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The map label for this gene is nhaC [H]

Identifier: 157960505

GI number: 157960505

Start: 837389

End: 838807

Strand: Reverse

Name: nhaC [H]

Synonym: Spea_0677

Alternate gene names: 157960505

Gene position: 838807-837389 (Counterclockwise)

Preceding gene: 157960509

Following gene: 157960504

Centisome position: 16.21

GC content: 45.03

Gene sequence:

>1419_bases
TTGTTCCAGCTAGGAGGGCAATGGGAACAATGGTTCGAAGCTAGGTTTAATATAAGAGAGATAACATTGACGACTTCAAA
TAATGCCCCAGAAGCCCAAAACGTAGCAGCAAGCACTGCTCCATCATTTTTAGCCCTAACGCCGCTATTTCTATTTCTAG
CCCTATTTATTGGTGCAGGCGTTTACTTTCAAAGCCAAGGTGTAGACTTTGCCTTTTACCAGTTACCGAGTGTAGTAGCG
ATTCTACCCGCTATTATTTTTGCTATTTTGATTTCAAAGCAAAAGCTTAACCAATCAATAGAAACCTTTTTAAACGGTAT
TGGCCATTCAAATATCATCGCCATGTGTATGATCTATTTGCTGGCTGGCGCCTTTGCTGCGGTAGCAAAAGCCACTGGCG
GTGTCGATGCTACTGTCGCACTGGGTCTATCTTTAGTGCCTTCAAACTTGTTACTACCAGGGTTTTTCGTAATTGCCGCC
TTTATTGCAACCGCGATGGGTACCTCTATGGGCACAATTGCGGCCGTTGCTCCAATTGCTTTAGGCGTTGCTAACGAAGC
ACAAATCGACTTAGCCATCATGGCGGGTGCGGTAATATCGGGGGCACTATTTGGTGATAATTTATCGATTATCTCTGATA
CCACCATTGCAGCCACCCGTACTCAAGGCTGTGAGATGAAAGACAAGTTCAGAGAAAACCTGATCTTCGCCATCCCAGCA
TCAATCATTACCTTAGTGATTTTCACTTTAGCAGGCCAAGGCCAAGCAGATGTAGCAGCGCAAGAGATCGACTTCGTTAA
AGTCATTCCTTACCTAACCATTTTGTTCTTGGCAGTTGCTGGTCTTAACGTATTCGTAGTGCTAACCATAGGTATTTTAT
TGGCGGGTATTACAGGCATCGCCACCATGGATTACGGCGTGATCCAATTCGGTAAAGACATCTATGCCGGTTTTGGTAGC
ATGCAAGAGATCTTTATCCTGTCTATGCTAGTCGGTGGTTTAGCGGCACTAATGCAGCAACAAGGTGGTCTAGCATTTGT
TAGCCAGCAGATTGAAAAACTAATTACACGTTTTTCTAAAGCCAAAGGCGAAGCATCATGCCGCGCATCAGAGCTTGGAA
TGGCCGGTATTGTTGCGGCAACTAACACCTGTGTGGCAAACAACACGGTATCGATTGTAGTTACTGGTGACATTGCAAAA
GATCTTGCCCAAAAACACGGTGTCACGCCAAAGCGTGCAGCCAGCATATTAGATATTTTCTCTTGTATCATTCAGGGTCT
TATCCCATACGGCGCTCAAGCACTACTCGTGGCCTCAACCTTTAGCCTATCTCCATTAGATGTGGTCACCCACGCTTGGT
ACTGTATGATCTTGGCAGTTGTAGCAGTCGTGATAGTGATATTTCGTAAGCGTAAGTAG

Upstream 100 bases:

>100_bases
AAACATCTAGACGTCTAAATTGACAGACGTCTTTCGATCTCATATCCTCTCAACTATTGAGATGTACCATTCTATGATTT
AGCTCAGGCTAATAAGTAGT

Downstream 100 bases:

>100_bases
GCCGTAAACGTAAATAGTCAGCCCATTTAATACATATTGGGTATAAAAGTGAGTTCTGACTCAACGCATTCTATAATCAA
GGAGTACATGAATATGTACT

Product: Na+/H+ antiporter NhaC

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MFQLGGQWEQWFEARFNIREITLTTSNNAPEAQNVAASTAPSFLALTPLFLFLALFIGAGVYFQSQGVDFAFYQLPSVVA
ILPAIIFAILISKQKLNQSIETFLNGIGHSNIIAMCMIYLLAGAFAAVAKATGGVDATVALGLSLVPSNLLLPGFFVIAA
FIATAMGTSMGTIAAVAPIALGVANEAQIDLAIMAGAVISGALFGDNLSIISDTTIAATRTQGCEMKDKFRENLIFAIPA
SIITLVIFTLAGQGQADVAAQEIDFVKVIPYLTILFLAVAGLNVFVVLTIGILLAGITGIATMDYGVIQFGKDIYAGFGS
MQEIFILSMLVGGLAALMQQQGGLAFVSQQIEKLITRFSKAKGEASCRASELGMAGIVAATNTCVANNTVSIVVTGDIAK
DLAQKHGVTPKRAASILDIFSCIIQGLIPYGAQALLVASTFSLSPLDVVTHAWYCMILAVVAVVIVIFRKRK

Sequences:

