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The map label for this gene is hisD [H]

Identifier: 160902480

GI number: 160902480

Start: 1084686

End: 1085813

Strand: Direct

Name: hisD [H]

Synonym: Pmob_1017

Alternate gene names: 160902480

Gene position: 1084686-1085813 (Clockwise)

Preceding gene: 160902479

Following gene: 160902481

Centisome position: 50.0

GC content: 36.79

Gene sequence:

>1128_bases
ATGGAATTACAGAGCTACGTTTCACAGATATTAAACGACATTAAAAACAACGGAATGCTTGCAGTAAAAAAGTATTCAAA
ACAGTTCGATAATTATGATGGTGATTTAGAATTAAAAGTTGAAGAATGGGATATTGACGAAGTAATCCCCGCGCAAGATA
AAGAAATTATAGAAAGAACGATTCAAAGGTTAGAGAATTACCATATAAAACAAAAAACAGAAGATATTATGTATTCAAAT
GAATACAACTCAACTTATGGACTGATTAATAGACCAATAAACAGGATAGGGATCTATGTTCCAGGAGGTAAACCCTTACC
TTCGAGTTTGTTGATGGTAGCTATTCCCGCCAAGATTGCAGGGGTAAAAGAAATGTTGATCACTTCCTCTCCAAAAGATG
GGTTAATAAACCCTTACATTATCTATATAGCAAAAAAGTTAGGGATAAAAGAAATTTACAAAATTGGTGGAATTCAAGCA
ATAGCCGCTATGACATACGGCATCGGCATGAAGAAAGTAGATAAAATATTTGGTCCTGGGAACCAATATGTGAATGAAGC
AAAACGACAGGTGTTTGGAGAAGTCGGGATAGACAGTTTGGCAGGACCATCAGAAATCTGTGTGATAGCTGATGAGACAG
CAAAACCAGAATACATTCTAAACGACTTGCTCTCCCAACTTGAACATGGTTATGAATCTAAAGCTTTCTTGGTCACTACA
TCAAAAGAATTATACGAATATTGTGAAAGAGAAGGGATAGATAGACACCTTTTCAAAAGTATAGAAGATTGTGCAGCTAA
AACCAACGAAATAGCGCCTGAGCATTTAGAGATAATGACAAAAGATCCTGAATCAGTACTACCTCTCATACAAAATGCTG
GAGCTGTTTATTTGGGAGATTACACGCCGGTACCGGCGGCGGATTATTTCTTAGGTGTTAACCACGTACTGCCAACAGGT
GGTGCAGCACGTTTCTCCTCCGTTTTGAACCTATCAGATTTTACAAAAAAAATATCCATCGCAAAAGTGAGTAAAGAAGA
ATTGTTAAAAGAGAGATACTTAGGTATAAGAATGGCGGAAATCGAAGGTATGTACCAACACAAAAAATCTATGGAGGTGA
GGAAATGA

Upstream 100 bases:

>100_bases
AATAAATAAAGCAAAGAATTATAAAAATGGGGTGAAAGGGCACTAAAGCAAATCCTACAGTTGCTAAGGTCAGTGCCAAA
AATCGAAGGAGGGAAAAATA

Downstream 100 bases:

>100_bases
GAAGAAAAACTGACGAAACAGACATAGAAATAAATTATTCTAAAGAATTATTTGTTGATACCGGGGATCCTGTGTTAAAT
CATTTATTGAAAACTCTATT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MELQSYVSQILNDIKNNGMLAVKKYSKQFDNYDGDLELKVEEWDIDEVIPAQDKEIIERTIQRLENYHIKQKTEDIMYSN
EYNSTYGLINRPINRIGIYVPGGKPLPSSLLMVAIPAKIAGVKEMLITSSPKDGLINPYIIYIAKKLGIKEIYKIGGIQA
IAAMTYGIGMKKVDKIFGPGNQYVNEAKRQVFGEVGIDSLAGPSEICVIADETAKPEYILNDLLSQLEHGYESKAFLVTT
SKELYEYCEREGIDRHLFKSIEDCAAKTNEIAPEHLEIMTKDPESVLPLIQNAGAVYLGDYTPVPAADYFLGVNHVLPTG
GAARFSSVLNLSDFTKKISIAKVSKEELLKERYLGIRMAEIEGMYQHKKSMEVRK

Sequences:

>Translated_375_residues
MELQSYVSQILNDIKNNGMLAVKKYSKQFDNYDGDLELKVEEWDIDEVIPAQDKEIIERTIQRLENYHIKQKTEDIMYSN
EYNSTYGLINRPINRIGIYVPGGKPLPSSLLMVAIPAKIAGVKEMLITSSPKDGLINPYIIYIAKKLGIKEIYKIGGIQA
IAAMTYGIGMKKVDKIFGPGNQYVNEAKRQVFGEVGIDSLAGPSEICVIADETAKPEYILNDLLSQLEHGYESKAFLVTT
SKELYEYCEREGIDRHLFKSIEDCAAKTNEIAPEHLEIMTKDPESVLPLIQNAGAVYLGDYTPVPAADYFLGVNHVLPTG
GAARFSSVLNLSDFTKKISIAKVSKEELLKERYLGIRMAEIEGMYQHKKSMEVRK
>Mature_375_residues
MELQSYVSQILNDIKNNGMLAVKKYSKQFDNYDGDLELKVEEWDIDEVIPAQDKEIIERTIQRLENYHIKQKTEDIMYSN
EYNSTYGLINRPINRIGIYVPGGKPLPSSLLMVAIPAKIAGVKEMLITSSPKDGLINPYIIYIAKKLGIKEIYKIGGIQA
IAAMTYGIGMKKVDKIFGPGNQYVNEAKRQVFGEVGIDSLAGPSEICVIADETAKPEYILNDLLSQLEHGYESKAFLVTT
SKELYEYCEREGIDRHLFKSIEDCAAKTNEIAPEHLEIMTKDPESVLPLIQNAGAVYLGDYTPVPAADYFLGVNHVLPTG
GAARFSSVLNLSDFTKKISIAKVSKEELLKERYLGIRMAEIEGMYQHKKSMEVRK

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=395, Percent_Identity=35.1898734177215, Blast_Score=241, Evalue=6e-65,
Organism=Saccharomyces cerevisiae, GI6319819, Length=411, Percent_Identity=32.360097323601, Blast_Score=210, Evalue=3e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 42105; Mature: 42105

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELQSYVSQILNDIKNNGMLAVKKYSKQFDNYDGDLELKVEEWDIDEVIPAQDKEIIERT
CCHHHHHHHHHHHHHCCCEEEEEHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHHH
IQRLENYHIKQKTEDIMYSNEYNSTYGLINRPINRIGIYVPGGKPLPSSLLMVAIPAKIA
HHHHHHCCHHHHHHHHEECCCCCCCHHHHHCCHHHEEEECCCCCCCCHHHEEEEHHHHHH
GVKEMLITSSPKDGLINPYIIYIAKKLGIKEIYKIGGIQAIAAMTYGIGMKKVDKIFGPG
HHHHHHHCCCCCCCCCCHHHEEHHHHHCHHHHHHHCCHHHHHHHHHCCCHHHHHHHHCCC
NQYVNEAKRQVFGEVGIDSLAGPSEICVIADETAKPEYILNDLLSQLEHGYESKAFLVTT
HHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEEC
SKELYEYCEREGIDRHLFKSIEDCAAKTNEIAPEHLEIMTKDPESVLPLIQNAGAVYLGD
CHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHEECCCHHHHHHHHHCCCEEEECC
YTPVPAADYFLGVNHVLPTGGAARFSSVLNLSDFTKKISIAKVSKEELLKERYLGIRMAE
CCCCCCHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHH
IEGMYQHKKSMEVRK
HHHHHHHHHHCCCCC
>Mature Secondary Structure
MELQSYVSQILNDIKNNGMLAVKKYSKQFDNYDGDLELKVEEWDIDEVIPAQDKEIIERT
CCHHHHHHHHHHHHHCCCEEEEEHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHHH
IQRLENYHIKQKTEDIMYSNEYNSTYGLINRPINRIGIYVPGGKPLPSSLLMVAIPAKIA
HHHHHHCCHHHHHHHHEECCCCCCCHHHHHCCHHHEEEECCCCCCCCHHHEEEEHHHHHH
GVKEMLITSSPKDGLINPYIIYIAKKLGIKEIYKIGGIQAIAAMTYGIGMKKVDKIFGPG
HHHHHHHCCCCCCCCCCHHHEEHHHHHCHHHHHHHCCHHHHHHHHHCCCHHHHHHHHCCC
NQYVNEAKRQVFGEVGIDSLAGPSEICVIADETAKPEYILNDLLSQLEHGYESKAFLVTT
HHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEEC
SKELYEYCEREGIDRHLFKSIEDCAAKTNEIAPEHLEIMTKDPESVLPLIQNAGAVYLGD
CHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHEECCCHHHHHHHHHCCCEEEECC
YTPVPAADYFLGVNHVLPTGGAARFSSVLNLSDFTKKISIAKVSKEELLKERYLGIRMAE
CCCCCCHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHH
IEGMYQHKKSMEVRK
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA