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The map label for this gene is yjcE [H]

Identifier: 157960886

GI number: 157960886

Start: 1281133

End: 1282419

Strand: Direct

Name: yjcE [H]

Synonym: Spea_1058

Alternate gene names: 157960886

Gene position: 1281133-1282419 (Clockwise)

Preceding gene: 157960885

Following gene: 157960889

Centisome position: 24.76

GC content: 43.05

Gene sequence:

>1287_bases
GTGACTAGTTACGAAATCCTATGCCTGCTATCTGCACTGTCTTTAGTCATTTCGCTTATTTCCTCCCGTTTACATCGCTG
GCAACAGACTATAACGATTACCGCCTTAGCTTTAGGCTTAAGCCTAATAATTTTAATTGCTGGTAAAACTTTTGGTGTAG
AACTCTATTCCACTTTAGTGACCGATTTAGAGCAACTCGATTTTAAAGCGTTATTACTCAATGGAATGTTAGGTTTCTTG
TTGTTTGCAGGGGCCTTGCAGATAAAGCTCAATGTACTCAAACAGCAGAGGTGGGAAATCTTTGTACTCGCCTTTGTCGG
TACCTTGATTTCCACCCTCATTATCGGTGGTTTGCTGTATGTGCTTTCTGGATTTTTAGGCCTACAGCTTAATTTTAGCT
ATTGCCTGTTGTTTGGAGCCTTGATATCTCCTACTGATCCTATTGCTGTGCTGGCGATAATTAAGCAGTTGGGGGCGCCA
GAAGATATCGCAATTCAAGTCGAAGGCGAGTCACTGTTTAATGACGGTATAGGATTAGTTATTTTCGTTGCCATATCTCA
GGTGGCTTTCTCCACAGAGCCGCTAACTTTTGCTGGTGTCAGTGGTTTATTTATTCGTGAGGCGTTAGGTGGACTGCTTT
ATGGCGGGGTGTTAGCTGCGATGCTTCATGGCATGCTGCATTTATCCGAAGATCGTACTCAGTACTTGTTAATGACACTT
TTAGTGCCAAGCGCAGGTTATGTGGGCGCAGATATGCTTGGAGTATCTGGCCCGTTAGCTATGGTGGCATCGGGGATCAT
CATAGGCAATGTCAGTGTACCTAAGTTACTCAAAGAGAGTGAGTGGGAGCATCTTGATAATTTTTGGCTGTTGATTGAGT
CTTTCTTTAACTCATTATTGTTCTTGCTGCTTGGCTTACTCTTGCTACTGATCCATTTTGACGCTGAGCTATGGTGGTTT
ATGTTGCTTTCAGTGCCTATTGTACTCGTTGGCCGCATCATCAGTATCTATCTTCCTTATTTCGGATTTAGGCGCTTTAA
GCGCTATAACTCTTATGCCGAGAAGATATTAGTTTGGGGCGGCCTACGTGGTGGCTTGGCTCTTGCTATGGCAATGAGTT
TACCTACTGGGGTATTGATTATATCTGGTAGCAATATTGATTTGCGTGAGTTACTTATGGTGATGACGTATGCGGTAGTA
GTGTTTTCAATACTCGTTCAAGGAACCACAATTCCAAGCTTAATCGATAAAAGTAACGCTGAGCATGCAGCTCAGCGTAA
ACCTTAA

Upstream 100 bases:

>100_bases
GTGGCCGAGTGTTTAAAGGCTGGTTGAGCCTAATTGAAGGCCGAAAAATCTAACCCTACATATCCTAATACTATATTTAG
AATCAGACTGAGAACCGCCT

Downstream 100 bases:

>100_bases
TCTGTACTAATTTGAACACTTACTCAAGATTCGCTCTGCTCTGACTCATAGCTGTTGCAGGTCATCGCGAGTATTGGCTA
GTGGTACAAATTACCTAATA

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MTSYEILCLLSALSLVISLISSRLHRWQQTITITALALGLSLIILIAGKTFGVELYSTLVTDLEQLDFKALLLNGMLGFL
LFAGALQIKLNVLKQQRWEIFVLAFVGTLISTLIIGGLLYVLSGFLGLQLNFSYCLLFGALISPTDPIAVLAIIKQLGAP
EDIAIQVEGESLFNDGIGLVIFVAISQVAFSTEPLTFAGVSGLFIREALGGLLYGGVLAAMLHGMLHLSEDRTQYLLMTL
LVPSAGYVGADMLGVSGPLAMVASGIIIGNVSVPKLLKESEWEHLDNFWLLIESFFNSLLFLLLGLLLLLIHFDAELWWF
MLLSVPIVLVGRIISIYLPYFGFRRFKRYNSYAEKILVWGGLRGGLALAMAMSLPTGVLIISGSNIDLRELLMVMTYAVV
VFSILVQGTTIPSLIDKSNAEHAAQRKP

Sequences:

>Translated_428_residues
MTSYEILCLLSALSLVISLISSRLHRWQQTITITALALGLSLIILIAGKTFGVELYSTLVTDLEQLDFKALLLNGMLGFL
LFAGALQIKLNVLKQQRWEIFVLAFVGTLISTLIIGGLLYVLSGFLGLQLNFSYCLLFGALISPTDPIAVLAIIKQLGAP
EDIAIQVEGESLFNDGIGLVIFVAISQVAFSTEPLTFAGVSGLFIREALGGLLYGGVLAAMLHGMLHLSEDRTQYLLMTL
LVPSAGYVGADMLGVSGPLAMVASGIIIGNVSVPKLLKESEWEHLDNFWLLIESFFNSLLFLLLGLLLLLIHFDAELWWF
MLLSVPIVLVGRIISIYLPYFGFRRFKRYNSYAEKILVWGGLRGGLALAMAMSLPTGVLIISGSNIDLRELLMVMTYAVV
VFSILVQGTTIPSLIDKSNAEHAAQRKP
>Mature_427_residues
TSYEILCLLSALSLVISLISSRLHRWQQTITITALALGLSLIILIAGKTFGVELYSTLVTDLEQLDFKALLLNGMLGFLL
FAGALQIKLNVLKQQRWEIFVLAFVGTLISTLIIGGLLYVLSGFLGLQLNFSYCLLFGALISPTDPIAVLAIIKQLGAPE
DIAIQVEGESLFNDGIGLVIFVAISQVAFSTEPLTFAGVSGLFIREALGGLLYGGVLAAMLHGMLHLSEDRTQYLLMTLL
VPSAGYVGADMLGVSGPLAMVASGIIIGNVSVPKLLKESEWEHLDNFWLLIESFFNSLLFLLLGLLLLLIHFDAELWWFM
LLSVPIVLVGRIISIYLPYFGFRRFKRYNSYAEKILVWGGLRGGLALAMAMSLPTGVLIISGSNIDLRELLMVMTYAVVV
FSILVQGTTIPSLIDKSNAEHAAQRKP

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI15529998, Length=341, Percent_Identity=26.6862170087977, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI148727259, Length=339, Percent_Identity=24.188790560472, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI194239733, Length=344, Percent_Identity=28.1976744186047, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI27734935, Length=375, Percent_Identity=24, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI5454070, Length=393, Percent_Identity=23.9185750636132, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI14211919, Length=404, Percent_Identity=23.7623762376238, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI27777632, Length=328, Percent_Identity=25.609756097561, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI294997330, Length=358, Percent_Identity=24.0223463687151, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI110227626, Length=358, Percent_Identity=24.0223463687151, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI41872703, Length=452, Percent_Identity=24.5575221238938, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI4759144, Length=348, Percent_Identity=27.0114942528736, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1790501, Length=455, Percent_Identity=28.1318681318681, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71999819, Length=345, Percent_Identity=26.9565217391304, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71999817, Length=345, Percent_Identity=26.9565217391304, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71999821, Length=345, Percent_Identity=26.9565217391304, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71987535, Length=348, Percent_Identity=25.2873563218391, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71987537, Length=348, Percent_Identity=25.2873563218391, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71992107, Length=314, Percent_Identity=23.8853503184713, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71992101, Length=314, Percent_Identity=23.8853503184713, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI25147678, Length=294, Percent_Identity=26.8707482993197, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71980847, Length=345, Percent_Identity=26.0869565217391, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71990924, Length=340, Percent_Identity=25, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71990932, Length=338, Percent_Identity=25.1479289940828, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI25150332, Length=331, Percent_Identity=23.2628398791541, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71993582, Length=288, Percent_Identity=25.6944444444444, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71993590, Length=288, Percent_Identity=25.6944444444444, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=308, Percent_Identity=26.9480519480519, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI221510740, Length=348, Percent_Identity=26.1494252873563, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24585580, Length=348, Percent_Identity=26.1494252873563, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24585578, Length=348, Percent_Identity=26.1494252873563, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI221510734, Length=348, Percent_Identity=26.1494252873563, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI221510738, Length=348, Percent_Identity=26.1494252873563, Blast_Score=95, Evalue=9e-20,
Organism=Drosophila melanogaster, GI281360447, Length=336, Percent_Identity=27.6785714285714, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI281364513, Length=371, Percent_Identity=24.5283018867925, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI221473212, Length=371, Percent_Identity=24.5283018867925, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI221473222, Length=371, Percent_Identity=24.5283018867925, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI221473215, Length=371, Percent_Identity=24.5283018867925, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI221510732, Length=348, Percent_Identity=26.1494252873563, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI221510736, Length=348, Percent_Identity=26.1494252873563, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 46688; Mature: 46556

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSYEILCLLSALSLVISLISSRLHRWQQTITITALALGLSLIILIAGKTFGVELYSTLV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
TDLEQLDFKALLLNGMLGFLLFAGALQIKLNVLKQQRWEIFVLAFVGTLISTLIIGGLLY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLSGFLGLQLNFSYCLLFGALISPTDPIAVLAIIKQLGAPEDIAIQVEGESLFNDGIGLV
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHHCCHHHH
IFVAISQVAFSTEPLTFAGVSGLFIREALGGLLYGGVLAAMLHGMLHLSEDRTQYLLMTL
HHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LVPSAGYVGADMLGVSGPLAMVASGIIIGNVSVPKLLKESEWEHLDNFWLLIESFFNSLL
HHCCCCCCCCHHHCCCCCHHHHHCCCEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHH
FLLLGLLLLLIHFDAELWWFMLLSVPIVLVGRIISIYLPYFGFRRFKRYNSYAEKILVWG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GLRGGLALAMAMSLPTGVLIISGSNIDLRELLMVMTYAVVVFSILVQGTTIPSLIDKSNA
CCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCC
EHAAQRKP
HHHHCCCC
>Mature Secondary Structure 
TSYEILCLLSALSLVISLISSRLHRWQQTITITALALGLSLIILIAGKTFGVELYSTLV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
TDLEQLDFKALLLNGMLGFLLFAGALQIKLNVLKQQRWEIFVLAFVGTLISTLIIGGLLY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLSGFLGLQLNFSYCLLFGALISPTDPIAVLAIIKQLGAPEDIAIQVEGESLFNDGIGLV
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHHCCHHHH
IFVAISQVAFSTEPLTFAGVSGLFIREALGGLLYGGVLAAMLHGMLHLSEDRTQYLLMTL
HHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LVPSAGYVGADMLGVSGPLAMVASGIIIGNVSVPKLLKESEWEHLDNFWLLIESFFNSLL
HHCCCCCCCCHHHCCCCCHHHHHCCCEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHH
FLLLGLLLLLIHFDAELWWFMLLSVPIVLVGRIISIYLPYFGFRRFKRYNSYAEKILVWG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GLRGGLALAMAMSLPTGVLIISGSNIDLRELLMVMTYAVVVFSILVQGTTIPSLIDKSNA
CCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCC
EHAAQRKP
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]