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The map label for this gene is esd [C]

Identifier: 161870178

GI number: 161870178

Start: 1211118

End: 1211846

Strand: Direct

Name: esd [C]

Synonym: NMCC_1218

Alternate gene names: 161870178

Gene position: 1211118-1211846 (Clockwise)

Preceding gene: 161870177

Following gene: 161870179

Centisome position: 56.24

GC content: 46.5

Gene sequence:

>729_bases
TTGCCAAATAATCCAGAAAATCGACCGCTTGGTGTGATTTATTGGCTTTCCGGCTTGACGTGTACGGAACAAAATTTCAT
TACCAAATCAGGCTTTCAGCGTTATGCGGCAGAACATCAAGTAATTGTGGTGGCCTCCGATACCAGCCCTCGCGGAGAGC
AAGTGCCGAACGATGATGCTTACGATTTAGGACAGGGTGCAGGCTTTTATTTGAATGCGACCGAACAGCCTTGGGCGGCG
AATTATCAAATGTATGATTACATTTTGAACGAGCTGCCCCGTCTGATTGAGAAACACTTTCCTACCAACGGCAAACGTTC
CATTATGGGGCATTCGATGGGCGGACACGGCGCATTGGTATTGGCACTACGGAATCGGGAACATTATCAAAGTGTTTCTG
CCTTTTCGCCTATTTTATCGCCAAGCCTCGTACCGTGGGGAGAAAAAGCCTTTACTGCTTATTTAGGAAAAGATCGCGAA
AAATGGCAGCAATATGATGCGAACTCACTCATTCAACAAGGCTATAAAGTGCAAGGTATGCGCATCGATCAAGGCTTGGA
AGATGAGTTTTTGCCGACACAATTGCGTACCGAAGATTTTATCGAAACCTGCCGTGCGGCAAACCAGCCGGTCGATGTGC
GTTTCCATAAAGGCTACGATCACAGCTATTACTTCATCGCCAGTTTTATTGGCGAGCATATTGCTTATCACGCCGCGTTT
TTGAAGTAA

Upstream 100 bases:

>100_bases
GATGAAACTGATTGAACAACATCAAATTTTTGGCGGTTCGCAACAAGTTTGGGCGCATCATGCCCAAACGCTGCAATGCG
AAATGAAATTTGCCGTCTAT

Downstream 100 bases:

>100_bases
ACCGAAGAGCGTTCAGTGTTCAAAGCAGTTTTGGGATAGCCGGCACGAGGGCGGTAAGAAGTGCCGGCAAAATACCAACA
TAAACGTATGCCGTCTGAAC

Product: esterase D

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MPNNPENRPLGVIYWLSGLTCTEQNFITKSGFQRYAAEHQVIVVASDTSPRGEQVPNDDAYDLGQGAGFYLNATEQPWAA
NYQMYDYILNELPRLIEKHFPTNGKRSIMGHSMGGHGALVLALRNREHYQSVSAFSPILSPSLVPWGEKAFTAYLGKDRE
KWQQYDANSLIQQGYKVQGMRIDQGLEDEFLPTQLRTEDFIETCRAANQPVDVRFHKGYDHSYYFIASFIGEHIAYHAAF
LK

Sequences:

>Translated_242_residues
MPNNPENRPLGVIYWLSGLTCTEQNFITKSGFQRYAAEHQVIVVASDTSPRGEQVPNDDAYDLGQGAGFYLNATEQPWAA
NYQMYDYILNELPRLIEKHFPTNGKRSIMGHSMGGHGALVLALRNREHYQSVSAFSPILSPSLVPWGEKAFTAYLGKDRE
KWQQYDANSLIQQGYKVQGMRIDQGLEDEFLPTQLRTEDFIETCRAANQPVDVRFHKGYDHSYYFIASFIGEHIAYHAAF
LK
>Mature_241_residues
PNNPENRPLGVIYWLSGLTCTEQNFITKSGFQRYAAEHQVIVVASDTSPRGEQVPNDDAYDLGQGAGFYLNATEQPWAAN
YQMYDYILNELPRLIEKHFPTNGKRSIMGHSMGGHGALVLALRNREHYQSVSAFSPILSPSLVPWGEKAFTAYLGKDREK
WQQYDANSLIQQGYKVQGMRIDQGLEDEFLPTQLRTEDFIETCRAANQPVDVRFHKGYDHSYYFIASFIGEHIAYHAAFL
K

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=245, Percent_Identity=53.0612244897959, Blast_Score=271, Evalue=5e-73,
Organism=Escherichia coli, GI1786551, Length=238, Percent_Identity=63.4453781512605, Blast_Score=323, Evalue=9e-90,
Organism=Escherichia coli, GI1788477, Length=232, Percent_Identity=53.8793103448276, Blast_Score=268, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17510185, Length=247, Percent_Identity=47.3684210526316, Blast_Score=226, Evalue=6e-60,
Organism=Saccharomyces cerevisiae, GI6322393, Length=250, Percent_Identity=43.6, Blast_Score=204, Evalue=9e-54,
Organism=Drosophila melanogaster, GI45551932, Length=246, Percent_Identity=50.8130081300813, Blast_Score=245, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24648347, Length=246, Percent_Identity=50.8130081300813, Blast_Score=244, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 27548; Mature: 27417

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNNPENRPLGVIYWLSGLTCTEQNFITKSGFQRYAAEHQVIVVASDTSPRGEQVPNDDA
CCCCCCCCCEEEEEEECCCEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCC
YDLGQGAGFYLNATEQPWAANYQMYDYILNELPRLIEKHFPTNGKRSIMGHSMGGHGALV
HHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCEEE
LALRNREHYQSVSAFSPILSPSLVPWGEKAFTAYLGKDREKWQQYDANSLIQQGYKVQGM
EEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHCCHHHHHHCCCEECCE
RIDQGLEDEFLPTQLRTEDFIETCRAANQPVDVRFHKGYDHSYYFIASFIGEHIAYHAAF
ECCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
LK
CC
>Mature Secondary Structure 
PNNPENRPLGVIYWLSGLTCTEQNFITKSGFQRYAAEHQVIVVASDTSPRGEQVPNDDA
CCCCCCCCEEEEEEECCCEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCC
YDLGQGAGFYLNATEQPWAANYQMYDYILNELPRLIEKHFPTNGKRSIMGHSMGGHGALV
HHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCEEE
LALRNREHYQSVSAFSPILSPSLVPWGEKAFTAYLGKDREKWQQYDANSLIQQGYKVQGM
EEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHCCHHHHHHCCCEECCE
RIDQGLEDEFLPTQLRTEDFIETCRAANQPVDVRFHKGYDHSYYFIASFIGEHIAYHAAF
ECCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
LK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]