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The map label for this gene is yeaE [H]

Identifier: 161523944

GI number: 161523944

Start: 836510

End: 837355

Strand: Direct

Name: yeaE [H]

Synonym: Bmul_0764

Alternate gene names: 161523944

Gene position: 836510-837355 (Clockwise)

Preceding gene: 161523942

Following gene: 161523950

Centisome position: 24.26

GC content: 69.86

Gene sequence:

>846_bases
ATGACAGACACGATGGCCACGGTCGTCCTGCCCGACGGCGAGACGATCCCGAAGCTCGGGCAGGGCACCTGGGAAATGGG
CGAACGGCCGGCGCGGCGCGCGGACGAGATCGCCGCGCTGCGCGAAGGCATCGCGCTCGGGATGACGCTGATCGATACCG
CGGAAATGTACGGCGAAGGCGCGACCGAGGCGCTCGTCGGCGAAGCGCTGCACGGCTTGCGCGACGACGTGTTTCTCGTC
AGCAAGGTCTACCCGCACCATGCGAGCCGGCGCGGTGTCGTCGCCGCGTGCGAGGCGAGCCTGAAGCGTCTGCGCACCGA
CCGTCTCGACCTGTATCTGCTGCACTGGCGCGGCTCGGTGCCGCTCGAGGAGACGGTCGAAGGCTTCGAGGCGCTGCGGC
GCGCCGGCAAGATTCGCCACTGGGGCGTCAGCAACTTCGACACCGCGGACATGATCGAACTCGTCGACGAAGCGGGCGGC
GCCGCGTGCGCGACCAACCAGATCCTCTACAACATCGCGCGGCGCGGCCCCGAATTCGACCTGCTGCCGTGGCTTGCCGA
GCACCGGATGCCGGCGATGGCGTACAGCCCGGTCGATCACGCGCGGCTGCCGAAACGCTCGCCGCTCGACGAGATCGCGC
GGCAACGCGGCGTGTCGGTGATGCGCGTCGCGCTGGCGTGGGTGCTCGCGCAGCCGGGCGTGTTCGCGATTCCGAAGGCG
TCGCGGATCGAGCACGTGCGCGACAATCGCGCGGCGCTCGAGCTGGTGCTGACCGACGACGAGCACGCGCAGCTCGATGC
GTATTTCCGCGCGCCGCGCAGCAAGCGGCCGCTCGAGATGCTGTGA

Upstream 100 bases:

>100_bases
GCGATCCTGCAGGTGCGTGCGGTGGCGATTGACTACACTGATACGTCGCATTCGATGCTTCGGCCGCGGTGCGCGGCCAC
GAATCCGCAGCGAGGAATTC

Downstream 100 bases:

>100_bases
GCGGCGGCGCGCGCGGTGCTCAGCGCGCCGGCGCGCCTGCCGCGCGCTGCCAGCGGTGGAACAGGATCGACGCGATCCAG
CAGACGATAAACAGCGCGAC

Product: aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MTDTMATVVLPDGETIPKLGQGTWEMGERPARRADEIAALREGIALGMTLIDTAEMYGEGATEALVGEALHGLRDDVFLV
SKVYPHHASRRGVVAACEASLKRLRTDRLDLYLLHWRGSVPLEETVEGFEALRRAGKIRHWGVSNFDTADMIELVDEAGG
AACATNQILYNIARRGPEFDLLPWLAEHRMPAMAYSPVDHARLPKRSPLDEIARQRGVSVMRVALAWVLAQPGVFAIPKA
SRIEHVRDNRAALELVLTDDEHAQLDAYFRAPRSKRPLEML

Sequences:

>Translated_281_residues
MTDTMATVVLPDGETIPKLGQGTWEMGERPARRADEIAALREGIALGMTLIDTAEMYGEGATEALVGEALHGLRDDVFLV
SKVYPHHASRRGVVAACEASLKRLRTDRLDLYLLHWRGSVPLEETVEGFEALRRAGKIRHWGVSNFDTADMIELVDEAGG
AACATNQILYNIARRGPEFDLLPWLAEHRMPAMAYSPVDHARLPKRSPLDEIARQRGVSVMRVALAWVLAQPGVFAIPKA
SRIEHVRDNRAALELVLTDDEHAQLDAYFRAPRSKRPLEML
>Mature_280_residues
TDTMATVVLPDGETIPKLGQGTWEMGERPARRADEIAALREGIALGMTLIDTAEMYGEGATEALVGEALHGLRDDVFLVS
KVYPHHASRRGVVAACEASLKRLRTDRLDLYLLHWRGSVPLEETVEGFEALRRAGKIRHWGVSNFDTADMIELVDEAGGA
ACATNQILYNIARRGPEFDLLPWLAEHRMPAMAYSPVDHARLPKRSPLDEIARQRGVSVMRVALAWVLAQPGVFAIPKAS
RIEHVRDNRAALELVLTDDEHAQLDAYFRAPRSKRPLEML

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI310109922, Length=294, Percent_Identity=28.2312925170068, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI5453543, Length=314, Percent_Identity=27.7070063694268, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI45446745, Length=314, Percent_Identity=28.0254777070064, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI4503285, Length=314, Percent_Identity=28.0254777070064, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI310109920, Length=314, Percent_Identity=27.7070063694268, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI24497585, Length=305, Percent_Identity=27.8688524590164, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI24497577, Length=320, Percent_Identity=25.3125, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI5174391, Length=320, Percent_Identity=25.3125, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI24497583, Length=308, Percent_Identity=26.9480519480519, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1788081, Length=272, Percent_Identity=54.7794117647059, Blast_Score=299, Evalue=2e-82,
Organism=Escherichia coli, GI87081735, Length=296, Percent_Identity=27.027027027027, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1787674, Length=283, Percent_Identity=28.2685512367491, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1786400, Length=248, Percent_Identity=26.6129032258064, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788070, Length=303, Percent_Identity=28.7128712871287, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1789199, Length=325, Percent_Identity=28.6153846153846, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI87082198, Length=271, Percent_Identity=27.3062730627306, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI48994888, Length=278, Percent_Identity=30.5755395683453, Blast_Score=85, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17552492, Length=271, Percent_Identity=28.4132841328413, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17561298, Length=297, Percent_Identity=29.96632996633, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17566692, Length=173, Percent_Identity=30.0578034682081, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17564128, Length=306, Percent_Identity=28.4313725490196, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17538386, Length=284, Percent_Identity=28.8732394366197, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71998625, Length=283, Percent_Identity=26.5017667844523, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17550248, Length=302, Percent_Identity=23.1788079470199, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17561300, Length=282, Percent_Identity=26.241134751773, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17537077, Length=301, Percent_Identity=24.9169435215947, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17537075, Length=311, Percent_Identity=24.4372990353698, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324694, Length=297, Percent_Identity=28.2828282828283, Blast_Score=90, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6320576, Length=314, Percent_Identity=27.3885350318471, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6325169, Length=291, Percent_Identity=23.3676975945017, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320079, Length=281, Percent_Identity=27.0462633451957, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24657054, Length=301, Percent_Identity=26.9102990033223, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45553081, Length=300, Percent_Identity=27, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24644950, Length=306, Percent_Identity=25.8169934640523, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI20129731, Length=308, Percent_Identity=26.2987012987013, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24662789, Length=284, Percent_Identity=26.056338028169, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 31234; Mature: 31103

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTMATVVLPDGETIPKLGQGTWEMGERPARRADEIAALREGIALGMTLIDTAEMYGEG
CCCCEEEEEECCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ATEALVGEALHGLRDDVFLVSKVYPHHASRRGVVAACEASLKRLRTDRLDLYLLHWRGSV
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCC
PLEETVEGFEALRRAGKIRHWGVSNFDTADMIELVDEAGGAACATNQILYNIARRGPEFD
CHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCC
LLPWLAEHRMPAMAYSPVDHARLPKRSPLDEIARQRGVSVMRVALAWVLAQPGVFAIPKA
HHHHHHHCCCCCCCCCCCHHHCCCCCCCHHHHHHHHCHHHHHHHHHHHHHCCCEEECCCH
SRIEHVRDNRAALELVLTDDEHAQLDAYFRAPRSKRPLEML
HHHHHHHCCCEEEEEEEECCCCHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TDTMATVVLPDGETIPKLGQGTWEMGERPARRADEIAALREGIALGMTLIDTAEMYGEG
CCCEEEEEECCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ATEALVGEALHGLRDDVFLVSKVYPHHASRRGVVAACEASLKRLRTDRLDLYLLHWRGSV
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCC
PLEETVEGFEALRRAGKIRHWGVSNFDTADMIELVDEAGGAACATNQILYNIARRGPEFD
CHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCC
LLPWLAEHRMPAMAYSPVDHARLPKRSPLDEIARQRGVSVMRVALAWVLAQPGVFAIPKA
HHHHHHHCCCCCCCCCCCHHHCCCCCCCHHHHHHHHCHHHHHHHHHHHHHCCCEEECCCH
SRIEHVRDNRAALELVLTDDEHAQLDAYFRAPRSKRPLEML
HHHHHHHCCCEEEEEEEECCCCHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]