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The map label for this gene is kynA [H]

Identifier: 161523898

GI number: 161523898

Start: 790985

End: 791947

Strand: Reverse

Name: kynA [H]

Synonym: Bmul_0718

Alternate gene names: 161523898

Gene position: 791947-790985 (Counterclockwise)

Preceding gene: 161523899

Following gene: 161523893

Centisome position: 22.97

GC content: 66.77

Gene sequence:

>963_bases
ATGCTGGAGACAGTCGTGAATTCTGGTCATATGCAGCCGCCCGGCAACGATGCGCCGGCGGGCTGCCCGTTCTCGGGCGC
ACGCGCGCAAGGTACGCAAGCCGCGCACGAAGCGCCGCACGTGCCGGGCGACGCCGGCGAGCAAGCCGGCTGGCACAACG
CGCAGCTCGATTTCTCGAAGTCGATGAGCTACGGCGACTACCTGTCGCTGAATGCGATCCTGAATGCGCAGCACCCGCTG
TCGCCCGATCACAACGAGATGCTGTTCATCATCCAGCATCAGACGAGCGAGCTGTGGATGAAGCTCGCGCTGTTCGAACT
GCGCGGCGCGCTCGATGCGGTGCGCAGCGATGCGCTGCCGCCCGCGTTCAAGATGCTCGCACGCGTCTCGCGGATCCTCG
AGCAGCTCGTGCAGGCGTGGAACGTGCTGTCGACGATGACGCCGTCCGAGTACTCGGCGATGCGGCCGTATCTCGGCCAG
TCGTCGGGTTTCCAGTCGTACCAGTACCGGCAGCTCGAATTCCTGCTCGGCAACAAGAACGCGCAGATGCTGCAGCCGCA
CGCGCACCGCCCCGACATCCTCGAACAGGTGCGCGCGACCCTCGACGCGCCGTCGTTCTACGACGAGGTCGTGCGTCTGC
TCGCGCGGCGCGGGTTCCCGATCGCGCCGTCGCGGCTCGATCGCGACTGGCGCCAGCCGACGCAGCACGACGAAACCGTC
GAGGCCGCGTGGCTCGAGGTGTACCGGCATCCGCAGCAGCACTGGGAGCTGTACGAGATGGCCGAGGAACTCGTCGATCT
CGAGGACGCGTTCCGCCAGTGGCGCTTCCGGCACGTGACGACGGTCGAGCGCATCATCGGCTTCAAGCAGGGCACCGGCG
GCACGAGCGGCGCGCCCTATCTGCGCAAGATGCTCGACGTCGTGCTGTTCCCCGAACTCTGGCACGTGCGCACGACGCTG
TAA

Upstream 100 bases:

>100_bases
ACCGACGCGTGGAAGGCGCCCGAGTACGCCGAGCGCGGCGCGGTGACCTGATCGCCGGCCGCCGCGGGCGCGCGCAGCGC
GTGCCGCGCCCCGTCATTCA

Downstream 100 bases:

>100_bases
CGCGTGAAGCTCGCGCCGCCCGGCGGGACCCTGCGGCATCGGGCAAGCAGCGCGAATGCGCAATGCATGCGCGCTACGCG
CCGTCACGACGACGTGCGAA

Product: tryptophan 2,3-dioxygenase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MLETVVNSGHMQPPGNDAPAGCPFSGARAQGTQAAHEAPHVPGDAGEQAGWHNAQLDFSKSMSYGDYLSLNAILNAQHPL
SPDHNEMLFIIQHQTSELWMKLALFELRGALDAVRSDALPPAFKMLARVSRILEQLVQAWNVLSTMTPSEYSAMRPYLGQ
SSGFQSYQYRQLEFLLGNKNAQMLQPHAHRPDILEQVRATLDAPSFYDEVVRLLARRGFPIAPSRLDRDWRQPTQHDETV
EAAWLEVYRHPQQHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVLFPELWHVRTTL

Sequences:

>Translated_320_residues
MLETVVNSGHMQPPGNDAPAGCPFSGARAQGTQAAHEAPHVPGDAGEQAGWHNAQLDFSKSMSYGDYLSLNAILNAQHPL
SPDHNEMLFIIQHQTSELWMKLALFELRGALDAVRSDALPPAFKMLARVSRILEQLVQAWNVLSTMTPSEYSAMRPYLGQ
SSGFQSYQYRQLEFLLGNKNAQMLQPHAHRPDILEQVRATLDAPSFYDEVVRLLARRGFPIAPSRLDRDWRQPTQHDETV
EAAWLEVYRHPQQHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVLFPELWHVRTTL
>Mature_320_residues
MLETVVNSGHMQPPGNDAPAGCPFSGARAQGTQAAHEAPHVPGDAGEQAGWHNAQLDFSKSMSYGDYLSLNAILNAQHPL
SPDHNEMLFIIQHQTSELWMKLALFELRGALDAVRSDALPPAFKMLARVSRILEQLVQAWNVLSTMTPSEYSAMRPYLGQ
SSGFQSYQYRQLEFLLGNKNAQMLQPHAHRPDILEQVRATLDAPSFYDEVVRLLARRGFPIAPSRLDRDWRQPTQHDETV
EAAWLEVYRHPQQHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVLFPELWHVRTTL

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring [H]

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI5032165, Length=170, Percent_Identity=35.8823529411765, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17552370, Length=374, Percent_Identity=26.4705882352941, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI32564651, Length=180, Percent_Identity=31.6666666666667, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17530891, Length=331, Percent_Identity=30.8157099697885, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017485
- InterPro:   IPR004981 [H]

Pfam domain/function: PF03301 Trp_dioxygenase [H]

EC number: =1.13.11.11 [H]

Molecular weight: Translated: 36412; Mature: 36412

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLETVVNSGHMQPPGNDAPAGCPFSGARAQGTQAAHEAPHVPGDAGEQAGWHNAQLDFSK
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHH
SMSYGDYLSLNAILNAQHPLSPDHNEMLFIIQHQTSELWMKLALFELRGALDAVRSDALP
CCCCCCEEEHHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCC
PAFKMLARVSRILEQLVQAWNVLSTMTPSEYSAMRPYLGQSSGFQSYQYRQLEFLLGNKN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCC
AQMLQPHAHRPDILEQVRATLDAPSFYDEVVRLLARRGFPIAPSRLDRDWRQPTQHDETV
HHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHCHHHCCCCCCCHHH
EAAWLEVYRHPQQHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPY
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
LRKMLDVVLFPELWHVRTTL
HHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLETVVNSGHMQPPGNDAPAGCPFSGARAQGTQAAHEAPHVPGDAGEQAGWHNAQLDFSK
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHH
SMSYGDYLSLNAILNAQHPLSPDHNEMLFIIQHQTSELWMKLALFELRGALDAVRSDALP
CCCCCCEEEHHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCC
PAFKMLARVSRILEQLVQAWNVLSTMTPSEYSAMRPYLGQSSGFQSYQYRQLEFLLGNKN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCC
AQMLQPHAHRPDILEQVRATLDAPSFYDEVVRLLARRGFPIAPSRLDRDWRQPTQHDETV
HHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHCHHHCCCCCCCHHH
EAAWLEVYRHPQQHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPY
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
LRKMLDVVLFPELWHVRTTL
HHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA