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The map label for this gene is prlC [H]

Identifier: 167622134

GI number: 167622134

Start: 228203

End: 230242

Strand: Direct

Name: prlC [H]

Synonym: Shal_0193

Alternate gene names: 167622134

Gene position: 228203-230242 (Clockwise)

Preceding gene: 167622130

Following gene: 167622135

Centisome position: 4.37

GC content: 48.19

Gene sequence:

>2040_bases
ATGAGCAATCCTTTGCTAAGCAGCGCCAAGCTACCGCCTTTTTCAAGTATTAAGCCAGAACATATTCAGCCCGCTGTCGA
GCAAGGTATTGCCGATTGTCGCCAAAAAATCGAAGAGGTGCTCAAGCATCAAGGTGAGTTTACATGGGATAACCTTGTGG
CACCGCTAGAGGAGACGGATGATCTGCTAGGCAAGATCTGGTCGCCTATTTCGCATATGAATTCGGTGGTGAGTAATGAA
GAGTGGCGCAAGGCTCATGATGCTTGCTTACCTCTATTATCTGAATACGGTACCTTTGTCGGTCAGCATCAGGGCTTGTA
TCAAGCTTACAAATCACTGGCTGAATCTGCAGAGTTTGCTCATTATTCACAAGCGCAGAAGAAGCTTATCGAAAACAGCC
TGCGAGACTTTGAATTATCGGGCATTGGTCTAAGCGATAGCGACAAGTTGCGCTACGGTGAATTGGTTAAGCGTATGTCA
GAGCTAACCAGCAACTTTTCTAATCAGTTACTCGATGCCACGCAAGCTTGGACTAAGCTGATCACCGATGAAGCCGATCT
TAAAGGTTTGCCTGAATCAGCAACTGCAGCAGCTAAGGCGATGGCAGAATCCAAGGAGCTAGACGGCTGGTTGTTTACCC
TGGATATTCCGTCCTACCTGCCAGTAATGATGTACAGTGAAAATCGCGAGCTTCGTGAAGAGTGCTACCGTGCCTTTATC
ACCCGCGCGTCGGATCAGGGTCCGAATGCCGGTGAGTTCGATAATGGTCCCTTGATGGATGAAATTTTAGTTTTGCGCCA
TGAGTTAGCGAATCTATTAGGCTTCGATAGCTTTTCTCATAAATCACTGGCGACTAAGATGGCTGAGTCACCAGCACAAG
TCTTAGACTTCCTAACCGAATTGGCGGCCCGCTCTAAGTCGCAAGGCGAGACAGAGCTGGCAGAGCTAAAAGAGTTTGCT
GAAAAAGAGTGTGGAGTGACAGAGCTCGAGCCATGGGATCTAAGCTTCTACGCTGAAAAGCTAAAGCACCATAGGTATGA
GATCTCACAAGAACTGCTGCGTCCATACTTCCCTGAAGATAAAGTCTTATCGGGTCTGTTCTATACGGTATCACGTCTAT
TTGGTTTGAAAGTCGAAGAGCAAAAAGAGTTCGACAGCTACCATAAAGATGTGCGCTTCTTTCATATTACCGACAGTAAC
AATGAGCATCGCGGCAGTTTTTATCTCGATCTCTATGCTCGTGAAGGTAAGCGTGGCGGTGCATGGATGGATGACTGCCG
TGCGCGCCGCATGACAGAAAATGGCTTACAAGATCCTGTGGCCTATTTAACCTGTAACTTTAACGCGCCAGTGGCGGGTA
AGCCTGCGCTGTTTACTCATGATGAAGTCACGACTCTATTCCACGAGTTTGGCCATGGTATTCATCATATGCTGACCAAA
ATCGATGTGGGCGGCGTATCGGGGATTAGCGGTGTACCTTGGGACGCGGTTGAGCTGCCAAGCCAGTTTATGGAGAACTG
GTGCTATGAGGAGGAGGCGTTGGCCGAGATCTCTGGCCATTACGAAACTGGCGAGCCATTACCTAAAGCTATGTTAGACA
AGATGTTAGCGGCGAAAAACTTCCAGTCAGGCATGATGATGTTACGTCAACTTGAGTTCTCACTATTCGACTTTAAAATG
CACCTAGAGTTTGATCCTGCTAAAGGCGCCGAGATCCAGCAAAAACTCGATGAGGTTCGTCAAGAGGTTGCGGTAATCGA
GGCGGCAGAGTTCAACCGTTTCCAACATAGCTTTGCCCATATCTTTGCGGGCGGTTACGCGGCGGGTTATTACAGCTATA
AGTGGGCGGAAGTGTTATCGGCCGATGCCTTCTCACTGTTCGAAGAGCAGGGGATCTTCAATGCAGAAACTGGACAGCGC
TTCCTTGAAAACATCTTAGAGATGGGCGGTAGCGAAGAGCCAATGGAGCTATTCAAACGTTTTCGTGGTCGTGAGCCGCA
AACCGATGCGCTGTTAAGACACAGTGGTATTAATGGTTAA