>Translated_472_residues
MFQLGGQWEQWFEARFNIREITLTTSNNAPEAQNVAASTAPSFLALTPLFLFLALFIGAGVYFQSQGVDFAFYQLPSVVA
ILPAIIFAILISKQKLNQSIETFLNGIGHSNIIAMCMIYLLAGAFAAVAKATGGVDATVALGLSLVPSNLLLPGFFVIAA
FIATAMGTSMGTIAAVAPIALGVANEAQIDLAIMAGAVISGALFGDNLSIISDTTIAATRTQGCEMKDKFRENLIFAIPA
SIITLVIFTLAGQGQADVAAQEIDFVKVIPYLTILFLAVAGLNVFVVLTIGILLAGITGIATMDYGVIQFGKDIYAGFGS
MQEIFILSMLVGGLAALMQQQGGLAFVSQQIEKLITRFSKAKGEASCRASELGMAGIVAATNTCVANNTVSIVVTGDIAK
DLAQKHGVTPKRAASILDIFSCIIQGLIPYGAQALLVASTFSLSPLDVVTHAWYCMILAVVAVVIVIFRKRK
>Mature_472_residues
MFQLGGQWEQWFEARFNIREITLTTSNNAPEAQNVAASTAPSFLALTPLFLFLALFIGAGVYFQSQGVDFAFYQLPSVVA
ILPAIIFAILISKQKLNQSIETFLNGIGHSNIIAMCMIYLLAGAFAAVAKATGGVDATVALGLSLVPSNLLLPGFFVIAA
FIATAMGTSMGTIAAVAPIALGVANEAQIDLAIMAGAVISGALFGDNLSIISDTTIAATRTQGCEMKDKFRENLIFAIPA
SIITLVIFTLAGQGQADVAAQEIDFVKVIPYLTILFLAVAGLNVFVVLTIGILLAGITGIATMDYGVIQFGKDIYAGFGS
MQEIFILSMLVGGLAALMQQQGGLAFVSQQIEKLITRFSKAKGEASCRASELGMAGIVAATNTCVANNTVSIVVTGDIAK
DLAQKHGVTPKRAASILDIFSCIIQGLIPYGAQALLVASTFSLSPLDVVTHAWYCMILAVVAVVIVIFRKRK

Specific function: Is a secondary, electrogenic Na(+)/H(+) antiporter that catalyzes Na(+) uptake and proton efflux. Makes modest contributions to pH homeostasis in the alkaline range of pH but is not contributor to Na(+) resistance. Appears to have a repressive effect on g

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 49627; Mature: 49627

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQLGGQWEQWFEARFNIREITLTTSNNAPEAQNVAASTAPSFLALTPLFLFLALFIGAG
CCCCCCCHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
VYFQSQGVDFAFYQLPSVVAILPAIIFAILISKQKLNQSIETFLNGIGHSNIIAMCMIYL
CEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LAGAFAAVAKATGGVDATVALGLSLVPSNLLLPGFFVIAAFIATAMGTSMGTIAAVAPIA
HHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LGVANEAQIDLAIMAGAVISGALFGDNLSIISDTTIAATRTQGCEMKDKFRENLIFAIPA
HCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCEEEECCCCCCCHHHHHHHCEEEEHHH
SIITLVIFTLAGQGQADVAAQEIDFVKVIPYLTILFLAVAGLNVFVVLTIGILLAGITGI
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATMDYGVIQFGKDIYAGFGSMQEIFILSMLVGGLAALMQQQGGLAFVSQQIEKLITRFSK
HHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AKGEASCRASELGMAGIVAATNTCVANNTVSIVVTGDIAKDLAQKHGVTPKRAASILDIF
CCCCCCCCHHHCCCHHHHHHCCCEEECCEEEEEEECHHHHHHHHHCCCCHHHHHHHHHHH
SCIIQGLIPYGAQALLVASTFSLSPLDVVTHAWYCMILAVVAVVIVIFRKRK
HHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFQLGGQWEQWFEARFNIREITLTTSNNAPEAQNVAASTAPSFLALTPLFLFLALFIGAG
CCCCCCCHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
VYFQSQGVDFAFYQLPSVVAILPAIIFAILISKQKLNQSIETFLNGIGHSNIIAMCMIYL
CEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LAGAFAAVAKATGGVDATVALGLSLVPSNLLLPGFFVIAAFIATAMGTSMGTIAAVAPIA
HHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LGVANEAQIDLAIMAGAVISGALFGDNLSIISDTTIAATRTQGCEMKDKFRENLIFAIPA
HCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCEEEECCCCCCCHHHHHHHCEEEEHHH
SIITLVIFTLAGQGQADVAAQEIDFVKVIPYLTILFLAVAGLNVFVVLTIGILLAGITGI
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATMDYGVIQFGKDIYAGFGSMQEIFILSMLVGGLAALMQQQGGLAFVSQQIEKLITRFSK
HHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AKGEASCRASELGMAGIVAATNTCVANNTVSIVVTGDIAKDLAQKHGVTPKRAASILDIF
CCCCCCCCHHHCCCHHHHHHCCCEEECCEEEEEEECHHHHHHHHHCCCCHHHHHHHHHHH
SCIIQGLIPYGAQALLVASTFSLSPLDVVTHAWYCMILAVVAVVIVIFRKRK
HHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 10903309; 11274110 [H]