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The map label for this gene is purE [H]

Identifier: 159897423

GI number: 159897423

Start: 1022185

End: 1022682

Strand: Reverse

Name: purE [H]

Synonym: Haur_0894

Alternate gene names: 159897423

Gene position: 1022682-1022185 (Counterclockwise)

Preceding gene: 159897424

Following gene: 159897421

Centisome position: 16.11

GC content: 52.21

Gene sequence:

>498_bases
ATGTCAGCCGTTGTTGGAATTGTGATGGGCAGTGATTCGGATTTAACGACCATGCAAGCAGCCGCCACTATTTGCCAAGA
ATTTGGCATTGGTTATGAAATGCGGGTGGTTTCGGCGCACCGCACGCCTGCCTTGATGGCCGAATATGGCCAAACCGCCC
ATGAACGCGGCCTCAAAGTGATCATCGCTGGGGCAGGCGGAGCAGCTCACTTGCCAGGTATGTTAGCGGCTTACACGCCC
TTGCCAGTGATTGGTGTGCCTGTGCCAATCGGCCACTTGCAAGGCGTTGATGCTTTGATGTCGATTGTGCAAATGCCAGG
CGGCGTGCCGGTTGCGACCGTCGCAATTGGCCAAGCCAAAAACGCAGGTTTATTGGCAATTCAAATTTTGGCCACCGCCG
ATGCTGCCTTACAAGCCAAATTGATTGAATACAAACAAACCATGGCCGCCGAATCGCAAGCCAAAAACGAGCGTCTGCAA
ACAACTATTAATCAATAA

Upstream 100 bases:

>100_bases
ATAATTGAGCAAACCAACCCACATGTCAAGCCAATCGAGCGTTGCAATGACGCACCTCGATCAACGCTTGGCATTTTTAA
TTTCTCGCCAAAGGAGCATT

Downstream 100 bases:

>100_bases
GCTTCTTTAACCACGAAGAACGCGAAGTTTCACGAAGGCTGATTCAGAGCATTGTTCAGGTTCTTGGTGGATCTTAAACA
GGGTTAAGCTCCCCTCGCCC

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 165; Mature: 164

Protein sequence:

>165_residues
MSAVVGIVMGSDSDLTTMQAAATICQEFGIGYEMRVVSAHRTPALMAEYGQTAHERGLKVIIAGAGGAAHLPGMLAAYTP
LPVIGVPVPIGHLQGVDALMSIVQMPGGVPVATVAIGQAKNAGLLAIQILATADAALQAKLIEYKQTMAAESQAKNERLQ
TTINQ

Sequences:

>Translated_165_residues
MSAVVGIVMGSDSDLTTMQAAATICQEFGIGYEMRVVSAHRTPALMAEYGQTAHERGLKVIIAGAGGAAHLPGMLAAYTP
LPVIGVPVPIGHLQGVDALMSIVQMPGGVPVATVAIGQAKNAGLLAIQILATADAALQAKLIEYKQTMAAESQAKNERLQ
TTINQ
>Mature_164_residues
SAVVGIVMGSDSDLTTMQAAATICQEFGIGYEMRVVSAHRTPALMAEYGQTAHERGLKVIIAGAGGAAHLPGMLAAYTPL
PVIGVPVPIGHLQGVDALMSIVQMPGGVPVATVAIGQAKNAGLLAIQILATADAALQAKLIEYKQTMAAESQAKNERLQT
TINQ

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=151, Percent_Identity=52.9801324503311, Blast_Score=127, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6324702, Length=158, Percent_Identity=55.0632911392405, Blast_Score=174, Evalue=5e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16975; Mature: 16844

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVVGIVMGSDSDLTTMQAAATICQEFGIGYEMRVVSAHRTPALMAEYGQTAHERGLKV
CCCEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHCCHHHHCCCEE
IIAGAGGAAHLPGMLAAYTPLPVIGVPVPIGHLQGVDALMSIVQMPGGVPVATVAIGQAK
EEECCCCCHHCCCHHHHCCCCCEEECCCCCHHHCCHHHHHHHHHCCCCCCEEEEEECCCC
NAGLLAIQILATADAALQAKLIEYKQTMAAESQAKNERLQTTINQ
CCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAVVGIVMGSDSDLTTMQAAATICQEFGIGYEMRVVSAHRTPALMAEYGQTAHERGLKV
CCEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHCCHHHHCCCEE
IIAGAGGAAHLPGMLAAYTPLPVIGVPVPIGHLQGVDALMSIVQMPGGVPVATVAIGQAK
EEECCCCCHHCCCHHHHCCCCCEEECCCCCHHHCCHHHHHHHHHCCCCCCEEEEEECCCC
NAGLLAIQILATADAALQAKLIEYKQTMAAESQAKNERLQTTINQ
CCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7489918; 11234002 [H]