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The map label for this gene is hemD [H]

Identifier: 167038986

GI number: 167038986

Start: 334216

End: 335709

Strand: Direct

Name: hemD [H]

Synonym: Teth514_0319

Alternate gene names: 167038986

Gene position: 334216-335709 (Clockwise)

Preceding gene: 167038985

Following gene: 167038987

Centisome position: 13.6

GC content: 34.14

Gene sequence:

>1494_bases
ATGTCAGGGATTGTATATTTGATCGGAGCAGGACCTGGAGATATTGGGCTTTTAACATTGAGAGCAGTCGAACTAATAAA
AAATGCAGATGTGCTGGTGTATGACAGGCTCATTAATGAAGATATTTTAAAAATGGCAAAAAAGGATGCAGAGCTTATTG
ATGTTGGAAAGTTTCCGGATAATCACAAAGTACCTCAAAGTAAAATAAATGAAATAATTGCGAAAAAGGCCCTTTCTGGC
AAAAAAGTAGCAAGAATTAAAGGAGGAGACCCTTTTGTATTCGGAAGAGGTGGCGAAGAAGCGGAATATCTTACACAAAA
AAGAATACCTTATGAGGTAGTGCCAGGCATAACATCTGCAGTGGCTGTCCTATCCTATGCAGGAATTCCTGTAACCCATA
GAGATTTAAGTTCGTCATTTCACGTAATAACGGGTCATGAATGGAAAGGGAAAGATAAAAAACTCGATTGGGAGGTCATA
TCAAAACTCGATGGGACACTTGTATTTCTCATGGGGATAAAAAATATAGAAAAAATTGTGAAAAAACTTCTCAATTACGG
CAAAGACCCTCATACACCGGCAGCAGTAATAATGGAAGGTACTACTCCAAACCAAAAAGTTGTGACTGCAAAACTCATTG
ATATTTCAAGTCTTGTACGAAAAGAAGGAATAAAAAATCCGGGAGTTTTTGCTGTAGGAGATGTTGTAACATTAAGGGAC
AGATTAAAATGGTATGAAAACAAAAAGCTTTTTGGGAAAAGGATTTTGCTTACAAGGACCTATGAACAATCACAGCAGAT
GAAAAAAATTTTGAGTGAAGAGGGAGCAGATGTTGTTGTTTGTCCTACTATTAAAATCACGCCGTTTTTAAATAATATAG
TAAAGTTTTTAGAAGAAATACATAAATTCGATTATGCTGTATTTACAAGTGTAAATGACGTTTGGAGTTTTATTGAAGCT
TCCCGAGAAAAAAGGGTTGATTTAAGAAATTTAAGAATTAAAGTAGTAGCGATAGGAAGTAAAACTGCGGAAGCTTTAGA
AAATATTTTTATATATCCAGATATAATTCCTGAGGAGTACACCTCATACTCTTTAGCAAATGCACTTAAAAAACATGTTG
AAGGAAAAAACATAGCGCTTTTGACTTCTCAGATAGGCGGGGATATATTGCTGGAAAGTCTAGGAAATTGTGCTAACGTA
CAAAAAATTGTCGCATATAAAAATGAACCAAATTATGAAATAAAGGAAAAGCTTATAAGTGAACTCCGCAAAGGAATAGA
TATTGCTGTATTTACAAGTTCCTCTACCTTTAATTATATGCATCAATTAATAGGAGACGAAATAAATCTTCTAAAAAACT
CTAAAATAGCTGCAATAGGACCTGTAACAAAGAAAGCTATAGAGGATAAAGGATTTAATGTAGACATAATGCCAAGTGAA
TACACAACGGAAAAACTTATTGAAGAAATATTAAAAAACTATCAAAACCAATAG

Upstream 100 bases:

>100_bases
ATCAAAAAGAGAATAAGCTTTTAAAAAGTGAAGTGACTGGCTTAATTGAAGAAACCGATAAAATGATAGAAAAGCTTATT
GAGGAATTTGGAGGTATATG

Downstream 100 bases:

>100_bases
AAAGAGGAGATAAAATGGATTTGGTAAAAAGGCCAAGAAGGCTTAGGATGAACAGTATTTTAAGGGAGATGATACGAGAA
ACTTCTTTAGATGTTGGTGA

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Uroporphyrinogen-III synthase; UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MSGIVYLIGAGPGDIGLLTLRAVELIKNADVLVYDRLINEDILKMAKKDAELIDVGKFPDNHKVPQSKINEIIAKKALSG
KKVARIKGGDPFVFGRGGEEAEYLTQKRIPYEVVPGITSAVAVLSYAGIPVTHRDLSSSFHVITGHEWKGKDKKLDWEVI
SKLDGTLVFLMGIKNIEKIVKKLLNYGKDPHTPAAVIMEGTTPNQKVVTAKLIDISSLVRKEGIKNPGVFAVGDVVTLRD
RLKWYENKKLFGKRILLTRTYEQSQQMKKILSEEGADVVVCPTIKITPFLNNIVKFLEEIHKFDYAVFTSVNDVWSFIEA
SREKRVDLRNLRIKVVAIGSKTAEALENIFIYPDIIPEEYTSYSLANALKKHVEGKNIALLTSQIGGDILLESLGNCANV
QKIVAYKNEPNYEIKEKLISELRKGIDIAVFTSSSTFNYMHQLIGDEINLLKNSKIAAIGPVTKKAIEDKGFNVDIMPSE
YTTEKLIEEILKNYQNQ

Sequences:

>Translated_497_residues
MSGIVYLIGAGPGDIGLLTLRAVELIKNADVLVYDRLINEDILKMAKKDAELIDVGKFPDNHKVPQSKINEIIAKKALSG
KKVARIKGGDPFVFGRGGEEAEYLTQKRIPYEVVPGITSAVAVLSYAGIPVTHRDLSSSFHVITGHEWKGKDKKLDWEVI
SKLDGTLVFLMGIKNIEKIVKKLLNYGKDPHTPAAVIMEGTTPNQKVVTAKLIDISSLVRKEGIKNPGVFAVGDVVTLRD
RLKWYENKKLFGKRILLTRTYEQSQQMKKILSEEGADVVVCPTIKITPFLNNIVKFLEEIHKFDYAVFTSVNDVWSFIEA
SREKRVDLRNLRIKVVAIGSKTAEALENIFIYPDIIPEEYTSYSLANALKKHVEGKNIALLTSQIGGDILLESLGNCANV
QKIVAYKNEPNYEIKEKLISELRKGIDIAVFTSSSTFNYMHQLIGDEINLLKNSKIAAIGPVTKKAIEDKGFNVDIMPSE
YTTEKLIEEILKNYQNQ
>Mature_496_residues
SGIVYLIGAGPGDIGLLTLRAVELIKNADVLVYDRLINEDILKMAKKDAELIDVGKFPDNHKVPQSKINEIIAKKALSGK
KVARIKGGDPFVFGRGGEEAEYLTQKRIPYEVVPGITSAVAVLSYAGIPVTHRDLSSSFHVITGHEWKGKDKKLDWEVIS
KLDGTLVFLMGIKNIEKIVKKLLNYGKDPHTPAAVIMEGTTPNQKVVTAKLIDISSLVRKEGIKNPGVFAVGDVVTLRDR
LKWYENKKLFGKRILLTRTYEQSQQMKKILSEEGADVVVCPTIKITPFLNNIVKFLEEIHKFDYAVFTSVNDVWSFIEAS
REKRVDLRNLRIKVVAIGSKTAEALENIFIYPDIIPEEYTSYSLANALKKHVEGKNIALLTSQIGGDILLESLGNCANVQ
KIVAYKNEPNYEIKEKLISELRKGIDIAVFTSSSTFNYMHQLIGDEINLLKNSKIAAIGPVTKKAIEDKGFNVDIMPSEY
TTEKLIEEILKNYQNQ

Specific function: May catalyze sequential reactions to synthesize uroporphyrinogen III from hydroxymethylbilane (HMB) and then precorrin-2, which are intermediate compounds in both vitamin B12 and siroheme biosyntheses [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=245, Percent_Identity=45.7142857142857, Blast_Score=234, Evalue=9e-63,
Organism=Saccharomyces cerevisiae, GI6322922, Length=254, Percent_Identity=34.6456692913386, Blast_Score=142, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR003754
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF02602 HEM4; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =4.2.1.75 [H]

Molecular weight: Translated: 55503; Mature: 55372

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGIVYLIGAGPGDIGLLTLRAVELIKNADVLVYDRLINEDILKMAKKDAELIDVGKFPD
CCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHCCCCEEECCCCCC
NHKVPQSKINEIIAKKALSGKKVARIKGGDPFVFGRGGEEAEYLTQKRIPYEVVPGITSA
CCCCCHHHHHHHHHHHHCCCCEEEEECCCCCEEECCCCCHHHHHHHHCCCHHHCCCHHHH
VAVLSYAGIPVTHRDLSSSFHVITGHEWKGKDKKLDWEVISKLDGTLVFLMGIKNIEKIV
HHHHHHCCCCEEHHHHCCCEEEEECCCCCCCCCCCCHHHHHHCCCCEEEEHHHHHHHHHH
KKLLNYGKDPHTPAAVIMEGTTPNQKVVTAKLIDISSLVRKEGIKNPGVFAVGDVVTLRD
HHHHHCCCCCCCCEEEEEECCCCCCEEEEEEHHHHHHHHHHCCCCCCCCEEECHHHHHHH
RLKWYENKKLFGKRILLTRTYEQSQQMKKILSEEGADVVVCPTIKITPFLNNIVKFLEEI
HHHHHHCCHHHCCEEEEEECHHHHHHHHHHHHHCCCCEEEECCEEECHHHHHHHHHHHHH
HKFDYAVFTSVNDVWSFIEASREKRVDLRNLRIKVVAIGSKTAEALENIFIYPDIIPEEY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHEEECCCCCCHHH
TSYSLANALKKHVEGKNIALLTSQIGGDILLESLGNCANVQKIVAYKNEPNYEIKEKLIS
HHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCCCCCHHHHEEECCCCCHHHHHHHHH
ELRKGIDIAVFTSSSTFNYMHQLIGDEINLLKNSKIAAIGPVTKKAIEDKGFNVDIMPSE
HHHCCCEEEEEECCCHHHHHHHHHCCHHHHHCCCCEEEECCHHHHHHHCCCCEEEECCCC
YTTEKLIEEILKNYQNQ
CCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SGIVYLIGAGPGDIGLLTLRAVELIKNADVLVYDRLINEDILKMAKKDAELIDVGKFPD
CCEEEEEECCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHCCCCEEECCCCCC
NHKVPQSKINEIIAKKALSGKKVARIKGGDPFVFGRGGEEAEYLTQKRIPYEVVPGITSA
CCCCCHHHHHHHHHHHHCCCCEEEEECCCCCEEECCCCCHHHHHHHHCCCHHHCCCHHHH
VAVLSYAGIPVTHRDLSSSFHVITGHEWKGKDKKLDWEVISKLDGTLVFLMGIKNIEKIV
HHHHHHCCCCEEHHHHCCCEEEEECCCCCCCCCCCCHHHHHHCCCCEEEEHHHHHHHHHH
KKLLNYGKDPHTPAAVIMEGTTPNQKVVTAKLIDISSLVRKEGIKNPGVFAVGDVVTLRD
HHHHHCCCCCCCCEEEEEECCCCCCEEEEEEHHHHHHHHHHCCCCCCCCEEECHHHHHHH
RLKWYENKKLFGKRILLTRTYEQSQQMKKILSEEGADVVVCPTIKITPFLNNIVKFLEEI
HHHHHHCCHHHCCEEEEEECHHHHHHHHHHHHHCCCCEEEECCEEECHHHHHHHHHHHHH
HKFDYAVFTSVNDVWSFIEASREKRVDLRNLRIKVVAIGSKTAEALENIFIYPDIIPEEY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHEEECCCCCCHHH
TSYSLANALKKHVEGKNIALLTSQIGGDILLESLGNCANVQKIVAYKNEPNYEIKEKLIS
HHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCCCCCHHHHEEECCCCCHHHHHHHHH
ELRKGIDIAVFTSSSTFNYMHQLIGDEINLLKNSKIAAIGPVTKKAIEDKGFNVDIMPSE
HHHCCCEEEEEECCCHHHHHHHHHCCHHHHHCCCCEEEECCHHHHHHHCCCCEEEECCCC
YTTEKLIEEILKNYQNQ
CCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7665501 [H]