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The map label for this gene is icd [H]

Identifier: 161523950

GI number: 161523950

Start: 842850

End: 844106

Strand: Direct

Name: icd [H]

Synonym: Bmul_0770

Alternate gene names: 161523950

Gene position: 842850-844106 (Clockwise)

Preceding gene: 161523944

Following gene: 161523951

Centisome position: 24.44

GC content: 63.01

Gene sequence:

>1257_bases
ATGCCGTATCAGCACATCAAGGTTCCGGACGGCGGTGACAAGATCACCGTCAACCAGGATTTCACGCTCAACGTTTCCGA
TCAGCCGATCATTCCGTATATCGAAGGCGACGGGACGGGCTTCGACATCACGCCGGTCATGATCAAGGTGGTCGATGCGG
CGGTCGAGGCGGCATACAAGGGCAAGCGCAAGATCCACTGGATGGAGATCTACGCCGGCGAGAAGGCGACCAAGGTGTAC
GGTCCGGACGTGTGGCTGCCGGACGAGACGCTGCAGGTGCTGAAGGAATACGTGGTGTCGATCAAGGGGCCGCTGACGAC
GCCGGTCGGCGGCGGCATCCGTTCGCTGAACGTCGCGCTGCGCCAGGAGCTCGATCTGTACGTGTGCCTGCGGCCGGTGC
GGTACTTCAAGGGCGTGCCGTCGCCGGTGCGCGAGCCGGAAAAGATCGACATGGTGATCTTCCGCGAGAACTCCGAAGAC
ATCTACGCCGGCATCGAATGGCCGGCCGGTTCCGAGCAGGCGAAGAAGGTGATCGCGTTCCTGCGCGACGAGATGGGCGT
GAAGAAGATCCGCTTCCCGGAAACGTCGGGGATCGGCGTGAAGCCCGTGTCGACGGAAGGCACCGAGCGCCTCGTGCGCA
AGGCGATCCAGTACGCGATCGACAACGATCGCAAGTCGGTCACGCTGGTGCACAAGGGCAACATCATGAAGTTCACGGAA
GGCCTGTTCCGTGACGCCGGCTATGCGCTCGCGCAGAAGGAATTCGGCGGCGAGCTGATCGACGGCGGCCCGTGGATGCG
CGTGAAGAACCCGAAGACGGGCGGCGAGATCGTGATCAAGGATTCGATCGCCGATGCGTTCCTGCAGCAGATCCTGCTGC
GCCCGGCCGAATACGACGTGATCGCGACGCTGAACCTGAACGGCGACTATATTTCGGACGCGCTCGCCGCGCAGGTCGGC
GGCATCGGCATCGCGCCCGGCGCGAACCTGTCGGATTCGGTCGCGATGTTCGAAGCGACGCACGGCACGGCGCCGAAGTA
TGCCGGCAAGGATTACGTGAACCCCGGTTCCGAGATCCTGTCGGCCGAAATGATGCTGCGCCACCTCGGCTGGACGGAAG
CGGCCGACACGATCATCGCCGCGATGGAGAAGTCGATCCTGCAGAAACGCGTCACGTACGACTTCGCGCGCCTGATGGAA
GGGGCGACGCAGGTGTCGTGCTCCGGTTTCGGCGAAGTGCTGATCGAGAACATGTAA

Upstream 100 bases:

>100_bases
TAGCGGCTCGCTGTCGGCGCCGGGGAGCTCAGGCCTTGCTCCTGCGGCGCGCGCAGCTTCGACCAGCAACACCTGCTCAG
CCACGTCACTGGAGTCGATC

Downstream 100 bases:

>100_bases
GACCCCTTCCGGGGTGGGCCGGCGCGCAGCCGGCCGCCCCGGCGCCTGCTGCCGGCGCCGGGGCGTTTCGTGGATGGCAG
CTTTGGCAGGGGGGCCCGAT

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MPYQHIKVPDGGDKITVNQDFTLNVSDQPIIPYIEGDGTGFDITPVMIKVVDAAVEAAYKGKRKIHWMEIYAGEKATKVY
GPDVWLPDETLQVLKEYVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYFKGVPSPVREPEKIDMVIFRENSED
IYAGIEWPAGSEQAKKVIAFLRDEMGVKKIRFPETSGIGVKPVSTEGTERLVRKAIQYAIDNDRKSVTLVHKGNIMKFTE
GLFRDAGYALAQKEFGGELIDGGPWMRVKNPKTGGEIVIKDSIADAFLQQILLRPAEYDVIATLNLNGDYISDALAAQVG
GIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHLGWTEAADTIIAAMEKSILQKRVTYDFARLME
GATQVSCSGFGEVLIENM

Sequences:

>Translated_418_residues
MPYQHIKVPDGGDKITVNQDFTLNVSDQPIIPYIEGDGTGFDITPVMIKVVDAAVEAAYKGKRKIHWMEIYAGEKATKVY
GPDVWLPDETLQVLKEYVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYFKGVPSPVREPEKIDMVIFRENSED
IYAGIEWPAGSEQAKKVIAFLRDEMGVKKIRFPETSGIGVKPVSTEGTERLVRKAIQYAIDNDRKSVTLVHKGNIMKFTE
GLFRDAGYALAQKEFGGELIDGGPWMRVKNPKTGGEIVIKDSIADAFLQQILLRPAEYDVIATLNLNGDYISDALAAQVG
GIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHLGWTEAADTIIAAMEKSILQKRVTYDFARLME
GATQVSCSGFGEVLIENM
>Mature_417_residues
PYQHIKVPDGGDKITVNQDFTLNVSDQPIIPYIEGDGTGFDITPVMIKVVDAAVEAAYKGKRKIHWMEIYAGEKATKVYG
PDVWLPDETLQVLKEYVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYFKGVPSPVREPEKIDMVIFRENSEDI
YAGIEWPAGSEQAKKVIAFLRDEMGVKKIRFPETSGIGVKPVSTEGTERLVRKAIQYAIDNDRKSVTLVHKGNIMKFTEG
LFRDAGYALAQKEFGGELIDGGPWMRVKNPKTGGEIVIKDSIADAFLQQILLRPAEYDVIATLNLNGDYISDALAAQVGG
IGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHLGWTEAADTIIAAMEKSILQKRVTYDFARLMEG
ATQVSCSGFGEVLIENM

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=403, Percent_Identity=32.258064516129, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI28178821, Length=354, Percent_Identity=29.0960451977401, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI28178816, Length=354, Percent_Identity=28.5310734463277, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI28178838, Length=281, Percent_Identity=29.8932384341637, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI4758582, Length=274, Percent_Identity=30.2919708029197, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI28178819, Length=183, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1787381, Length=411, Percent_Identity=76.6423357664234, Blast_Score=649, Evalue=0.0,
Organism=Escherichia coli, GI1788101, Length=377, Percent_Identity=28.3819628647215, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI87081683, Length=398, Percent_Identity=24.6231155778894, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71986051, Length=380, Percent_Identity=32.1052631578947, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI25144293, Length=305, Percent_Identity=31.4754098360656, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17505779, Length=312, Percent_Identity=30.7692307692308, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17550882, Length=260, Percent_Identity=28.8461538461538, Blast_Score=98, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6324709, Length=398, Percent_Identity=28.894472361809, Blast_Score=156, Evalue=7e-39,
Organism=Saccharomyces cerevisiae, GI6322097, Length=363, Percent_Identity=30.3030303030303, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6324291, Length=370, Percent_Identity=30.5405405405405, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6319830, Length=361, Percent_Identity=24.9307479224377, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24643268, Length=383, Percent_Identity=33.6814621409922, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24643270, Length=383, Percent_Identity=33.6814621409922, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24661184, Length=393, Percent_Identity=31.2977099236641, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI161078639, Length=306, Percent_Identity=29.7385620915033, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI161078637, Length=303, Percent_Identity=30.03300330033, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI161078635, Length=303, Percent_Identity=30.03300330033, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI161078633, Length=306, Percent_Identity=29.7385620915033, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24650122, Length=306, Percent_Identity=29.7385620915033, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI20130355, Length=356, Percent_Identity=26.4044943820225, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI281362242, Length=325, Percent_Identity=28.6153846153846, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24648872, Length=325, Percent_Identity=28.6153846153846, Blast_Score=90, Evalue=4e-18,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45880; Mature: 45749

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYQHIKVPDGGDKITVNQDFTLNVSDQPIIPYIEGDGTGFDITPVMIKVVDAAVEAAYK
CCCCEEECCCCCCEEEECCCEEEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHC
GKRKIHWMEIYAGEKATKVYGPDVWLPDETLQVLKEYVVSIKGPLTTPVGGGIRSLNVAL
CCCEEEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
RQELDLYVCLRPVRYFKGVPSPVREPEKIDMVIFRENSEDIYAGIEWPAGSEQAKKVIAF
HHCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHH
LRDEMGVKKIRFPETSGIGVKPVSTEGTERLVRKAIQYAIDNDRKSVTLVHKGNIMKFTE
HHHHCCCCEEECCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHH
GLFRDAGYALAQKEFGGELIDGGPWMRVKNPKTGGEIVIKDSIADAFLQQILLRPAEYDV
HHHHHCCHHHHHHHHCCEEECCCCEEEECCCCCCCEEEEECHHHHHHHHHHHCCCCCCCE
IATLNLNGDYISDALAAQVGGIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEIL
EEEEECCCCHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHH
SAEMMLRHLGWTEAADTIIAAMEKSILQKRVTYDFARLMEGATQVSCSGFGEVLIENM
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHCCCC
>Mature Secondary Structure 
PYQHIKVPDGGDKITVNQDFTLNVSDQPIIPYIEGDGTGFDITPVMIKVVDAAVEAAYK
CCCEEECCCCCCEEEECCCEEEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHC
GKRKIHWMEIYAGEKATKVYGPDVWLPDETLQVLKEYVVSIKGPLTTPVGGGIRSLNVAL
CCCEEEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
RQELDLYVCLRPVRYFKGVPSPVREPEKIDMVIFRENSEDIYAGIEWPAGSEQAKKVIAF
HHCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHH
LRDEMGVKKIRFPETSGIGVKPVSTEGTERLVRKAIQYAIDNDRKSVTLVHKGNIMKFTE
HHHHCCCCEEECCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHH
GLFRDAGYALAQKEFGGELIDGGPWMRVKNPKTGGEIVIKDSIADAFLQQILLRPAEYDV
HHHHHCCHHHHHHHHCCEEECCCCEEEECCCCCCCEEEEECHHHHHHHHHHHCCCCCCCE
IATLNLNGDYISDALAAQVGGIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEIL
EEEEECCCCHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHH
SAEMMLRHLGWTEAADTIIAAMEKSILQKRVTYDFARLMEGATQVSCSGFGEVLIENM
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10361714; 10556719; 12704232 [H]