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The map label for this gene is hemC [H]

Identifier: 167038985

GI number: 167038985

Start: 333317

End: 334216

Strand: Direct

Name: hemC [H]

Synonym: Teth514_0318

Alternate gene names: 167038985

Gene position: 333317-334216 (Clockwise)

Preceding gene: 167038984

Following gene: 167038986

Centisome position: 13.56

GC content: 36.22

Gene sequence:

>900_bases
ATGAAAAAAGTTATAAAAGTCGGCACAAGGTCAAGTGAATTGGCTTTAAAGCAAACTGCAATGGTTATAAATGAAATAAA
AAAGTTTAGGCAGGATTTTGAATTTGAAATAGTAAAGATAACCACACAAGGGGATGCATTAATTGACAAACCTGTTAGTG
AAATAGGGGGAAAAGGGGTTTTTGTAAAAGAAATAGAAAGTGCATTGCTCAAAGGCGAAATTGACATGGCAGTCCACAGC
ATGAAGGACATGCCTTATGAAATACCTAAAGGGCTCAAGCTCATGGCAGTTTTAAAAAGAGAAGACCCAAAGGATGTGTT
TGTTTCAGGAGATGGTACGCAATTTATGGATTTAAAAGAAGGGGCTAAAATTGGGACCAGCAGTTTAAGAAGGCAAGTGC
AGCTTAAAGCTTTAAAGCCAGACATACAGATTGTTCCAATAAGAGGTAATGTGAGGACGAGGCTCAAAAAAATGGAAGAA
CTAAACCTTGACGGCATTGTTTTGTCAGCGGCGGGTTTGCACAGGTTAGGATTGGAGAATATTATTACTGAATATTTTCC
ACCTGATGTAGTTGTACCAGCACCTTGTCAGGGAATTCTTGCAGTAGAAATTGCAGAAAGTTTTGATAATATATTTCAAG
AGTTTTATCCCTACATTGTTGATAGAAAAACATTTTTTGAGGCTTCTGTTGAAAGGGAACTTCTAAAAGCCTTTGGAGTT
AATTGTAGACAGCCTTTTGGTGCCTATGCCCAATACAGAAAAGAGGAAGACGAAGAAAAAATAAACATAAAAGTTGCTTA
TCAAAAAGAGAATAAGCTTTTAAAAAGTGAAGTGACTGGCTTAATTGAAGAAACCGATAAAATGATAGAAAAGCTTATTG
AGGAATTTGGAGGTATATGA

Upstream 100 bases:

>100_bases
GGAAAATATAAAAATCGCTTTAAAAAGAGTTGCAAATAAAATGGCTAATAAAATGATAACATACCTTAAAGAAAATGCAT
ATTAGAATCTGGAGGGAAAG

Downstream 100 bases:

>100_bases
TGTCAGGGATTGTATATTTGATCGGAGCAGGACCTGGAGATATTGGGCTTTTAACATTGAGAGCAGTCGAACTAATAAAA
AATGCAGATGTGCTGGTGTA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MKKVIKVGTRSSELALKQTAMVINEIKKFRQDFEFEIVKITTQGDALIDKPVSEIGGKGVFVKEIESALLKGEIDMAVHS
MKDMPYEIPKGLKLMAVLKREDPKDVFVSGDGTQFMDLKEGAKIGTSSLRRQVQLKALKPDIQIVPIRGNVRTRLKKMEE
LNLDGIVLSAAGLHRLGLENIITEYFPPDVVVPAPCQGILAVEIAESFDNIFQEFYPYIVDRKTFFEASVERELLKAFGV
NCRQPFGAYAQYRKEEDEEKINIKVAYQKENKLLKSEVTGLIEETDKMIEKLIEEFGGI

Sequences:

>Translated_299_residues
MKKVIKVGTRSSELALKQTAMVINEIKKFRQDFEFEIVKITTQGDALIDKPVSEIGGKGVFVKEIESALLKGEIDMAVHS
MKDMPYEIPKGLKLMAVLKREDPKDVFVSGDGTQFMDLKEGAKIGTSSLRRQVQLKALKPDIQIVPIRGNVRTRLKKMEE
LNLDGIVLSAAGLHRLGLENIITEYFPPDVVVPAPCQGILAVEIAESFDNIFQEFYPYIVDRKTFFEASVERELLKAFGV
NCRQPFGAYAQYRKEEDEEKINIKVAYQKENKLLKSEVTGLIEETDKMIEKLIEEFGGI
>Mature_299_residues
MKKVIKVGTRSSELALKQTAMVINEIKKFRQDFEFEIVKITTQGDALIDKPVSEIGGKGVFVKEIESALLKGEIDMAVHS
MKDMPYEIPKGLKLMAVLKREDPKDVFVSGDGTQFMDLKEGAKIGTSSLRRQVQLKALKPDIQIVPIRGNVRTRLKKMEE
LNLDGIVLSAAGLHRLGLENIITEYFPPDVVVPAPCQGILAVEIAESFDNIFQEFYPYIVDRKTFFEASVERELLKAFGV
NCRQPFGAYAQYRKEEDEEKINIKVAYQKENKLLKSEVTGLIEETDKMIEKLIEEFGGI

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=255, Percent_Identity=36.4705882352941, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI66933009, Length=255, Percent_Identity=36.4705882352941, Blast_Score=166, Evalue=4e-41,
Organism=Escherichia coli, GI48994974, Length=296, Percent_Identity=37.1621621621622, Blast_Score=204, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6319996, Length=262, Percent_Identity=33.969465648855, Blast_Score=151, Evalue=1e-37,
Organism=Drosophila melanogaster, GI20130425, Length=259, Percent_Identity=36.6795366795367, Blast_Score=167, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33762; Mature: 33762

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVIKVGTRSSELALKQTAMVINEIKKFRQDFEFEIVKITTQGDALIDKPVSEIGGKGV
CCCCEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHCCHHHHCCCCE
FVKEIESALLKGEIDMAVHSMKDMPYEIPKGLKLMAVLKREDPKDVFVSGDGTQFMDLKE
EHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCEEEEHHC
GAKIGTSSLRRQVQLKALKPDIQIVPIRGNVRTRLKKMEELNLDGIVLSAAGLHRLGLEN
CCCCCHHHHHHHHHHHEECCCCEEEEECCCHHHHHHHHHHCCCCEEEEECCCHHHHCHHH
IITEYFPPDVVVPAPCQGILAVEIAESFDNIFQEFYPYIVDRKTFFEASVERELLKAFGV
HHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
NCRQPFGAYAQYRKEEDEEKINIKVAYQKENKLLKSEVTGLIEETDKMIEKLIEEFGGI
CCCCCHHHHHHHHCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKVIKVGTRSSELALKQTAMVINEIKKFRQDFEFEIVKITTQGDALIDKPVSEIGGKGV
CCCCEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHCCHHHHCCCCE
FVKEIESALLKGEIDMAVHSMKDMPYEIPKGLKLMAVLKREDPKDVFVSGDGTQFMDLKE
EHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCEEEEHHC
GAKIGTSSLRRQVQLKALKPDIQIVPIRGNVRTRLKKMEELNLDGIVLSAAGLHRLGLEN
CCCCCHHHHHHHHHHHEECCCCEEEEECCCHHHHHHHHHHCCCCEEEEECCCHHHHCHHH
IITEYFPPDVVVPAPCQGILAVEIAESFDNIFQEFYPYIVDRKTFFEASVERELLKAFGV
HHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
NCRQPFGAYAQYRKEEDEEKINIKVAYQKENKLLKSEVTGLIEETDKMIEKLIEEFGGI
CCCCCHHHHHHHHCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA