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The map label for this gene is fhs [H]

Identifier: 161869376

GI number: 161869376

Start: 385585

End: 387261

Strand: Direct

Name: fhs [H]

Synonym: NMCC_0383

Alternate gene names: 161869376

Gene position: 385585-387261 (Clockwise)

Preceding gene: 161869374

Following gene: 161869377

Centisome position: 17.91

GC content: 55.64

Gene sequence:

>1677_bases
ATGAGCTTCAAAACCGATGCCGAAATCGCCCAGTCTTCCACCATGCGCCCGATTGGCGAAATTGCCGCCAAGCTGGGCCT
GAACGCCGACAACATTGAGCCTTACGGTCACTACAAAGCCAAAATCAATCCTGCCGAAGCATTCAAGCTGCCGCAAAAAC
AAGGCCGTCTGATTTTGGTTACTGCCATTAATCCGACTCCTGCGGGTGAGGGTAAAACCACAGTAACCATCGGTTTGGCG
GATGCGTTGCGCCATATCGGCAAAGACTCGGTTATCGCCCTACGCGAACCTTCTTTGGGGCCGGTGTTCGGTGTTAAAGG
CGGTGCGGCAGGCGGCGGCTATGCCCAAGTTTTGCCGATGGAAGACATCAACCTGCACTTCACCGGAGATTTTCACGCCA
TCGGTGCGGCAAATAATCTGCTTGCCGCGATGCTCGACAACCATATCTATCAGGGCAACGAGTTGGACATCGACCCCAAA
CGCGTGCTGTGGCGGCGCGTGGTCGATATGAACGACCGTCAGTTGCGCAACATCATCGACGGCATGGGCAAACCTGTTGA
CGGCGTGATGCGTCCCGACGGTTTCGATATTACCGTTGCCTCCGAAGTGATGGCGGTATTCTGTCTTGCCAAAGACATCA
GCGATTTGAAAGAGCGTTTGGGCAACATCCTTGTCGCCTACGCCAAAGACGGCAGCCCCGTTTACGCCAAAGATTTGAAA
GCGAATGGCGCGATGGCGGCATTGCTTAAAGATGCGATTAAGCCCAACTTGGTGCAAACCATCGAAGGCACGCCCGCCTT
CGTACACGGCGGCCCGTTCGCCAACATCGCCCACGGCTGCAACTCCGTAACCGCAACCCGTCTGGCGAAACACCTTGCCG
ATTACGCCGTAACCGAAGCAGGCTTCGGCGCGGACTTGGGCGCGGAAAAATTCTGCGACATCAAATGCCGCCTTGCCGGT
TTGAAACCTGATGCGGCTGTTGTCGTGGCGACTGTCCGCGCGTTGAAATATAACGGCGGCGTGGAACGCGCCAACCTCGG
CGAAGAAAATTTAGACGCTTTGGAAAAAGGTTTGCCCAACCTGCTGAAACACATTTCCAACCTGAAAAACGTATTCGGAC
TGCCCGTCGTCGTTGCGCTCAACCGCTTCGTGTCCGACTCCGATGCCGAGTTGGCGATGATTGAAAAAGCCTGTGCCGAA
CACGGCGTTGAAGTTTCCCTGACCGAAGTGTGGGGCAAAGGTGGTGCGGGCGGCGCGGATTTGGCGCGCAAAGTCGTCAA
CGCCATTGAAAGTCAAACCAATAACTTCGGTTTCGCCTACGATGTCGAGTTGGGCATCAAAGACAAAATCCGTGCGATTG
CCCAAAAAGTGTACGGCGCGGAAGATGTTGATTTCAGCGCGGAAGCGTCTGCCGAAATCGCTTCACTGGAAAAACTGGGC
TTGGACAAAATGCCGATCTGCATGGCGAAAACCCAATACTCTTTGAGTGACAACGCCAAACTGTTGGGCTGCCCCGAAGG
CTTCCGCATCGCCGTGCGCGGCATCACCGTTTCCGCCGGCGCGGGCTTCATCGTCGCGCTGTGCGGCAATATGATGAAGA
TGCCGGGTCTGCCGAAAGTTCCGGCCGCCGAGAAAATCGATGTGGACGAACACGGCGTGATTCACGGCTTGTTCTGA

Upstream 100 bases:

>100_bases
GCGGATAACGTTATAATATGCCTGATATTATTTTCAATCCACCTGTTTGTCGCCTGATGCTTTCAGACGGTATGTCCCTC
CTCATTTCTAAAGGAAAATC

Downstream 100 bases:

>100_bases
ACGGTTTTTGAAACCAGATGCCGTCTGAAGCCGTTTCAGACGGCATTTTTTCGGAACGCGGGCGGCGGTATGCTATAATC
CGCCGTTAAATTTCTCTATT

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS [H]

Number of amino acids: Translated: 558; Mature: 557

Protein sequence:

>558_residues
MSFKTDAEIAQSSTMRPIGEIAAKLGLNADNIEPYGHYKAKINPAEAFKLPQKQGRLILVTAINPTPAGEGKTTVTIGLA
DALRHIGKDSVIALREPSLGPVFGVKGGAAGGGYAQVLPMEDINLHFTGDFHAIGAANNLLAAMLDNHIYQGNELDIDPK
RVLWRRVVDMNDRQLRNIIDGMGKPVDGVMRPDGFDITVASEVMAVFCLAKDISDLKERLGNILVAYAKDGSPVYAKDLK
ANGAMAALLKDAIKPNLVQTIEGTPAFVHGGPFANIAHGCNSVTATRLAKHLADYAVTEAGFGADLGAEKFCDIKCRLAG
LKPDAAVVVATVRALKYNGGVERANLGEENLDALEKGLPNLLKHISNLKNVFGLPVVVALNRFVSDSDAELAMIEKACAE
HGVEVSLTEVWGKGGAGGADLARKVVNAIESQTNNFGFAYDVELGIKDKIRAIAQKVYGAEDVDFSAEASAEIASLEKLG
LDKMPICMAKTQYSLSDNAKLLGCPEGFRIAVRGITVSAGAGFIVALCGNMMKMPGLPKVPAAEKIDVDEHGVIHGLF

Sequences:

>Translated_558_residues
MSFKTDAEIAQSSTMRPIGEIAAKLGLNADNIEPYGHYKAKINPAEAFKLPQKQGRLILVTAINPTPAGEGKTTVTIGLA
DALRHIGKDSVIALREPSLGPVFGVKGGAAGGGYAQVLPMEDINLHFTGDFHAIGAANNLLAAMLDNHIYQGNELDIDPK
RVLWRRVVDMNDRQLRNIIDGMGKPVDGVMRPDGFDITVASEVMAVFCLAKDISDLKERLGNILVAYAKDGSPVYAKDLK
ANGAMAALLKDAIKPNLVQTIEGTPAFVHGGPFANIAHGCNSVTATRLAKHLADYAVTEAGFGADLGAEKFCDIKCRLAG
LKPDAAVVVATVRALKYNGGVERANLGEENLDALEKGLPNLLKHISNLKNVFGLPVVVALNRFVSDSDAELAMIEKACAE
HGVEVSLTEVWGKGGAGGADLARKVVNAIESQTNNFGFAYDVELGIKDKIRAIAQKVYGAEDVDFSAEASAEIASLEKLG
LDKMPICMAKTQYSLSDNAKLLGCPEGFRIAVRGITVSAGAGFIVALCGNMMKMPGLPKVPAAEKIDVDEHGVIHGLF
>Mature_557_residues
SFKTDAEIAQSSTMRPIGEIAAKLGLNADNIEPYGHYKAKINPAEAFKLPQKQGRLILVTAINPTPAGEGKTTVTIGLAD
ALRHIGKDSVIALREPSLGPVFGVKGGAAGGGYAQVLPMEDINLHFTGDFHAIGAANNLLAAMLDNHIYQGNELDIDPKR
VLWRRVVDMNDRQLRNIIDGMGKPVDGVMRPDGFDITVASEVMAVFCLAKDISDLKERLGNILVAYAKDGSPVYAKDLKA
NGAMAALLKDAIKPNLVQTIEGTPAFVHGGPFANIAHGCNSVTATRLAKHLADYAVTEAGFGADLGAEKFCDIKCRLAGL
KPDAAVVVATVRALKYNGGVERANLGEENLDALEKGLPNLLKHISNLKNVFGLPVVVALNRFVSDSDAELAMIEKACAEH
GVEVSLTEVWGKGGAGGADLARKVVNAIESQTNNFGFAYDVELGIKDKIRAIAQKVYGAEDVDFSAEASAEIASLEKLGL
DKMPICMAKTQYSLSDNAKLLGCPEGFRIAVRGITVSAGAGFIVALCGNMMKMPGLPKVPAAEKIDVDEHGVIHGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=621, Percent_Identity=44.4444444444444, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI36796743, Length=620, Percent_Identity=45.9677419354839, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI310124614, Length=86, Percent_Identity=45.3488372093023, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17568737, Length=623, Percent_Identity=41.091492776886, Blast_Score=429, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17568739, Length=623, Percent_Identity=41.091492776886, Blast_Score=429, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6319558, Length=632, Percent_Identity=43.5126582278481, Blast_Score=464, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6321643, Length=627, Percent_Identity=44.0191387559809, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24645718, Length=620, Percent_Identity=45.1612903225806, Blast_Score=482, Evalue=1e-136,
Organism=Drosophila melanogaster, GI17137370, Length=620, Percent_Identity=45.1612903225806, Blast_Score=482, Evalue=1e-136,
Organism=Drosophila melanogaster, GI62472483, Length=620, Percent_Identity=45.1612903225806, Blast_Score=482, Evalue=1e-136,
Organism=Drosophila melanogaster, GI45551871, Length=620, Percent_Identity=45.1612903225806, Blast_Score=482, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 59104; Mature: 58973

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00721 FTHFS_1 ; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFKTDAEIAQSSTMRPIGEIAAKLGLNADNIEPYGHYKAKINPAEAFKLPQKQGRLILV
CCCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHCCCCCCCCEEEE
TAINPTPAGEGKTTVTIGLADALRHIGKDSVIALREPSLGPVFGVKGGAAGGGYAQVLPM
EEECCCCCCCCCEEEEEEHHHHHHHCCCCCEEEEECCCCCCEEECCCCCCCCCCEEEEEE
EDINLHFTGDFHAIGAANNLLAAMLDNHIYQGNELDIDPKRVLWRRVVDMNDRQLRNIID
CCCEEEECCCEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHH
GMGKPVDGVMRPDGFDITVASEVMAVFCLAKDISDLKERLGNILVAYAKDGSPVYAKDLK
HCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEHHHCC
ANGAMAALLKDAIKPNLVQTIEGTPAFVHGGPFANIAHGCNSVTATRLAKHLADYAVTEA
CCCHHHHHHHHHCCCCHHHHCCCCCEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHCC
GFGADLGAEKFCDIKCRLAGLKPDAAVVVATVRALKYNGGVERANLGEENLDALEKGLPN
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
LLKHISNLKNVFGLPVVVALNRFVSDSDAELAMIEKACAEHGVEVSLTEVWGKGGAGGAD
HHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEHHHCCCCCCCHHH
LARKVVNAIESQTNNFGFAYDVELGIKDKIRAIAQKVYGAEDVDFSAEASAEIASLEKLG
HHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCC
LDKMPICMAKTQYSLSDNAKLLGCPEGFRIAVRGITVSAGAGFIVALCGNMMKMPGLPKV
CCCCCEEEECCCCCCCCCCEEEECCCCCEEEEEEEEEECCCCHHHHHHHHHHHCCCCCCC
PAAEKIDVDEHGVIHGLF
CCCCCCCCCCCCCEECCC
>Mature Secondary Structure 
SFKTDAEIAQSSTMRPIGEIAAKLGLNADNIEPYGHYKAKINPAEAFKLPQKQGRLILV
CCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHCCCCCCCCEEEE
TAINPTPAGEGKTTVTIGLADALRHIGKDSVIALREPSLGPVFGVKGGAAGGGYAQVLPM
EEECCCCCCCCCEEEEEEHHHHHHHCCCCCEEEEECCCCCCEEECCCCCCCCCCEEEEEE
EDINLHFTGDFHAIGAANNLLAAMLDNHIYQGNELDIDPKRVLWRRVVDMNDRQLRNIID
CCCEEEECCCEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHH
GMGKPVDGVMRPDGFDITVASEVMAVFCLAKDISDLKERLGNILVAYAKDGSPVYAKDLK
HCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEHHHCC
ANGAMAALLKDAIKPNLVQTIEGTPAFVHGGPFANIAHGCNSVTATRLAKHLADYAVTEA
CCCHHHHHHHHHCCCCHHHHCCCCCEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHCC
GFGADLGAEKFCDIKCRLAGLKPDAAVVVATVRALKYNGGVERANLGEENLDALEKGLPN
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
LLKHISNLKNVFGLPVVVALNRFVSDSDAELAMIEKACAEHGVEVSLTEVWGKGGAGGAD
HHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEHHHCCCCCCCHHH
LARKVVNAIESQTNNFGFAYDVELGIKDKIRAIAQKVYGAEDVDFSAEASAEIASLEKLG
HHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCC
LDKMPICMAKTQYSLSDNAKLLGCPEGFRIAVRGITVSAGAGFIVALCGNMMKMPGLPKV
CCCCCEEEECCCCCCCCCCEEEECCCCCEEEEEEEEEECCCCHHHHHHHHHHHCCCCCCC
PAAEKIDVDEHGVIHGLF
CCCCCCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA