Click here to switch to the map view.

The map label for this gene is ppiB [H]

Identifier: 157962506

GI number: 157962506

Start: 3273368

End: 3273862

Strand: Direct

Name: ppiB [H]

Synonym: Spea_2685

Alternate gene names: 157962506

Gene position: 3273368-3273862 (Clockwise)

Preceding gene: 157962504

Following gene: 157962507

Centisome position: 63.26

GC content: 42.63

Gene sequence:

>495_bases
ATGATCACATTGCATACCAACCACGGCGAAATCAAACTAGCCCTAAATGCTGAAAAAGCACCAAACACTGCAGCTAACTT
CATTAACTATGTTAAAGAAGGTTTCTACGATGGTACTGTTTTTCACCGTGTAATCGACGGTTTCATGATCCAAGGTGGTG
GTTTCACTGAAGATATGGGTCAAAAGCGTCCTAACGAAACAATTGAAAACGAAGCCAATAACGGTTTATCGAACAAAATC
GGTACTATCGCTATGGCGCGTACTTCTGATCCACATTCAGCGACAGCTCAGTTCTTCATCAACGTTGGCGACAACACTTT
CCTAGACTTTAAGTCTGAGTCTGCGCAAGGCTGGGGTTACTGTGTATTCGGTGAAGTAGTTGAAGGTATGGACGTAGTTA
ACAAGATCAAAGCAGTTAGCACTGGTAACCGTGGCATGCATCAAGATGTTCCTCTTGAGACTGTTATCATCGAAAAAGTG
ACTATCGAAGAGTAA

Upstream 100 bases:

>100_bases
TTAATTCGACAAGCTAAACACACAATGCTTTATGGCATTGGGCAATTACGTTAGAATCCAGCCATAATCGACAACGTATT
AAATAACGAGAGTTTTAAAT

Downstream 100 bases:

>100_bases
TATCCCCTCGATGCGCACTCTATTTGTGGGCGATTTGCACTTAAGTGCAGATCGCCCCGATATTACCCAAGCTTTCCTTG
AATTTCTCGACACTCAACTT

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MITLHTNHGEIKLALNAEKAPNTAANFINYVKEGFYDGTVFHRVIDGFMIQGGGFTEDMGQKRPNETIENEANNGLSNKI
GTIAMARTSDPHSATAQFFINVGDNTFLDFKSESAQGWGYCVFGEVVEGMDVVNKIKAVSTGNRGMHQDVPLETVIIEKV
TIEE

Sequences:

>Translated_164_residues
MITLHTNHGEIKLALNAEKAPNTAANFINYVKEGFYDGTVFHRVIDGFMIQGGGFTEDMGQKRPNETIENEANNGLSNKI
GTIAMARTSDPHSATAQFFINVGDNTFLDFKSESAQGWGYCVFGEVVEGMDVVNKIKAVSTGNRGMHQDVPLETVIIEKV
TIEE
>Mature_164_residues
MITLHTNHGEIKLALNAEKAPNTAANFINYVKEGFYDGTVFHRVIDGFMIQGGGFTEDMGQKRPNETIENEANNGLSNKI
GTIAMARTSDPHSATAQFFINVGDNTFLDFKSESAQGWGYCVFGEVVEGMDVVNKIKAVSTGNRGMHQDVPLETVIIEKV
TIEE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=167, Percent_Identity=31.7365269461078, Blast_Score=84, Evalue=4e-17,
Organism=Homo sapiens, GI7706339, Length=165, Percent_Identity=33.9393939393939, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI22547215, Length=168, Percent_Identity=33.9285714285714, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI22547212, Length=164, Percent_Identity=34.1463414634146, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI7657473, Length=164, Percent_Identity=34.1463414634146, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI24308049, Length=166, Percent_Identity=33.7349397590361, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI310129267, Length=141, Percent_Identity=34.0425531914894, Blast_Score=67, Evalue=6e-12,
Organism=Homo sapiens, GI310120620, Length=141, Percent_Identity=34.0425531914894, Blast_Score=67, Evalue=6e-12,
Organism=Homo sapiens, GI4758950, Length=160, Percent_Identity=33.125, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI10863927, Length=141, Percent_Identity=34.7517730496454, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI310110104, Length=141, Percent_Identity=35.4609929078014, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI64276486, Length=132, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1786736, Length=164, Percent_Identity=67.0731707317073, Blast_Score=231, Evalue=1e-62,
Organism=Escherichia coli, GI1789763, Length=156, Percent_Identity=57.6923076923077, Blast_Score=184, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71980594, Length=164, Percent_Identity=32.3170731707317, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17506311, Length=163, Percent_Identity=33.1288343558282, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71980590, Length=146, Percent_Identity=32.1917808219178, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=170, Percent_Identity=32.3529411764706, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17552780, Length=156, Percent_Identity=35.8974358974359, Blast_Score=73, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17532641, Length=165, Percent_Identity=30.9090909090909, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17506307, Length=156, Percent_Identity=35.8974358974359, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17551282, Length=161, Percent_Identity=33.5403726708075, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17551284, Length=161, Percent_Identity=33.5403726708075, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17539498, Length=139, Percent_Identity=35.2517985611511, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321848, Length=162, Percent_Identity=37.037037037037, Blast_Score=70, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320510, Length=156, Percent_Identity=35.2564102564103, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320359, Length=144, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=8e-12,
Organism=Drosophila melanogaster, GI17986117, Length=168, Percent_Identity=33.3333333333333, Blast_Score=83, Evalue=7e-17,
Organism=Drosophila melanogaster, GI19922376, Length=168, Percent_Identity=30.3571428571429, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24664125, Length=156, Percent_Identity=33.974358974359, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21357783, Length=156, Percent_Identity=33.974358974359, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45549139, Length=141, Percent_Identity=36.8794326241135, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19922912, Length=135, Percent_Identity=34.8148148148148, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24652460, Length=161, Percent_Identity=29.1925465838509, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17647301, Length=155, Percent_Identity=32.9032258064516, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17973; Mature: 17973

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00761 SPASE_I_3 ; PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITLHTNHGEIKLALNAEKAPNTAANFINYVKEGFYDGTVFHRVIDGFMIQGGGFTEDMG
CEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCEEECCCCCCHHHH
QKRPNETIENEANNGLSNKIGTIAMARTSDPHSATAQFFINVGDNTFLDFKSESAQGWGY
CCCCCCHHHHHCCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCEEEEECCCCCCCCEE
CVFGEVVEGMDVVNKIKAVSTGNRGMHQDVPLETVIIEKVTIEE
EEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCC
>Mature Secondary Structure
MITLHTNHGEIKLALNAEKAPNTAANFINYVKEGFYDGTVFHRVIDGFMIQGGGFTEDMG
CEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCEEECCCCCCHHHH
QKRPNETIENEANNGLSNKIGTIAMARTSDPHSATAQFFINVGDNTFLDFKSESAQGWGY
CCCCCCHHHHHCCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCEEEEECCCCCCCCEE
CVFGEVVEGMDVVNKIKAVSTGNRGMHQDVPLETVIIEKVTIEE
EEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2007139; 9278503; 1864365; 9298646; 9600841; 1606970; 8601841 [H]