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The map label for this gene is kynU [H]

Identifier: 161523899

GI number: 161523899

Start: 791997

End: 793253

Strand: Reverse

Name: kynU [H]

Synonym: Bmul_0719

Alternate gene names: 161523899

Gene position: 793253-791997 (Counterclockwise)

Preceding gene: 161523900

Following gene: 161523898

Centisome position: 23.0

GC content: 69.21

Gene sequence:

>1257_bases
ATGATGATCAAGACCCGTGAAGATGCGCTCGCGCTCGATCGCGACGATCCGCTTGCCCCGTTGCGCAGCCAGTTCGCACT
GCCCGACGGCGTGATCTACCTCGACGGCAACTCGCTCGGCGCGCAGCCTCGCGCGTCGGCTGCGCGTGCGCAACAGGTGA
TCGGCGCCGAATGGGGCGAAGGCCTGATCCGCAGCTGGAACACCGCAGGCTGGTTCGCGCTGCCGCGCCGCCTCGGCGAC
AAGCTCGCGACGCTGATCGGCGGCGCGCCCGGCGAAACCGTCGTGACCGACACGATTTCGATCAACCTGTTCAAGCTGCT
GTCGGCGATGCTGCGCCATCAGGCCGAACGCGCGCCCGAGCGCCGCGTGATCGTGTCGGAGCGCTCGAACTTCCCGACCG
ACCTCTATATCGCGCAGGGGCTCATCGAGCAGCTCGGCGGCGACTACGAACTGCGCCTGATCGACGATCCCGCCGAGCTG
CCCGACGCGCTCGGCCCGGACACCGCCGTCGCGATGATTACGCACGTGAACTACCGCACCGGCTACATGCACGACATGGC
CGCCGTCACGCAGCTCGCGCACGATGCGGGCGCGCTGATGCTCTGGGATCTCGCGCACTCGGCCGGCGCGGTGCCGGTCG
ACCTGAACGGCGCGCATGCGGACGGCGCGGTCGGCTGCACGTACAAGTATCTGAACGGCGGCCCCGGCTCGCCGGCGTTC
GTGTGGGTGCCGCAGCGCCACCACGCGCATTTCTCGCAGCCGCTGTCCGGCTGGTGGGGCCATCGCGCGCCGTTCGCGAT
GCAGCCCGGCTTCGCGCCCGACGCCGGCATCGCGCGTTTCCTGTGCGGCACGCAGCCGATCGTGTCGATGTCGATGGTCG
AATGCGGGCTCGACGTGTTCCTGCAGACCGACATGCACGCGATCCGCCGCAAGTCGCTCGCGCTGACCGACGCGTTCATC
GCGCTCGTCGAGGCACGCTGCGCGGGCCGCTCGCTGAAGCTCGTCACGCCGCGCGCGCACCATCAGCGCGGTTCGCAGGC
GAGCTTCGAGCATCCTCACGGCTATGAAGTGATGCAGGCGCTGATCGCGCGCGGCGTGATCGGCGACTACCGCGAGCCGT
ACGTGCTGCGCTTCGGCTTTACGCCGCTCTATACGCGCTTCGTCGACGTGTGGGATGCCGTCGAGACGCTGCGCGAGATT
CTCGACACCGACGCGTGGAAGGCGCCCGAGTACGCCGAGCGCGGCGCGGTGACCTGA

Upstream 100 bases:

>100_bases
TGCCGCTCAAATTCGCGACGCTCGACGCGAGCCCCGTGCGCGCCGTCCTGCGCGCGCTGCCCGCGCGCGCCGCCTGATTC
TTTCGACCGACGAACCCACC

Downstream 100 bases:

>100_bases
TCGCCGGCCGCCGCGGGCGCGCGCAGCGCGTGCCGCGCCCCGTCATTCAATGCTGGAGACAGTCGTGAATTCTGGTCATA
TGCAGCCGCCCGGCAACGAT

Product: kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MMIKTREDALALDRDDPLAPLRSQFALPDGVIYLDGNSLGAQPRASAARAQQVIGAEWGEGLIRSWNTAGWFALPRRLGD
KLATLIGGAPGETVVTDTISINLFKLLSAMLRHQAERAPERRVIVSERSNFPTDLYIAQGLIEQLGGDYELRLIDDPAEL
PDALGPDTAVAMITHVNYRTGYMHDMAAVTQLAHDAGALMLWDLAHSAGAVPVDLNGAHADGAVGCTYKYLNGGPGSPAF
VWVPQRHHAHFSQPLSGWWGHRAPFAMQPGFAPDAGIARFLCGTQPIVSMSMVECGLDVFLQTDMHAIRRKSLALTDAFI
ALVEARCAGRSLKLVTPRAHHQRGSQASFEHPHGYEVMQALIARGVIGDYREPYVLRFGFTPLYTRFVDVWDAVETLREI
LDTDAWKAPEYAERGAVT

Sequences:

>Translated_418_residues
MMIKTREDALALDRDDPLAPLRSQFALPDGVIYLDGNSLGAQPRASAARAQQVIGAEWGEGLIRSWNTAGWFALPRRLGD
KLATLIGGAPGETVVTDTISINLFKLLSAMLRHQAERAPERRVIVSERSNFPTDLYIAQGLIEQLGGDYELRLIDDPAEL
PDALGPDTAVAMITHVNYRTGYMHDMAAVTQLAHDAGALMLWDLAHSAGAVPVDLNGAHADGAVGCTYKYLNGGPGSPAF
VWVPQRHHAHFSQPLSGWWGHRAPFAMQPGFAPDAGIARFLCGTQPIVSMSMVECGLDVFLQTDMHAIRRKSLALTDAFI
ALVEARCAGRSLKLVTPRAHHQRGSQASFEHPHGYEVMQALIARGVIGDYREPYVLRFGFTPLYTRFVDVWDAVETLREI
LDTDAWKAPEYAERGAVT
>Mature_418_residues
MMIKTREDALALDRDDPLAPLRSQFALPDGVIYLDGNSLGAQPRASAARAQQVIGAEWGEGLIRSWNTAGWFALPRRLGD
KLATLIGGAPGETVVTDTISINLFKLLSAMLRHQAERAPERRVIVSERSNFPTDLYIAQGLIEQLGGDYELRLIDDPAEL
PDALGPDTAVAMITHVNYRTGYMHDMAAVTQLAHDAGALMLWDLAHSAGAVPVDLNGAHADGAVGCTYKYLNGGPGSPAF
VWVPQRHHAHFSQPLSGWWGHRAPFAMQPGFAPDAGIARFLCGTQPIVSMSMVECGLDVFLQTDMHAIRRKSLALTDAFI
ALVEARCAGRSLKLVTPRAHHQRGSQASFEHPHGYEVMQALIARGVIGDYREPYVLRFGFTPLYTRFVDVWDAVETLREI
LDTDAWKAPEYAERGAVT

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=449, Percent_Identity=27.8396436525612, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI74101437, Length=284, Percent_Identity=26.056338028169, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17550466, Length=395, Percent_Identity=27.0886075949367, Blast_Score=144, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6323261, Length=457, Percent_Identity=28.6652078774617, Blast_Score=145, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 45744; Mature: 45744

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMIKTREDALALDRDDPLAPLRSQFALPDGVIYLDGNSLGAQPRASAARAQQVIGAEWGE
CCCCCCCCCCCCCCCCCCHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCC
GLIRSWNTAGWFALPRRLGDKLATLIGGAPGETVVTDTISINLFKLLSAMLRHQAERAPE
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCC
RRVIVSERSNFPTDLYIAQGLIEQLGGDYELRLIDDPAELPDALGPDTAVAMITHVNYRT
CEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHCCHHCCCCHHEEEEEECCCCC
GYMHDMAAVTQLAHDAGALMLWDLAHSAGAVPVDLNGAHADGAVGCTYKYLNGGPGSPAF
CHHHHHHHHHHHHHHCCCEEEEEHHHCCCCCEEECCCCCCCCCCEEEEEECCCCCCCCEE
VWVPQRHHAHFSQPLSGWWGHRAPFAMQPGFAPDAGIARFLCGTQPIVSMSMVECGLDVF
EECCCHHCCCCCCCHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCHHHH
LQTDMHAIRRKSLALTDAFIALVEARCAGRSLKLVTPRAHHQRGSQASFEHPHGYEVMQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCCCCCCCCCHHHHHH
LIARGVIGDYREPYVLRFGFTPLYTRFVDVWDAVETLREILDTDAWKAPEYAERGAVT
HHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCC
>Mature Secondary Structure
MMIKTREDALALDRDDPLAPLRSQFALPDGVIYLDGNSLGAQPRASAARAQQVIGAEWGE
CCCCCCCCCCCCCCCCCCHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCC
GLIRSWNTAGWFALPRRLGDKLATLIGGAPGETVVTDTISINLFKLLSAMLRHQAERAPE
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCC
RRVIVSERSNFPTDLYIAQGLIEQLGGDYELRLIDDPAELPDALGPDTAVAMITHVNYRT
CEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHCCHHCCCCHHEEEEEECCCCC
GYMHDMAAVTQLAHDAGALMLWDLAHSAGAVPVDLNGAHADGAVGCTYKYLNGGPGSPAF
CHHHHHHHHHHHHHHCCCEEEEEHHHCCCCCEEECCCCCCCCCCEEEEEECCCCCCCCEE
VWVPQRHHAHFSQPLSGWWGHRAPFAMQPGFAPDAGIARFLCGTQPIVSMSMVECGLDVF
EECCCHHCCCCCCCHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCHHHH
LQTDMHAIRRKSLALTDAFIALVEARCAGRSLKLVTPRAHHQRGSQASFEHPHGYEVMQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCCCCCCCCCHHHHHH
LIARGVIGDYREPYVLRFGFTPLYTRFVDVWDAVETLREILDTDAWKAPEYAERGAVT
HHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA