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The map label for this gene is ltaE [H]

Identifier: 157960970

GI number: 157960970

Start: 1378189

End: 1379205

Strand: Direct

Name: ltaE [H]

Synonym: Spea_1142

Alternate gene names: 157960970

Gene position: 1378189-1379205 (Clockwise)

Preceding gene: 157960968

Following gene: 157960978

Centisome position: 26.63

GC content: 45.92

Gene sequence:

>1017_bases
ATGATTGATTTTCGCAGTGATACGGTCACTAAGCCTACGGCTGCTATGCGCGCCGCTATTAGTCAGGCTGAAGTAGGGGA
TGATGTTTATGGCGATGATCCAAGTGTTAACTACCTTGAAGATATGGCCGCAGAGATGTTTGGTTATGATAATGCATTAT
TTACCTCTTCAGGGACTCAAGCAAATTTACTTGCCTTGATGGCACACTGTGAGCGCGGCGATGAATACCTATGTGGTCAA
CAAGCTCATAACTATAAGTTTGAAGGTGGTGGGGCGGCAGTTCTAGGAAGTATCCAGCCACAGCCACTAACAAACCAAGC
TGATGGCAGTATCTTATTAAGCGATATCGAGGCAGCGATTAAGCCCGATGATATTCATTTTGCGCGTACGCGTTTATTGA
GTTTAGAAAATACCATTGGCGGTAAGATAGTCCCGCAGGAATATTTAGCCTCGGCTCAAGCGCTTGCGTTTGAACGCGGT
TTGAAAATTCACTTAGATGGCGCACGTGTGGCTAATGCCGCTGTTGCACAAAATATTCCGATGACCGAAATAACTCAGTA
TTTCGACTCTGTCTCAATCTGTCTATCTAAGGGATTATGTGCGCCAGTAGGCTCGATCCTTCTGGGGGATGAGCGTTTAA
TTACCAAGGCGAGACGCTGGCGTAAAGTGCTTGGTGGCGGTATGCGCCAAGCTGGGATCTTAGCCTCTGCTGCGACGCTT
GCATTGACCGAACAGGTAGAGCGTTTAGCAGAAGATCATGATAATGCTGCTTATCTTGCTGCCGAGCTTGCTTTGATTGA
AGGCTTTGAGGTCGATATGTCACAGGTGCAAACCAATATGGTGTTTGCTGCGGTAAGTGACAAGATTGATACCAAAGCGC
TGGCATTAGAATTGAAAGCTAAAGGTATTTTATTGAGCCCAGGTAAAACGATTCGTTTAGTGACCCATGCCGATATTTCT
AGAGCCGATATCACGTTTTTTATCAGTGAATTAAAGGGACTGCTAAGCCGCGGTTAA

Upstream 100 bases:

>100_bases
TTCTATCAATTGTAAACTTAAGTTTTTTTCTGGTAGTTGGCAGCAGGCCACAGTAATATTGAGCAATATTTGATGATTCC
AGATCTAGAGACTTGAGATA

Downstream 100 bases:

>100_bases
CTTGATTTATTTGATAGCTAAAAATAAAAACCTAGGCAATAGCCTAGGTTTTTTGTTTTTAGCCCTAAACCACCTACTTC
AGTAGGTGGTTATCATCAAT

Product: threonine aldolase

Products: NA

Alternate protein names: Low-specificity L-TA [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MIDFRSDTVTKPTAAMRAAISQAEVGDDVYGDDPSVNYLEDMAAEMFGYDNALFTSSGTQANLLALMAHCERGDEYLCGQ
QAHNYKFEGGGAAVLGSIQPQPLTNQADGSILLSDIEAAIKPDDIHFARTRLLSLENTIGGKIVPQEYLASAQALAFERG
LKIHLDGARVANAAVAQNIPMTEITQYFDSVSICLSKGLCAPVGSILLGDERLITKARRWRKVLGGGMRQAGILASAATL
ALTEQVERLAEDHDNAAYLAAELALIEGFEVDMSQVQTNMVFAAVSDKIDTKALALELKAKGILLSPGKTIRLVTHADIS
RADITFFISELKGLLSRG

Sequences:

>Translated_338_residues
MIDFRSDTVTKPTAAMRAAISQAEVGDDVYGDDPSVNYLEDMAAEMFGYDNALFTSSGTQANLLALMAHCERGDEYLCGQ
QAHNYKFEGGGAAVLGSIQPQPLTNQADGSILLSDIEAAIKPDDIHFARTRLLSLENTIGGKIVPQEYLASAQALAFERG
LKIHLDGARVANAAVAQNIPMTEITQYFDSVSICLSKGLCAPVGSILLGDERLITKARRWRKVLGGGMRQAGILASAATL
ALTEQVERLAEDHDNAAYLAAELALIEGFEVDMSQVQTNMVFAAVSDKIDTKALALELKAKGILLSPGKTIRLVTHADIS
RADITFFISELKGLLSRG
>Mature_338_residues
MIDFRSDTVTKPTAAMRAAISQAEVGDDVYGDDPSVNYLEDMAAEMFGYDNALFTSSGTQANLLALMAHCERGDEYLCGQ
QAHNYKFEGGGAAVLGSIQPQPLTNQADGSILLSDIEAAIKPDDIHFARTRLLSLENTIGGKIVPQEYLASAQALAFERG
LKIHLDGARVANAAVAQNIPMTEITQYFDSVSICLSKGLCAPVGSILLGDERLITKARRWRKVLGGGMRQAGILASAATL
ALTEQVERLAEDHDNAAYLAAELALIEGFEVDMSQVQTNMVFAAVSDKIDTKALALELKAKGILLSPGKTIRLVTHADIS
RADITFFISELKGLLSRG

Specific function: Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates [H]

COG id: COG2008

COG function: function code E; Threonine aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1787095, Length=337, Percent_Identity=54.3026706231454, Blast_Score=370, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI193206522, Length=346, Percent_Identity=41.0404624277457, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI193206520, Length=346, Percent_Identity=41.0404624277457, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI193206524, Length=346, Percent_Identity=41.0404624277457, Blast_Score=243, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6320789, Length=283, Percent_Identity=39.5759717314488, Blast_Score=194, Evalue=1e-50,
Organism=Drosophila melanogaster, GI21355439, Length=299, Percent_Identity=44.4816053511706, Blast_Score=243, Evalue=1e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: =4.1.2.5 [H]

Molecular weight: Translated: 36236; Mature: 36236

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDFRSDTVTKPTAAMRAAISQAEVGDDVYGDDPSVNYLEDMAAEMFGYDNALFTSSGTQ
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCH
ANLLALMAHCERGDEYLCGQQAHNYKFEGGGAAVLGSIQPQPLTNQADGSILLSDIEAAI
HHHHHHHHHHCCCCCCCCCCCCCCEEECCCCEEEEECCCCCCCCCCCCCCEEEECHHHHC
KPDDIHFARTRLLSLENTIGGKIVPQEYLASAQALAFERGLKIHLDGARVANAAVAQNIP
CCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCC
MTEITQYFDSVSICLSKGLCAPVGSILLGDERLITKARRWRKVLGGGMRQAGILASAATL
HHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ALTEQVERLAEDHDNAAYLAAELALIEGFEVDMSQVQTNMVFAAVSDKIDTKALALELKA
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHEEEECCCCCCCHHEEEEEEE
KGILLSPGKTIRLVTHADISRADITFFISELKGLLSRG
CEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIDFRSDTVTKPTAAMRAAISQAEVGDDVYGDDPSVNYLEDMAAEMFGYDNALFTSSGTQ
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCH
ANLLALMAHCERGDEYLCGQQAHNYKFEGGGAAVLGSIQPQPLTNQADGSILLSDIEAAI
HHHHHHHHHHCCCCCCCCCCCCCCEEECCCCEEEEECCCCCCCCCCCCCCEEEECHHHHC
KPDDIHFARTRLLSLENTIGGKIVPQEYLASAQALAFERGLKIHLDGARVANAAVAQNIP
CCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCC
MTEITQYFDSVSICLSKGLCAPVGSILLGDERLITKARRWRKVLGGGMRQAGILASAATL
HHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ALTEQVERLAEDHDNAAYLAAELALIEGFEVDMSQVQTNMVFAAVSDKIDTKALALELKA
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHEEEECCCCCCCHHEEEEEEE
KGILLSPGKTIRLVTHADISRADITFFISELKGLLSRG
CEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]