Upstream 100 bases:

>100_bases
GAGCTGACATTATTTCCAAAGAATAATGGGCTAAATATTGAATAACCACTCGTTAGCCCTTATCTCTTAACTATCAACAT
AGAATGTTAAGGAATCATTG

Downstream 100 bases:

>100_bases
TAACAACCTCGATTAGTATTAACTGTCGATATCCATCTGTAAAAAAGGCGCTTAAAGCGCCTTTTTTACATGCGTCAGTT
CACACTTGTTATCAGGTATG

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 679; Mature: 678

Protein sequence:

>679_residues
MSNPLLSSAKLPPFSSIKPEHIQPAVEQGIADCRQKIEEVLKHQGEFTWDNLVAPLEETDDLLGKIWSPISHMNSVVSNE
EWRKAHDACLPLLSEYGTFVGQHQGLYQAYKSLAESAEFAHYSQAQKKLIENSLRDFELSGIGLSDSDKLRYGELVKRMS
ELTSNFSNQLLDATQAWTKLITDEADLKGLPESATAAAKAMAESKELDGWLFTLDIPSYLPVMMYSENRELREECYRAFI
TRASDQGPNAGEFDNGPLMDEILVLRHELANLLGFDSFSHKSLATKMAESPAQVLDFLTELAARSKSQGETELAELKEFA
EKECGVTELEPWDLSFYAEKLKHHRYEISQELLRPYFPEDKVLSGLFYTVSRLFGLKVEEQKEFDSYHKDVRFFHITDSN
NEHRGSFYLDLYAREGKRGGAWMDDCRARRMTENGLQDPVAYLTCNFNAPVAGKPALFTHDEVTTLFHEFGHGIHHMLTK
IDVGGVSGISGVPWDAVELPSQFMENWCYEEEALAEISGHYETGEPLPKAMLDKMLAAKNFQSGMMMLRQLEFSLFDFKM
HLEFDPAKGAEIQQKLDEVRQEVAVIEAAEFNRFQHSFAHIFAGGYAAGYYSYKWAEVLSADAFSLFEEQGIFNAETGQR
FLENILEMGGSEEPMELFKRFRGREPQTDALLRHSGING

Sequences:

>Translated_679_residues
MSNPLLSSAKLPPFSSIKPEHIQPAVEQGIADCRQKIEEVLKHQGEFTWDNLVAPLEETDDLLGKIWSPISHMNSVVSNE
EWRKAHDACLPLLSEYGTFVGQHQGLYQAYKSLAESAEFAHYSQAQKKLIENSLRDFELSGIGLSDSDKLRYGELVKRMS
ELTSNFSNQLLDATQAWTKLITDEADLKGLPESATAAAKAMAESKELDGWLFTLDIPSYLPVMMYSENRELREECYRAFI
TRASDQGPNAGEFDNGPLMDEILVLRHELANLLGFDSFSHKSLATKMAESPAQVLDFLTELAARSKSQGETELAELKEFA
EKECGVTELEPWDLSFYAEKLKHHRYEISQELLRPYFPEDKVLSGLFYTVSRLFGLKVEEQKEFDSYHKDVRFFHITDSN
NEHRGSFYLDLYAREGKRGGAWMDDCRARRMTENGLQDPVAYLTCNFNAPVAGKPALFTHDEVTTLFHEFGHGIHHMLTK
IDVGGVSGISGVPWDAVELPSQFMENWCYEEEALAEISGHYETGEPLPKAMLDKMLAAKNFQSGMMMLRQLEFSLFDFKM
HLEFDPAKGAEIQQKLDEVRQEVAVIEAAEFNRFQHSFAHIFAGGYAAGYYSYKWAEVLSADAFSLFEEQGIFNAETGQR
FLENILEMGGSEEPMELFKRFRGREPQTDALLRHSGING
>Mature_678_residues
SNPLLSSAKLPPFSSIKPEHIQPAVEQGIADCRQKIEEVLKHQGEFTWDNLVAPLEETDDLLGKIWSPISHMNSVVSNEE
WRKAHDACLPLLSEYGTFVGQHQGLYQAYKSLAESAEFAHYSQAQKKLIENSLRDFELSGIGLSDSDKLRYGELVKRMSE
LTSNFSNQLLDATQAWTKLITDEADLKGLPESATAAAKAMAESKELDGWLFTLDIPSYLPVMMYSENRELREECYRAFIT
RASDQGPNAGEFDNGPLMDEILVLRHELANLLGFDSFSHKSLATKMAESPAQVLDFLTELAARSKSQGETELAELKEFAE
KECGVTELEPWDLSFYAEKLKHHRYEISQELLRPYFPEDKVLSGLFYTVSRLFGLKVEEQKEFDSYHKDVRFFHITDSNN
EHRGSFYLDLYAREGKRGGAWMDDCRARRMTENGLQDPVAYLTCNFNAPVAGKPALFTHDEVTTLFHEFGHGIHHMLTKI
DVGGVSGISGVPWDAVELPSQFMENWCYEEEALAEISGHYETGEPLPKAMLDKMLAAKNFQSGMMMLRQLEFSLFDFKMH
LEFDPAKGAEIQQKLDEVRQEVAVIEAAEFNRFQHSFAHIFAGGYAAGYYSYKWAEVLSADAFSLFEEQGIFNAETGQRF
LENILEMGGSEEPMELFKRFRGREPQTDALLRHSGING

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=595, Percent_Identity=31.4285714285714, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI14149738, Length=673, Percent_Identity=30.0148588410104, Blast_Score=278, Evalue=1e-74,
Organism=Homo sapiens, GI156105687, Length=593, Percent_Identity=26.4755480607083, Blast_Score=180, Evalue=3e-45,
Organism=Escherichia coli, GI1789913, Length=680, Percent_Identity=65.2941176470588, Blast_Score=934, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=687, Percent_Identity=32.0232896652111, Blast_Score=333, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI71999758, Length=565, Percent_Identity=26.0176991150442, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI32565901, Length=628, Percent_Identity=23.0891719745223, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319793, Length=690, Percent_Identity=28.9855072463768, Blast_Score=281, Evalue=3e-76,
Organism=Saccharomyces cerevisiae, GI6322715, Length=701, Percent_Identity=24.8216833095578, Blast_Score=130, Evalue=6e-31,
Organism=Drosophila melanogaster, GI21356111, Length=585, Percent_Identity=28.7179487179487, Blast_Score=232, Evalue=6e-61,
Organism=Drosophila melanogaster, GI20129717, Length=628, Percent_Identity=23.2484076433121, Blast_Score=165, Evalue=8e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 76989; Mature: 76858

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPLLSSAKLPPFSSIKPEHIQPAVEQGIADCRQKIEEVLKHQGEFTWDNLVAPLEETD
CCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHH
DLLGKIWSPISHMNSVVSNEEWRKAHDACLPLLSEYGTFVGQHQGLYQAYKSLAESAEFA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HYSQAQKKLIENSLRDFELSGIGLSDSDKLRYGELVKRMSELTSNFSNQLLDATQAWTKL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITDEADLKGLPESATAAAKAMAESKELDGWLFTLDIPSYLPVMMYSENRELREECYRAFI
HCCCHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHCCCCHHHHHHHHHHHH
TRASDQGPNAGEFDNGPLMDEILVLRHELANLLGFDSFSHKSLATKMAESPAQVLDFLTE
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHH
LAARSKSQGETELAELKEFAEKECGVTELEPWDLSFYAEKLKHHRYEISQELLRPYFPED
HHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCH
KVLSGLFYTVSRLFGLKVEEQKEFDSYHKDVRFFHITDSNNEHRGSFYLDLYAREGKRGG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEEEECCCCCCCCCEEEEEEECCCCCCC
AWMDDCRARRMTENGLQDPVAYLTCNFNAPVAGKPALFTHDEVTTLFHEFGHGIHHMLTK
CCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHH
IDVGGVSGISGVPWDAVELPSQFMENWCYEEEALAEISGHYETGEPLPKAMLDKMLAAKN
HCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
FQSGMMMLRQLEFSLFDFKMHLEFDPAKGAEIQQKLDEVRQEVAVIEAAEFNRFQHSFAH
HHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFAGGYAAGYYSYKWAEVLSADAFSLFEEQGIFNAETGQRFLENILEMGGSEEPMELFKR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
FRGREPQTDALLRHSGING
HCCCCCCHHHHHHHCCCCC
>Mature Secondary Structure 
SNPLLSSAKLPPFSSIKPEHIQPAVEQGIADCRQKIEEVLKHQGEFTWDNLVAPLEETD
CCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHH
DLLGKIWSPISHMNSVVSNEEWRKAHDACLPLLSEYGTFVGQHQGLYQAYKSLAESAEFA
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HYSQAQKKLIENSLRDFELSGIGLSDSDKLRYGELVKRMSELTSNFSNQLLDATQAWTKL
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITDEADLKGLPESATAAAKAMAESKELDGWLFTLDIPSYLPVMMYSENRELREECYRAFI
HCCCHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHCCCCHHHHHHHHHHHH
TRASDQGPNAGEFDNGPLMDEILVLRHELANLLGFDSFSHKSLATKMAESPAQVLDFLTE
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHH
LAARSKSQGETELAELKEFAEKECGVTELEPWDLSFYAEKLKHHRYEISQELLRPYFPED
HHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCH
KVLSGLFYTVSRLFGLKVEEQKEFDSYHKDVRFFHITDSNNEHRGSFYLDLYAREGKRGG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEEEECCCCCCCCCEEEEEEECCCCCCC
AWMDDCRARRMTENGLQDPVAYLTCNFNAPVAGKPALFTHDEVTTLFHEFGHGIHHMLTK
CCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHH
IDVGGVSGISGVPWDAVELPSQFMENWCYEEEALAEISGHYETGEPLPKAMLDKMLAAKN
HCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
FQSGMMMLRQLEFSLFDFKMHLEFDPAKGAEIQQKLDEVRQEVAVIEAAEFNRFQHSFAH
HHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFAGGYAAGYYSYKWAEVLSADAFSLFEEQGIFNAETGQRFLENILEMGGSEEPMELFKR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
FRGREPQTDALLRHSGING
HCCCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]