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The map label for this gene is lpxH

Identifier: 157962507

GI number: 157962507

Start: 3273873

End: 3274589

Strand: Direct

Name: lpxH

Synonym: Spea_2686

Alternate gene names: 157962507

Gene position: 3273873-3274589 (Clockwise)

Preceding gene: 157962506

Following gene: 157962509

Centisome position: 63.27

GC content: 46.44

Gene sequence:

>717_bases
ATGCGCACTCTATTTGTGGGCGATTTGCACTTAAGTGCAGATCGCCCCGATATTACCCAAGCTTTCCTTGAATTTCTCGA
CACTCAACTTCACGATACCGACGCTTTATATATTCTTGGTGATCTTTTTGAAGTATGGGTTGGCGACGATATTGCTGAGC
CTTTTGTCAACCAACTAGTCGATGCCATTAAACACGCCTCTGAAAAGCTGCCTGTTTACTTTATTCACGGTAATAGAGAC
TTTCTCATTGGAGAGGCATTTGCAAAACGCTGCGGTATGACACTATTGCCCGAGGTCTATAGCCTAGACTTATATGGCGT
TTCTACGGTGATCCTACACGGCGATAGCCTATGTACCCTCGATAAGTCTTATCAACGCTTTAGAGCGTTTCGCAATCAGG
GCTGGGCGAAATGGCTGTATGCTCATTTACCGAAGTCTAAACGTCTCGGTATTGCAGCGAAGCTTCGTGCTAAAAGCCAA
AGCAGTAATCAGCAAAAAAGCTATACCATTATGGATGTAGAGCCTGATGCAGTAATGGACCTGCTCGACGCAACCCAAAC
TCAGCAGATGATCCATGGTCACACTCACCGACCTGATATACATCAACTTGCTCACGGCAAACGTCGCATCGTTGTTGGTG
ACTGGTATGAGCAAGGCAGCATGCTAAGTGTCAGTCAAGACGGTGTCGAGCTAATCGAGCTTCCTTTCGGCAAGTAG

Upstream 100 bases:

>100_bases
ATCAAAGCAGTTAGCACTGGTAACCGTGGCATGCATCAAGATGTTCCTCTTGAGACTGTTATCATCGAAAAAGTGACTAT
CGAAGAGTAATATCCCCTCG

Downstream 100 bases:

>100_bases
TTAACTACTTGCCTCTTTATCGACATGCCTATTATTAGCAAGTTCAGCAACAGACCTAAATAGCTGCTAACTCAGTACAG
GTGAGCCACTATGAAACTTA

Product: UDP-2,3-diacylglucosamine hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MRTLFVGDLHLSADRPDITQAFLEFLDTQLHDTDALYILGDLFEVWVGDDIAEPFVNQLVDAIKHASEKLPVYFIHGNRD
FLIGEAFAKRCGMTLLPEVYSLDLYGVSTVILHGDSLCTLDKSYQRFRAFRNQGWAKWLYAHLPKSKRLGIAAKLRAKSQ
SSNQQKSYTIMDVEPDAVMDLLDATQTQQMIHGHTHRPDIHQLAHGKRRIVVGDWYEQGSMLSVSQDGVELIELPFGK

Sequences:

>Translated_238_residues
MRTLFVGDLHLSADRPDITQAFLEFLDTQLHDTDALYILGDLFEVWVGDDIAEPFVNQLVDAIKHASEKLPVYFIHGNRD
FLIGEAFAKRCGMTLLPEVYSLDLYGVSTVILHGDSLCTLDKSYQRFRAFRNQGWAKWLYAHLPKSKRLGIAAKLRAKSQ
SSNQQKSYTIMDVEPDAVMDLLDATQTQQMIHGHTHRPDIHQLAHGKRRIVVGDWYEQGSMLSVSQDGVELIELPFGK
>Mature_238_residues
MRTLFVGDLHLSADRPDITQAFLEFLDTQLHDTDALYILGDLFEVWVGDDIAEPFVNQLVDAIKHASEKLPVYFIHGNRD
FLIGEAFAKRCGMTLLPEVYSLDLYGVSTVILHGDSLCTLDKSYQRFRAFRNQGWAKWLYAHLPKSKRLGIAAKLRAKSQ
SSNQQKSYTIMDVEPDAVMDLLDATQTQQMIHGHTHRPDIHQLAHGKRRIVVGDWYEQGSMLSVSQDGVELIELPFGK

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family

Homologues:

Organism=Escherichia coli, GI1786735, Length=240, Percent_Identity=50, Blast_Score=244, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXH_SHEPA (A8H619)

Other databases:

- EMBL:   CP000851
- RefSeq:   YP_001502541.1
- ProteinModelPortal:   A8H619
- STRING:   A8H619
- GeneID:   5663079
- GenomeReviews:   CP000851_GR
- KEGG:   spl:Spea_2686
- NMPDR:   fig|398579.3.peg.2322
- eggNOG:   COG2908
- HOGENOM:   HBG288883
- OMA:   CHGDTLC
- ProtClustDB:   PRK05340
- BioCyc:   SPEA398579:SPEA_2686-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00575
- InterPro:   IPR004843
- InterPro:   IPR010138
- TIGRFAMs:   TIGR01854

Pfam domain/function: PF00149 Metallophos

EC number: 3.6.1.-

Molecular weight: Translated: 27029; Mature: 27029

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLFVGDLHLSADRPDITQAFLEFLDTQLHDTDALYILGDLFEVWVGDDIAEPFVNQLV
CCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
DAIKHASEKLPVYFIHGNRDFLIGEAFAKRCGMTLLPEVYSLDLYGVSTVILHGDSLCTL
HHHHHHHCCCCEEEEECCCCEEEHHHHHHHCCCCCCCHHHEEEHHCCEEEEEECCCEEEH
DKSYQRFRAFRNQGWAKWLYAHLPKSKRLGIAAKLRAKSQSSNQQKSYTIMDVEPDAVMD
HHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCEEEEECCHHHHHH
LLDATQTQQMIHGHTHRPDIHQLAHGKRRIVVGDWYEQGSMLSVSQDGVELIELPFGK
HHHHHHHHHHHHCCCCCCHHHHHHCCCEEEEEECCCCCCCEEEECCCCCEEEECCCCC
>Mature Secondary Structure
MRTLFVGDLHLSADRPDITQAFLEFLDTQLHDTDALYILGDLFEVWVGDDIAEPFVNQLV
CCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
DAIKHASEKLPVYFIHGNRDFLIGEAFAKRCGMTLLPEVYSLDLYGVSTVILHGDSLCTL
HHHHHHHCCCCEEEEECCCCEEEHHHHHHHCCCCCCCHHHEEEHHCCEEEEEECCCEEEH
DKSYQRFRAFRNQGWAKWLYAHLPKSKRLGIAAKLRAKSQSSNQQKSYTIMDVEPDAVMD
HHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCEEEEECCHHHHHH
LLDATQTQQMIHGHTHRPDIHQLAHGKRRIVVGDWYEQGSMLSVSQDGVELIELPFGK
HHHHHHHHHHHHCCCCCCHHHHHHCCCEEEEEECCCCCCCEEEECCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA