355, Percent_Identity=25.0704225352113, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1786912, Length=222, Percent_Identity=32.4324324324324, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI87082128, Length=254, Percent_Identity=27.5590551181102, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1786600, Length=209, Percent_Identity=30.1435406698565, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790861, Length=286, Percent_Identity=26.2237762237762, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI48994928, Length=224, Percent_Identity=26.7857142857143, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788549, Length=230, Percent_Identity=30, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788279, Length=258, Percent_Identity=25.5813953488372, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1786783, Length=287, Percent_Identity=25.0871080139373, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI145693157, Length=248, Percent_Identity=25, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790436, Length=226, Percent_Identity=25.6637168141593, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87081816, Length=251, Percent_Identity=25.8964143426295, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788713, Length=272, Percent_Identity=23.8970588235294, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1787374, Length=280, Percent_Identity=24.6428571428571, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789403, Length=278, Percent_Identity=26.2589928057554, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790300, Length=251, Percent_Identity=27.4900398406374, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47172; Mature: 47172

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIGCLLLTNQLVSYISVAVYFIKPSYQQINQLIARQVKLLFVGGIDIGREHLTMVDALN
CEEHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHC
AKVRDDTMQFYNLKQARQAGIDRATYYSFLSSQMSEYLGGEAEVRIAQGEEFEIWIRPPQ
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEECCC
APSIWIRVPLTGLNEKNLSPLTLYLMVIGALSVAGGWWFARQQNRPLRRLQKAAIAVSRG
CCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHCCC
DYPDPLPLSGSTEIVEVTNTFNQMSHSMKQLEQDRALLMAGISHDLRTPLTRIRLASEMM
CCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VEEDQYLKDGIVNDIEDMDAIINQFISYIRQDQEGTRELEQINDLIQDVIQAESNREGSI
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
DSELVECPRIPMQGIAVKRVLSNLVENAYRYGNGWVRINSQFNGQYVGFSVEDNGPGIDE
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEEEEECCCCCCCCH
EQIPKLFQPFTQGDTARGSVGSGLGLAIIKRIVDRHQGKVILTNRSEGGLHAQVWLPIE
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEEECC
>Mature Secondary Structure
MLIGCLLLTNQLVSYISVAVYFIKPSYQQINQLIARQVKLLFVGGIDIGREHLTMVDALN
CEEHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHC
AKVRDDTMQFYNLKQARQAGIDRATYYSFLSSQMSEYLGGEAEVRIAQGEEFEIWIRPPQ
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEECCC
APSIWIRVPLTGLNEKNLSPLTLYLMVIGALSVAGGWWFARQQNRPLRRLQKAAIAVSRG
CCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHCCC
DYPDPLPLSGSTEIVEVTNTFNQMSHSMKQLEQDRALLMAGISHDLRTPLTRIRLASEMM
CCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VEEDQYLKDGIVNDIEDMDAIINQFISYIRQDQEGTRELEQINDLIQDVIQAESNREGSI
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
DSELVECPRIPMQGIAVKRVLSNLVENAYRYGNGWVRINSQFNGQYVGFSVEDNGPGIDE
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEEEEECCCCCCCCH
EQIPKLFQPFTQGDTARGSVGSGLGLAIIKRIVDRHQGKVILTNRSEGGLHAQVWLPIE
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]