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The map label for this gene is strD [H]

Identifier: 161869374

GI number: 161869374

Start: 384250

End: 384945

Strand: Direct

Name: strD [H]

Synonym: NMCC_0381

Alternate gene names: 161869374

Gene position: 384250-384945 (Clockwise)

Preceding gene: 161869373

Following gene: 161869376

Centisome position: 17.84

GC content: 60.06

Gene sequence:

>696_bases
ATGAAAGCGATGATACTGGCGGCAGGACGCGGCGAGCGTATGCGCCCTTTGACCGATACCACTCCGAAGCCGCTGCTCGA
TGTGGCGGGTAAGCCTCTAATCGGTTGGCACCTATGCCGTCTGAAGCAGGCGGGGTTTACCGAAATCGTCATCAACCACG
CTTGGCTGGGCCGGCAGATAGAAGATGCTTTGGGCGACGGCTCGGCTTATGGCGTGAACATCGCCTATTCGCCCGAACCC
GCAGGCGGTTTGGAAACGGCAGGCGGCATCGCGCAGGCATTGCCGCTGTTGGGTGGGCAGCCGTTTTTGGTGGTCAACGG
CGACGTGCTGACCGACATCGATTTTACCGCCGCGTTTCAGGCGGCATCGTCCCTGCCGGAACATATTTCCGCCCATCTGT
GGCTGGTGGAAAATCCGCCGCACAACCCCGACGGCGATTTTTCCCTGCTGCCCGACGGCAGCGTGCGGCCGGAAGTAAAT
GGCGGCAACGGATTGACATTCAGCGGCGTGGGTATTTACCGTCCTGAAATGTTTGACGGAATCGAAGCGGGCAGTGTGGC
GAAACTCGCGCCCGTATTGCGTGGCGAAATGCGGCAAAACCGCGTGAGCGGTCAGAAGCATACGGGCTTGTGGCTGGATG
TCGGCACGGTATGCCGTCTGAAAGAGGCTCAAGCCCTTGCAGGGGCTTGGAAGTAA

Upstream 100 bases:

>100_bases
CGTCAGGCTCGACGAAATCAAAAACTGCGGGTGCAAACGCCCCGCGCTGCTGTATTTCAGACGGCAGTTTAGATTTTTAG
ACTGATATTCGGACAGATAT

Downstream 100 bases:

>100_bases
AAACCCGGTTTCAGACGGTATGGCGGATTCGGTTTAACGTTTCAACGCCAGCACCAACACGCCCGCCGTTACCAGCCCCA
AGCCTATCCATTCCTGCGTG

Product: sugar-phosphate nucleotidyl transferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MKAMILAAGRGERMRPLTDTTPKPLLDVAGKPLIGWHLCRLKQAGFTEIVINHAWLGRQIEDALGDGSAYGVNIAYSPEP
AGGLETAGGIAQALPLLGGQPFLVVNGDVLTDIDFTAAFQAASSLPEHISAHLWLVENPPHNPDGDFSLLPDGSVRPEVN
GGNGLTFSGVGIYRPEMFDGIEAGSVAKLAPVLRGEMRQNRVSGQKHTGLWLDVGTVCRLKEAQALAGAWK

Sequences:

>Translated_231_residues
MKAMILAAGRGERMRPLTDTTPKPLLDVAGKPLIGWHLCRLKQAGFTEIVINHAWLGRQIEDALGDGSAYGVNIAYSPEP
AGGLETAGGIAQALPLLGGQPFLVVNGDVLTDIDFTAAFQAASSLPEHISAHLWLVENPPHNPDGDFSLLPDGSVRPEVN
GGNGLTFSGVGIYRPEMFDGIEAGSVAKLAPVLRGEMRQNRVSGQKHTGLWLDVGTVCRLKEAQALAGAWK
>Mature_231_residues
MKAMILAAGRGERMRPLTDTTPKPLLDVAGKPLIGWHLCRLKQAGFTEIVINHAWLGRQIEDALGDGSAYGVNIAYSPEP
AGGLETAGGIAQALPLLGGQPFLVVNGDVLTDIDFTAAFQAASSLPEHISAHLWLVENPPHNPDGDFSLLPDGSVRPEVN
GGNGLTFSGVGIYRPEMFDGIEAGSVAKLAPVLRGEMRQNRVSGQKHTGLWLDVGTVCRLKEAQALAGAWK

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=224, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI11761619, Length=224, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=3e-16,
Organism=Escherichia coli, GI1788351, Length=246, Percent_Identity=27.2357723577236, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790224, Length=255, Percent_Identity=26.6666666666667, Blast_Score=62, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI133931050, Length=223, Percent_Identity=28.6995515695067, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6320148, Length=227, Percent_Identity=30.3964757709251, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21355443, Length=228, Percent_Identity=29.3859649122807, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24644084, Length=228, Percent_Identity=29.3859649122807, Blast_Score=91, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 24477; Mature: 24477

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAMILAAGRGERMRPLTDTTPKPLLDVAGKPLIGWHLCRLKQAGFTEIVINHAWLGRQI
CCEEEEECCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHCCCEEEEEEHHHCCCHH
EDALGDGSAYGVNIAYSPEPAGGLETAGGIAQALPLLGGQPFLVVNGDVLTDIDFTAAFQ
HHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCEEECCCHHHHHH
AASSLPEHISAHLWLVENPPHNPDGDFSLLPDGSVRPEVNGGNGLTFSGVGIYRPEMFDG
HHHCCHHHHEEEEEEEECCCCCCCCCEEECCCCCCCCCCCCCCCEEECCCEEECCHHHCC
IEAGSVAKLAPVLRGEMRQNRVSGQKHTGLWLDVGTVCRLKEAQALAGAWK
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKAMILAAGRGERMRPLTDTTPKPLLDVAGKPLIGWHLCRLKQAGFTEIVINHAWLGRQI
CCEEEEECCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHCCCEEEEEEHHHCCCHH
EDALGDGSAYGVNIAYSPEPAGGLETAGGIAQALPLLGGQPFLVVNGDVLTDIDFTAAFQ
HHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCEEECCCHHHHHH
AASSLPEHISAHLWLVENPPHNPDGDFSLLPDGSVRPEVNGGNGLTFSGVGIYRPEMFDG
HHHCCHHHHEEEEEEEECCCCCCCCCEEECCCCCCCCCCCCCCCEEECCCEEECCHHHCC
IEAGSVAKLAPVLRGEMRQNRVSGQKHTGLWLDVGTVCRLKEAQALAGAWK
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]