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The map label for this gene is adhC [H]

Identifier: 161870177

GI number: 161870177

Start: 1209874

End: 1211010

Strand: Direct

Name: adhC [H]

Synonym: NMCC_1217

Alternate gene names: 161870177

Gene position: 1209874-1211010 (Clockwise)

Preceding gene: 161870175

Following gene: 161870178

Centisome position: 56.18

GC content: 48.2

Gene sequence:

>1137_bases
ATGGAAATGAAACAAACCGATTCAACCATCAAATCTCGTGCGGCGGTGGCATTCGCCCCTAACCAACCCTTACAAATTGT
GGAAATCGACGTAGAAATGCCGCGTAAAGGCGAGGTGTTAATCCGCAATACCCACACTGGCGTGTGCCATACTGATGCGT
TTACGTTATCAGGAAGCGATCCTGAAGGCGTATTCCCTGTGGTGCTTGGACACGAAGGTGCGGGTGTGGTCGTTGCTGTG
GGCGAAGGTGTGTCAAGCGTAAAACCGGGTGATCACGTGATTCCGCTTTACACCGCCGAATGTGGCGAATGTGAGTTTTG
TTGTTCAGGTAAAACCAACTTGTGCGTCTCAGTGCGTGATACACAAGGTAAAGGCTTAATGCCGGACGGCACGACGCGTT
TTTCTTATCAAGGTCAGCCGATTTATCACTATATGGGCTGTTCGACTTTCAGTGAATACTCCGTTGTTGCCGAAGTTTCA
CTGGCGAAAATCAACCCTGAAGCCAACCATGAACAAGTATGTTTGCTCGGCTGCGGCGTTACCACAGGTATTGGCGCGGT
GCATAATACGGCAAAAGTGCAAGAAGGCGACTCTGTTGCCGTGTTTGGCTTGGGAGCGATTGGTTTGGCTGTGGTGCAAG
GTGCGCGCCAAGCCAAAGCAGGCCGCATCATCGCCATTGATACCAATCCCGCAAAATTTGAGTTGGCAAAACAGTTTGGT
GCAACGGATTGTTTGAACCCGAACGATTACGATAAACCAATTAAAGATGTGTTGTTAGACATCAACAAATGGGGCATTGA
CCATACCTTTGAATGTATCGGCAATGTAAACGTAATGCGTCAAGCATTAGAAAGTGCACATCGTGGTTGGGGTCAATCCA
TTATCATCGGCGTAGCAGGTGCAGGACAAGAAATTTCAACGCGTCCGTTCCAGTTGGTAACAGGTCGTGTTTGGAAAGGT
TCAGCATTTGGCGGTGTGAAAGGCCGCTCCGAGCTTCCGAAAATGGTGGAAGATTCAATGAAAGGCGACATTGAGTTAGA
ACCGTTTGTAACCCACACAATGACACTCGATCAAATCAATAAAGCCTTTGAGTTAATGCACGAAGGTAAATCGATCCGCG
CCGTTATTCACTACTAA

Upstream 100 bases:

>100_bases
AACAGTAAAAAACACTTGCTTTAGAGTTAACTCTAAAGTGTAAACTGTTGCTATGTTGCTCAGGTAAGGCAACTTTGTCA
ATGAATTAAGAGGAAAGACA

Downstream 100 bases:

>100_bases
GGTATGCGATGAAACTGATTGAACAACATCAAATTTTTGGCGGTTCGCAACAAGTTTGGGCGCATCATGCCCAAACGCTG
CAATGCGAAATGAAATTTGC

Product: alcohol dehydrogenase class-III

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MEMKQTDSTIKSRAAVAFAPNQPLQIVEIDVEMPRKGEVLIRNTHTGVCHTDAFTLSGSDPEGVFPVVLGHEGAGVVVAV
GEGVSSVKPGDHVIPLYTAECGECEFCCSGKTNLCVSVRDTQGKGLMPDGTTRFSYQGQPIYHYMGCSTFSEYSVVAEVS
LAKINPEANHEQVCLLGCGVTTGIGAVHNTAKVQEGDSVAVFGLGAIGLAVVQGARQAKAGRIIAIDTNPAKFELAKQFG
ATDCLNPNDYDKPIKDVLLDINKWGIDHTFECIGNVNVMRQALESAHRGWGQSIIIGVAGAGQEISTRPFQLVTGRVWKG
SAFGGVKGRSELPKMVEDSMKGDIELEPFVTHTMTLDQINKAFELMHEGKSIRAVIHY

