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The map label for this gene is disA [H]

Identifier: 160901849

GI number: 160901849

Start: 392993

End: 394102

Strand: Direct

Name: disA [H]

Synonym: Pmob_0365

Alternate gene names: 160901849

Gene position: 392993-394102 (Clockwise)

Preceding gene: 160901848

Following gene: 160901850

Centisome position: 18.11

GC content: 33.78

Gene sequence:

>1110_bases
TTGAATGAGAAATTAGAAAGAATTTTTGAATTGTTGGCTCCGGGAAAGCCTATTAGAAAAGGTATAGACAGGATAATGGA
AGCAAATTTGGGGGCTTTGTTGTTTTTTTGCTCACAACCTGAAAAGCACCTTAAAGAAGGTCTAATACAGTTAGGCTTTA
GAGTTGATTCGGATTTTTTACCTGAAAAAATTTATGAACTTTCAAAAATGGATGGGGCTATTGTTTTAAACAGTGATGGA
ACTCAAATTCTTGCAGCGAATGCACAACTTAATCCCGATAAGAGCATACCTAGTTCAGAAACCGGAATGAGACACAAAAC
TGCAGAAAAAGTGTCTATTCAAACGGGAGATTTAACAGTCGCAGTTTCTAAAAGAAGAAATATTGTTTCAGTGTATTATA
ATAAAATGAAATACGAACTTCTACCTGAAAATGTTTTATTTGCTAGATTAAATCAAGAAATTACCATTGCACAAAGATAT
AGACAAAGCTTTATGAACCTTTTAGACTATCTGAACATCGAAGAGACAAGGGGAAATGTAAGTCTCTCTGACGTTGTTGA
GATACTTTCCAAAGGTTTGCTAACGATAAAAATTGTACAAAGAGCTGAAAAATATTTATTAGAATTAGGAGAAATCGCTG
GAAGTGCAAAATTAGAATACGAAGAAATCTTAAGGACAGTCCCTAAGTATGTGGGTGCTGTTATAATGGATTACAGCTCA
GAAAACTTAAAGTATCAAAGACCCGAAGATGCGACAAGCATATTCAAAGAATTAGACTTTAACGATTTGGTCGATCCCTT
CAAAATAGCAAAAACTTTAGGTTATATTGATGTTTCATCTGAAGACGATCTGGAAGAAACAGCTTTAACATCAAGAGGCT
ACAGAATCCTTTATTCTACTAAGTTACCAACTTCTGCGGTAAAAAAAGTTGTGGAAAGTTTTAAAAACCTTCAAGAATTA
ATGAACGCCACTTTTGAAGAATTAACAGATATAAGCGGAATCGGCAAAAGAAGGGCGGAAATAATCTTGGGAACATTGAA
TAAAAAGAAAAGAGAAAAAGAGGAAATAGAAGAGGAAACTGCACAAATAATAAGCAAAGAAAAGAAGTAA

Upstream 100 bases:

>100_bases
ATAGTTATTCCAAAAAATCTTTCCCCTAGAAAAAACTCTATTATAGTTGCAGAAAGTGTAAAAGATTTGATAAAATTATT
CAAAAAAGGGGGATAAAATT

Downstream 100 bases:

>100_bases
TAACACTATTAATAGTTTTTCAATTTAATATTGTAAAAACATCACAATTTTAGAGGTGAAGAAATATAACAACTTTAGCA
AGAAACAAAAAAGCTACTCA

Product: DNA integrity scanning protein DisA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MNEKLERIFELLAPGKPIRKGIDRIMEANLGALLFFCSQPEKHLKEGLIQLGFRVDSDFLPEKIYELSKMDGAIVLNSDG
TQILAANAQLNPDKSIPSSETGMRHKTAEKVSIQTGDLTVAVSKRRNIVSVYYNKMKYELLPENVLFARLNQEITIAQRY
RQSFMNLLDYLNIEETRGNVSLSDVVEILSKGLLTIKIVQRAEKYLLELGEIAGSAKLEYEEILRTVPKYVGAVIMDYSS
ENLKYQRPEDATSIFKELDFNDLVDPFKIAKTLGYIDVSSEDDLEETALTSRGYRILYSTKLPTSAVKKVVESFKNLQEL
MNATFEELTDISGIGKRRAEIILGTLNKKKREKEEIEEETAQIISKEKK

Sequences:

>Translated_369_residues
MNEKLERIFELLAPGKPIRKGIDRIMEANLGALLFFCSQPEKHLKEGLIQLGFRVDSDFLPEKIYELSKMDGAIVLNSDG
TQILAANAQLNPDKSIPSSETGMRHKTAEKVSIQTGDLTVAVSKRRNIVSVYYNKMKYELLPENVLFARLNQEITIAQRY
RQSFMNLLDYLNIEETRGNVSLSDVVEILSKGLLTIKIVQRAEKYLLELGEIAGSAKLEYEEILRTVPKYVGAVIMDYSS
ENLKYQRPEDATSIFKELDFNDLVDPFKIAKTLGYIDVSSEDDLEETALTSRGYRILYSTKLPTSAVKKVVESFKNLQEL
MNATFEELTDISGIGKRRAEIILGTLNKKKREKEEIEEETAQIISKEKK
>Mature_369_residues
MNEKLERIFELLAPGKPIRKGIDRIMEANLGALLFFCSQPEKHLKEGLIQLGFRVDSDFLPEKIYELSKMDGAIVLNSDG
TQILAANAQLNPDKSIPSSETGMRHKTAEKVSIQTGDLTVAVSKRRNIVSVYYNKMKYELLPENVLFARLNQEITIAQRY
RQSFMNLLDYLNIEETRGNVSLSDVVEILSKGLLTIKIVQRAEKYLLELGEIAGSAKLEYEEILRTVPKYVGAVIMDYSS
ENLKYQRPEDATSIFKELDFNDLVDPFKIAKTLGYIDVSSEDDLEETALTSRGYRILYSTKLPTSAVKKVVESFKNLQEL
MNATFEELTDISGIGKRRAEIILGTLNKKKREKEEIEEETAQIISKEKK

Specific function: Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions [H]

COG id: COG1623

COG function: function code R; Predicted nucleic-acid-binding protein (contains the HHH domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the disA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018906
- InterPro:   IPR003390
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994 [H]

Pfam domain/function: PF10635 DisA-linker; PF02457 DisA_N; PF00633 HHH [H]

EC number: NA

Molecular weight: Translated: 41906; Mature: 41906

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEKLERIFELLAPGKPIRKGIDRIMEANLGALLFFCSQPEKHLKEGLIQLGFRVDSDFL
CCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCHH
PEKIYELSKMDGAIVLNSDGTQILAANAQLNPDKSIPSSETGMRHKTAEKVSIQTGDLTV
HHHHHHHHHCCCEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHEEEEECCEEE
AVSKRRNIVSVYYNKMKYELLPENVLFARLNQEITIAQRYRQSFMNLLDYLNIEETRGNV
EECCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHCCCCC
SLSDVVEILSKGLLTIKIVQRAEKYLLELGEIAGSAKLEYEEILRTVPKYVGAVIMDYSS
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCC
ENLKYQRPEDATSIFKELDFNDLVDPFKIAKTLGYIDVSSEDDLEETALTSRGYRILYST
CCCCCCCCHHHHHHHHHCCHHHCCCHHHHHHHHCCEECCCCCCHHHHHHHHCCEEEEEEC
KLPTSAVKKVVESFKNLQELMNATFEELTDISGIGKRRAEIILGTLNKKKREKEEIEEET
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHEECCCHHHHHHHHHHHHH
AQIISKEKK
HHHHHCCCC
>Mature Secondary Structure
MNEKLERIFELLAPGKPIRKGIDRIMEANLGALLFFCSQPEKHLKEGLIQLGFRVDSDFL
CCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCHH
PEKIYELSKMDGAIVLNSDGTQILAANAQLNPDKSIPSSETGMRHKTAEKVSIQTGDLTV
HHHHHHHHHCCCEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHEEEEECCEEE
AVSKRRNIVSVYYNKMKYELLPENVLFARLNQEITIAQRYRQSFMNLLDYLNIEETRGNV
EECCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHCCCCC
SLSDVVEILSKGLLTIKIVQRAEKYLLELGEIAGSAKLEYEEILRTVPKYVGAVIMDYSS
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCC
ENLKYQRPEDATSIFKELDFNDLVDPFKIAKTLGYIDVSSEDDLEETALTSRGYRILYST
CCCCCCCCHHHHHHHHHCCHHHCCCHHHHHHHHCCEECCCCCCHHHHHHHHCCEEEEEEC
KLPTSAVKKVVESFKNLQELMNATFEELTDISGIGKRRAEIILGTLNKKKREKEEIEEET
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHEECCCHHHHHHHHHHHHH
AQIISKEKK
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]