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The map label for this gene is yisK [H]

Identifier: 158423507

GI number: 158423507

Start: 2157078

End: 2157929

Strand: Direct

Name: yisK [H]

Synonym: AZC_1883

Alternate gene names: 158423507

Gene position: 2157078-2157929 (Clockwise)

Preceding gene: 158423506

Following gene: 158423508

Centisome position: 40.17

GC content: 65.49

Gene sequence:

>852_bases
ATGAAGCTCCTGTCCTATGCGATAGGGGGTGCTGAAAGCTGGGGCGCCGTGACGGACGCCGGCGTCGTCGATCTTGCCCA
AGCCGTGCCCGCTTGCCCGACGCTCGCGGATTTCATCGGTAGCCCGGACTTCGAGCAGCGGGACGCGCTGCTGGCCGGCC
GATCGGGCGCGGTGATCCCGCTCCACGATATCCGCTTCCTTCCGGTCATTCCCCGGCCGGAGAAGATCGTCTGCGTGCTG
CGCAACTATCACGAGCCGGACGCGGGTCCGGATGCGCTGCCCCCGCCGGCCTTCCCGCCCATCTTCCTCAGGGTGTGGCG
CTCGCAGGTGGGGCATCTGGCGCCCGTCATCCGCCCCCGCGTCTCGACGCAGCTTGATTTCGAGGGCGAGCTGGCCGTGA
TGATCGGCAAGGCCGGCCGGCATATTCCGGCTGAGACCGCGCTCGATCATGTGGCCGGCTATTCCATCTACAATGATGTG
AGCGTGCGGGACTGGCAGCGGCACGCCCAGCAGATCGCCTCGGGTAAGAATTTCATCGGCACGGGGCCGTTCGGCCCATG
GATGGTGACGGCGGATGAAATCCCGAACCCGTCCGGCCTTGCCCTCAGCACCCGGCTGAATGGCGAAACGGTGCAAAGCT
CGGACACATCGCGCCTCATCTTCGATGTGCCCGCGCTCATTGCCTATTGCTCCACCATCTTCGATCTCGTGCCGGGGGAT
GTAATTGTCACCGGCACGCCGGGTGGTGCGGGCTTCACCCGCAAGCCGCCGCTCTATCTCAAGCCGGGAGACCGGGTCGA
GGTGGAGATTGCCCGTATCGGCACGCTCAGCAACGACGTCATCGACGAATAG

Upstream 100 bases:

>100_bases
CCCGGCTCGGGGTGACGATCCCCGAAGCTCTCCAAGCGGCCTGAACCGGCACAAGACCGGACATCGGCGGCATCAGACCG
CCACGGGAAGGAAACGTGCC

Downstream 100 bases:

>100_bases
GCCGCACAAGACGGCATGACCGGATCGGGAGGAAACCCATGAAACTTCAGGCCCTGGCGCTCGGCGCCGCCATCCTTGTC
CTACCCCTTACGGGCAGCCT

Product: fumarylacetoacetate (FAA) hydrolase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MKLLSYAIGGAESWGAVTDAGVVDLAQAVPACPTLADFIGSPDFEQRDALLAGRSGAVIPLHDIRFLPVIPRPEKIVCVL
RNYHEPDAGPDALPPPAFPPIFLRVWRSQVGHLAPVIRPRVSTQLDFEGELAVMIGKAGRHIPAETALDHVAGYSIYNDV
SVRDWQRHAQQIASGKNFIGTGPFGPWMVTADEIPNPSGLALSTRLNGETVQSSDTSRLIFDVPALIAYCSTIFDLVPGD
VIVTGTPGGAGFTRKPPLYLKPGDRVEVEIARIGTLSNDVIDE

Sequences:

>Translated_283_residues
MKLLSYAIGGAESWGAVTDAGVVDLAQAVPACPTLADFIGSPDFEQRDALLAGRSGAVIPLHDIRFLPVIPRPEKIVCVL
RNYHEPDAGPDALPPPAFPPIFLRVWRSQVGHLAPVIRPRVSTQLDFEGELAVMIGKAGRHIPAETALDHVAGYSIYNDV
SVRDWQRHAQQIASGKNFIGTGPFGPWMVTADEIPNPSGLALSTRLNGETVQSSDTSRLIFDVPALIAYCSTIFDLVPGD
VIVTGTPGGAGFTRKPPLYLKPGDRVEVEIARIGTLSNDVIDE
>Mature_283_residues
MKLLSYAIGGAESWGAVTDAGVVDLAQAVPACPTLADFIGSPDFEQRDALLAGRSGAVIPLHDIRFLPVIPRPEKIVCVL
RNYHEPDAGPDALPPPAFPPIFLRVWRSQVGHLAPVIRPRVSTQLDFEGELAVMIGKAGRHIPAETALDHVAGYSIYNDV
SVRDWQRHAQQIASGKNFIGTGPFGPWMVTADEIPNPSGLALSTRLNGETVQSSDTSRLIFDVPALIAYCSTIFDLVPGD
VIVTGTPGGAGFTRKPPLYLKPGDRVEVEIARIGTLSNDVIDE

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=270, Percent_Identity=41.8518518518518, Blast_Score=191, Evalue=6e-49,
Organism=Homo sapiens, GI40786394, Length=270, Percent_Identity=41.4814814814815, Blast_Score=188, Evalue=4e-48,
Organism=Homo sapiens, GI13654274, Length=184, Percent_Identity=34.7826086956522, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI215422413, Length=184, Percent_Identity=34.7826086956522, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI66348062, Length=184, Percent_Identity=34.7826086956522, Blast_Score=106, Evalue=2e-23,
Organism=Escherichia coli, GI1787428, Length=183, Percent_Identity=32.2404371584699, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17557057, Length=181, Percent_Identity=35.9116022099448, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI28572127, Length=221, Percent_Identity=38.4615384615385, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24663695, Length=277, Percent_Identity=31.0469314079422, Blast_Score=134, Evalue=7e-32,
Organism=Drosophila melanogaster, GI28571789, Length=214, Percent_Identity=30.3738317757009, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 30347; Mature: 30347

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLSYAIGGAESWGAVTDAGVVDLAQAVPACPTLADFIGSPDFEQRDALLAGRSGAVIP
CCHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHCCCCCCEEE
LHDIRFLPVIPRPEKIVCVLRNYHEPDAGPDALPPPAFPPIFLRVWRSQVGHLAPVIRPR
ECCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
VSTQLDFEGELAVMIGKAGRHIPAETALDHVAGYSIYNDVSVRDWQRHAQQIASGKNFIG
CCCEECCCCCEEEEEECCCCCCCHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHCCCCEEE
TGPFGPWMVTADEIPNPSGLALSTRLNGETVQSSDTSRLIFDVPALIAYCSTIFDLVPGD
CCCCCCEEEECCCCCCCCCEEEEEECCCCEECCCCCCEEEEHHHHHHHHHHHHHHHCCCC
VIVTGTPGGAGFTRKPPLYLKPGDRVEVEIARIGTLSNDVIDE
EEEEECCCCCCCCCCCCEEECCCCCEEEEEEEECCCCHHHCCC
>Mature Secondary Structure
MKLLSYAIGGAESWGAVTDAGVVDLAQAVPACPTLADFIGSPDFEQRDALLAGRSGAVIP
CCHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHCCCCCCEEE
LHDIRFLPVIPRPEKIVCVLRNYHEPDAGPDALPPPAFPPIFLRVWRSQVGHLAPVIRPR
ECCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
VSTQLDFEGELAVMIGKAGRHIPAETALDHVAGYSIYNDVSVRDWQRHAQQIASGKNFIG
CCCEECCCCCEEEEEECCCCCCCHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHCCCCEEE
TGPFGPWMVTADEIPNPSGLALSTRLNGETVQSSDTSRLIFDVPALIAYCSTIFDLVPGD
CCCCCCEEEECCCCCCCCCEEEEEECCCCEECCCCCCEEEEHHHHHHHHHHHHHHHCCCC
VIVTGTPGGAGFTRKPPLYLKPGDRVEVEIARIGTLSNDVIDE
EEEEECCCCCCCCCCCCEEECCCCCEEEEEEEECCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377 [H]