Sequences:

>Translated_378_residues
MEMKQTDSTIKSRAAVAFAPNQPLQIVEIDVEMPRKGEVLIRNTHTGVCHTDAFTLSGSDPEGVFPVVLGHEGAGVVVAV
GEGVSSVKPGDHVIPLYTAECGECEFCCSGKTNLCVSVRDTQGKGLMPDGTTRFSYQGQPIYHYMGCSTFSEYSVVAEVS
LAKINPEANHEQVCLLGCGVTTGIGAVHNTAKVQEGDSVAVFGLGAIGLAVVQGARQAKAGRIIAIDTNPAKFELAKQFG
ATDCLNPNDYDKPIKDVLLDINKWGIDHTFECIGNVNVMRQALESAHRGWGQSIIIGVAGAGQEISTRPFQLVTGRVWKG
SAFGGVKGRSELPKMVEDSMKGDIELEPFVTHTMTLDQINKAFELMHEGKSIRAVIHY
>Mature_378_residues
MEMKQTDSTIKSRAAVAFAPNQPLQIVEIDVEMPRKGEVLIRNTHTGVCHTDAFTLSGSDPEGVFPVVLGHEGAGVVVAV
GEGVSSVKPGDHVIPLYTAECGECEFCCSGKTNLCVSVRDTQGKGLMPDGTTRFSYQGQPIYHYMGCSTFSEYSVVAEVS
LAKINPEANHEQVCLLGCGVTTGIGAVHNTAKVQEGDSVAVFGLGAIGLAVVQGARQAKAGRIIAIDTNPAKFELAKQFG
ATDCLNPNDYDKPIKDVLLDINKWGIDHTFECIGNVNVMRQALESAHRGWGQSIIIGVAGAGQEISTRPFQLVTGRVWKG
SAFGGVKGRSELPKMVEDSMKGDIELEPFVTHTMTLDQINKAFELMHEGKSIRAVIHY

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=370, Percent_Identity=59.7297297297297, Blast_Score=461, Evalue=1e-130,
Organism=Homo sapiens, GI34577061, Length=378, Percent_Identity=44.973544973545, Blast_Score=356, Evalue=2e-98,
Organism=Homo sapiens, GI156523966, Length=374, Percent_Identity=45.4545454545455, Blast_Score=355, Evalue=5e-98,
Organism=Homo sapiens, GI71565152, Length=381, Percent_Identity=45.9317585301837, Blast_Score=353, Evalue=1e-97,
Organism=Homo sapiens, GI4501939, Length=368, Percent_Identity=45.6521739130435, Blast_Score=348, Evalue=3e-96,
Organism=Homo sapiens, GI4501933, Length=378, Percent_Identity=44.1798941798942, Blast_Score=346, Evalue=2e-95,
Organism=Homo sapiens, GI4501929, Length=378, Percent_Identity=43.6507936507937, Blast_Score=344, Evalue=6e-95,
Organism=Homo sapiens, GI262073058, Length=369, Percent_Identity=44.4444444444444, Blast_Score=342, Evalue=4e-94,
Organism=Homo sapiens, GI71743840, Length=377, Percent_Identity=43.7665782493369, Blast_Score=341, Evalue=6e-94,
Organism=Homo sapiens, GI156627571, Length=365, Percent_Identity=25.2054794520548, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=89.7018970189702, Blast_Score=667, Evalue=0.0,
Organism=Escherichia coli, GI1787863, Length=356, Percent_Identity=28.3707865168539, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI87082125, Length=383, Percent_Identity=24.5430809399478, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788073, Length=364, Percent_Identity=26.0989010989011, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790045, Length=358, Percent_Identity=26.2569832402235, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI87081918, Length=220, Percent_Identity=32.7272727272727, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1786825, Length=362, Percent_Identity=24.3093922651934, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1786518, Length=369, Percent_Identity=28.4552845528455, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788407, Length=235, Percent_Identity=26.8085106382979, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788075, Length=366, Percent_Identity=24.3169398907104, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI226510992, Length=240, Percent_Identity=29.5833333333333, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=56.3002680965147, Blast_Score=450, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=56, Blast_Score=445, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17565904, Length=338, Percent_Identity=56.8047337278106, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI71988145, Length=229, Percent_Identity=30.5676855895196, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562584, Length=360, Percent_Identity=24.1666666666667, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562582, Length=375, Percent_Identity=25.6, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=60.377358490566, Blast_Score=466, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6323729, Length=378, Percent_Identity=28.3068783068783, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319621, Length=281, Percent_Identity=29.5373665480427, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=311, Percent_Identity=29.2604501607717, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6324486, Length=366, Percent_Identity=27.3224043715847, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322619, Length=355, Percent_Identity=26.7605633802817, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6319955, Length=355, Percent_Identity=26.7605633802817, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17737895, Length=371, Percent_Identity=61.9946091644205, Blast_Score=480, Evalue=1e-136,
Organism=Drosophila melanogaster, GI17137530, Length=347, Percent_Identity=25.6484149855908, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17737897, Length=211, Percent_Identity=28.9099526066351, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 40508; Mature: 40508

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMKQTDSTIKSRAAVAFAPNQPLQIVEIDVEMPRKGEVLIRNTHTGVCHTDAFTLSGSD
CCCCHHHHHHHHCEEEEECCCCCEEEEEEEECCCCCCCEEEEECCCCEEECCEEEECCCC
PEGVFPVVLGHEGAGVVVAVGEGVSSVKPGDHVIPLYTAECGECEFCCSGKTNLCVSVRD
CCCEEEEEECCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCEEEEEEE
TQGKGLMPDGTTRFSYQGQPIYHYMGCSTFSEYSVVAEVSLAKINPEANHEQVCLLGCGV
CCCCCCCCCCCEEEEECCCCEEEEECCCCCCCCEEEEEEEEEEECCCCCCCEEEEEECCH
TTGIGAVHNTAKVQEGDSVAVFGLGAIGLAVVQGARQAKAGRIIAIDTNPAKFELAKQFG
HHCCCHHCCCCEECCCCCEEEEEHHHHHHHHHHCHHHHCCCEEEEEECCCCHHHHHHHCC
ATDCLNPNDYDKPIKDVLLDINKWGIDHTFECIGNVNVMRQALESAHRGWGQSIIIGVAG
CCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEEEC
AGQEISTRPFQLVTGRVWKGSAFGGVKGRSELPKMVEDSMKGDIELEPFVTHTMTLDQIN
CCCCCCCCCEEEEECEEECCCCCCCCCCHHHHHHHHHHHCCCCEEECCEEEEEEEHHHHH
KAFELMHEGKSIRAVIHY
HHHHHHHCCCCEEEEEEC
>Mature Secondary Structure
MEMKQTDSTIKSRAAVAFAPNQPLQIVEIDVEMPRKGEVLIRNTHTGVCHTDAFTLSGSD
CCCCHHHHHHHHCEEEEECCCCCEEEEEEEECCCCCCCEEEEECCCCEEECCEEEECCCC
PEGVFPVVLGHEGAGVVVAVGEGVSSVKPGDHVIPLYTAECGECEFCCSGKTNLCVSVRD
CCCEEEEEECCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCEEEEEEE
TQGKGLMPDGTTRFSYQGQPIYHYMGCSTFSEYSVVAEVSLAKINPEANHEQVCLLGCGV
CCCCCCCCCCCEEEEECCCCEEEEECCCCCCCCEEEEEEEEEEECCCCCCCEEEEEECCH
TTGIGAVHNTAKVQEGDSVAVFGLGAIGLAVVQGARQAKAGRIIAIDTNPAKFELAKQFG
HHCCCHHCCCCEECCCCCEEEEEHHHHHHHHHHCHHHHCCCEEEEEECCCCHHHHHHHCC
ATDCLNPNDYDKPIKDVLLDINKWGIDHTFECIGNVNVMRQALESAHRGWGQSIIIGVAG
CCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEEEC
AGQEISTRPFQLVTGRVWKGSAFGGVKGRSELPKMVEDSMKGDIELEPFVTHTMTLDQIN
CCCCCCCCCEEEEECEEECCCCCCCCCCHHHHHHHHHHHCCCCEEECCEEEEEEEHHHHH
KAFELMHEGKSIRAVIHY
HHHHHHHCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]