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The map label for this gene is hemB [H]

Identifier: 167038987

GI number: 167038987

Start: 335724

End: 336698

Strand: Direct

Name: hemB [H]

Synonym: Teth514_0320

Alternate gene names: 167038987

Gene position: 335724-336698 (Clockwise)

Preceding gene: 167038986

Following gene: 167038988

Centisome position: 13.66

GC content: 37.64

Gene sequence:

>975_bases
ATGGATTTGGTAAAAAGGCCAAGAAGGCTTAGGATGAACAGTATTTTAAGGGAGATGATACGAGAAACTTCTTTAGATGT
TGGTGACCTTATATATCCTCTTTTTGTTGTGCCAGGAGATAATATAAAAGAAGAGATAGATTCAATGCCGGGTGTTTACC
ATTTTTCTATAGATTTGCTTGTAGAAGAAGTTAAAGAAGTGCGTGACCTTGGAATTCCTGCTATTTTACTTTTTGGTGTG
CCTTCATATAAAGATGAATTAGGGTCAGAGGCTTATAGTGAGGAAGGCATCGTTCAAAAAGCGGTGAGAGAAATAAAAGA
AAAAGTGCCTGAAATTGTGGTAATAACAGATGTGTGTATGTGTGGGTATACAATTCATGGTCACTGTGGAATTGTTGAAA
ATGGACAAGTTGTAAATGACAAAACGATAGATTACATCGCTAAAATAGCCTTGTCCCATGTTGAGGCAGGGGCGGATATT
GTAGCGCCTTCTGACATGATGGATGGAAGAGTAGCTGCCATAAGAAAGCTTTTAGATAGTAAAGGATTTGTAAACACACC
TATTATGGCTTACAGTGCTAAATACGCTTCCTCTTTTTATGGACCTTTTAGAGAAGCAGCAAATTCTTTCCCACAATTTG
GCGACAGAAAGTCTTATCAAATGGACTATGGAAACTCCAACGAAGCCTTAAGAGAAATAGCTCTTGACATTGAAGAAGGA
GCAGATATTGTCATGGTAAAGCCGGCACTTTCTTATCTTGATATTATAAGGCGGGTAAAGGATAATTTCAACATTCCTAT
TGCTGCTTATAATGTAAGTGGAGAATATTCAATGGTAAAGGCGGCAGCTAAGATGGGTTGGATTGATGAAAAATCGGTAG
TCTTAGAAATACTCACTTCAATTAAAAGGGCAGGGGCAGACATAGTTATAACCTACTTTGCAAAGGATGTTGCAAAATGG
TTTATTACCCTATAA

Upstream 100 bases:

>100_bases
AAGGATTTAATGTAGACATAATGCCAAGTGAATACACAACGGAAAAACTTATTGAAGAAATATTAAAAAACTATCAAAAC
CAATAGAAAGAGGAGATAAA

Downstream 100 bases:

>100_bases
TGCTTAATATAAAAAACAAAAAATGCCTTGTTGTAGGGGGTGGCAAAGTTGCTCTTAGAAAAATTTTATCTCTTGTTGAA
GGAGAAGCTTTAGTTACTGC

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MDLVKRPRRLRMNSILREMIRETSLDVGDLIYPLFVVPGDNIKEEIDSMPGVYHFSIDLLVEEVKEVRDLGIPAILLFGV
PSYKDELGSEAYSEEGIVQKAVREIKEKVPEIVVITDVCMCGYTIHGHCGIVENGQVVNDKTIDYIAKIALSHVEAGADI
VAPSDMMDGRVAAIRKLLDSKGFVNTPIMAYSAKYASSFYGPFREAANSFPQFGDRKSYQMDYGNSNEALREIALDIEEG
ADIVMVKPALSYLDIIRRVKDNFNIPIAAYNVSGEYSMVKAAAKMGWIDEKSVVLEILTSIKRAGADIVITYFAKDVAKW
FITL

Sequences:

>Translated_324_residues
MDLVKRPRRLRMNSILREMIRETSLDVGDLIYPLFVVPGDNIKEEIDSMPGVYHFSIDLLVEEVKEVRDLGIPAILLFGV
PSYKDELGSEAYSEEGIVQKAVREIKEKVPEIVVITDVCMCGYTIHGHCGIVENGQVVNDKTIDYIAKIALSHVEAGADI
VAPSDMMDGRVAAIRKLLDSKGFVNTPIMAYSAKYASSFYGPFREAANSFPQFGDRKSYQMDYGNSNEALREIALDIEEG
ADIVMVKPALSYLDIIRRVKDNFNIPIAAYNVSGEYSMVKAAAKMGWIDEKSVVLEILTSIKRAGADIVITYFAKDVAKW
FITL
>Mature_324_residues
MDLVKRPRRLRMNSILREMIRETSLDVGDLIYPLFVVPGDNIKEEIDSMPGVYHFSIDLLVEEVKEVRDLGIPAILLFGV
PSYKDELGSEAYSEEGIVQKAVREIKEKVPEIVVITDVCMCGYTIHGHCGIVENGQVVNDKTIDYIAKIALSHVEAGADI
VAPSDMMDGRVAAIRKLLDSKGFVNTPIMAYSAKYASSFYGPFREAANSFPQFGDRKSYQMDYGNSNEALREIALDIEEG
ADIVMVKPALSYLDIIRRVKDNFNIPIAAYNVSGEYSMVKAAAKMGWIDEKSVVLEILTSIKRAGADIVITYFAKDVAKW
FITL

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=304, Percent_Identity=45.7236842105263, Blast_Score=282, Evalue=2e-76,
Organism=Escherichia coli, GI87081728, Length=318, Percent_Identity=50, Blast_Score=317, Evalue=7e-88,
Organism=Saccharomyces cerevisiae, GI6321398, Length=315, Percent_Identity=38.7301587301587, Blast_Score=235, Evalue=9e-63,
Organism=Drosophila melanogaster, GI21358291, Length=306, Percent_Identity=43.4640522875817, Blast_Score=263, Evalue=1e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36094; Mature: 36094

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLVKRPRRLRMNSILREMIRETSLDVGDLIYPLFVVPGDNIKEEIDSMPGVYHFSIDLL
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEECCCCHHHHHHCCCCEEEHHHHHH
VEEVKEVRDLGIPAILLFGVPSYKDELGSEAYSEEGIVQKAVREIKEKVPEIVVITDVCM
HHHHHHHHHCCCCEEEEECCCCHHHHHCCHHHHHCHHHHHHHHHHHHHCCCEEEEEHHHH
CGYTIHGHCGIVENGQVVNDKTIDYIAKIALSHVEAGADIVAPSDMMDGRVAAIRKLLDS
HCCEEECCCCEECCCEEECCHHHHHHHHHHHHHHHCCCCEECCCHHCCCHHHHHHHHHHC
KGFVNTPIMAYSAKYASSFYGPFREAANSFPQFGDRKSYQMDYGNSNEALREIALDIEEG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHHHHHHCCC
ADIVMVKPALSYLDIIRRVKDNFNIPIAAYNVSGEYSMVKAAAKMGWIDEKSVVLEILTS
CCEEEECHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHH
IKRAGADIVITYFAKDVAKWFITL
HHHCCCCEEEHHHHHHHHHHHHCC
>Mature Secondary Structure
MDLVKRPRRLRMNSILREMIRETSLDVGDLIYPLFVVPGDNIKEEIDSMPGVYHFSIDLL
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEECCCCHHHHHHCCCCEEEHHHHHH
VEEVKEVRDLGIPAILLFGVPSYKDELGSEAYSEEGIVQKAVREIKEKVPEIVVITDVCM
HHHHHHHHHCCCCEEEEECCCCHHHHHCCHHHHHCHHHHHHHHHHHHHCCCEEEEEHHHH
CGYTIHGHCGIVENGQVVNDKTIDYIAKIALSHVEAGADIVAPSDMMDGRVAAIRKLLDS
HCCEEECCCCEECCCEEECCHHHHHHHHHHHHHHHCCCCEECCCHHCCCHHHHHHHHHHC
KGFVNTPIMAYSAKYASSFYGPFREAANSFPQFGDRKSYQMDYGNSNEALREIALDIEEG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHHHHHHCCC
ADIVMVKPALSYLDIIRRVKDNFNIPIAAYNVSGEYSMVKAAAKMGWIDEKSVVLEILTS
CCEEEECHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHH
IKRAGADIVITYFAKDVAKWFITL
HHHCCCCEEEHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8123787 [H]