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The map label for this gene is hisB [H]

Identifier: 160902481

GI number: 160902481

Start: 1085810

End: 1086346

Strand: Direct

Name: hisB [H]

Synonym: Pmob_1018

Alternate gene names: 160902481

Gene position: 1085810-1086346 (Clockwise)

Preceding gene: 160902480

Following gene: 160902482

Centisome position: 50.05

GC content: 34.64

Gene sequence:

>537_bases
ATGAGAAGAAAAACTGACGAAACAGACATAGAAATAAATTATTCTAAAGAATTATTTGTTGATACCGGGGATCCTGTGTT
AAATCATTTATTGAAAACTCTATTCTACTACATGGAAAAGGACGTAATCATCAAGGCAAAGTTCGACCTTAATCACCATT
TATGGGAAGATATGGGAATAACAATCGGCCAATTTTTAAAGAACGAAGTGGAAGGTAAGAAAATAAAAAGGTTTGGGACC
TCCATCTTACCGATGGACGATGCCCTTATTCTCGTTTCGATTGATATTTCAAGATCCTATACAAACATAGATATCAACAT
CAAAGATGCTGAAAAAGGTTTTGAATTAGGTAACTTCAAAGAATTAGTTCTAGGGTTGTCAAGGTATTTGCAATCAACTA
TCCATATTAAGCAAATAAATGGTGAAAACGCTCATCATATAATTGAAGCTTCTTTCAAGGCATTGGGTAGCGCTTTAAAA
ACGGCCCTTGAACCAAGTGACAAACTCGAAAGTACAAATAGGGTTTACGAAGTATAG

Upstream 100 bases:

>100_bases
AAGTGAGTAAAGAAGAATTGTTAAAAGAGAGATACTTAGGTATAAGAATGGCGGAAATCGAAGGTATGTACCAACACAAA
AAATCTATGGAGGTGAGGAA

Downstream 100 bases:

>100_bases
AGGTGGTAGATATGCAGAAAATAGTCATATTAAATGGTGGAGTTGGTAACTTTTCAAATGTCCAAAAAGCTGTCGGAGGT
ATTATTAGCAATGAAATAAA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 178; Mature: 178

Protein sequence:

>178_residues
MRRKTDETDIEINYSKELFVDTGDPVLNHLLKTLFYYMEKDVIIKAKFDLNHHLWEDMGITIGQFLKNEVEGKKIKRFGT
SILPMDDALILVSIDISRSYTNIDINIKDAEKGFELGNFKELVLGLSRYLQSTIHIKQINGENAHHIIEASFKALGSALK
TALEPSDKLESTNRVYEV

Sequences:

>Translated_178_residues
MRRKTDETDIEINYSKELFVDTGDPVLNHLLKTLFYYMEKDVIIKAKFDLNHHLWEDMGITIGQFLKNEVEGKKIKRFGT
SILPMDDALILVSIDISRSYTNIDINIKDAEKGFELGNFKELVLGLSRYLQSTIHIKQINGENAHHIIEASFKALGSALK
TALEPSDKLESTNRVYEV
>Mature_178_residues
MRRKTDETDIEINYSKELFVDTGDPVLNHLLKTLFYYMEKDVIIKAKFDLNHHLWEDMGITIGQFLKNEVEGKKIKRFGT
SILPMDDALILVSIDISRSYTNIDINIKDAEKGFELGNFKELVLGLSRYLQSTIHIKQINGENAHHIIEASFKALGSALK
TALEPSDKLESTNRVYEV

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=184, Percent_Identity=30.9782608695652, Blast_Score=61, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324776, Length=161, Percent_Identity=28.5714285714286, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 20389; Mature: 20389

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRKTDETDIEINYSKELFVDTGDPVLNHLLKTLFYYMEKDVIIKAKFDLNHHLWEDMGI
CCCCCCCCCEEEEECCEEEEECCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHCC
TIGQFLKNEVEGKKIKRFGTSILPMDDALILVSIDISRSYTNIDINIKDAEKGFELGNFK
HHHHHHHHHCCCHHHHHHCCCCCCCCCEEEEEEEECCCCEEEEEEEEECCCCCCCCCCHH
ELVLGLSRYLQSTIHIKQINGENAHHIIEASFKALGSALKTALEPSDKLESTNRVYEV
HHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEECC
>Mature Secondary Structure
MRRKTDETDIEINYSKELFVDTGDPVLNHLLKTLFYYMEKDVIIKAKFDLNHHLWEDMGI
CCCCCCCCCEEEEECCEEEEECCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHCC
TIGQFLKNEVEGKKIKRFGTSILPMDDALILVSIDISRSYTNIDINIKDAEKGFELGNFK
HHHHHHHHHCCCHHHHHHCCCCCCCCCEEEEEEEECCCCEEEEEEEEECCCCCCCCCCHH
ELVLGLSRYLQSTIHIKQINGENAHHIIEASFKALGSALKTALEPSDKLESTNRVYEV
HHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA