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The map label for this gene is serA [H]

Identifier: 157960460

GI number: 157960460

Start: 781736

End: 782965

Strand: Reverse

Name: serA [H]

Synonym: Spea_0631

Alternate gene names: 157960460

Gene position: 782965-781736 (Counterclockwise)

Preceding gene: 157960468

Following gene: 157960459

Centisome position: 15.13

GC content: 49.02

Gene sequence:

>1230_bases
ATGGCGAAACACTCGCTGGACAAGGATAGAATTAAGATCCTGCTGTTGGAAGGCGTCCACCAATCTGCGGTAGATGTGTT
TGAACGTGCGGGTTACACCAACATTGAATATCACAAAGCATCACTAGCAGAAGATGAATTACACGCTGCTGTAAAAGATG
CACACTTCATTGGTATCCGCTCCCGTACCCAATTGACTGAAGAAGTATTATCCCAAGCCGACAAACTCGTTGGTATTGGT
TGTTTCTGTATCGGCACCAACCAAGTCAGTCTCGCAGCGGCTGAAAAACTGGGGATCCCAGTATTCAACGCACCATTCTC
AAATACGCGCAGCGTAGCTGAGCTGGTATTGGGCGAAATCATCATGTTACTGCGCGGGATCCCGCAGCGTAATGCTTTGG
CTCATCGCGGCGGCTGGCTAAAGAGCGCTTCAGGTAGCTTTGAAGCTCGCGGTAAAACATTAGGTGTTATCGGCTACGGC
CATATTGGTACCCAGCTTGGTATTCTTGCTGAAACACTTGGTATGCGCGTTGTGTTCTTCGATATTGAAGATAAGCTACC
GCTAGGTAACGCCCAGCAAGTACACTCACTACAGCAACTGCTATCGATTGCCGATGTAGTCAGTTTGCACGTACCAGAAA
CAGCACAGACAAAAGAGATGATAGGTCACGAAGAACTGGCCAGCATGCGTAAAGGCAGCATTCTGATCAATGCCTCTCGC
GGTACTGTGGTCGATATCGACGCTCTAGCCGCCTCATTAAAAGAGGAACATCTGGCGGGCGCGGCAATTGACGTATTCCC
TGTTGAGCCAAAGTCGAATGATGACGAATTCCTTAGCCCACTCCGCGGCCTAGATAACGTGCTACTGACCCCACATGTTG
GCGGCAGCACGGCGGAAGCACAGGAAAATATCGGTATCGAAGTTGCGGGTAAGCTAGCTAAATACTCAGACAATGGTTCA
ACTATGACGGCGGTTAACTTCCCTGAAGTGTCGCTCGCTCAACACTCTGGTACGTCGCGCTTACTGCATATTCATCGTAA
CCGTCCGGGTATTCTTATCCAGATTAACTCGGCATTTGCAGAAAAAGGCATCAACATTGCTGCTCAGTATCTACAGACCA
CCGCTGAAATTGGTTACGTAGTAATGGAAGTCGATTCTGATAAGGCTGATGAAGCGCTTGTCGAGATGCAAGCGATTGAA
GGCACGATTAGAACTCGCCTGCTTCACTGA

Upstream 100 bases:

>100_bases
ACAGTCTATACCCAAACCACTCCTACAACGTAGAGTTTAGTCGTCTCTGCGGTGGCATTAAGTATACATAATACAAATAA
ACTAAAAGGGTACATAAATC

Downstream 100 bases:

>100_bases
TATTTTAGTGATGCAAAGCCGATATAATCAGCCATAAAATAAGGCCGTATAATTCACTTTATACGGCCTTTATTTTTTAT
CTCTTATACCAATCAGTATA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MAKHSLDKDRIKILLLEGVHQSAVDVFERAGYTNIEYHKASLAEDELHAAVKDAHFIGIRSRTQLTEEVLSQADKLVGIG
CFCIGTNQVSLAAAEKLGIPVFNAPFSNTRSVAELVLGEIIMLLRGIPQRNALAHRGGWLKSASGSFEARGKTLGVIGYG
HIGTQLGILAETLGMRVVFFDIEDKLPLGNAQQVHSLQQLLSIADVVSLHVPETAQTKEMIGHEELASMRKGSILINASR
GTVVDIDALAASLKEEHLAGAAIDVFPVEPKSNDDEFLSPLRGLDNVLLTPHVGGSTAEAQENIGIEVAGKLAKYSDNGS
TMTAVNFPEVSLAQHSGTSRLLHIHRNRPGILIQINSAFAEKGINIAAQYLQTTAEIGYVVMEVDSDKADEALVEMQAIE
GTIRTRLLH

Sequences:

>Translated_409_residues
MAKHSLDKDRIKILLLEGVHQSAVDVFERAGYTNIEYHKASLAEDELHAAVKDAHFIGIRSRTQLTEEVLSQADKLVGIG
CFCIGTNQVSLAAAEKLGIPVFNAPFSNTRSVAELVLGEIIMLLRGIPQRNALAHRGGWLKSASGSFEARGKTLGVIGYG
HIGTQLGILAETLGMRVVFFDIEDKLPLGNAQQVHSLQQLLSIADVVSLHVPETAQTKEMIGHEELASMRKGSILINASR
GTVVDIDALAASLKEEHLAGAAIDVFPVEPKSNDDEFLSPLRGLDNVLLTPHVGGSTAEAQENIGIEVAGKLAKYSDNGS
TMTAVNFPEVSLAQHSGTSRLLHIHRNRPGILIQINSAFAEKGINIAAQYLQTTAEIGYVVMEVDSDKADEALVEMQAIE
GTIRTRLLH
>Mature_408_residues
AKHSLDKDRIKILLLEGVHQSAVDVFERAGYTNIEYHKASLAEDELHAAVKDAHFIGIRSRTQLTEEVLSQADKLVGIGC
FCIGTNQVSLAAAEKLGIPVFNAPFSNTRSVAELVLGEIIMLLRGIPQRNALAHRGGWLKSASGSFEARGKTLGVIGYGH
IGTQLGILAETLGMRVVFFDIEDKLPLGNAQQVHSLQQLLSIADVVSLHVPETAQTKEMIGHEELASMRKGSILINASRG
TVVDIDALAASLKEEHLAGAAIDVFPVEPKSNDDEFLSPLRGLDNVLLTPHVGGSTAEAQENIGIEVAGKLAKYSDNGST
MTAVNFPEVSLAQHSGTSRLLHIHRNRPGILIQINSAFAEKGINIAAQYLQTTAEIGYVVMEVDSDKADEALVEMQAIEG
TIRTRLLH

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=361, Percent_Identity=30.7479224376731, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI145580578, Length=253, Percent_Identity=34.3873517786561, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI4557499, Length=253, Percent_Identity=34.3873517786561, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI145580575, Length=253, Percent_Identity=34.3873517786561, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI61743967, Length=263, Percent_Identity=31.9391634980989, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI4557497, Length=263, Percent_Identity=31.9391634980989, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI6912396, Length=274, Percent_Identity=24.8175182481752, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1789279, Length=411, Percent_Identity=68.3698296836983, Blast_Score=575, Evalue=1e-165,
Organism=Escherichia coli, GI1787645, Length=237, Percent_Identity=31.6455696202532, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI87082289, Length=251, Percent_Identity=29.0836653386454, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1788660, Length=310, Percent_Identity=27.741935483871, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=328, Percent_Identity=33.5365853658537, Blast_Score=161, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI25147481, Length=252, Percent_Identity=28.968253968254, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322116, Length=388, Percent_Identity=50.2577319587629, Blast_Score=383, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6320925, Length=414, Percent_Identity=48.3091787439614, Blast_Score=382, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6324055, Length=230, Percent_Identity=26.9565217391304, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324964, Length=256, Percent_Identity=25.78125, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19921140, Length=301, Percent_Identity=31.5614617940199, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24646446, Length=260, Percent_Identity=31.1538461538462, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646448, Length=260, Percent_Identity=31.1538461538462, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646452, Length=260, Percent_Identity=31.1538461538462, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646450, Length=260, Percent_Identity=31.1538461538462, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI62472511, Length=260, Percent_Identity=31.1538461538462, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28574286, Length=264, Percent_Identity=27.2727272727273, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28571528, Length=297, Percent_Identity=26.2626262626263, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45552429, Length=257, Percent_Identity=26.4591439688716, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24585514, Length=257, Percent_Identity=26.4591439688716, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28574282, Length=257, Percent_Identity=26.4591439688716, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28574284, Length=257, Percent_Identity=26.4591439688716, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45551003, Length=257, Percent_Identity=26.4591439688716, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24585516, Length=301, Percent_Identity=22.9235880398671, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44051; Mature: 43920

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKHSLDKDRIKILLLEGVHQSAVDVFERAGYTNIEYHKASLAEDELHAAVKDAHFIGIR
CCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCEEHHHHCCHHHHHHHHHHHEEEEEC
SRTQLTEEVLSQADKLVGIGCFCIGTNQVSLAAAEKLGIPVFNAPFSNTRSVAELVLGEI
HHHHHHHHHHHHHHHEEEEEEEEEECCCEEEHHHHHCCCCEECCCCCCHHHHHHHHHHHH
IMLLRGIPQRNALAHRGGWLKSASGSFEARGKTLGVIGYGHIGTQLGILAETLGMRVVFF
HHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCEEEEE
DIEDKLPLGNAQQVHSLQQLLSIADVVSLHVPETAQTKEMIGHEELASMRKGSILINASR
ECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCHHHHHHHCCCCEEEECCC
GTVVDIDALAASLKEEHLAGAAIDVFPVEPKSNDDEFLSPLRGLDNVLLTPHVGGSTAEA
CCEEEHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCH
QENIGIEVAGKLAKYSDNGSTMTAVNFPEVSLAQHSGTSRLLHIHRNRPGILIQINSAFA
HHCCCEEEECCHHEECCCCCEEEEECCCCCCHHHCCCCCEEEEEECCCCCEEEEECHHHH
EKGINIAAQYLQTTAEIGYVVMEVDSDKADEALVEMQAIEGTIRTRLLH
HCCHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKHSLDKDRIKILLLEGVHQSAVDVFERAGYTNIEYHKASLAEDELHAAVKDAHFIGIR
CCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCEEHHHHCCHHHHHHHHHHHEEEEEC
SRTQLTEEVLSQADKLVGIGCFCIGTNQVSLAAAEKLGIPVFNAPFSNTRSVAELVLGEI
HHHHHHHHHHHHHHHEEEEEEEEEECCCEEEHHHHHCCCCEECCCCCCHHHHHHHHHHHH
IMLLRGIPQRNALAHRGGWLKSASGSFEARGKTLGVIGYGHIGTQLGILAETLGMRVVFF
HHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCEEEEE
DIEDKLPLGNAQQVHSLQQLLSIADVVSLHVPETAQTKEMIGHEELASMRKGSILINASR
ECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCHHHHHHHCCCCEEEECCC
GTVVDIDALAASLKEEHLAGAAIDVFPVEPKSNDDEFLSPLRGLDNVLLTPHVGGSTAEA
CCEEEHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCH
QENIGIEVAGKLAKYSDNGSTMTAVNFPEVSLAQHSGTSRLLHIHRNRPGILIQINSAFA
HHCCCEEEECCHHEECCCCCEEEEECCCCCCHHHCCCCCEEEEEECCCCCEEEEECHHHH
EKGINIAAQYLQTTAEIGYVVMEVDSDKADEALVEMQAIEGTIRTRLLH
HCCHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]