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The map label for this gene is hmrR [H]

Identifier: 157962594

GI number: 157962594

Start: 3390501

End: 3390899

Strand: Direct

Name: hmrR [H]

Synonym: Spea_2773

Alternate gene names: 157962594

Gene position: 3390501-3390899 (Clockwise)

Preceding gene: 157962589

Following gene: 157962607

Centisome position: 65.52

GC content: 47.87

Gene sequence:

>399_bases
ATGAGAATTGGGGAAGTTGCAAAATTAACTGGGTTATCGGTCAAGAGTATTCGTTACTACCATGATATTGGACTGGTGCT
TGGCCAACGAGGCGATAACGGTTACCGCGAGTACAGCCAAGGCTCGATTGAGGCGCTGCAGTTTATCCAACACTGCCGCG
CTTTAGGCTTTGCCTTGGAAGATTGTAAGGCGCTGCTCGAGCTACAAAATAACCACAGCCGAAATGCTGCAGATGTGAAA
GCCGTTGCGACTCACCACCTGCAAGATATTGAAAACCGAATAAGCCAACTCAGTATATTAAGAGATCAATTAGCCCAGCT
CATTCACGACTGCCAAGGTGGTGAACAGCCTAACTGCGCCATACTCACAGGCTTAAAACAACCCTGTTCTGCGAAGTGA

Upstream 100 bases:

>100_bases
TCAGAACACTTCCTAATTTGTTTCTTTATAGAATGAAGCGTAATGTCTCCTACAGGGGGAGAGTCAAATATCTAATAGAT
TTAATTTTAGGAGAGAACGG

Downstream 100 bases:

>100_bases
AAAAGCTACCTGCGGCGTAGGTTATCGATATTTTCAATCGCCAAAGCAGGAATACTACCCGCAGGGGTAAAGCCAAAGAT
CTGGCCGTAGAAAGAGAGCT

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 132; Mature: 132

Protein sequence:

>132_residues
MRIGEVAKLTGLSVKSIRYYHDIGLVLGQRGDNGYREYSQGSIEALQFIQHCRALGFALEDCKALLELQNNHSRNAADVK
AVATHHLQDIENRISQLSILRDQLAQLIHDCQGGEQPNCAILTGLKQPCSAK

Sequences:

>Translated_132_residues
MRIGEVAKLTGLSVKSIRYYHDIGLVLGQRGDNGYREYSQGSIEALQFIQHCRALGFALEDCKALLELQNNHSRNAADVK
AVATHHLQDIENRISQLSILRDQLAQLIHDCQGGEQPNCAILTGLKQPCSAK
>Mature_132_residues
MRIGEVAKLTGLSVKSIRYYHDIGLVLGQRGDNGYREYSQGSIEALQFIQHCRALGFALEDCKALLELQNNHSRNAADVK
AVATHHLQDIENRISQLSILRDQLAQLIHDCQGGEQPNCAILTGLKQPCSAK

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=130, Percent_Identity=39.2307692307692, Blast_Score=97, Evalue=3e-22,
Organism=Escherichia coli, GI1789687, Length=133, Percent_Identity=32.3308270676692, Blast_Score=74, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 14611; Mature: 14611

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGEVAKLTGLSVKSIRYYHDIGLVLGQRGDNGYREYSQGSIEALQFIQHCRALGFALE
CCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHH
DCKALLELQNNHSRNAADVKAVATHHLQDIENRISQLSILRDQLAQLIHDCQGGEQPNCA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
ILTGLKQPCSAK
EEECCCCCCCCC
>Mature Secondary Structure
MRIGEVAKLTGLSVKSIRYYHDIGLVLGQRGDNGYREYSQGSIEALQFIQHCRALGFALE
CCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHH
DCKALLELQNNHSRNAADVKAVATHHLQDIENRISQLSILRDQLAQLIHDCQGGEQPNCA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
ILTGLKQPCSAK
EEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]