Click here to switch to the map view.

The map label for this gene is hgdC [H]

Identifier: 167040529

GI number: 167040529

Start: 1912688

End: 1914307

Strand: Reverse

Name: hgdC [H]

Synonym: Teth514_1898

Alternate gene names: 167040529

Gene position: 1914307-1912688 (Counterclockwise)

Preceding gene: 167040530

Following gene: 167040528

Centisome position: 77.9

GC content: 35.0

Gene sequence:

>1620_bases
TTGATAGGGTACATTTGCAAATACACGCCTGTAGAAATAATCGAAGCTTTTGGAGAAAAACCGGTAAGACTTGATCCAGG
ATATAAGTCTCATGAGCGTGCTGAAGCACTGATTCATTCAAATATGTGCAGCTTTGCAAAAGGGGTTTTGGAAAATATAA
TTGAAAATAATATTGAAGAGGTTGTATTAACTGCCTGTTGTGATAGTATAAAAAGACTTTATGATGTGTTAAAAGATAAA
GTAAAATTTATCCATCTTCTAGACCTCCCCAGAAAAAAAGATCTTCTCGCAATAGATCTTTTTTACAATGAAATAATTGA
ATTTATAGAAGCGTATCAGGCCTTTAAAAACAAGAGTTTTGATGAAGAGAGTTTGCTAAAAATTCTAGAAAGCAAGTCTT
TTAATAAAGAAGAATCCGCTGAAAGCATTGCTATATTAGGTGCGAGGCTTAAAGATGATGTTATAGAAAAAATCAGAAAT
TCTTGTACAGCAAACGTAATAAATTTTACCTGCACAGGTGAAGAAAGAGTATTCAATATTGAAGCAAAAGATAATTTATT
AAAAAGCTACGCGGAATCGCTTCTTAATTTTACACCCTGTATGAGAATGGCAGAAGATCGAAGCAAGTTAATCAATAAAG
AATTGAAGGGGATAATATACAACACCATAAAGTTCTGTGATTTTTATTCCTATGAATATGCTGAACTCAAAAGCAGAGCA
GACATCCCACTTTTAAAAATTGAAACTGACTATAACGATTCAAATAGCGGACAGATTTTAACAAGAATAGATGCTTTTTT
GGAATCAACCGGTATAAAAAAGATGGAAAAACAGAAAGCCAAGAAAGGATATTTTGTAGGAGTGGATAGTGGCTCTACTT
CTACAAATGTAGTCATAATCGACGAAAACAAAAACGTAATATCATATTCTATTATTCCAACAGGTCCTAAAGCTCTAGAA
AGTGCTTTTAAAGCTTTTGAAATTGCTTTAAACAGTGCGGGCCTTCAAAAAAAGGATATTACATCAATAGTAGCAACAGG
GTATGGAAGAGTAAGCATTCCCTTTGCAGATAGAATTATAACTGAAATTACCTGTCACGGAAAAGGCGCATTTTTTATAG
ACAATGCTATTAGAACTGTTATAGATATAGGTGGACAGGATAGCAAAGTGATAAGGTTAGATGACAGCGGCAATGTTATT
GATTTTGTGATGAATGACAAATGTTCAGCAGGGACAGGCCGGTTTCTTGAAGTAATGGCGAGAACGTTAGGCATTTCAAT
AGAAGAAATGGCAAAAGTCCATAAGGAAGTAAAAGAAAATATCACGATTACCAGTATGTGCACTGTATTTGCAGAATCGG
AAGTAATATCTCTTATTGCCCAAAATAAGGACCAGAGGGATATAATACATGCCCTCAATAAATCCATTGCTTCAAAAGCT
ATTTCCCTGGTCGACAGAATAGGGAGAAAAGGAAAATACATGATGACAGGGGGCGTTGCCAAAAATCAGGGAGTAGTTTA
TGCCATCGAAAGCAGGCTCGGCGAAAAACTTATAATTCCATTTGAACCACAGATTATTGGAGCACTTGGAGCAGCGCTAA
TTTCACTTGAAGGTAAATGA

Upstream 100 bases:

>100_bases
GGGGATTGTGTAGACAAAAGAAATAATCAAGAGGGACAGAATAGGACGAGGCTCGAAGCCTTTCTTGAAATGCTCTAGTA
ATCCTTCTGGAGGTGAAAAA

Downstream 100 bases:

>100_bases
GGGCATCACTATAGTCAATTAATTTTTAAGAGGGATGCTTATGCTCAGTCATGAGGATTATCAAAAGATTGTAAATAGGC
TTATGAATATTCTTGGCAAA

Product: putative CoA-substrate-specific enzyme activase

Products: NA

Alternate protein names: 2-hydroxyglutaryl-CoA dehydratase component A [H]

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MIGYICKYTPVEIIEAFGEKPVRLDPGYKSHERAEALIHSNMCSFAKGVLENIIENNIEEVVLTACCDSIKRLYDVLKDK
VKFIHLLDLPRKKDLLAIDLFYNEIIEFIEAYQAFKNKSFDEESLLKILESKSFNKEESAESIAILGARLKDDVIEKIRN
SCTANVINFTCTGEERVFNIEAKDNLLKSYAESLLNFTPCMRMAEDRSKLINKELKGIIYNTIKFCDFYSYEYAELKSRA
DIPLLKIETDYNDSNSGQILTRIDAFLESTGIKKMEKQKAKKGYFVGVDSGSTSTNVVIIDENKNVISYSIIPTGPKALE
SAFKAFEIALNSAGLQKKDITSIVATGYGRVSIPFADRIITEITCHGKGAFFIDNAIRTVIDIGGQDSKVIRLDDSGNVI
DFVMNDKCSAGTGRFLEVMARTLGISIEEMAKVHKEVKENITITSMCTVFAESEVISLIAQNKDQRDIIHALNKSIASKA
ISLVDRIGRKGKYMMTGGVAKNQGVVYAIESRLGEKLIIPFEPQIIGALGAALISLEGK

Sequences:

>Translated_539_residues
MIGYICKYTPVEIIEAFGEKPVRLDPGYKSHERAEALIHSNMCSFAKGVLENIIENNIEEVVLTACCDSIKRLYDVLKDK
VKFIHLLDLPRKKDLLAIDLFYNEIIEFIEAYQAFKNKSFDEESLLKILESKSFNKEESAESIAILGARLKDDVIEKIRN
SCTANVINFTCTGEERVFNIEAKDNLLKSYAESLLNFTPCMRMAEDRSKLINKELKGIIYNTIKFCDFYSYEYAELKSRA
DIPLLKIETDYNDSNSGQILTRIDAFLESTGIKKMEKQKAKKGYFVGVDSGSTSTNVVIIDENKNVISYSIIPTGPKALE
SAFKAFEIALNSAGLQKKDITSIVATGYGRVSIPFADRIITEITCHGKGAFFIDNAIRTVIDIGGQDSKVIRLDDSGNVI
DFVMNDKCSAGTGRFLEVMARTLGISIEEMAKVHKEVKENITITSMCTVFAESEVISLIAQNKDQRDIIHALNKSIASKA
ISLVDRIGRKGKYMMTGGVAKNQGVVYAIESRLGEKLIIPFEPQIIGALGAALISLEGK
>Mature_539_residues
MIGYICKYTPVEIIEAFGEKPVRLDPGYKSHERAEALIHSNMCSFAKGVLENIIENNIEEVVLTACCDSIKRLYDVLKDK
VKFIHLLDLPRKKDLLAIDLFYNEIIEFIEAYQAFKNKSFDEESLLKILESKSFNKEESAESIAILGARLKDDVIEKIRN
SCTANVINFTCTGEERVFNIEAKDNLLKSYAESLLNFTPCMRMAEDRSKLINKELKGIIYNTIKFCDFYSYEYAELKSRA
DIPLLKIETDYNDSNSGQILTRIDAFLESTGIKKMEKQKAKKGYFVGVDSGSTSTNVVIIDENKNVISYSIIPTGPKALE
SAFKAFEIALNSAGLQKKDITSIVATGYGRVSIPFADRIITEITCHGKGAFFIDNAIRTVIDIGGQDSKVIRLDDSGNVI
DFVMNDKCSAGTGRFLEVMARTLGISIEEMAKVHKEVKENITITSMCTVFAESEVISLIAQNKDQRDIIHALNKSIASKA
ISLVDRIGRKGKYMMTGGVAKNQGVVYAIESRLGEKLIIPFEPQIIGALGAALISLEGK

Specific function: Required for the activation of (R)-2-hydroxyglutaryl-CoA dehydratase. This protein is extremely sensitive towards oxygen [H]

COG id: COG1924

COG function: function code I; Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli yjiL and M.jannaschii MJ0004 and MJ0800 [H]

Homologues:

Organism=Escherichia coli, GI87082426, Length=255, Percent_Identity=43.1372549019608, Blast_Score=191, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002731
- InterPro:   IPR008275 [H]

Pfam domain/function: PF01869 BcrAD_BadFG [H]

EC number: NA

Molecular weight: Translated: 59997; Mature: 59997

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGYICKYTPVEIIEAFGEKPVRLDPGYKSHERAEALIHSNMCSFAKGVLENIIENNIEE
CCCCEECCCHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VVLTACCDSIKRLYDVLKDKVKFIHLLDLPRKKDLLAIDLFYNEIIEFIEAYQAFKNKSF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCC
DEESLLKILESKSFNKEESAESIAILGARLKDDVIEKIRNSCTANVINFTCTGEERVFNI
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEE
EAKDNLLKSYAESLLNFTPCMRMAEDRSKLINKELKGIIYNTIKFCDFYSYEYAELKSRA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCC
DIPLLKIETDYNDSNSGQILTRIDAFLESTGIKKMEKQKAKKGYFVGVDSGSTSTNVVII
CCCEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCCCEEEEEE
DENKNVISYSIIPTGPKALESAFKAFEIALNSAGLQKKDITSIVATGYGRVSIPFADRII
ECCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEECCHHHHHH
TEITCHGKGAFFIDNAIRTVIDIGGQDSKVIRLDDSGNVIDFVMNDKCSAGTGRFLEVMA
HHEEECCCCCEEEHHHHHHHHHCCCCCCEEEEECCCCCEEEEEECCCCCCCCHHHHHHHH
RTLGISIEEMAKVHKEVKENITITSMCTVFAESEVISLIAQNKDQRDIIHALNKSIASKA
HHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ISLVDRIGRKGKYMMTGGVAKNQGVVYAIESRLGEKLIIPFEPQIIGALGAALISLEGK
HHHHHHHCCCCCEEEECCCCCCCCEEEEEECCCCCEEEECCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIGYICKYTPVEIIEAFGEKPVRLDPGYKSHERAEALIHSNMCSFAKGVLENIIENNIEE
CCCCEECCCHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VVLTACCDSIKRLYDVLKDKVKFIHLLDLPRKKDLLAIDLFYNEIIEFIEAYQAFKNKSF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCC
DEESLLKILESKSFNKEESAESIAILGARLKDDVIEKIRNSCTANVINFTCTGEERVFNI
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEE
EAKDNLLKSYAESLLNFTPCMRMAEDRSKLINKELKGIIYNTIKFCDFYSYEYAELKSRA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCC
DIPLLKIETDYNDSNSGQILTRIDAFLESTGIKKMEKQKAKKGYFVGVDSGSTSTNVVII
CCCEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCCCEEEEEE
DENKNVISYSIIPTGPKALESAFKAFEIALNSAGLQKKDITSIVATGYGRVSIPFADRII
ECCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEECCHHHHHH
TEITCHGKGAFFIDNAIRTVIDIGGQDSKVIRLDDSGNVIDFVMNDKCSAGTGRFLEVMA
HHEEECCCCCEEEHHHHHHHHHCCCCCCEEEEECCCCCEEEEEECCCCCCCCHHHHHHHH
RTLGISIEEMAKVHKEVKENITITSMCTVFAESEVISLIAQNKDQRDIIHALNKSIASKA
HHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ISLVDRIGRKGKYMMTGGVAKNQGVVYAIESRLGEKLIIPFEPQIIGALGAALISLEGK
HHHHHHHCCCCCEEEECCCCCCCCEEEEEECCCCCEEEECCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8365476; 2659350; 7607244; 11106419; 11243821 [H]