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The map label for this gene is cobB [H]

Identifier: 159899690

GI number: 159899690

Start: 4009574

End: 4010308

Strand: Reverse

Name: cobB [H]

Synonym: Haur_3172

Alternate gene names: 159899690

Gene position: 4010308-4009574 (Counterclockwise)

Preceding gene: 159899691

Following gene: 159899689

Centisome position: 63.19

GC content: 52.65

Gene sequence:

>735_bases
GTGTTCGATTTGCCAGACGTTTTGTTGCAACGCTTACGCAATGCCCAATCAATTACAGTGCTGACAGGTGGGGGTTTGGC
TCAAGAGTGTGGGATTCCAAGTTTTCGCGAGGCCCAGCAACTCGATTCACGTTGGGCTGGCTACGAGCCGCAAGAACTGG
CAACGGTTGAGGCATTTTTGCGCAATCCACGCTTGGTTTGGGAATGGTTTGCCTATCGGCGTGGTTTGGCCGAGGCGGCT
CAACCAAGCGCAGCCCATTATGCCTTGGTGGATTTAGAGCAACTTATGCCAAAGTTCAAGCTGATTACCCAAGCCACCGA
TGGATTGCATTGGCGAGCAGGCAGCCGTGAATTGATCGAACTGCATGGCAATTTAGCTCGAATGCGCTCCTATGAAGATG
GCGGTATGGTCGATTCGTGGGATGAAACCGAAATTCCGCCGCGCTGCCCGCGAACTGGCGGCTATCTGCGCCCTGATGTA
GTGTTGTATGGCGAAGGTGTGCCACGCGAACGTTTGCGCGAAGCTGATCAAGCGACCATGTGTGATGTTTTTCTGTGCAT
TGGCACCGATTCAGTTGTGCAGCCCGCCGCCTCGTTGCCATTGCATGCTAAACGTCATGGTGCAACCGTGATTGAAATTA
ACCGCCAGCCCTCGACCTTTGGCTTTTTTACCGATCATGCCTTCCATGGCAAATTGGCCGAACTATTACCACAATTAGTT
GCTGCGCTTGAGTAA

Upstream 100 bases:

>100_bases
GCGGAATTGTCTGGATCAATATTGTCTTTGAAAAAGATGGTCAAGCGATGACCGGCTGGATTTCGCGTGATCTTTTGCAG
CAGGAGGAAACCCCTTGAGC

Downstream 100 bases:

>100_bases
TTGACTTGATTAGAGAGGAGTTGGTTATGGCCAAGTTTCCCGAAGAGCTTCTACAACGCTTACGCCAAGCCGAGCGAATC
GCAATTTTGACTGGAGCTGG

Product: silent information regulator protein Sir2

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MFDLPDVLLQRLRNAQSITVLTGGGLAQECGIPSFREAQQLDSRWAGYEPQELATVEAFLRNPRLVWEWFAYRRGLAEAA
QPSAAHYALVDLEQLMPKFKLITQATDGLHWRAGSRELIELHGNLARMRSYEDGGMVDSWDETEIPPRCPRTGGYLRPDV
VLYGEGVPRERLREADQATMCDVFLCIGTDSVVQPAASLPLHAKRHGATVIEINRQPSTFGFFTDHAFHGKLAELLPQLV
AALE

Sequences:

>Translated_244_residues
MFDLPDVLLQRLRNAQSITVLTGGGLAQECGIPSFREAQQLDSRWAGYEPQELATVEAFLRNPRLVWEWFAYRRGLAEAA
QPSAAHYALVDLEQLMPKFKLITQATDGLHWRAGSRELIELHGNLARMRSYEDGGMVDSWDETEIPPRCPRTGGYLRPDV
VLYGEGVPRERLREADQATMCDVFLCIGTDSVVQPAASLPLHAKRHGATVIEINRQPSTFGFFTDHAFHGKLAELLPQLV
AALE
>Mature_244_residues
MFDLPDVLLQRLRNAQSITVLTGGGLAQECGIPSFREAQQLDSRWAGYEPQELATVEAFLRNPRLVWEWFAYRRGLAEAA
QPSAAHYALVDLEQLMPKFKLITQATDGLHWRAGSRELIELHGNLARMRSYEDGGMVDSWDETEIPPRCPRTGGYLRPDV
VLYGEGVPRERLREADQATMCDVFLCIGTDSVVQPAASLPLHAKRHGATVIEINRQPSTFGFFTDHAFHGKLAELLPQLV
AALE

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=248, Percent_Identity=34.2741935483871, Blast_Score=130, Evalue=9e-31,
Organism=Homo sapiens, GI6912664, Length=262, Percent_Identity=32.824427480916, Blast_Score=127, Evalue=7e-30,
Organism=Homo sapiens, GI13787215, Length=240, Percent_Identity=33.3333333333333, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI6912660, Length=220, Percent_Identity=30.4545454545455, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI7657575, Length=229, Percent_Identity=29.2576419213974, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI63054862, Length=209, Percent_Identity=29.6650717703349, Blast_Score=74, Evalue=9e-14,
Organism=Escherichia coli, GI308199517, Length=232, Percent_Identity=37.0689655172414, Blast_Score=129, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17541892, Length=219, Percent_Identity=25.5707762557078, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI28571445, Length=208, Percent_Identity=29.3269230769231, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24648389, Length=202, Percent_Identity=28.7128712871287, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 27297; Mature: 27297

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDLPDVLLQRLRNAQSITVLTGGGLAQECGIPSFREAQQLDSRWAGYEPQELATVEAFL
CCCCHHHHHHHHCCCCEEEEEECCCCHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHH
RNPRLVWEWFAYRRGLAEAAQPSAAHYALVDLEQLMPKFKLITQATDGLHWRAGSRELIE
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHH
LHGNLARMRSYEDGGMVDSWDETEIPPRCPRTGGYLRPDVVLYGEGVPRERLREADQATM
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHH
CDVFLCIGTDSVVQPAASLPLHAKRHGATVIEINRQPSTFGFFTDHAFHGKLAELLPQLV
HHEEEEECCCHHHHHHHCCCCCHHHCCCEEEEECCCCCCEEEECCCCCCCHHHHHHHHHH
AALE
HHCC
>Mature Secondary Structure
MFDLPDVLLQRLRNAQSITVLTGGGLAQECGIPSFREAQQLDSRWAGYEPQELATVEAFL
CCCCHHHHHHHHCCCCEEEEEECCCCHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHH
RNPRLVWEWFAYRRGLAEAAQPSAAHYALVDLEQLMPKFKLITQATDGLHWRAGSRELIE
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHH
LHGNLARMRSYEDGGMVDSWDETEIPPRCPRTGGYLRPDVVLYGEGVPRERLREADQATM
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHH
CDVFLCIGTDSVVQPAASLPLHAKRHGATVIEINRQPSTFGFFTDHAFHGKLAELLPQLV
HHEEEEECCCHHHHHHHCCCCCHHHCCCEEEEECCCCCCEEEECCCCCCCHHHHHHHHHH
AALE
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]